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Deletion of a 1,049 bp sequence from the 5′UTR upstream of the SiHEC3 gene induces a seed non-shattering mutation in sesame

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Journal of Integrative Agriculture 2024年第8期23卷 2589-2604页

作者： Ming Ju Guiting Li Qiuzhen Tian Hengchun Cao Qin Ma Yinghui Duan Hui Guo Zhanyou Zhang Yingying Huang huili wang Haiyang Zhang Hongmei Miao The Shennong Laboratory Zhengzhou 450002China Henan Sesame Research Center Henan Academy of Agricultural SciencesZhengzhou 450002China Key Laboratory of Specific Oilseed Crops Genomics of Henan Province Henan Sesame Research CenterHenan Academy of Agricultural SciencesZhengzhou 450002China

Sesame is a labor intensive crop with limited mechanized harvesting mainly due to the seed shattering(SS)*** this study,we performed a genetic analysis of the seed-shattering resistance(SR)trait with a SR sesame mutant *** the SS type,the parenchyma cells in the abscission zone of the 12M07 mutant are arranged loosely but adhere to the seed *** analysis of six generations derived from 12M07(SR)×Xiangcheng Dazibai(SS)showed that the SR trait is recessive and controlled by a single gene *** mapping of the F2population with 888,619 variants(single-nucleotide polymorphisms(SNPs)and insertion-deletion(InDels))and 31,884 structural variations(SVs)determined that only SV12002 in the 5′upstream region of gene Sindi0765000(named SiHEC3)in Chr.3 was significantly associated with the SR ***3 encodes the bHLH transcription factor.A 1,049 bp deletion occurred in the 5′UTR of Sihec3 in ***3 is mainly expressed in developing placental tissues,with the expression peaking in capsules at 45 days after pollination.A dual-luciferase reporter assay in tobacco confirmed that the promoter activity of Sihec3 was reduced because of the deletion of the 1,049 bp promoter ***–protein interaction network analysis showed that HEC3 is co-expressed with nine key proteins,such as SHATTERPROOF1(SHP1)and SEEDSTICK(STK)which participate in the secondary wall biosynthesis of the abscission layer in *** findings of this study show the important function of Sihec3corresponding with the SR trait and supply the genetic information for breeding new varieties that are amenable to mechanized harvesting in sesame and other crops.

关键词： sesame(Sesamum indicum L.) association mapping seed shattering structure variation bHLH transcription factor

Gene replacement therapy in Bietti crystalline corneoretinal dystrophy:an open-label,single-arm,exploratory trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2275-2284页

作者： Jinyuan wang Jinlu Zhang Shicheng Yu Hongyan Li Shaohong Chen Jingting Luo Haibo wang Yuxia Guan Haihan Zhang Shiyi Yin huili wang Heping Li Junle Liu Jingyuan Zhu Qiong Yang Ying Sha Chuan Zhang Yuhang Yang Xuan Yang Xifang Zhang Xiuli Zhao Likun wang Liping Yang Wenbin Wei Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical University100730 BeijingChina School of Clinical Medicine Tsinghua University100084 BeijingChina Chigenovo Co. Ltd.102206 BeijingChina Department of Ophthalmology Peking University Third HospitalBeijing Key Laboratory of Restoration of Damaged Ocular NervePeking University Third Hospital100191 BeijingChina Department of Ophthalmology The Third People’s Hospital of Dalian116091 DalianChina Department of Biomedical Informatics School of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina Institute of Systems Biomedicine Department of PathologySchool of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina

Bietti crystalline corneoretinal dystrophy is an inherited retinal disease caused by mutations in CYP4V2,which results in blindness in the working-age population,and there is currently no available ***,we report the results of the first-in-human clinical trial(NCT04722107)of gene therapy for Bietti crystalline corneoretinal dystrophy,including 12 participants who were followed up for 180-365 *** open-label,single-arm exploratory trial aimed to assess the safety and efficacy of a recombinant adeno-associated-virus-serotype-2/8 vector encoding the human CYP4V2 protein(rAAV2/8-hCYP4V2).Participants received a single unilateral subretinal injection of 7.5×10^(10)vector genomes of rAAV2/***,73 treatment-emergent adverse events were reported,with the majority(98.6%)being of mild or moderate intensity and considered to be procedure-or corticosteroid-related;no treatment-related serious adverse events or local/systemic immune toxicities were *** with that measured at baseline,77.8%of the treated eyes showed improvement in best-corrected visual acuity(BCVA)on day 180,with a mean±standard deviation increase of 9.0±10.8 letters in the 9 eyes analyzed(p=0.021).By day 365,80%of the treated eyes showed an increase in BCVA,with a mean increase of 11.0±10.6 letters in the 5 eyes assessed(p=0.125).Importantly,the patients’improvement observed using multifocal electroretinogram,microperimetry,and Visual Function Questionnaire-25 further supported the beneficial effects of the *** conclude that the favorable safety profile and visual improvements identified in this trial encourage the continued development of rAAV2/8-hCYP4V2(named ZVS101e).

关键词： cor dystrophy crystalline

Embodied Meaning in Comprehending Abstract Chinese Counterfactuals

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Chinese Journal of Applied Linguistics 2024年第3期47卷 414-432,524页

作者： Xueyan LI Yahui ZHAO huili wang Xue ZHANG School of Foreign Languages Dalian University of Technology School of Foreign Languages Hangzhou City University Hangzhou Collaborative Innovation Institute of Language Services School of Foreign Languages Dalian Polytechnic University

Embodied cognition theories propose that language comprehension triggers a sensorimotor system in the ***,most previous research has paid much attention to concrete and factual sentences,and little emphasis has been put on the research of abstract and counterfactual *** primary challenges for embodied theories lie in elucidating the meanings of abstract and counterfactual *** most prevalent explanation is that abstract and counterfactual sentences are grounded in the activation of a sensorimotor system,in exactly the same way as concrete and factual *** present research employed a dual-task experimental paradigm to investigate whether the embodied meaning is activated in comprehending action-related abstract Chinese counterfactual sentences through the presence or absence of action-sentence compatibility effect(ACE).Participants were instructed to read and listen to the action-related abstract Chinese factual or counterfactual sentences describing an abstract transfer word towards or away from them,and then move their fingers towards or away from them to press the buttons in the same direction as the motion cue of the transfer *** action-sentence compatibility effect was observed in both abstract factual and counterfactual sentences,in line with the embodied cognition theories,which indicated that the embodied meanings were activated in both action-related abstract factuals and counterfactuals.

关键词： action-sentence compatibility effect embodiment abstract counterfactuals language comprehension

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三腹板预制U形节段梁吊装工况受力性能研究

隧道与轨道交通 2024年第1期 44-46,81,82页

作者：王会丽上海公路桥梁(集团)有限公司

预制U形节段梁为大开口薄壁构件,是一种梁、板组合的空间结构,但其空间受力效应明显,剪滞效应使得断面上的应力分布复杂。依托“轨道交通预制节段双线薄壁槽型梁设计施工关键技术研究”项目,运用有限元软件对三腹板预制U形梁不同方案下... 详细信息

预制U形节段梁为大开口薄壁构件,是一种梁、板组合的空间结构,但其空间受力效应明显,剪滞效应使得断面上的应力分布复杂。依托“轨道交通预制节段双线薄壁槽型梁设计施工关键技术研究”项目,运用有限元软件对三腹板预制U形梁不同方案下的吊装工况进行了模拟分析,研究了三腹板预制U形梁在吊装阶段的应力状态。通过吊腹板和吊底板等不同吊装方案的比选,最终确定了合理的吊点布设方案,并为后续施工提供了指导建议。

关键词：三腹板预制U形节段梁吊装受力性能

低频神经肌肉治疗仪联合盆底持续性强化训练对自然分娩初产妇康复情况的影响

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临床医学研究与实践 2024年第4期9卷 179-182页

作者：王慧丽商丘市中医院河南商丘476000

目的探讨低频神经肌肉治疗仪联合盆底持续性强化训练对自然分娩初产妇康复情况的影响。方法选取2019年1月至2022年6月于我院自然分娩的80例初产妇为研究对象,采用随机数字表法将其分为对照组与康复组,每组40例。对照组接受常规护理,康... 详细信息

目的探讨低频神经肌肉治疗仪联合盆底持续性强化训练对自然分娩初产妇康复情况的影响。方法选取2019年1月至2022年6月于我院自然分娩的80例初产妇为研究对象,采用随机数字表法将其分为对照组与康复组,每组40例。对照组接受常规护理,康复组在常规护理基础上接受低频神经肌肉治疗仪联合盆底持续性强化训练。比较两组的干预效果。结果干预后,康复组的Ⅰ类、Ⅱ类肌纤维肌力的持续收缩压大于对照组,收缩持续时间长于对照组(P<0.05)。干预后,康复组的膀胱颈移动度、膀胱尿道后角及肛提裂孔面积小于对照组(P<0.05)。干预后,康复组的女性性功能指数(FSFI)评分高于对照组,盆底功能障碍问卷-20(PFDI-20)评分低于对照组(P<0.05)。结论低频神经肌肉治疗仪联合盆底持续性强化训练可明显改善自然分娩初产妇的盆底结构,提高盆底肌力。

关键词：自然分娩初产妇低频神经肌肉治疗仪盆底持续性强化训练康复情况

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戏剧融入高校美育的应用路径研究

洛阳师范学院学报 2024年第1期43卷 80-83页

作者：王惠丽洛阳师范学院文学院河南洛阳471934

戏剧是促进高校美育发展的一个重要载体,戏剧融入高校美育不仅丰富了美育教学内容、教学方法和美学理论,还能促进学生正确价值观的建立,开阔其艺术知识视野,提高学生审美能力。部分高校过多重视智育教育,存在对美育重视不够、美育师资... 详细信息

戏剧是促进高校美育发展的一个重要载体,戏剧融入高校美育不仅丰富了美育教学内容、教学方法和美学理论,还能促进学生正确价值观的建立,开阔其艺术知识视野,提高学生审美能力。部分高校过多重视智育教育,存在对美育重视不够、美育师资力量薄弱以及美育课程设置不合理等问题。戏剧具有教育性、趣味性、艺术性等特征,是促进高校美育发展的一个重要途径。将戏剧融入高校美育应在课程设置上细分化和系统化,将戏剧作品进一步精品化、经典化,并借助多媒体、互联网开拓多样的教学方式,开展多元的戏剧实践活动,以构建智慧化美育设施,形成戏剧美育新生态。

关键词：高校美育戏剧路径

煤电行业建设项目碳排放环境影响评价技术方法研究:以黄河流域为例

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环境科学研究 2024年第1期37卷 180-189页

作者：王慧丽郑逸璇宋晓晖王圣陈潇君严刚生态环境部环境规划院北京100012 国电环境保护研究院江苏南京210031

煤电行业是黄河流域内二氧化碳和大气污染物排放的主要来源,将煤电行业碳排放影响评价纳入环境影响评价体系,能够有效助推黄河流域实现减污降碳协同增效.本文以煤电行业碳排放主要影响因素为基础,设计了能够涵盖碳排放全过程的评价指标... 详细信息

煤电行业是黄河流域内二氧化碳和大气污染物排放的主要来源,将煤电行业碳排放影响评价纳入环境影响评价体系,能够有效助推黄河流域实现减污降碳协同增效.本文以煤电行业碳排放主要影响因素为基础,设计了能够涵盖碳排放全过程的评价指标体系,并结合先进技术、标准规范要求等设定差异化评价基准,构建以约束评价为主、兼顾指导性评价的评价方法,并采用评价方法中的核心评价指标碳排放绩效,对黄河流域现役煤电机组和“十四五”期间新增煤电机组进行碳减排潜力分析.结果表明,通过优化项目设计可实现流域内现役煤电机组碳排放量下降12.7%,“十四五”期间新建煤电机组碳排放增量下降27.1%,其中新增煤电机组装机占比较高的内蒙古自治区、陕西省可实现新增煤电机组碳排放分别下降30.7%和23.0%.研究显示,黄河流域内碳减排潜力大,建议针对黄河流域内碳排放绩效水平较差的特点,从燃煤小机组淘汰、低碳清洁燃料替代等方式推动煤电行业综合治理,建立协同技术相关指标数据管理台账,出台火电行业碳排放影响评价指南,为煤电行业新增建设项目减污降碳协同增效提供有力有效的政策工具.

关键词：煤电行业黄河流域碳排放影响评价减污降碳协同增效碳排放绩效

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Ca同位素地球化学及其地质应用

江西科学 2024年第2期42卷 326-331页

作者：王慧丽曹俊东华理工大学地球科学学院南昌330013

Ca作为主要的造岩元素,在各类地质过程均能显示出不同程度的分馏,使之成为研究不同地质过程的潜在地球化学指标和示踪剂。随着分析技术的发展,作为新兴的Ca同位素被越来越多地应用于地质学的不同领域,尤其在近十年取得了丰富的研究成果... 详细信息

Ca作为主要的造岩元素,在各类地质过程均能显示出不同程度的分馏,使之成为研究不同地质过程的潜在地球化学指标和示踪剂。随着分析技术的发展,作为新兴的Ca同位素被越来越多地应用于地质学的不同领域,尤其在近十年取得了丰富的研究成果。在简要介绍Ca同位素标准物质和分析方法的基础上,详细阐述了Ca同位素在地质学3个领域方面的应用,包括:1)Ca同位素在行星地质方面的应用,探究陨石、月球等天体成因与演化过程以及早期地球特征;2)Ca同位素在深部地质过程方面的应用,可有效示踪地幔交代、大陆俯冲和深部碳循环等;3)Ca同位素在低温过程方面的应用,重建海水演化和河流、地下水与冷泉系统。通过上述重要地质过程中研究成果的系统总结,旨在加深对Ca同位素体系的深入理解,并对Mg-K-Ca多元同位素联合示踪的应用进行了展望。

关键词： Ca同位素行星地质深部地质过程低温过程多元联合示踪

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油松高世代种子园亲本选择策略研究

北京林业大学学报 2024年第4期46卷 28-39页

作者：孙凡马彦广刘占民杨博宁王辉丽李伟北京林业大学生物科学与技术学院林木遗传育种全国实验室林木育种与生态修复国家工程研究中心北京100083 山西省吕梁山国有林管理局油松种子园山西临汾041300 平泉市国有七沟林场河北承德067509

【目的】通过油松高世代种子园建园亲本2种选择策略的对比与评价,为高世代高产稳产油松建园亲本选择策略的确定提供科学依据。【方法】以山西省隰县上庄油松初级种子园自由授粉子代测定林为基本群体,对42个油松半同胞家系的生长性状进... 详细信息

【目的】通过油松高世代种子园建园亲本2种选择策略的对比与评价,为高世代高产稳产油松建园亲本选择策略的确定提供科学依据。【方法】以山西省隰县上庄油松初级种子园自由授粉子代测定林为基本群体,对42个油松半同胞家系的生长性状进行遗传变异分析,采用配合选择策略和最优单株直接选择策略筛选油松第二代种子园建园亲本,对比分析两种选择策略下,筛选出的优良单株的各性状平均生长量和平均预期遗传增益。【结果】油松半同胞家系间和家系内胸径、树高和材积生长均达到了极显著差异水平(P<0.01),配合选择策略与最优单株直接选择策略分别选出30个优良单株,其中有19个相同、11个不同。最优单株直接选择策略所筛选的11个特有优良单株的平均胸径、树高和材积生长量分别高出配合选择策略所筛选的11个特有优良单株7.72%、18.56%和31.01%,所筛选的30个优良单株的平均胸径、树高和材积的预期遗传增益比配合选择策略筛选的30个优良单株分别增加了15.52%、121.78%和29.38%。与每一优良家系入选1个优良单株的配合选择策略不同,最优单株直接选择策略筛选出的30个优良单株中,有29个优良单株分属于19个优良家系,另外1个优良单株(D12)属于非优良家系。【结论】配合选择策略会导致部分优良单株资源损失,最优单株直接选择策略更适合用于油松高世代种子园亲本材料的筛选。

关键词：油松高世代种子园亲本配合选择优良单株选择