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Human microbiome is a diagnostic biomarker in hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2020年第2期19卷 109-115页

作者： Ben-Chen rao Jia-Min Lou Wei-Jie Wang Ang Li Guang-ying Cui Zu-Jiang Yu Zhi-Gang Ren Department of Infectious Diseases the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Gene Hospital of Henan Province Precision Medicine Centerthe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Hepatobiliary and Pancreatic Surgery the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Background:Hepatocellular carcinoma(HCC)is the third leading cause of cancer mortality *** evidence indicates a close relationship between HCC and the human ***,we reviewed the important potential of the human microbiota as a diagnostic biomarker of *** sources:Several innovative studies have investigated the characteristics of the gut and oral micro-biomes in patients with HCC and proposed that the human microbiome has the potential to be a diag-nostic biomarker of *** from February 1999 to February 2019 was searched in the PubMed database using the keywords"microbiota"or"microbiome"or"microbe"and"liver cancer"or"hepato-cellular carcinoma",and the results of clinical and experimental studies were ***:Specific changes occur in the human microbiome of patients with ***,the gut mi-crobiome and oral microbiome can be used as non-invasive diagnostic biomarkers for ***,they also have certain diagnostic potential for precancerous diseases of *** diagnostic potential of the blood microbiota and ascites microbiota in HCC will be gradually discovered in the ***:The human microbiome is valuable to the diagnosis of HCC and provides a novel strategy for targeted therapy of *** human microbiome may be widely used in the diagnosis,treatment and prognosis for multiple system diseases or cancers in the future.

关键词： Human microbiome Gut microbiome Oral microbiome Hepatocellular carcinoma Diagnostic biomarker

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Decellularized Disc Hydrogels for hBMSCs tissue-specific differentiation and tissue regeneration

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Bioactive Materials 2021年第10期6卷 3541-3556页

作者： Yizhong Peng Xiangcheng Qing hui Lin Donghua Huang Jinye Li Shuo Tian Sheng Liu Xiao Lv Kaige Ma Rui Li Zilong rao ying Bai Songfeng Chen Ming Lei Daping Quan Zengwu Shao Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Musculoskeletal Tumor Center Department of OrthopedicsThe Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina School of Chemistry Sun Yat-sen UniversityGuangzhou510127China School of Materials Science and Engineering Sun Yat-sen UniversityGuangzhou510127China Department of Orthopaedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou City450052China

Tissue specificity,a key factor in the decellularized tissue matrix(DTM),has shown bioactive functionalities in tuning cell fate-e.g.,the differentiation of mesenchymal stem ***,cell fate is also determined by the living microenvironment,including material composition and spatial ***,two neighboring tissues within intervertebral discs,the nucleus pulposus(NP)and annulus fibrosus(AF),were carefully processed into DTM hydrogels(abbreviated DNP-G and DAF-G,respectively)to determine the tissue-specific effects on stem cell fate,such as specific components and different culturing methods,as well as in vivo *** differences in their protein compositions were identified by proteomic ***,the fate of human bone marrow mesenchymal stem cells(hBMSCs)also responds to both culturing methods and ***,hBMSCs cultured with DNP-G(3D)differentiated into NP-like cells,while hBMSCs cultured with DAF-G(2D)underwent AF-like differentiation,indicating a close correlation with the native microenvironments of NP and AF cells,***,we found that the integrin-mediated RhoA/LATS/YAP1 signaling pathway was activated in DAF-G(2D)-induced AF-specific ***,the activation of YAP1 determined the tendency of NP-or AF-specific differentiation and played opposite regulatory ***,DNP-G and DAF-G specifically promoted tissue regeneration in NP degeneration and AF defect rat models,*** conclusion,DNP-G and DAF-G can specifically determine the fate of stem cells through the integrin-mediated RhoA/LATS/YAP1 signaling pathway,and this tissue specificity is both compositional and spatial,supporting the utilization of tissue-specific DTM in advanced treatments of intervertebral disc degeneration.

关键词： Tissue specificity Decellularized tissue matrix Intervertebral disc Differentiation YAP1

The Characterizations of Hyper-Star Graphs Induced by Linearly Separable Boolean Functions

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Chinese Journal of Electronics 2018年第1期27卷 19-25页

作者： rao Yanyi ZHANG Xianda Department of Automation Tsinghua University

A hyper-star is a graph consisting of the union of some hypercubes with at least one common vertex. The graph induced by a linearly separable Boolean function is a hyper-star. We obtain some properties of hyper-stars and give a decomposition algorithm of a hyperstar. We give a determination condition for a *** determination condition yields an algorithm of constructing all hyper-stars of n vertices in time O（n3）.

关键词： Boolean function Hypercube Hyper-star Algorithm

Blind Equalization Using Coordinate Mapping for 4-PAM and 16-QAM Signals

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Chinese Journal of Electronics 2014年第1期23卷 124-128页

作者： rao Wei Nanchang Institute of Technology

It is well known that the famous Constant modulus algorithm(CMA) presents a large steady-state Mean square error(MSE) for nonconstant modulus signals. In this paper a coordinate mapping approach for a4-PAM nonconstant modulus signal is described which can change the signal to an Offset QPSK(OQPSK) constant modulus signal. And a new algorithm based on this approach is proposed which is also suitable for a 16-QAM signal. For the 4-PAM and 16-QAM nonconstant modulus signals the proposed algorithm can achieve a zero steadystate MSE in a noiseless environment but CMA *** analysis and simulations results demonstrate the high performance of the proposed algorithm.

关键词： Blind equalization Constant modulus algorithm Coordinate mapping

DIMENSIONS AND GAUGES FOR SYMMETRIC CANTOR SETS

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Analysis in Theory and Applications 1995年第4期11卷 108-110页

作者： Feng Dejun, rao hui, Wen Zhiying, Wu Jun(Wuhan University, China) Department of Mathematics Wuhan University Wuhan PRC

*** definitions and notions 1.1. Hausdorff gauge and Packing gaugeA funciton h:[0.1]→ R is said to be a dimension function if it has the following properties:(1)h(t)is continuous and increasing, h(0)=0, h(t)>0 when t... 详细信息

关键词： DIMENSIONS AND GAUGES FOR SYMMETRIC CANTOR SETS

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Hepatoprotective and antioxidant capacity of Melochia corchorifolia extracts

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Asian Pacific Journal of Tropical Medicine 2013年第7期6卷 537-543页

作者： B Ganga rao Y Venkateswara rao T Mallikarjuna rao A.U College of Pharmaceutical Sciences Andhra UniversityVisakhapatnamAndhra PradeshIndia-530003 Department of Botany College of Science and TechnologyAndhra University.VisakhapatnamAndhra PradeshIndia-530003

Objective:To evaluate bepato protective and antioxidant capacity of Melochia corchorifolia （***）aerial part ***:Antioxidant activitywas evaluated by using three free radicals（Superoxide,Hydroxyl and DPPH） and hepatoprotective activity was assessed against CCl4 induced liver intoxication in ***:The extracts produced concentration dependent percentage protection in decrease of serum enzymes and percentage inhibition on free *** all extracts methanol extract showed better activity with percentage protection of SGOT（78.98%）,SGPT（79.65%）,ALP（82.48%） and total bilirubin（80.0%）levels against CCl4 liver intoxication and also methanolic extract showed better activity with IC50 values on superoxide. hydroxyl and DPPH radicals were 127μg.240μg and 179μ***:From the results obtained during the study it could be concluded that *** aerial part extracts have antioxidant and hepaloprotective *** study is necessary for isolation and characterization of bioactive molecules which are responsible for hepatoprotective and antioxidant activity.

关键词： Melochia corchorifolia Aerial parts Free radicals Antioxidant Activity CCl_4 Hepatoprotective activity

Effect of transient scrotal hyperthermia on sperm parameters, seminal plasma biochemical markers, and oxidative stress in men

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Asian Journal of Andrology 2015年第4期17卷 668-675页

作者： Meng rao Xiao-Ling Zhao Jing Yang Shi-Fu HU hui Lei Wei Xia Chang-Hong Zhu Family Planning Research Institute Tengii Medical College Huazhong University of Science and Technology Wuhan China Reproductive Medicine Center TongjiMedical College Huazhong University of Science and Technology Wuhan China

In this experimental prospective study, we aimed to analyze the effect of transient scrotal hyperthermia on the male reproductive organs, from the perspective of sperm parameters, semen plasma biochemical markers, and oxidative stress, to evaluate whether different frequencies of heat exposure cause different degrees of damage to spermatogenesis. Two groups of volunteers （10 per group） received testicular warming in a 43~C water bath 10 times, for 30 min each time： group 1：10 consecutive days; group 2： once every 3 days. Sperm parameters, epididymis and accessory sex gland function, semen plasma oxidative stress and serum sex hormones were tested before treatment and in the 16-week recovery period after treatment. At last, we found an obvious reversible decrease in sperm concentration （P = 0.005 for Group 1 and P = 0.008 for Group 2 when the minimums were compared with baseline levels, the same below）, motility （P= 0.009 and 0.021, respectively）, the hypoosmotic swelling test score （P-- 0.007 and 0.008, respectively）, total acrosin activity （P = 0.018 and 0.009, respectively）, and an increase in the seminal plasma malondialdehyde concentration （P = 0.005 and 0.017, respectively）. The decrease of sperm concentration was greater for Group 2 than for Group 1 （P = 0.031）. We concluded that transient scrotal hyperthermia seriously, but reversibly, negatively affected the spermatogenesis, oxidative stress may be involved in this process. In addition, intermittent heat exposure more seriously suppresses the spermatogenesis compared to consecutive heat exposure. This may be indicative for clinical infertility etiology analysis and the design of contraceptive methods based on heat stress.

关键词： hyperthermia oxidative stress seminal plasma biochemical markers sperm parameters spermatogenesis

Novel Porous Polyethersulfone Beads as Matrix to Immobilize Comamonas testosteroni sp. bdq06 in Quinoline Biodegradation

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Chemical Research in Chinese Universities 2015年第4期31卷 645-650页

作者： GENG Zhi ZHU Suiyi YU Yang LU ying LIN rao GUO Shujun BIAN Dejun YANG Xia HUO Mingxin HUO Hongliang College of Environment Jilin Engineering Research Centre for Municipal Wastewater Treatment and Water Quality Protection Northeast Normal University Changchun 130117 P R. China Jilin Key Laboratory for Municipal Wastewater Treatment Changchun Institute of Technology Changchun 130020 P R. China Petro China Jilin Petrolchemical Company Jilin 132022 P. R. China Department of Sustainability Sciences Lakehead University Orillia L3V OB9 Canada

Novel matrix beads for the immobilization of strain Comamonas testosteroni sp. bdq06 to degrade quino- line were fabricated from polyethersulfone（PES）. The beads have an average size of 3 mm and a surface dense layer of 20 microns. To help adhesion and proliferation of bacterial cells, the surfaces of the PES beads were etched, and numerous holes about 1.5 micrometers in diameter were generated as tunnels for cell colonizing in the larger internal cavities of about 5 micrometers in diameter. The quinoline degradation was remarkably enhanced by the cells immo- bilized in PES beads compared with that by the free cells at pH 5.0 or 10.0 and a temperature of 40 ℃. The enhanced degradation of quinoline was contributed to the biofilm on the surface of PES beads, resulting in the significant re- duction of retention time from 9 h to 2 h. Furthermore, the beads remain intact after the ultrasonic treatment of them for 30 rain or recycling 50 times, indicating that they have excellent mechanical strength, flexibility and swelling ca- pacity. Thus, PES beads have great potential to be matrix for the cell immobilization in bioaugmentation.

关键词： Polycthcrsulfonc Biodcgradation Immobilization Quinolinc

Optimizing machining parameters of wire-EDM process to cut Al7075/SiCp composites using an integrated statistical approach

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Advances in Manufacturing 2016年第3期4卷 202-216页

作者： Thella Babu rao Department of Mechanical Engineering K L UniversityGreen Fields Vaddeswaram GunturAndhra Pradesh 522502 India

Metal matrix composites （MMCs） as advanced materials, while producing the components with high dimensional accuracy and intricate shapes, are more complex and cost effective for machining than conventional alloys. It is due to the presence of discontinuously distributed hard ceramic with the MMCs and involvement of a large number of machining control variables. However, determination of optimal machining conditions helps the process engineer to make the process efficient and effec- tive. In the present investigation a novel hybrid multi-response optimization approach is proposed to derive the economic machining conditions for MMCs. This hybrid approach integrates the concepts of grey relational analysis （GRA）, principal component analysis （PCA） and Taguchi method （TM） to derive the optimal machining conditions. The machining experiments are planned to machine A17075/SiCp MMCs using wire-electrical discharge machining （WEDM） process. SiC particulate size and its weight percentage are explicitly considered here as the process variables along with the WEDM input variables. The derived optimal process responses are confirmed by the experimental validation tests and the results show satisfactory. The practical possibility of the derived optimal machining conditions is also analyzed and presented using scanning electron microscope （SEM） examinations. According to the growing industrial need of making high performance, low cost components, this investigation provides a simple and sequential approach to enhance the WEDM performance while machining MMCs.

关键词： Al7075/SiCP metal matrix composites(MMCs) Wire-electrical discharge machining (WEDM)Principal component analysis (PCA) Grey relationalanalysis (GRA) Taguchi method (TM)