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Distribution and changes in hepatitis C virus genotype in China from 2010 to 2020

World Journal of Clinical Cases 2022年第14期10卷 4480-4493页

作者： Jia Yang hui-Xin Liu ying-ying Su Zhi-Sheng Liang hui-ying rao Peking University Hepatology Institute Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseasesPeking University People’s HospitalBeijing 100044China Department of Clinical Epidemiology and Biostatistics Peking University People’s HospitalBeijing 100044China National Institute of Diagnostics and Vaccine Development in Infectious Diseases School of Public HealthXiamen UniversityXiamen 361000Fujian ProvinceChina Department of Global Health School of Public HealthPeking UniversityBeijing 100044China

BACKGROUND Hepatitis C virus(HCV)causes a large number of infections *** infections seem to be increasing according to a report of the World Health Organization in *** direct-acting antivirals are quite effective for most genotypes of the HCV,some genotypes fail to ***,the trend of genotype distribution is vital to better control the development of this *** To analyze the distribution and trends of the HCV genotype before and after the emergence of direct-acting antivirals in *** We searched all literature published in five electronic databases-China National Knowledge Infrastructure,Wan Fang Data,VIP Chinese Journal Database,Chinese Biomedical Literature Service System,and PubMed-from January 1,2010 to December 31,*** search strategy combined medical subject headings and free-text terms,including“hepatitis C virus”or“HCV”and“genotype”or“subtype”and“China”or“Chinese”.Additional relevant articles were searched by manual *** were extracted to build a *** of the data were totaled according to regions,periods,routes of transmission,and *** percentages in various stratifications were *** There were 76110 samples from 30 provinces included in the *** 1(G1)accounted for 58.2%of cases nationwide,followed by G2,G6,G3b,G3a,unclassified and mixed infections(17.5%,7.8%,6.4%,4.9%,1.8%,and 1.2%,respectively).The constitution of genotype varied among different regions,with G6 and G3b being more common in the south and southwest,respectively(28.1%,15.4%).The past ten years have witnessed a decrease in G1 and G2 and an increase in G3 and G6 in almost all *** drug-use population had the most abundant genotypes,with G6 ranking first(33.3%),followed by G1 and G3b(23.4%,18.5%).CONCLUSION G3 and G6 pose a new challenge for HCV *** study revealed the distribution of HCV genotypes in China over the past 10 years,providing information for HCV management strategie

关键词： Hepacivirus Genotype China Drug users Direct-acting antiviral Hepatitis C virus

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Histopathology and the predominantly progressive,indeterminate and predominately regressive score in hepatitis C virus patients after direct-acting antivirals therapy

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World Journal of Gastroenterology 2021年第5期27卷 404-415页

作者： Rui Huang hui-ying rao Ming Yang ying-hui Gao Jian Wang Qian Jin Dan-Li Ma Lai Wei Peking University Hepatology Institute Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseasesBeijing International Cooperation Base for Science and Technology on NAFLD DiagnosisPeking University People’s HospitalBeijing 100044China Hepatopancreatobiliary Center Beijing Tsinghua Changgung HospitalTsinghua UniversityBeijing 102218China

BACKGROUND Histological changes after direct-acting antivirals(DAAs)therapy in hepatitis C virus(HCV)patients has not been *** the predominantly progressive,indeterminate and predominately regressive(P-I-R)score,evaluating fibrosis activity in hepatitis B virus patients has predictive value in HCV patients has not been *** To identify histological changes after DAAs therapy and to evaluate the predictive value of the P-I-R score in HCV *** Chronic HCV patients with paired liver biopsy specimens before and after DAAs treatment were *** virologic response(SVR)was defined as an undetectable serum HCV RNA level at 24 wk after treatment *** Ishak system and P-I-R score were *** improvement and fibrosis regression were defined as a≥2-points decrease in the histology activity index(HAI)score and a≥1-point decrease in the Ishak fibrosis score,*** progression was defined as a≥1-point increase in the Ishak fibrosis *** improvement was defined as a≥2-points decrease in the HAI score without worsening of the Ishak fibrosis score after DAAs *** P-I-R score was also assessed.“absolutely reversing or advancing”was defined as the same directionality implied by both change in the Ishak score and posttreatment P-I-R score;and“probably reversing or advancing”was defined as only one parameter showing *** Thirty-eight chronic HCV patients with paired liver biopsy specimens before and after DAAs treatment were *** mean age of these patients was 40.9±14.6 years and there were 53%(20/38)***-four percent(13/38)of patients were ***-two percent(31/38)of patients achieved inflammation *** median HAI score decreased significantly after SVR(pretreatment 7.0 vs posttreatment 2.0,Z=-5.146,P=0.000).Thirty-seven percent(14/38)of patients achieved fibrosis *** median Ishak score decreased significantly afte

关键词： Hepatitis C virus Direct-acting antiviral agents Necroinflammation Fibrosis Predominantly progressive,indeterminate and predominately regressive score Histopathology

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CD4^+CXCR5^+ T cells activate CD27^+IgG^+ B cells via IL-21 in patients with hepatitis C virus infection

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Hepatobiliary & Pancreatic Diseases International 2016年第1期15卷 55-64页

作者： Fan-Yun Kong Bo Feng Heng-hui Zhang hui-ying rao Jiang-Hua Wang Xu Cong Lai Wei Peking University People’s Hospital Peking University Hepatology InstituteBeijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases

BACKGROUND： Chronic hepatitis C virus （HCV） infection causes the skewing and activation of B cell subsets, but the characteristics of IgG＋ B cells in patients with chronic hepa- titis C （CHC） infection have not been thoroughly elucidated. CD4＋CXCR5＋ follicular helper T （Tfh） cells, via interleukin （IL）-21 secretion, activate B cells. However, the role of CD4＋CXCR5＋ T cells in the activation ofIgG＋ B cells in CHC patients is not clear. METHODS： The frequency of IgG＋ B cells, including CD27-IgG＋ B and CD27＋IgG＋ B cells, the expression of the activation markers （CD86 and CD95） in IgG＋ B cells, and the percentage of circu- lating CD4＋CXCR5＋ T cells were detected by flow cytometry in CHC patients （n=70） and healthy controls （n=25）. The con- centrations of serum IL-21 were analyzed using ELISA. The role of CD4＋CXCR5＋ T cells in the activation of IgG＋ B cells was investigated using a co-culture system. RESULTS： A significantly lower proportion of CD27＋IgG＋ B cells with increased expression of CD86 and CD95 was observed in CHC patients. The expression of CD95 was negatively correlated with the percentage of CD27＋IgG＋ B cells, and it contributed to CD27＋IgG＋ B cell apoptosis. Circulating CD4＋CXCR5＋ T cells and serum IL-21 were significantly increased in CHC patients. Moreover, circulating CD4＋CXCR5＋ T cells from CHC patients induced higher expressions of CD86 and CD95 in CD27＋IgG＋ B cells in a co-culture system; the blockade of the IL-21 decreased the expression levels of CD86 and CD95 in CD27＋IgG＋ B ***： HCV infection increased the frequency of CD4＋CXCR5＋ T cells and decreased the frequency of CD27＋IgG＋ B cells. CD4＋CXCR5＋ T cells activated CD27＋IgG＋ B cells via the secretion of IL-21.

关键词： chronic hepatitis C IgG+ B cells CD4+CXCR5+ T cells

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Gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acidenhanced magnetic resonance imaging for evaluating fibrosis regression in chronic hepatitis C patients after direct-acting antiviral

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World Journal of Gastroenterology 2022年第20期28卷 2214-2226页

作者： Xiao-He Li Rui Huang Ming Yang Jian Wang ying-hui Gao Qian Jin Dan-Li Ma Lai Wei hui-ying rao Peking University Hepatology Institute Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseasesBeijing International Cooperation Base for Science and Technology on NAFLD DiagnosisPeking University People’s HospitalBeijing 100044China Hepatopancreatobiliary Center Beijing Tsinghua Changgung HospitalTsinghua UniversityBeijing 100044China

BACKGROUND Direct acting antiviral(DAA)therapy has enabled hepatitis C virus infection to become curable,while histological changes remain *** valid noninvasive methods can be confirmed for use in ***-ethoxybenzyl-diethylenetriamine penta-acetic acid(Gd-EOB-DTPA)is a liver-specific magnetic resonance imaging(MRI)contrast,related to liver function in the hepatobiliary phase(HBP).Whether Gd-EOB-DTPA-enhanced MRI can be used in the diagnosis and follow up of hepatic fibrosis in patients with chronic hepatitis C(CHC)has not been *** To investigate the diagnostic and follow-up values of Gd-EOB-DTPA-enhanced MRI for hepatic histology in patients with *** Patients with CHC were invited to undergo Gd-EOB-DTPA-enhanced MRI and liver biopsy before treatment,and those with paired qualified MRI and liver biopsy specimens were *** elastography(TE)and blood tests were also *** treated with DAAs who achieved 24-wk sustained virological response(SVR)underwent Gd-EOB-DTPA-enhanced MRI and liver biopsy *** signal intensity(SI)of the liver and muscle were measured in the unenhanced phase(UEP)(SI_(UEP-liver),SI_(UEP-muscle))and HBP(SI_(HBP-liver),SI_(HBP-muscle))via *** contrast enhancement index(CEI)was calculated as[(SI_(HBP-liver)/SI_(HBP-muscle))]/[(SI_(UEP-liver)/SI_(UEP-muscle))].Liver stiffness measurement(LSM)was confirmed with *** markers,aspartate aminotransferase-to-platelet ratio index(APRI)and Fibrosis-4(FIB-4),were also calculated according to blood *** grade of inflammation and stage of fibrosis were evaluated with the modified histology activity index(mHAI)and Ishak fibrosis score,*** regression was defined as a≥1-point decrease in the Ishak fibrosis *** correlation between the CEI and liver pathology was *** diagnostic and follow-up values of the CEI,LSM,and serologic markers were *** Thirty-nine patients with CHC wer

关键词： Gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid-enhanced magnetic resonance imaging Contrast enhancement index Hepatitis C virus Direct acting antiviral Sustained virological response Fibrosis regression

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Direct-acting Antiviral Agents Resistance-associated Polymorphisms in Chinese Treatment-na（i）ve Patients Infected with Genotype 1b Hepatitis C Virus

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Chinese Medical Journal 2015年第19期128卷 2625-2631页

作者： Ye Wang hui-ying rao Xing-Wang Xie Lai Wei Peking University People's Hospital Peking University Hepatology InstituteBeijing Key Laboratory for Hepatitis C and Immunotherapy for Liver DiseaseBeijing 100044China

Background：It has been reported that several baseline polymorphisms of direct-acting antivirals （DAAs） agents resistance-associated variants （RAVs） would affect the treatment outcomes of patients chronically infected with hepatitis C virus （CHC）.The aim of this study is to investigate the prevalence of DAAs RAVs in treatment-na（i）ve GT1b CHC ***：Direct sequencing and ultra-deep sequencing of the HCV NS3,NS5A,and NS5B gene were performed in baseline serum samples of treatment-ha（i）ve patients infected with genotype lb hepatitis C virus （HCVs）.Results：One hundred and sixty CHC patients were *** sequence information was obtained for 145 patients （NS3）,148 patients （NS5A）,and 137 patients （NS5B）.Treatment-failure associated variants of DAAs were detected：56.6％（82/145） of the patients presented S122G for simeprevir （NS3 protease inhibitor）;10.1％（14/148） of the patients presented Y93H for daclatasvir and ledipasvir （NS5A protein inhibitors）;94.2％（129/137） of the patients presented C316N for sofosbuvir （NS5B polymerase inhibitor）.Nearly,all of the DAAs RAVs detected by ultra-deep sequencing could be detected by direct ***：The majority of genotype lb CHC patients in China present a virus population carrying HCV DAAs *** sequencing of HCV genome might need to be performed when patients infected with GTlb HCV receiving DAAs-containing regimens in *** sequencing would be quite quantified for the work.

关键词： Antiviral Resistance Direct Antiviral Agents Hepatitis C Virus

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Evaluation of cross-reactive antibody response to HVR1 in chronic hepatitis C

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World Journal of Gastroenterology 2010年第35期16卷 4460-4466页

作者： Bing-Shui Xiu Xiao-Yan Feng Jing He Guo-Hua Wang He-Qiu Zhang Xiao-Guo Song Kun Chen Shi-Gan Ling Cui-Xia Zhu Xiang-ying Zhang Lai Wei hui-ying rao Institute of Basic Medical Sciences Academy of Military Medical Sciences Beijing 100850 China National Institute for Control of Pharma-ceutical and Biological Products Beijing 100050 China Hepatology Institute People Hospital Peking University Beijing 100044China

AIM:To evaluate the presence and cross-reactive anti-bodies against hypervariable region 1(HVR1) in hepatitis C virus(HCV) infected patients and its relationship with the progression of the ***:Sixteen representative HVR1 proteins selected from a unique set of 1600 natural sequences were used to semiquantitate the cross-reactivity of HVR1 antibodies in the sera of HCV ***-five chronic HCV patients including 23 with asymptomatic mild hepatitis,18 with chronic hepatitis and 16 with liver cirrhosis patients were ***:The degree of the cross-reactivity of anti-HVR1 antibodies in 23 patients with mild asymptomatic hepatitis was 3.09 ± 2.68,which was signif icantly lower than in those with chronic hepatitis(5.44 ± 3.93,P < 0.05) and liver cirrhosis(7.44 ± 3.90,P < 0.01).No correlation was observed between the broadness of the cross-reactivity anti-HVR1 antibodies and patient's age,infection time,serum alanine aminotransferase activity,or serum HCV-RNA *** was the breath of cross-reactivity rather than the presence of anti-HVR1 antibody in HCV sera that was associated with the progression of liver ***:The broadly cross-reactive HVR1 antibodies generated in natural HCV patients can not neutralize the virus,which results in persistent infection in patients with chronic hepatitis.

关键词： Hepatitis C virus Hypervariable region 1 Cross-reactivity

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Impact of hepatitis C virus genotype 3 on liver disease progression in a Chinese national cohort

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Chinese Medical Journal 2020年第3期133卷 253-261页

作者： Nan Wu hui-ying rao Wei-Bo Yang Zhi-Liang Gao Rui-Feng Yang Ran Fei ying-hui Gao Qian Jin Lai Wei Peking University People’s Hospital Peking University Hepatology InstituteBeijing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseaseBeijing 100044China Department of Infectious Diseases The First Affiliated Hospital of Kunming Medical CollegeKunmingYunnan 650032China Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdong 510630China Hepatopancreatobiliary Center Beijing Tsinghua Changgung HospitalInstitute for Precision MedicineTsinghua UniversityBeijing 102218China

Background:Hepatitis C virus(HCV)genotype 3,particularly subtype 3b,is increasing in prevalence and distribution in *** study evaluated the prevalence,regional distribution,clinical characteristics,host factors,treatment outcomes,and disease progression of patients with HCV genotype 3 in ***:A 5-year follow-up was preceded by a cross-sectional *** choices were at the discretion of treating *** infection time to overall-disease-progression(defined by≥1 of:newly diagnosed cirrhosis;cirrhosis at baseline,Child-Turcotte-Pugh score increased 2 points or more;progression from compensated cirrhosis to decompensated cirrhosis;hepatocellular carcinoma;liver transplantation;or death)was calculated using the Kaplan-Meier *** regression analyses were conducted to evaluate the risk factors for disease ***:The cross-sectional study enrolled 997 patients,including 91 with HCV genotype 3 *** them,subtype 3b(57.1%)was more dominant than subtype 3a(38.5%).Five hundred and twelve patients were included into the follow-up *** patients analyzed for estimated infection time to overall-disease-progression,52/304(17.1%)patients with HCV genotype 1 and 4/41(9.8%)with HCV genotype 3(4/26 with genotype 3b,0/13 with genotype 3a,and 0/2 with undefined subtype of genotype 3)experienced *** with HCV genotype 3 were younger than those with genotype 1(mean age:39.5±8.7 vs.46.9±13.6 years)and demonstrated more rapid disease progression(mean estimated infection time to overall-disease-progression 27.1 vs.35.6 years).Conclusions:HCV genotype 3,specifically subtype 3b,is associated with more rapid progression of liver *** analysis to compare HCV subtype 3a and 3b is needed in high prevalence regions.

关键词： Hepatitis C virus genotype 3 Chronic hepatitis C Disease progression

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Patient Education Improves Patient Knowledge and Acceptance on Antiviral Therapy of Hepatitis C in Rural China

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Chinese Medical Journal 2017年第22期130卷 2750-2751页

作者： Ming Yang hui-ying rao Bo Feng Elizabeth WU Lai Wei Anna S Lok Peking University Hepatology Institute Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases Peking University People's Hospital Beijing 100044 China Division of Gastroenterology and Hepatology University of Michigan Health System Ann Arbor MI 48109 USA

It is estimated that 130-150 million people are chronically infected with hepatitis C virus （HCV） worldwide. During the late 1980s and early 1990s, illegal commercial plasma or blood donation practices were common in selected rural areas of China, which caused a rapid spread of HCV infection. Cross-sectional studies have showed that the prevalence rates of HCV infection in former paid plasma or blood donors varied from 9.6% to 72.8%. Chronic HCV infection can cause cirrhosis, liver failure, and hepatocellular carcinoma （HCC）, and is a major global health problem.

关键词： Barriers to Care Hepatitis C Prevention Transmission

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Toric人工晶状体术后旋转的影响因素及处理原则

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国际眼科杂志 2022年第10期22卷 1662-1665页

作者：陈紫亮饶惠英福建医科大学省立临床医学院福建省福州市350001 福建省立医院眼科福建省福州市350001

现代白内障手术已经转变成屈光性手术,因此安全有效地矫正散光是现代白内障手术的重要组成部分。Toric IOL(IOL)植入术因其高度的可预测性及安全性已经逐渐成为白内障术中矫正0.75D以上角膜规则散光的首选方式。Toric IOL需要植入在一... 详细信息

现代白内障手术已经转变成屈光性手术,因此安全有效地矫正散光是现代白内障手术的重要组成部分。Toric IOL(IOL)植入术因其高度的可预测性及安全性已经逐渐成为白内障术中矫正0.75D以上角膜规则散光的首选方式。Toric IOL需要植入在一个精准的轴位才能达到良好的散光矫正效果。Toric IOL错位的主要原因是术后旋转,这通常在术后不久发生。术后大幅度的旋转会降低Toric IOL的散光矫正效果,甚至在新的轴位上产生散光。术后IOL旋转的原因是多元化的,临床医生需要对此深入了解以最大幅度地减少旋转。大幅度旋转后的处理一般选择复位手术,手术时机的把握也尤为重要。本文就Toric IOL术后旋转的影响因素及处理原则进行综述。

关键词：白内障手术 Toric人工晶状体角膜散光旋转稳定性高度近视复位手术

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白内障超声乳化术中灌注液迷流的相关研究

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国际眼科杂志 2023年第11期23卷 1821-1825页

作者：王艺儒饶惠英福建医科大学省立临床医学院中国福建省福州市350001 福建省立医院眼科中国福建省福州市350001

灌注液迷流综合征(infusion misdirection syndrome,IMS)是白内障超声乳化术中突发的一类罕见且处理棘手的并发症,其通常发生于白内障术中水分离、超声乳化或灌注抽吸(irrigation/aspiration,I/A)时。在悬韧带松弛、晶状体脱位、后囊膜... 详细信息

灌注液迷流综合征(infusion misdirection syndrome,IMS)是白内障超声乳化术中突发的一类罕见且处理棘手的并发症,其通常发生于白内障术中水分离、超声乳化或灌注抽吸(irrigation/aspiration,I/A)时。在悬韧带松弛、晶状体脱位、后囊膜破裂、眼前段拥挤、高灌注压等因素下,灌注液积聚于玻璃体腔中或玻璃体后,造成眼内压升高、前房变浅甚至消失进而导致手术难以进行。这需与暴发性脉络膜上腔出血(suprachoroidal hemorrhage,SCH)、囊袋阻滞综合征(capsular block syndrome,CBS)等进行鉴别。在经过术中紧急处理,如:休息联合甘露醇静滴、玻璃体腔穿刺抽液或玻璃体切除后,患眼术后均能获得良好预后。本文围绕白内障超声乳化术中灌注液迷流的发病机制、诊断及鉴别、术中紧急处理方式、预防及预后进行详细综述,以期为眼科医生提供临床指导。

关键词：灌注液迷流综合征白内障超声乳化术发病机制处理方法

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