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Carboniferous biogenic sedimentary structures on the northwestern margin of Jungar Basin

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Chinese Science Bulletin 1999年第4期44卷 368-372页

作者： huijuan jin Yuci Li Chinese Acad Sci Lanzhou Inst Geol Lanzhou 730000 Peoples R China

Volcanic clastic rocks of 2 300 m thick are developed in the Carboniferous of the Halaalate Mountains in the northwestern margin of the Jungar Basin. The research of sedimentology indicates that they were formed by the sedimentation of deep-water enviroment. They could be divided into three ichnofacies from the lower part to the upper part, i.e. deep-sea ichnofacies, Nereites ichnofacies, and Zoophycos ichnofacies. From the vertical evolution of biogenic structures and ichnofacies it could be considered that during the Carboniferious a batheyl basin was gradually changed into a semideep sea basin where progradational sediments in the sea regression were deposited. The Carboniferous represents the sedimentary characteristics during a sea-level falling cycle.

关键词： biogenic sedimentary structures Carboniferous Jungar Basin.

Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents

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Acta Pharmaceutica Sinica B 2015年第4期5卷 285-299页

作者： Dhulfiqar Ali Abed Melanie Goldstein Haifa Albanyan huijuan jin Longqin Hu Department of Medicinal Chemistry Ernest Mario School of Pharmacy Rutgers The State University of New Jersey School of Pharmaceutical Sciences Shanxi Medical University

The Keap1–Nrf2–ARE pathway is an important antioxidant defense mechanism that protects cells from oxidative stress and the Keap1–Nrf2 protein–protein interaction(PPI) has become an important drug target to upregulate the expression of ARE-controlled cytoprotective oxidative stress response enzymes in the development of therapeutic and preventive agents for a number of diseases and conditions. However, most known Nrf2 activators/ARE inducers are indirect inhibitors of Keap1–Nrf2PPI and they are electrophilic species that act by modifying the sulfhydryl groups of Keap1's cysteine residues. The electrophilicity of these indirect inhibitors may cause "off-target" side effects by reacting with cysteine residues of other important cellular proteins. Efforts have recently been focused on the development of direct inhibitors of Keap1–Nrf2 PPI. This article reviews these recent research efforts including the development of high throughput screening assays, the discovery of peptide and small molecule direct inhibitors, and the biophysical characterization of the binding of these inhibitors to the target Keap1 Kelch domain protein. These non-covalent direct inhibitors of Keap1–Nrf2 PPI could potentially be developed into effective therapeutic or preventive agents for a variety of diseases and conditions.

关键词： Oxidative stress Keap1 Nrf2 Direct inhibitors of protein–protein interaction High throughput screening assays Structure–activity relationships X-ray crystallography

Influence of γ-irradiation on Properties of Amorphous Fe78B13Si9 Alloy Studied by Mössbauer Spectroscopy and Bending Test

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Chinese Physics Letters 1991年第2期8卷 86-89页

作者： ZHANG Guilin LIU Wenhong ZHANG Hui CHANG Ruqin jin huijuan XU Guiqin YANG Yi Shanghai Institute of Nuclear Research Academia SinicaShanghai 201800 Shanghai Iron and Steel Research Institute Shanghai 200940

The influence ofγ-irradiation on properties of METGLAS 2605S2 and FC3-1 Fe78B13Si9 has been investigated by Möissbauer spectroscopy and bending *** ductility and orientation of magnetization were changed byγ-*** pro... 详细信息

关键词： ductility Fe78B13Si9 stress

Behavior of Medium-frequency Core Loss in Fe-based Nanocrystalline Soft Magnetic Alloys

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Journal of Materials Science & Technology 2000年第3期16卷 332-336页

作者： Yanzhong ZHANG, huijuan jin and Ying SHI (Research Centre, Shanghai Iron and Steel Research Institute, Shanghai 200940, China) Research Centre Shanghai Iron and Steel Research Institute Shanghai 200940 China

The dependences of the power loss per cycle on frequency have been investigated in the ranges of 100 Hz<= f<=25000 Hz and 0.1 T< =Bm <=1.0 T for three main original magnetic states in five sorts of Fe-based nanocrystalline soft magnetic alloys. The measured and calculated results showed that the total power loss per cycle clearly exhibited a nonlinear behavior in the range below 3 kHz～5 kHz depending on both the magnetic state and the value of Dm, whereas it showed a quasi-linear behavior above this range. The total loss was decomposed into hysteresis loss, classical eddy current loss and excess loss, the obvious nonlinear behavior has been confirmed to be completely determined by the dependence of the excess loss on frequency. It has been indicated that the change rate of the excess loss per cycle with respect to frequency sharp decreases with increasing frequency in the range below about 3 kHz～5 kHz, wherease the rate of change slowly varies above this range, thus leading to the quasilinear behavior of the total loss per cycle. In this paper, some linear expressions of the total loss per cycle has been given in a wider medium-frequency segment, which can be used for roughly estimating the total loss.

关键词： Behavior of Medium-frequency Core Loss in Fe-based Nanocrystalline Soft Magnetic Alloys Core Fe high

Microstructure of Differently Annealed NanocrystallineFe_(72.7)Cu_1Nb_(1.8)Mo_2Si_(13)B_(9.5) Alloy

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Journal of Materials Science & Technology 1998年第4期14卷 327-330页

作者： YanZhong ZHANG and huijuan jin (Shanghai Key Lab. of Metallic Functional Materials, Shanghai Iron and Steel Research Institute,Shanghai 200940, China) Shanghai Key Lab. of Metallic Functional Materials Shanghai Iron and Steel Research Institute Shanghai 200940 China

The microstructure of differently annealed nanocrystalline Fe72.7Cu1Nb1.8Mo2Si13B9.5 alloy was investigated by using Mssbauer spectroscopy and transmission electron microscope. The specimens were isochronally annealed at temperatures between 480℃ and 600℃ for 0.5 h. The experimental results show that the microstructure mainly consists of the nanoscale bcc α-Fe(Si) grains and the residual amorphous matrix phase. A trace paramagnetic phase was found for annealing about above 500℃. The volume fraction of cr-Fe(Si) grain increases with increasing annealing temperature, whereas the average size of grain is almost unchanged above 480℃ up to 580℃. The calculated thickness of the intergranular layer of the residual amorphous matrix clearly decreases with increasing annealing temperature.

关键词： Mo2Si Microstructure of Differently Annealed NanocrystallineFe Si Alloy Cu1Nb

Physical and mental health conditions of young college students with different Traditional Chinese Medicine constitutions in Zhejiang Province of China

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Journal of Traditional Chinese Medicine 2015年第6期35卷 703-708页

作者： Lv Heli Zhu Li Chen Zhiqiang jin huijuan jin Lei Public Sports and Art Department Zhejiang University

OBJECTIVE: To investigate Traditional Chinese Medicine(TCM) constitutions of youths in colleges,and their physical and mental health conditions of different TCM constitutions, so as to provide a theoretical basis for the TCM way to improve young people's physical and mental ***: The Standard TCM Constitutions' Classification and Determination Questionnaire was used to measure the body health condition, and the Symptom Checklist 90 Questionnaire and the Questionnaire of the National Student Physical Health Standards were used to determine mental and physical health conditions respectively in 1421 young participants validly answering the questionnaires in Zhejiang ***: The participants had a mean age of 19.96years(SD = 0.95 years) with the majority of females(55.10%). One fourth of the 1421 participants were the Ping-he constitution and others were the tendency constitutions. Participants with Ping-he module(which has characteristics of moderate posture,rosy, energetic and is a healthy condition in TCM)were healthier than those with tendency constitutions in physical and mental health, with 65.81 ±7.83(men) and 77.99 ± 7.24(women) scores in the physical test and around 1.25 scores in the mental health test. College students with combined biased constitutions were more likely suffer force, sensitive, depression and ***: Most of college students have a tendency or biased constitution which could be more likely to suffer suboptimal health status and diseases. Youths in college themselves and health providers should pay more attention to their potential health issues and make proper healthcare plan according to their own TCM constitution.

关键词： Mental health Physical constitutiontheory Medicine, Chinese traditional Question-naires Young adult

Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study

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Stroke & Vascular Neurology 2020年第3期5卷 279-284页

作者： Yanan Li Man Li Mengdie Wang Yifan Zhou Jiang Chang Ying Xian David Wang Ling Mao huijuan jin Bo Hu Department of Neurology Union Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Epidemiology and Biostatistics Key Laboratory for Environment and HealthSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Duke Clinical Research Institute and Department of Neurology Duke University Medical CenterDurhamNorth CarolinaUSA Neurovascular Division Department of NeurologyBarrow Neurological Institute/Saint Joseph Hospital Medical CenterPhoenixArizonaUSA

Background and purpose COVID-19 is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2).Apart from respiratory complications,acute cerebrovascular disease(CVD)has been observed in some patients with ***,we described the clinical characteristics,laboratory features,treatment and outcomes of CVD complicating SARS-CoV-2 *** and methods Demographic and clinical characteristics,laboratory findings,treatments and clinical outcomes were collected and *** characteristics and laboratory findings of patients with COVID-19 with or without new-onset CVD were *** Of 219 patients with COVID-19,10(4.6%)developed acute ischaemic stroke and 1(0.5%)had intracerebral ***-19 with new onset of CVD were significantly older(75.7±10.8 years vs 52.1±15.3 years,p<0.001),more likely to present with severe COVID-19(81.8%vs 39.9%,p<0.01)and were more likely to have cardiovascular risk factors,including hypertension,diabetes and medical history of CVD(all p<0.05).In addition,they were more likely to have increased inflammatory response and hypercoagulable state as reflected in C reactive protein(51.1(1.3-127.9)vs 12.1(0.1-212.0)mg/L,p<0.05)and D-dimer(6.9(0.3-20.0)vs 0.5(0.1-20.0)mg/L,p<0.001).Of 10 patients with ischemic stroke;6 received antiplatelet treatment with aspirin or clopidogrel;and 3 of them *** other four patients received anticoagulant treatment with enoxaparin and 2 of them *** of 24 March 2020,six patients with CVD died(54.5%).Conclusion Acute CVD is not uncommon in *** findings suggest that older patients with risk factors are more likely to develop *** development of CVD is an important negative prognostic factor which requires further study to identify optimal management strategy to combat the COVID-19 outbreak.

关键词： Acute acute likely

Melatonin changes in the pineal gland of sleep-deprived rats following habenular nucleus lesion

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Neural Regeneration Research 2011年第9期6卷 681-685页

作者： huijuan jin Meiying Song Min Huang Manli Wang Hua Zhao Department of Physiology Norman Bethune College of Medicine Jifin University Changchun 130021 Jilin Province China

The habenular nucleus （Hb） is an important structure that regulates the function of the pineal gland which may affect melatonin content in the pineal gland after sleep deprivation （SD）. In the present study, high performance liquid chromatography showed that the melatonin content in the pineal gland was significantly reduced, and y-aminobutyric acid content in the Hb was significantly increased after SD. Furthermore, the melatonin content in the pineal gland was markedly reduced after Hb lesion under normal sleep and SD conditions. Immunohistochemistry showed that the number of Fos-positive neurons was significantly decreased in the lateral and medial Hb after SD. The findings demonstrate that the reduction of melatonin in the pineal gland after SD is related to decreased activity of Hb neurons, and that the Hb can regulate sleep-wake rhythm by influencing melatonin secretion in the pineal gland.

关键词： Habenular nucleus melatonin pineal gland sleep deprivation neural regeneration

General Properties of Low-frequency Power Losses in Fe-based Nanocrystalline Soft Magnetic Alloys

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Journal of Materials Science & Technology 2000年第1期16卷 37-44页

作者： Yanzhong ZHANG, huijuan jin and Ying SHI (Shanghai Key Laboratory for Research and Developing and Applications of Metallic Function Materials, Research Center, Shanghai Iron and Steel Research institute,Shanghai 200940, China) Shanghai Key Lab. for Research and Developing and Applications of Metallic Function Materials Research Center Shanghai Iron and Steel Research Institute Shanghai 200940 China

The dependences of the power loss per cycle on frequency f and amplitude flux density Bm have been investigated for the three main original magnetic states in five sorts of Fe-based nanocrystalline soft magnetic alloys in the ranges of 10 Hz<=f<=1000 Hz and 0.4 T<= Bm <=1.0 T. The total loss P is decomposed into the sum of the hysteresis loss Physt, the classical eddy current loss Pel and the excess loss Pexc. Physt has been found to be proportional to Bm^2 and f. The behavior of Pexc/f vs f being equivalent to P/f vs f clearly exhibits nonlinearity in the range not more than about 120 Hz, whereas the behavior of P/f vs f roughly shows linearity in the range far above 100 Hz and not more than 1000 Hz. In the range up to 1000 Hz, Physt is dominant in the original high permeability state and the state of low residual flux density, whereas Pexc in the state of high residual flux density is dominant in the wider range above about 100 Hz. The framework of the statistical theory of power loss has been used for representing the behavior of Pexc/f vs f. It has been found that the number n of the simultaneously active 'Magnetic Objects' linearly varies as n = n0 + Hexc/H0 as a function of the dynamic field Hexc in the range below about 120 Hz, whereas n approximately follows a law of the form n = n0 + (Hexc/H0)^m with 1 < m < 2 in the range far above 100 Hz and not more than 1000 Hz. The values of the field HO in principle related to the microstructure and the domain structure have been calculated for the three states.

关键词： General Properties of Low-frequency Power Losses in Fe-based Nanocrystalline Soft Magnetic Alloys Fe