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Chinese Journal of Chemistry 2022年第9期40卷 1033-1038页

作者： Tongtong Li Xiaokai Cheng Jiamin Lu huifeng wang Qun Fang Zhan Lu Department of Chemistry Zhejiang University 866 Yuhangtang roadHangzhouZhejiang 310058China College of Chemistry ZhengzhouUniversityZhengzhouHenan 450001China Hangzhou Innovation Center Zhejang UniversityHangzhouZhejiang 311200China

The asymmetric reductive arylation and alkenylation of benzylic chloride under photoredox/nickel dual catalysis using chiral bimidazoline(Bilm)ligand is reported to access 1,1-diaryl alkanes and aryl allylic compounds with good yield as well as stereo-and *** protocol uses more commercially available and less expensive C(sp^(2))-Br as the electrophile coupling partner.A primary result using alkenyl chloride and alkyl chloride is also *** functional groups are tolerated and the applications of this method are investigated by late-stage functionalization and gram-scale reaction.

关键词： Cross-coupling Photocatalysis Enantioselectivity Stereoselectivity Bimidazoline

Pseudo-beam method for compressive buckling characteristics analysis of space inflatable load-carrying structures

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Acta Mechanica Sinica 2009年第5期25卷 659-668页

作者： Changguo wang huifeng Tan Xingwen Du Center for Composite Materials,Harbin Institute of Technology, 150001 Harbin, China Center for Composite Materials Harbin Institute of Technology Harbin China

This paper extends Le van＇s work to the case of nonlinear problem and the complicated configuration. The wrinkling stress distribution and the pressure effects are also included in our analysis. Pseudo-beam method is presented based on the inflatable beam theory to model the inflatable structures as a set of inflatable beam elements with a prestressed state. In this method, the discretized nonlinear equations are given based upon the virtual work principle with a 3-node Timoshenko＇s beam model. Finite element simulation is performed by using a 3-node BEAM189 element incorporating ANSYS nonlinear program. The pressure effect is equivalent included in our method by modifying beam element cross-section parameters related to pressure. A benchmark example, the bending case of an inflatable cantilever beam, is performed to verify the accuracy of our proposed method. The comparisons reveal that the numerical results obtained with our method are close to open published analytical and membrane finite element results. The method is then used to evaluate the whole buckling and the loadcarrying characteristics of an inflatable support frame subjected to a compression force. The wrinkling stress and region characteristics are also shown in the end. This method gives better convergence characteristics, and requires much less computation time. It is very effective to deal with the whole load-carrying ability analytical problems for large scale inflatable structures with complex configuration.

关键词： Inflatable structure - Pseudo-beam method Inflatable beam theory Nonlinear buckling finite element

Efficacy of Qiancao(Radix Rubiae Cordifoliae) and Haipiaoxiao(Endoconcha Sepiellae), a traditional Chinese herb pair, on abnormal uterine bleeding in rats with incomplete abortion

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Journal of Traditional Chinese Medicine 2022年第5期42卷 758-763页

作者： ZHANG Tiantian LI Guowen CHU Zhifeng LI Jie YU Lijun GAO Yuan wang huifeng Department of Pharmacy Shanghai Songjiang Fangta Hospital of TCMShanghai 201600China Department of Pharmacy Shanghai TCM-Integrated HospitalShanghai 200080China Department of Traditional Chinese Medicine Shanghai Songjiang Fangta Hospital of TCMShanghai 201600China

OBJECTIVE: To investigate the most effective weight ratio of Qiancao(Radix Rubiae Cordifoliae) and Haipiaoxiao(Endoconcha Sepiellae) used to produce decoction for the treatment of abnormal uterine bleeding(AUB) in rats with incomplete abortion, and to study the possible mechanism. METHODS: The models of AUB were established by incomplete drug abortion with mifepristone and misoprostol in pregnant rats. The therapeutic effects of decoctions made by eight different weight ratios of Qiancao(Radix Rubiae Cordifoliae) and Haipiaoxiao(Endoconcha Sepiellae) were observed. RESULTS: Statistical analysis revealed that the most effective weight ratio of Qiancao(Radix Rubiae Cordifoliae) and Haipiaoxiao(Endoconcha Sepiellae) to treat AUB in this study was 2∶1. CONCLUSION: The insights gained from this study would improve understanding of the mechanisms involved in the effect of Qiancao(Radix Rubiae Cordifoliae) and Haipiaoxiao(Endoconcha Sepiellae) on AUB.

关键词： uterine hemorrhage Qiancao(Radix Rubiae Cordifoliae) Haipiaoxiao(Endoconcha Sepiellae) herb pair weight ratio

基于网络药理学和分子对接探究莪术-三棱药对治疗前列腺癌的作用机制

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数理医药学杂志 2024年第1期37卷 22-33页

作者：张蝶刘曾晶蒙秋霞王慧丰胡艳玲广西医科大学再生医学与医用生物资源开发应用省部共建协同创新中心南宁530022 广西医科大学信息与管理学院南宁530022 广西医科大学基础医学院人体解剖学教研室南宁530022 广西医科大学生命科学研究院南宁530022 广西医科大学基因组与个性化医学研究中心南宁530022

目的探究莪术-三棱药对治疗前列腺癌(prostate cancer,PCa)的药物活性成分、核心靶点及分子机制。方法基于HERB和PubChem数据库获取莪术-三棱的药物活性成分和作用靶点,利用Genecards、OMIM、PhamGkb、TTD、DrugBank数据库获取PCa疾病靶... 详细信息

目的探究莪术-三棱药对治疗前列腺癌(prostate cancer,PCa)的药物活性成分、核心靶点及分子机制。方法基于HERB和PubChem数据库获取莪术-三棱的药物活性成分和作用靶点,利用Genecards、OMIM、PhamGkb、TTD、DrugBank数据库获取PCa疾病靶点,药物靶点和疾病靶点取交集得到共同靶点。采用Cytoscape 3.9.0软件构建莪术-三棱活性成分与PCa靶点网络,将交集靶点导入String数据库构建蛋白-蛋白相互作用网络(protein-protein interaction network,PPI),对潜在靶点进行基因本体(gene gontology,GO)功能富集分析和京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)通路富集分析,最后利用AutoDockTools 1.5.7等软件对核心靶点和药物关键活性成分进行分子对接验证。结果共筛选得到72种药物活性成分和760个有效活性成分靶点,PCa疾病相关靶点13001个,交集靶点为659个。药物关键核心成分为莪术双环烯酮、无患子皂苷B、花椒麻素、(2s)-3',4'-亚甲二氧基-5,7-二甲氧基黄酮、芹菜素、天人菊内酯、山奈酚、三棱酸、脱甲氧姜黄素以及5,7,2',3'-四羟基黄酮。PPI网络分析得到SRC、TP53、MAPK3、MAPK1、STAT3、HSP90AA1、AKT1、PIK3R1、RHOA、GRB2核心靶点。GO和KEGG富集分析显示,莪术-三棱治疗PCa主要涉及细胞增殖、凋亡、迁移和信号转导等信号通路。分子对接结果显示核心靶点与活性成分之间存在较强的结合力。结论本研究揭示了莪术-三棱抗PCa的关键活性成分及其与潜在靶点的相互作用,凸显了其多成分、多靶点相互作用的特性,为深入研究莪术-三棱治疗PCa提供了有价值的参考。

关键词：莪术-三棱药对前列腺癌网络药理学分子对接

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Complex Traffic Scene Image Classification Based on Sparse Optimization Boundary Semantics Deep Learning

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Wuhan University Journal of Natural Sciences 2023年第2期28卷 150-162页

作者： ZHOU Xiwei wang huifeng LI Saisai PENG Haonan WU Jianfeng School of Electronic&Control Engineering Chang'an UniversityXi'an 710064ShaanxiChina

With the rapid development of intelligent traffic information monitoring technology,accurate identification of vehicles,pedestrians and other objects on the road has become particularly ***,in order to improve the recognition and classification accuracy of image objects in complex traffic scenes,this paper proposes a segmentation method of semantic redefine segmentation using image boundary ***,we use the Seg Net semantic segmentation model to obtain the rough classification features of the vehicle road object,then use the simple linear iterative clustering(SLIC)algorithm to obtain the over segmented area of the image,which can determine the classification of each pixel in each super pixel area,and then optimize the target segmentation of the boundary and small areas in the vehicle road ***,the edge recovery ability of condition random field(CRF)is used to refine the image *** experimental results show that compared with FCN-8s and Seg Net,the pixel accuracy of the proposed algorithm in this paper improves by 2.33%and 0.57%,*** compared with Unet,the algorithm in this paper performs better when dealing with multi-target segmentation.

关键词： traffic scene SegNet image classification simple linear iterative clustering(SLIC) conditional random field boundary number

基于网络药理和分子对接探讨莪术-三棱药对治疗卵巢癌的作用机制

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右江民族医学院学报 2024年第2期46卷 177-184页

作者：刘曾晶张蝶蒙秋霞王慧丰胡艳玲广西医科大学信息与管理学院广西南宁530022 广西医科大学再生医学与医用生物资源开发应用省部共建协同创新中心广西南宁530022 广西医科大学基础医学院广西南宁530022 广西医科大学生命科学研究院广西南宁530022 广西医科大学基因组与个性化医学研究中心广西南宁530022

目的探索莪术-三棱药对治疗卵巢癌的有效活性成分与分子生物学机制。方法通过HERB及PubChem数据库检索并筛选出莪术及三棱的有效活性成分和相应的作用靶点;运用Therapeutic Targets、OMIM及GeneCard等数据库检索卵巢癌的疾病靶点。运用C... 详细信息

目的探索莪术-三棱药对治疗卵巢癌的有效活性成分与分子生物学机制。方法通过HERB及PubChem数据库检索并筛选出莪术及三棱的有效活性成分和相应的作用靶点;运用Therapeutic Targets、OMIM及GeneCard等数据库检索卵巢癌的疾病靶点。运用Cytoscape 3.9.0软件绘制药物-成分-靶点网络图,采用STRING数据库及Cytoscape 3.9.0构建PPI网络图,进而使用Cytoscape中MCODE插件筛选出排名前10的核心靶点;使用R 4.2.2对作用靶点进行GO及KEGG通路富集分析;最后使用Auto Dock Vina等软件进行分子对接,验证核心成分与核心靶点的相互作用。结果筛选出了72种活性成分、760个作用靶点,莪术-三棱药对与卵巢癌共同靶基因有617个。核心成分为多梗白菜菊素、天人菊内酯、大花旋覆花素、山奈酚,PPI网络揭示了其主要的靶点,包括MAPK1、MAPK3、JAK1、JAK3、STAT3、MAP2K1、IL6、TYK2、KRAS以及SRC。KEGG富集分析显示共涉及186条通路,根据P<0.05提取与卵巢癌关联紧密的30条通路,主要包括cAMP信号通路、癌症中的蛋白聚糖通路、PI3K-AKT信号通路等。分子对接结果表明,活性成分与核心靶点之间展现出良好的结合亲和性。结论三棱及莪术药对在卵巢癌的综合治疗方面具有多成分、多靶点及多通路的特征,为该药对在临床中的应用提供了信息支撑。

关键词：卵巢癌莪术三棱网络药理分子对接

Controlled preparation and self-assembly of NdVO_4 nanocrystals

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Journal of Rare Earths 2018年第2期36卷 179-183页

作者： Li Tian Yan Li huifeng wang Shanmin Chen Jinjing wang Zhen Guo Qiang Liu Qi Luo Yingjie Li Fafa Wu School of Materials Science and Engineering Hunan Provincial Key Defense Laboratory of High Temperature Wear-resisting Materials and Preparation Technology Hunan University of Science and Technology State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of Sciences

Phase-pure t-NdVO_4 nanocrystals with different shapes have been synthesized by facile and repeatable hydrothermal methods. The as-synthesized t-NdVO_4 nanoparticles were characterized by various techniques of X-ray diffraction（XRD）. scanning electron microscope（SEM） and transmission electron microscope（TEM）. The growth process and assembly behavior of t-NdVO_4 nanorod arrays were investigated. The results show that the morphology of t-NdV04 nanocrystals is greatly related to the pH value of precursor solution and that strong basic solution is not in favor of the formation of t-NdVO_4 nanoparticles. Due to the strong adhesive action and stabilization of OH^-ions to some crystal faces of NdVO_4, neodymium vanadate crystallite grows into oriented short nanorods and then into nanorod arrays. The shape, crystalline and dimension of NdVO_4 nanocrystals can be effectively governed in our work.

关键词： Inorganic compounds Nanostructures Chemical synthesis X-ray diffraction Rare earths

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新沂河沭东段现状行洪能力复核

水利技术监督 2024年第9期 303-306页

作者：郑君玉王慧凤黄逸宸高坤叶晓晶王志伟江苏省水利勘测设计研究院有限公司江苏扬州225127 中水淮河规划设计研究院有限公司安徽合肥230041 河海大学环境学院江苏南京210000

为分析新沂河沭东段现状行洪能力,文章利用新沂河沭东段实测断面和流量水位资料,采用天然河道恒定非均匀流计算公式率定糙率并推求河道现状行洪能力。结果表明:新沂河实际糙率远大于《沂沭泗河洪水东调南下续建工程实施规划》设计糙率;... 详细信息

为分析新沂河沭东段现状行洪能力,文章利用新沂河沭东段实测断面和流量水位资料,采用天然河道恒定非均匀流计算公式率定糙率并推求河道现状行洪能力。结果表明:新沂河实际糙率远大于《沂沭泗河洪水东调南下续建工程实施规划》设计糙率;新沂河沭东段现状行洪能力不满足原设计能力;新沂河沭东段现状行洪能力主要受滩地作物和生产桥等下垫面变化的影响。研究结果可以为新沂河提标工程提供技术支撑。

关键词：新沂河糙率行洪能力

Cushioning Performance of a Novel Polyurethane Foam Material Applied in Fragile Packaging

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Acta Mechanica Solida Sinica 2024年第3期37卷 487-497页

作者： huifeng Xi Chunqiu Guo Jinbiao Yang Xiaogang wang Bowei wang Shiqing Huang Zhiwei wang School of Mechanics and Construction Engineering Jinan UniversityGuangzhou510632China College of Packing Engineering Jinan UniversityZhuhai519070China MOE Key Lab of Disaster Forecast and Control in Engineering Jinan UniversityGuangzhou510632China Foshan Soft Valley Technology Co. Ltd.Foshan528000China

For fragile products,packaging requires cushioning protection to prevent irreversible damage from accidental falls,transportation impacts,and other *** new polyurethane foam(PUF)material demonstrates superior cushioning and vibration isolation performance in practical applications,effectively minimizing damage from *** and vibration experiments were conducted on packages comprising novel PUF,expandable polyethylene,ethylene-vinyl acetate copolymer foam,and *** verify that the new PUF material outperforms in cushioning and vibration isolation,as observed from the acceleration ***,a random vibration analysis of a packaging unit involving different thicknesses of PUF materials and bracelets reveals the enhanced vibration isolation effect within a specific thickness *** vibration results of the bracelet’s outer packaging align closely with finite element simulation results,validating the effectiveness of designing and optimizing the outer *** finite element simulation,deeper understanding and prediction of the bracelet’s vibration response under various conditions is achieved,facilitating optimized packaging design for better protection and vibration damping.

关键词： Flexible polyurethane foam Packaging of fragile goods Nonlinear dynamics Vibration frequency Finite element simulation

Combined Promoting Effects of Specific Organic Functional Groups and Alumina Surface Characteristics for the Design of a Highly Efficient NiMo/Al_(2)O_(3) Hydrodesulfurization Catalyst

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China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 1-11页

作者： Li huifeng Li Mingfeng Zhang Le wang Wei Nie Hong National Energy R&D Center of Petroleum Refining Technology SINOPEC Research Institute of Petroleum Processing Co.Ltd.Beijing 100083China

To prepare a highly efficient NiMo/Al_(2)O_(3) hydrodesulfurization catalyst,the combined effects of specific organic functional groups and alumina surface characteristics were ***,the correlation between the surface characteristics of four different alumina and the existing Mo species states was *** was found that the Mo equilibrium adsorption capacity can be used as a specific descriptor to quantitatively evaluate the changes in surface characteristics of different alumina.A lower Mo equilibrium adsorption capacity for alumina means weaker metal-support interaction and the loaded Mo species are easier to transform into ***,the Mo-O-Al bonds still exist at the metal-support *** introduction of cationic surfactant hecadecyl trimethyl ammonium bromide(CTAB)can further improve Mo species dispersion through electrostatic attraction with Mo anions and interaction of its alkyl chain with the alumina surface;meanwhile,the introduction of ethylenediamine tetraacetic acid(EDTA)can complex with Ni ions to enhance the Ni-promoting effect on ***,the NiMo catalyst designed using alumina with lower Mo equilibrium adsorption capacity and the simultaneous addition of EDTA and CTAB exhibits the highest hydrodesulfurization activity for 4,6-dimethyl dibenzothiophene because of its proper metal-support interaction and more well-dispersed Ni-Mo-S active phases.

关键词： alumina Mo equilibrium adsorption capacity organic functional groups metal-support interaction hydrodesulfurization