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Function Combined Method for Design Innovation of Children's Bike

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Chinese Journal of Mechanical Engineering 2013年第2期26卷 242-247页

作者： WU Xiaoli qiu Tingting CHEN huijuan School of Mechanical and Electrical Engineering Hohai University Changzhou Key Digital Manufacturing Technology Laboratory Hohai University Suning Appliance Co. Ltd.

As children mature, bike products for children in the market develop at the same time, and the conditions are frequently updated. Certain problems occur when using a bike, such as cycle overlapping, repeating function, and short life cycle, which go against the principles of energy conservation and the environmental protection intensive design concept. In this paper, a rational multi-function method of design through functional superposition, transformation, and technical implementation is proposed. An organic combination of frog-style scooter and children’s tricycle is developed using the multi-function method. From the ergonomic perspective, the paper elaborates on the body size of children aged 5 to 12 and effectively extracts data for a multi-function children’s bike, which can be used for gliding and riding. By inverting the body, parts can be interchanged between the handles and the pedals of the bike. Finally, the paper provides a detailed analysis of the components and structural design, body material, and processing technology of the bike. The study of Industrial Product Innovation Design provides an effective design method to solve the bicycle problems, extends the function problems, improves the product market situation, and enhances the energy saving feature while implementing intensive product development effectively at the same time.

关键词： children’s bike function combined method ergonomics function transformed

山核桃内生细菌ZL34的鉴定、抑菌活性及发酵培养基优化

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中国生物防治学报 2024年第4期40卷 894-904页

作者：竺利红邱海萍项慧娟刘浩施跃峰袁玉伟浙江省农业科学院植物保护与微生物研究所杭州市淳安县石林镇人民政府天津科技大学生物工程学院

茶藨子葡萄座腔菌Botryosphaeria dothidea引起的山核桃干腐病是目前山核桃林最为严重的病害之一。菌株ZL34是从山核桃根系中分离到的一株对茶藨子葡萄座腔菌有较强抑菌活性的内生细菌，为明确其分类地位、抑菌活性和优化发酵培养基，... 详细信息

茶藨子葡萄座腔菌Botryosphaeria dothidea引起的山核桃干腐病是目前山核桃林最为严重的病害之一。菌株ZL34是从山核桃根系中分离到的一株对茶藨子葡萄座腔菌有较强抑菌活性的内生细菌，为明确其分类地位、抑菌活性和优化发酵培养基，采用形态学观察、生理生化特征研究及分子生物学方法对菌株ZL34进行种属鉴定；采用平板对峙法和杯碟法测定了菌株ZL34的抗菌谱；采用插片法、生长速率法和琼脂平板法测定了菌株ZL34对茶藨子葡萄座腔菌的抑菌活性；采用正交试验优化其发酵配方。结果表明，菌株ZL34为贝莱斯芽胞杆菌Bacillus velezensis，其不仅对茶藨子葡萄座腔菌具有较强的抑菌活性，还对尖孢镰刀菌Fusarium oxysporum和金黄色葡萄球菌Staphylococcus aureus等多种病原真菌和细菌具有较强的抑菌活性。菌株ZL34发酵上清液可显著抑制茶藨子葡萄座腔菌菌丝的生长，其中5倍稀释液的抑制率为96.48%，但对孢子的萌发率无明显影响。受抑制的菌丝色素积累明显，其中气生菌丝表现为异常突起和膨大，形成孔洞，基内菌丝产生大量的分生孢子。筛选到由4%黄豆饼粉、4%玉米粉、0.5%尿素、0.6%（NH4）2HPO4、0.35%CaCO3和pH7.0组成的发酵配方，发酵液活菌量为6.97×10～9 CFU/mL，比优化前提高了44.79%，上清液20倍稀释液对茶藨子葡萄座腔菌的抑菌率为87.16%，比优化前提高了45.41%。本研究表明，贝莱斯芽胞杆菌ZL34对茶藨子葡萄座腔菌菌丝的生长有较强抑制作用，并建立了高产芽胞和高活性的发酵配方，为山核桃干腐病生防制剂的开发提供了研究基础。

关键词：茶藨子葡萄座腔菌贝莱斯芽胞杆菌鉴定抑菌活性山核桃

An Efficient, Three-component One-pot Preparation of 1,4-Dihydropyridines Containing Novel Substituted Pyrazole under Sulfamic Acid Catalysis

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Chinese Journal of Chemistry 2011年第3期29卷 511-514页

作者： Li, Jianping qiu, Jikuan Li, huijuan Zhang, Guisheng College of Chemistry and Environmental Science Key Labaratory of Green Chemical Media and Reactions Ministry of Education Henan Normal University Xinxiang Henan 453007 China

An efficient approach to 1,4-dihydropyridines containing novel substituted pyrazole is achieved via threecomponent reaction of pyrazolyl aldehyde, β-ketoester, and ammonium acetate in one-pot under sulfamic acid cata... 详细信息

关键词： Hantzsch reaction 1,4-dihydropyridines pyrazole sulfamic acid catalysis synthesis

Shanghai Gynecologic Oncology Group’s consensus on the academic and industry’s clinical trial types

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中华医学杂志(英文版) 2024年第14期137卷 1744-1746页

作者： Shi Tingyan Liu Jihong Zhu Jianqing Wang Xipeng Jiang Wei Lu Xin Feng Weiwei Zhou Shengtao Shen Yang Chen Gang Wu Zhenyu Zou Dongling Wu Peng Yang huijuan Wu Sufang Zhu Tao Wang Huaying Zhang Yingli qiu Lihua Guo Xiaoqing Xiang Libing Zhang Wei Ren Yulan Feng Yanling Liu Yanfei Chen Xiaojun Zang Rongyu Department of Gynecologic Oncology Fudan University Zhongshan Hospital Institute for Ovarian Cancer Fudan University Shanghai China Department of Gynecologic Oncology Sun Yat-Sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou Guangdong China Department of Gynecologic Oncology Zhejiang Cancer Hospital Hangzhou Zhejiang China Department of Obstetrics and Gynecology Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai China Department of Gynecology Obstetrics and Gynecology Hospital Fudan University Shanghai China Department of Obstetrics and Gynecology Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China Department of Obstetrics and Gynecology Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE and State Key Laboratory of Biotherapy West China Second Hospital Sichuan University and Collaborative Innovation Center Chengdu Sichuan China Department of Obstetrics and Gynecology Zhongda Hospital School of Medicine Southeast University Nanjing Jiangsu China National Clinical Research Center for Gynecology and Obstetrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China School of Public Health Key Laboratory of Public Health Safety and Collaborative Innovation Center of Social Risks Governance in Health Fudan University Shanghai China Gynecologic Oncology Center Chongqing University Cancer Hospital Chongqing China Department of Obstetrics and Gynecology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Department of Gynecologic Oncology Fudan University Shanghai Cancer Center Shanghai China Department of Obstetrics and Gynecology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Obstetrics and Gynecology Renji Hospital School of Medicine

Shanghai Gynecologic Oncology Group (SGOG, www. ***), established in 2009, is a non-profit organization of clinical research and the full member of Gynecology Cancer Intergroup (GCIG) since 2012. It was guided by Drs. Jinghe Lang (China), Gavin Stuart (Canada) (2009-2020); Drs. Jinghe Lang (China), Ding Ma (China) (2021-) and was supported by Dr. Zeyi Cao (2009-2012). The mission of SGOG is to actively promote the investigator-initiated trial (IIT) in gynecologic cancers, particularly the innovative phase II clinical trials. Followed by the high quality of management in investigators’ training, trial development, human resources, and research funding, SGOG has initiated phase III clinical trials to improve the future clinical practice. SGOG aims to obtain reliable data by conducting systematic, standardized, and high-quality clinical trials, to guide the clinical practice of ovarian cancer, endometrial cancer, and cervical cancer in China. SGOG holds group meetings twice a year, and actively participates in GCIG international communication and cooperation that expands its international and national influence in the field of clinical research in gynecologic cancers. This coordination is not only particularly relevant between academic groups but also with national and/or international industry partners.

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经皮椎体成形术治疗老年胸腰椎骨折对患者手术创伤程度及脊柱功能的影响

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中外医疗 2024年第4期43卷 62-66页

作者：曹宇星邹慧娟邱春华东台市中医院骨伤科江苏东台224200

目的探讨经皮椎体成形术(Percutaneous Vertebroplasty,PVP)治疗老年胸腰椎骨折对患者手术创伤程度、脊柱功能的影响。方法方便选取2022年2月-2023年2月东台市中医院骨伤科收治的84例老年胸腰椎骨折患者为研究对象,以随机数生成器将患... 详细信息

目的探讨经皮椎体成形术(Percutaneous Vertebroplasty,PVP)治疗老年胸腰椎骨折对患者手术创伤程度、脊柱功能的影响。方法方便选取2022年2月-2023年2月东台市中医院骨伤科收治的84例老年胸腰椎骨折患者为研究对象,以随机数生成器将患者分成两组,各42例。其中切开组应用切开复位内固定治疗;观察组应用PVP术式治疗。对比两组手术创伤程度(出血量、切口长度、住院时间),脊柱功能(椎体前缘高度、后凸Cobb角),Oswestry功能障碍指数(Oswestry Dability Index,ODI),数字模拟评分法(Numeric Rating Scale,NRS),Barthel指数评分(Barthel Index,BI),世界卫生组织生活质量量表(WHO Quality of Life,WHOQOL)。结果观察组出血量、切口长度、住院时间分别为(52.11±13.83)mL、(4.58±1.26)cm、(10.59±2.48)d,切开组对应指标分别为(116.79±15.98)mL、(11.86±2.95)cm、(13.75±2.64)d,观察组指标水平均优于切开组,差异有统计学意义(t=19.835、14.708、5.654,P均0.05);术后两组椎体前缘高度增加,后凸Cobb角减小,差异无统计学意义(P均>0.05)。观察组患者的ODI、NRS、BI以及WHOQOL评分均优于切开组,差异有统计学意义(P均<0.05)。结论PVP术式在治疗老年胸腰椎骨折患者中表现出令人满意的效果,能够控制手术创伤,促进脊柱功能恢复,并且有助于降低术后脊柱功能障碍、疼痛水平,能够使患者获得更全面的自主生活能力和更高的生活质量。

关键词：经皮椎体成形术老年患者胸腰椎骨折脊柱功能手术创伤

初诊鼻咽癌中医证型与临床分期及EBV-DNA相关性研究

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中国中西医结合耳鼻咽喉科杂志 2011年第6期19卷 404-407页

作者：张蓓汪桃利黄圆圆丘惠娟胡丕丽王艳玲中山大学肿瘤防治中心广州510060 深圳市中医院

目的中医治疗是鼻咽癌综合治疗中的一个重要组成部分,辨证论治是中医治病的精髓。本研究拟观察初诊鼻咽癌患者中医证型与临床分期及EBV-DNA浓度的相关性,为鼻咽癌各中医证型的预后判断及治疗提供依据。方法自2007年7月～2008年8月,共收... 详细信息

目的中医治疗是鼻咽癌综合治疗中的一个重要组成部分,辨证论治是中医治病的精髓。本研究拟观察初诊鼻咽癌患者中医证型与临床分期及EBV-DNA浓度的相关性,为鼻咽癌各中医证型的预后判断及治疗提供依据。方法自2007年7月～2008年8月,共收集94例初诊未治且无远处转移的鼻咽癌患者,采集中医分型、TNM分期以及血浆EBV-DNA浓度等信息,分析三者相关性。结果肺热型的T分期、N分期及TNM分期均较低,EBV-DNA浓度在四型中最低(P=0.001);痰凝型N_2+N_3期占60%;血瘀型T_3+T_4期占93%;血瘀痰凝型均为Ⅲ、Ⅳ期,N_2+N_3期占55%,T_3+T_4期占91%,该型EBV-DNA浓度在四型中最高(P=0.001)。结论随着初诊鼻咽癌患者临床分期的升高,其EBV-DNA浓度逐渐增高,中医证型则呈现"肺热型→痰凝型或血瘀型→血瘀痰凝型"的变化趋势;三者之间存在一定的相关性。

关键词：鼻咽癌中医辨证分型 EB病毒DNA 临床分期

深圳市三级医院静脉用药调配中心的现状与服务效能:基于13家医院的横断面调研

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儿科药学杂志 2024年第8期30卷 28-31页

作者：甘金芳李楚玉邱文涛林哲思刘妙娜郭惠娟国家感染性疾病临床医学研究中心深圳市第三人民医院南方科技大学第二附属医院广东深圳518112 深圳市宝安区妇幼保健院广东深圳518133

目的:调研广东省深圳市三级医院静脉用药调配中心(PIVAS)的现状,为PIVAS的建设和发展提供参考。方法:设计问卷,对广东省深圳市三级医院的PIVAS进行多中心横断面调研,包含PIVAS开展时间、PIVAS数量、床位数目、面积、设备配备、人员模式... 详细信息

目的:调研广东省深圳市三级医院静脉用药调配中心(PIVAS)的现状,为PIVAS的建设和发展提供参考。方法:设计问卷,对广东省深圳市三级医院的PIVAS进行多中心横断面调研,包含PIVAS开展时间、PIVAS数量、床位数目、面积、设备配备、人员模式、成本和收益等数据,分析各医疗机构中PIVAS建设的差异。结果:收集问卷13份,回复率为100%。PIVAS运行时间1~10年不等(中位数5年);建筑面积135~760 m^(2),其中≤500 m^(2)占53.85%(7/13),>500 m^(2)占46.15%(6/13);日均调配输液量≤500袋占53.85%(7/13),501~1000袋占15.38%(2/13),1001~2000袋占30.77%(4/13);PIVAS人员模式方面,采用药学管理占84.62%(11/13),药护管理占15.38%(2/13)。有84.62%机构认为PIVAS目前的普通药物与抗生素配置费收取不合理,100%认为PIVAS目前的抗肿瘤药物配置费、肠外营养配置费收取不合理。结论:近年来,广东省深圳市三级医院PIVAS逐步发展壮大,新开的PIVAS增加了许多信息化、智能化设备投入,成本也随之增加。因PIVAS工作人员紧缺,大部分医疗机构仅开展了部分液体调配,无法开展全院区的全医嘱调配。目前,总体的配置费标准偏低,一定程度上影响了PIVAS发展。

关键词：静脉用药调配中心成本收费调研

改良型患者主观整体评估量表在恶性肿瘤患者中的应用价值

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江苏医药 2024年第8期50卷 803-806页

作者：张世杰许莉华肖媛媛邱滨李琳赖慧娟赣州市立医院药剂科江西341000 赣州市立医院肿瘤内科江西341000

目的评估改良型患者主观整体评估量表(mPG-SGA)在恶性肿瘤患者中的临床应用价值。方法同时采用mPG-SGA和营养风险筛查2002量表(NRS2002)对100例恶性肿瘤患者进行营养筛查和评估,并分析两种营养评估方法的一致性、相关性及筛查价值。结果... 详细信息

目的评估改良型患者主观整体评估量表(mPG-SGA)在恶性肿瘤患者中的临床应用价值。方法同时采用mPG-SGA和营养风险筛查2002量表(NRS2002)对100例恶性肿瘤患者进行营养筛查和评估,并分析两种营养评估方法的一致性、相关性及筛查价值。结果NRS2002筛查出26例患者存在营养风险(NRS2002评分≥3分);mPG-SGA筛查出31例患者存在营养不良(mPG-SGA评分≥3分)。mPG-SGA与NRS2002的营养评价结果有统计学差异(P0.05)。mPG-SGA评分取最佳诊断界值为1分时,其对应的灵敏度和特异度分别为100%和60.2%;NRS2002评分取最佳诊断界值为2分时,其对应的灵敏度和特异度分别为100%和46.9%。结论mPG-SGA是一种使用简单、快速、灵敏度和特异度较高的营养评价方法,适用于恶性肿瘤患者的营养筛查与评估。

关键词：改良型患者主观整体评估量表营养风险筛查2002量表恶性肿瘤

Abnormal intra-network architecture in extra-striate cortices in amblyopia: a resting state fMRI study

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Eye and Vision 2019年第1期6卷 156-163页

作者： Zhuo Lu Yufeng Huang Qilin Lu Lixia Feng Benedictor Alexander Nguchu Yanming Wang huijuan Wang Geng Li Yifeng Zhou Bensheng qiu Jiawei Zhou Xiaoxiao Wang Center for Biomedical Engineering University of Science and Technology of ChinaHefeiAnhui 230027People’s Republic of China Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Science University of Science and Technology of ChinaHefeiAnhui 230027People’s Republic of China CAS Key Laboratory of Brain Function and Diseases and School of Life Sciences University of Science and Technology of ChinaHefeiAnhui 230027People’s Republic of China Shenyang Aerospace University ShenyangLiaoning 110136People’s Republic of China Department of Ophthalmology First Affiliated Hospital of Anhui Medical UniversityHefeiAnhuiPeople’s Republic of China Asia Pediatric Ophthalmologist Association Rm 2006CC Wu Bldg.302-308 Hennessy Rd.WanchaiHong KongPeople’s Republic of China School of Ophthalmology and Optometry and Eye hospital Wenzhou Medical UniversityWenzhouZhejiang 325003People’s Republic of China

Background:Amblyopia(lazy eye)is one of the most common causes of monocular visual *** investigation has shown that amblyopes suffer from a range of deficits not only in the primary visual cortex but also the extra-striate visual ***,amblyopic brain processing deficits in large-scale information networks especially in the visual network remain ***:Through resting state functional magnetic resonance imaging(rs-fMRI),we studied the functional connectivity and efficiency of the brain visual processing networks in 18 anisometropic amblyopic patients and 18 healthy controls(HCs).Results:We found a loss of functional correlation within the higher visual network(HVN)and the visuospatial network(VSN)in ***,compared with HCs,amblyopic patients exhibited disruptions in local efficiency in the V3v(third visual cortex,ventral part)and V4(fourth visual cortex)of the HVN,as well as in the PFt,hIP3(human intraparietal area 3),and BA7p(Brodmann area 7 posterior)of the *** significant alterations were found in the primary visual network(PVN).Conclusion:Our results indicate that amblyopia results in an intrinsic decrease of both network functional correlations and local efficiencies in the extra-striate visual networks.

关键词： Amblyopia fMRI Resting state Extra-striate cortices Visuospatial network Graph analysis