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Effect of thermodynamic parameters on prediction of phase behavior and process design of extractive distillation

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Chinese Journal of Chemical Engineering 2018年第5期26卷 993-1002页

作者： huijia Huixin Wang Kang Ma Mengxiao Yu Zhaoyou Zhu Yinglong Wang College of Chemical Engineering Qingdao University of Science and Technology Qingdao 266042 China National Registration Center for Chemicals SINOPEC Research Institute of Safety Engineering Qingdao 266071 China

Extractive distillation was investigated for separation of the minimum azeotrope of n-propanol/water, via the Aspen Plus simulation platform. Experimental data of n-propanol/water, which could pass the thermodynamic consistency test, were regressed to get suitable binary interaction parameters(BIPs) by the UNIQUAC thermodynamic model. The azeotrope system was heterogeneous in the simulation with built-in BIPs, which was contrary to the experimental data. The study focused on the effect of thermodynamic parameters on the prediction of phase behavior, and process design of extractive distillation. N-methyl-2-pyrrolidone(NMP) and ethylene glycol were used as solvents to implement the separation. Processes with built-in and regressed BIPs were explored,based on the minimum total annual cost(TAC). There were significant differences in the phase behavior simulation using different thermodynamic parameters, which showed the importance of BIPs in the design and optimization of extractive distillation.

关键词： Extractive distillation Thermodynamic parameters Phase behavior UNIQUAC TAC

Flatness maintenance and roughness reduction of silicon mirror in chemical mechanical polishing process

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Science China(Technological Sciences) 2020年第1期63卷 166-172页

作者： JIANG BoCheng ZHAO DeWen WANG BingQuan ZHAO huijia LIU YuHong LU XinChun Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China Hwatsing Technology Co. LtdTianjin 300350China

As an important optical component in laser system,silicon mirror surface is required to have micron-level flatness and subnanometer-level *** research concentrates on how to improve roughness as far as possible while maintaining flatness of silicon mirror surface during chemical mechanical polishing(CMP)process.A polishing edge effect model is established to explain the reason of flatness deterioration,and a roughness theoretical model is set up to get the limit of perfect surface *** on the models above,a polishing device is designed to maintain the surface flatness,and the optimized polishing process parameters are obtained by orthogonal tests to get a near-perfect surface *** the maintenance of flatness and the improvement of roughness can be achieved at the same time in one step of CMP *** work can be a guide for silicon mirror manufacture to improve optical reflection performance significantly.

关键词： chemical mechanical polishing silicon mirror flatness maintenance roughness reduction

基于MRI特征构建模型预测乳腺癌Ki-67表达水平

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中国介入影像与治疗学 2024年第4期21卷 220-223页

作者：郭艺文娣娣刘会佳逯慧珍郭敏陈安琪宦怡魏梦绮空军军医大学第一附属医院放射科陕西西安710032

目的观察基于MRI特征构建的模型预测乳腺癌Ki-67表达水平的价值。方法回顾性分析62例接受MR检查的女性乳腺癌患者,根据Ki-67表达水平将其分为低表达组(n=8)与高表达组(n=54);比较组间计数资料,构建logistic回归模型,预测乳腺癌Ki-67表... 详细信息

目的观察基于MRI特征构建的模型预测乳腺癌Ki-67表达水平的价值。方法回顾性分析62例接受MR检查的女性乳腺癌患者,根据Ki-67表达水平将其分为低表达组(n=8)与高表达组(n=54);比较组间计数资料,构建logistic回归模型,预测乳腺癌Ki-67表达水平;以线性相关分析评估患者年龄、乳腺癌病灶最大径及表观弥散系数(ADC)值与Ki-67表达水平的相关性,构建多元线性模型;绘制受试者工作特征曲线,以曲线下面积(AUC)评估各模型的预测效能。结果乳腺癌病灶位置及分叶征均为预测其Ki-67表达水平的独立影响因素(P均0.05);故基于病灶最大径及ADC值构建线性模型。回归模型位置+分叶预测乳腺癌Ki-67表达水平的效能(AUC=0.903)高于回归模型位置及回归模型分叶(AUC=0.743、0.817)而与线性模型(AUC=0.852)相当。结论基于MRI特征构建的模型可有效预测乳腺癌Ki-67表达水平;其中,回归模型位置+分叶及线性模型的预测效能较高。

关键词：乳腺肿瘤磁共振成像 Ki-67抗原

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Interactions between background matching and disruptive colouration： Experiments using human predators and virtual crabs

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Current Zoology 2015年第4期61卷 718-728页

作者： Peter A. TODD huijia PHUA Kok Ben TOH Experimental Marine Ecology Laboratory Department of Biological Sciences National University of Singapore 14 Science Drive 4 Blk S3 #02-05 Singapore 117543

Interactions between disruptive colouration and the match between prey and background spot size were manipulated in two experiments that used time taken by human ＇predators＇ to find artificial prey （virtual crab morphs） against heterogeneous backgrounds as a measure of the their camouflage. Experiment 1, in which the spots and their placement imitated the arrangement on the crab Carcinus maenas, tested whether high and low contrast spots touching the body outline （disruptive ＇edge＇ morphs） made the artificial prey more difficult to detect than when the spots did not touch the outline （non-disruptive ＇inner＇ morphs） against three different backgrounds：＇small＇, ＇middle＇ and ＇large＇ spot size. In Experiment 2, the range of spot sizes and their positions （＇edge＇ and ＇inner＇） on the crab morphs were varied to determine the most effective combination against the ＇mid- dle＇ background. Altogether, 640 volunteers participated in these computer trials, representing a high degree of independent replication. All patterned morphs were significantly harder to detect than plain morphs, indicating that possessing at least some degree of background matching can provide camouflage. Both experiments demonstrated that various morphs, though not having the same spot sizes as the background, had similar or better survivorship as those with matching spot sizes--indicating that opti- mal camouflage did not come from background matching alone. In Experiment 2, edge-disrupted morphs consistently took longer to find than their non-disruptive counterparts. The relative effects of edge disruption, contrast, and background/prey spot size are clearly context-dependent, highlighting the complexity of prey concealment [Current Zoology 61 （4）： 718-728, 2015].

关键词： Background matching Camouflage Carcinus maenas Crypsis Disruptive colouration Predation

复方五指毛桃膏对小鼠慢性疲劳综合征的改善作用

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广东药科大学学报 2024年第3期40卷 11-17页

作者：梁惠嘉史爽王纠邓亚利华南农业大学制药工程系广东广州510642 广东药科大学新药研发中心/广东省药物新剂型重点实验室广东广州510006

目的研究复方五指毛桃膏对肝郁脾虚型慢性疲劳综合征小鼠的改善作用。方法构建昆明小鼠肝郁脾虚型慢性疲劳综合征(CFS)病理模型,随机分为空白组、模型组、诺迪康胶囊阳性对照组(145.6 mg/kg)和复方五指毛桃膏高、中、低剂量组(5.2 g/kg... 详细信息

目的研究复方五指毛桃膏对肝郁脾虚型慢性疲劳综合征小鼠的改善作用。方法构建昆明小鼠肝郁脾虚型慢性疲劳综合征(CFS)病理模型,随机分为空白组、模型组、诺迪康胶囊阳性对照组(145.6 mg/kg)和复方五指毛桃膏高、中、低剂量组(5.2 g/kg、2.6 g/kg、1.3 g/kg)。连续灌胃治疗28 d,观测小鼠悬尾实验及旷场实验的活动状态,检测抗氧化应激能力、免疫器官系数和肝糖原、超氧化物歧化酶(SOD)、白细胞介素-2(IL-2)、干扰素-γ(IFN-γ)、5-羟色胺(5-HT)、多巴胺(DA)水平。结果与模型组相比,复方五指毛桃膏高、中、低剂量组悬尾不动时间缩短(P<0.01)、旷场活动明显增加(P<0.01);在极端环境中生存时间延长(P<0.01);胸腺、脾脏系数均有提高(P<0.01);肝糖原、SOD、IL-2、IFN-γ、5-HT含量升高(P<0.01),DA含量降低(P<0.01)。结论复方五指毛桃膏可增强小鼠抗氧化应激能力,缓解小鼠慢性疲劳和不良情绪,增强机体免疫力,对CFS有较好的疗效。

关键词：复方五指毛桃膏慢性疲劳综合征氧化应激免疫功能神经内分泌

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血清Cys-C、Hcy对前列腺癌患者骨转移的预测价值分析

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淮海医药 2024年第5期42卷 450-453页

作者：张伟伟黄晓辉殷慧佳河南许昌医院检验科河南许昌461000 新乡医学院第一附属医院影像科河南新乡453199

目的:探究前列腺癌(PCa)患者发生骨转移的影响因素及血清胱抑素C(Cys-C)、同型半胱氨酸(Hcy)对PCa骨转移的预测价值。方法:选取2021年6月—2023年7月某院就诊的PCa患者86例为研究对象,根据放射性核素骨显像诊断是否发生骨转移分为骨转移... 详细信息

目的:探究前列腺癌(PCa)患者发生骨转移的影响因素及血清胱抑素C(Cys-C)、同型半胱氨酸(Hcy)对PCa骨转移的预测价值。方法:选取2021年6月—2023年7月某院就诊的PCa患者86例为研究对象,根据放射性核素骨显像诊断是否发生骨转移分为骨转移组(40例)和无骨转移组(46例)。采用单因素、多因素Logistic回归方程分析PCa患者发生骨转移的影响因素;ROC分析血清Cys-C、Hcy单独及联合检测对PCa患者骨转移的预测价值。结果:单因素分析显示,2组间年龄、体质量指数、有无淋巴结转移比较差异无统计学意义(P>0.05);骨转移组临床T分期≥T2c、Gleason评分≥8分患者比例及血清总前列腺特异性抗原(PSA)、Cys-C、Hcy水平高于无骨转移组,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,临床T分期≥T2c、Gleason评分≥8分及高PSA、Cys-C、Hcy水平均是影响PCa患者骨转移的独立危险因素(P<0.05)。ROC分析显示,血清Cys-C、Hcy预测PCa患者发生骨转移的AUC分别为0.855、0.625;二者联合检测的AUC为0.945,特异度为0.826,灵敏度为0.900。结论:血清Cys-C、Hcy联合检测对PCa患者骨转移有较高预测价值,可与患者临床T分期、Gleason评分、PSA水平等共同评估患者病情,对指导临床后续治疗意义重大,具有较高的临床应用价值。

关键词：前列腺肿瘤骨转移胱抑素C 同型半胱氨酸预测价值

医联体模式下“互联网+护理服务”运行效果探讨

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上海护理 2024年第2期24卷 57-61页

作者：益伟清张翠红黄慧佳上海市第八人民医院上海200235

在国家政策的支持下,初步构建基于第三方平台的医联体模式下的“互联网+护理服务”,为区域内有就医需求的患者提供及时方便的上门护理服务,以改善患者就医体验。2019年5月至2022年10月期间由上海市二级医院主导,联合紧密医联体下的5家... 详细信息

在国家政策的支持下,初步构建基于第三方平台的医联体模式下的“互联网+护理服务”,为区域内有就医需求的患者提供及时方便的上门护理服务,以改善患者就医体验。2019年5月至2022年10月期间由上海市二级医院主导,联合紧密医联体下的5家社区卫生服务中心,利用第三方平台,共实施医联体模式“互联网+护理服务”上门服务700多例,所提供的护理项目均收到良好效果,患者及家属对于上门服务满意度较高。医联体模式“互联网+护理服务”改善了患者就医体验,同时有助于提升医联体护士专科护理水平,体现护士职业价值感,缓解看病难等社会问题。

关键词：医联体模式互联网+护理服务运行初探

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Using log mining to analyze user behavior on search engine

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Frontiers of Electrical and Electronic Engineering in China 2012年第2期7卷 254-260页

作者： Ke XIE huijia YU Rongwei CEN State Key Laboratory of Intelligent Technology and Systems Tsinghua National Laboratory for Information Science and TechnologyDepartment of Computer Science and TechnologyTsinghua UniversityBeijing 100084China

Users＇ behavior analysis has become one of the most important research topics, especially in terms of performance optimization, architecture analysis, and system maintenance, due to the rapid growth of search engine users. By adequately performing analysis on log data, researchers and Internet companies can get guidance to better search engines. In this paper, we perform our analysis based on approximately 750million entries of search requests obtained from log of a real commercial search engine. Several aspects of users＇ behavior are studied, including query length, ratio of query refining, recommendation access, and so on. Different information needs may lead to different behaviors, and we address this discussion in this paper. We firmly believe that these analyses would be helpful with respect of improving both effectiveness and efficiency of search engines.

关键词： user behavior analysis search engine webinformation retrieval

围孕期叶酸补充对子代6岁智商影响及孕期坚果摄入和母乳喂养的效应修饰作用

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中国公共卫生 2024年第1期40卷 29-35页

作者：苏慧佳谢珍珍孙松林陈瑶奚健雅梁红袁伟纪红蕾上海市生物医药技术研究院国家卫生健康委员会计划生育药具重点实验室上海市疾病与健康基因组学重点实验室上海200237

目的评估母亲围孕期叶酸补充与子代远期智力发育的关联,并检验孕期食用坚果和母乳喂养对该关联可能产生的效应修饰作用。方法2012年4—12月上海闵行出生队列建立时,通过结构式问卷收集母亲围孕期叶酸补充情况、坚果食用频率等信息;子代... 详细信息

目的评估母亲围孕期叶酸补充与子代远期智力发育的关联,并检验孕期食用坚果和母乳喂养对该关联可能产生的效应修饰作用。方法2012年4—12月上海闵行出生队列建立时,通过结构式问卷收集母亲围孕期叶酸补充情况、坚果食用频率等信息;子代出生后,通过随访收集纯母乳喂养时长等信息,并于子代6岁时,由经过专业培训的调查员利用第四版《韦氏儿童智力量表》中文版简版对其进行智力水平测试。最终纳入信息完整的530对母子,采用多因素线性回归模型分析母亲围孕期叶酸补充与子代6岁智商分数的关联,并探讨母亲孕期坚果食用频率及产后纯母乳喂养时长的潜在效应修饰作用。结果多因素分析结果显示,对于母亲围孕期叶酸补充的子代,其知觉推理分数提高4.57分(95%CI=0.13~9.02)。母亲孕前开始补充叶酸与孕后开始补充叶酸与子代知觉推理分数关联的效应值相近,分别为4.41(95%CI=-0.25~9.07)和4.71(95%CI=0.11~9.31)。另外,上述关联在母亲孕期坚果食用频率≤2 d/周、纯母乳喂养时长<6个月的研究对象中更强;前者,母亲围孕期补充叶酸的子代知觉推理分数提高5.80分(95%CI=0.52~11.08),后者母亲围孕期补充叶酸的子代知觉推理分数提高6.36分(95%CI=0.89~11.83)。结论母亲围孕期叶酸补充与子代6岁时知觉推理分数的提高有关,提示围孕期叶酸补充对子代远期智力发育的保护作用。该保护作用在母亲孕期坚果食用频率≤2 d/周或子代纯母乳喂养时长<6个月的研究人群中更强。

关键词：叶酸围孕期子代智商效应修饰队列研究