检索结果-南通市图书馆

Long-term hyperglycemia aggravatesα-synuclein aggregation and dopaminergic neuronal loss in a Parkinson’s disease mouse model

引用

Translational Neurodegeneration 2022年第1期11卷 747-762页

作者： Yi-Qing Lv Lin Yuan Yan Sun Hao-wen Dou Ji-hui Su Zhi-pan Hou Jia-Yi Li wen Li Laboratory of Research in Parkinson’s Disease and Related Disorders Health Sciences InstituteChina Medical UniversityShenyang 110122China Neural Plasticity and Repair Unit Department of Experimental Medical SciencesLund University22184 LundSweden

Background:Growing evidence suggests an association between Parkinson’s disease(PD)and diabetes mellitus(DM).At the cellular level,long-term elevated levels of glucose have been shown to lead to nigrostriatal degeneration in PD ***,the underlying mechanism is still ***,we have elucidated the potential of type 2 diabetes mellitus(T2DM)in facilitating PD progression,involving aggregation of both alpha-synuclein(α-syn)and islet amyloid polypeptide in the pancreatic and brain ***,due to the complicated effect of insulin resistance on PD onset,the actual mechanism of hyperglycemia-induced dopaminergic degeneration remains ***:We employed the type 1 diabetes mellitus(T1DM)model induced by streptozotocin(STZ)injection in a transgenic mouse line(BAC-α-syn-GFP)overexpressing humanα-syn,to investigate the direct effect of elevated blood glucose on nigrostriatal ***:STZ treatment induced more severe pathological alterations in the pancreatic islets and T1DM symptoms inα-syn-overexpressing mice than in wild-type mice,at one month and three months after STZ *** tests evaluating motor performance confirmed the nigrostriatal ***,there was a marked decrease in dopaminergic profiles and an increase ofα-syn accumulation and Serine 129(S129)phosphorylation in STZ-treatedα-syn mice compared with the vehicle-treated *** addition,more severe neuroinflammation was observed in the brains of the STZ-treatedα-syn ***:Our results solidify the potential link between DM and PD,providing insights into how hyperglycemia induces nigrostriatal degeneration and contributes to pathogenic mechanisms in PD.

关键词： Hyperglycemia Diabetes mellitus Parkinson’s disease Neurodegeneration Neuroinflammation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Design of a NIM-based DAQ system

引用

Nuclear Science and Techniques 2017年第10期28卷 37-43页

作者： wen-Xiong Zhou Yan-Yu Wang Liang-Ming pan College of Power Engineering Chongqing UniversityChongqing 400044China Postdoctoral Station Chongqing UniversityChongqing 400044China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China

In order to satisfy the requirements of beam measurement in the heavy ion medical machine and other small nuclear physics experiments, we designed and built a nuclear instrumentation module-based data acquisition system. This is composed of a set of functional modules and a purpose-built bus. One of the modules operates as a master, collecting data from the other slave modules. It then sends the data to the back-end computer via *** addition to the hardware, dedicated software has been designed and implemented. In this paper, we provide a detailed description of the architecture of the system, the data frame, and the software. The bus is the central part of the system. It can transmit data from the slave modules to the master at 33 MB/s. The frame used to transmit the data also ensures its integrity and monitors the hardware architecture. The client software is designed to process data in real time and store data on a hard disk for later analysis.

关键词：数据采集系统软件设计数据仓库功能模块专用软件硬件结构核物理实验医疗机械

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Autonomous Formation Flight Control of Large-Sized Flapping-Wing Flying Robots Based on Leader–Follower Strategy

引用

Journal of Bionic Engineering 2023年第6期20卷 2542-2558页

作者： hui Xu Yuanpeng Wang Erzhen pan wenfu Xu Dong Xue School of Mechanical Engineering and Automation Harbin Instwitute of TechnologyShenzhen518055China State Key Laboratory of Robotics and System Harbin Institute of TechnologyHarbin150000China School of Aeronautics Northwestern Polytechnical UniversityXi’an710072China

Birds in nature exhibit excellent long-distance flight capabilities through formation flight,which could reduce energy consumption and improve flight *** by the biological habits of birds,this paper proposes an autonomous formation flight control method for Large-sized Flapping-Wing Flying Robots(LFWFRs),which can enhance their search range and flight ***,the kinematics model for LFWFRs is ***,an autonomous flight controller based on this model is designed,which has multiple flight control modes,including attitude stabilization,course keeping,hovering,and so ***,a formation flight control method is proposed based on the leader–follower strategy and periodic characteristics of flapping-wing *** up and down fluctuation of the fuselage of each LFWFR during wing flapping is considered in the control algorithm to keep the relative distance,which overcomes the trajectory divergence caused by sensor delay and fuselage ***,typical formation flight modes are realized,including straight formation,circular formation,and switching ***,the outdoor formation flight experiment is carried out,and the proposed autonomous formation flight control method is verified in real environment.

关键词： Bionic Large-sized flapping-wing flying robot HIT-Phoenix Periodic flight characteristics Formation flight Leader follower strategy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Broadband and perfect terahertz absorber based on multilayer metamaterial with cross-ring patterned structures

引用

Optoelectronics Letters 2025年第1期 1-6页

作者： wen Jin LIU Zhanzhi WU Zhengwei pan Yu ZHANG Ying School of Science Xi'an Shiyou University Shaanxi Key Laboratory of Measurement and Control Technology for Oil and Gas Wells

Broadband and perfect terahertz absorber based on multilayer metamaterial using cross-ring patterned structures is proposed and investigated. The structure of the absorber is double absorption layers consisting of a chromium cross ring and eight isosceles right triangles. The unique structure of the double absorbing layers excites the electric dipole multimode resonance, giving rise to high absorption performance. Meanwhile, the influence of construal parameters on absorber behavior is also discussed. The numerical results show that the absorption achieves over 90% ranging from 2.45 THz to 6.25 THz and 99% absorption in the range of 3.7—5.3 THz. The realization of broadband and perfect absorber is described using the impedance matching principle. It is obviously found that the absorber is insensitive to the high angle of incidence for both transverse electric(TE) and transverse magnetic(TM) polarizations. Compared with the former reports, this absorber has remarkable improved absorption efficiency and smaller period. The terahertz absorber may be found applications in the fields of energy capture and thermal detection.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

虚拟仪器平台下旋转机械振动应用研究

引用

太原学院学报（自然科学版） 2025年第1期43卷 63-70页

作者：曹慧张锐英潘琦方遒安徽新闻出版职业技术学院机电信息系安徽合肥230601

利用LabVIEW软件图形化程序和可视化前面板,基于旋转机械结构和运动特点构建虚拟仪器仿真平台基本框架,设计了与真实仪器功能相当的旋转机械齿轮振动虚拟仿真研究平台。通过仿真验证,齿轮振动虚拟仿真平台能够有效采集振动信号,并对振... 详细信息

利用LabVIEW软件图形化程序和可视化前面板,基于旋转机械结构和运动特点构建虚拟仪器仿真平台基本框架,设计了与真实仪器功能相当的旋转机械齿轮振动虚拟仿真研究平台。通过仿真验证,齿轮振动虚拟仿真平台能够有效采集振动信号,并对振动信号特征进行提取和分析,测试结果与旋转机械齿轮实际振动情况一致。开发的虚拟仿真平台达到了预期功能目标,为旋转机械关键部件振动检测和故障诊断提供了可视化技术支持,降低了旋转机械故障检测成本。

关键词：齿轮振动虚拟仪器图形化程序前面板频谱分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Theoretical Studies on the Ground State and Excited State of 2,7′- （Ethylene）-bis-8-hydroxyquinoline

引用

Chinese Journal of Chemical Physics 2008年第3期21卷 263-269页

作者： hui-xue Li Su-juan pan Xiao-feng Wang Tai Xiao Biochemical College of Tianshui Normal University Tianshui 741000 China College of Chemical Engineering Northwest Normal University Lanzhou 730070 China

2,7′-（Ethylene）-bis-8-hydroxyquinoline was optimized with DFT/B3LYP and ab initio HF methods, so ion- ization potential and electron affinity could be determined. Absorption spectrum was calculated by ZINDO and TD-DFT. CIS method was used to calculate the S1 excited states of the compound and afterwards the emission spectrum was computed. When the solvent effect was taken into account, the computed results show encouraging agreement with known experimental data. The results of analyzing the relationship between the energies and absorption spectra indicate that the ability to transporting electrons is strengthened compared with 8-hydroxyquinoline and that absorption and emission spectra are red-shifted. The intramoleeular reor- ganization energy of tris（2,7′-（ethylene）-bis-8-hydroxyquinoline）-aluminum implies its electron transporting property is worse than tris（8-hydroxyquinoline）-aluminum. The predicted maximum emission wavelength is red-shifted compared with tris（8-hydroxyquinoline）-aluminum.

关键词： 2,7′(Ethylene)-bis-8-hydroxyquinoline Absorption spectrum Emission spectrum Densityfunctional theory

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Omega-Liutex method for the interaction among wave, current and fixed vertical cylinder

引用

Journal of Hydrodynamics 2023年第1期35卷 83-94页

作者： Bo Han Zhi pan Wei-wen Zhao De-cheng Wan Computational Marine Hydrodynamics Lab(CMHL) School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China Wuhan Second Ship Design and Research Institute Wuhan430205China

This paper presents a numerical investigation of the interaction among wave,flow and a fixed cylinder using the naoe-FOAM-SJTU solver,which is a viscous solver for hydrodynamics based on *** simulation considers the strong nonlinear interaction among a regular wave,flow,and a single fixed cylinder due to viscosity,which is common in offshore *** study focus on the vortex induced by viscosity and its significant role in hydrodynamic performance computation.A mesh convergence study is conducted prior to the simulation,and a proper set of mesh is *** simultaneous generation of the regular wave and flow is realized using the numerical field boundary,and the wave propagation is *** results of wave elevation and pressures captured by wave gauges and probes around the fixed cylinder are compared with experiment *** structure of vortices is displayed at significant times,and the phenomena of wave elevation and pressure changes around the cylinder are analyzed in detail using the Omega-Liutex identification method.

关键词： Wave-current interaction vortex Omega-Liutex method naoe-FOAM-SJTU solver numerical simulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Strong Inclusion Complexation Using Hydroxypropyl-β-Cyclodextrin as Host Molecule

引用

Chinese Chemical Letters 1997年第3期8卷 219-220页

作者： Shu Qin LIU hui Zhi FAN wen hui JIA Jing Hao pan(To whom correspondence should be addressed.) (Department of Chemistry, Shanxi University,Taiyuan 030006) SHANXI UNIV DEPT CHEMTAIYUAN 030006PEOPLES R CHINA

Inclusion complexes of nitro-compounds using β-cyclodextrin and hydroxypropyl-β-cyclodextrin as host molecule have been studied by cyclic voltammetric method. The inclusion constants of the corresponding complexes h... 详细信息

关键词： HP Strong Inclusion Complexation Using Hydroxypropyl CD Cyclodextrin as Host Molecule

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

VIBRATION ANALYSIS OF ELASTIC PLATE SUBMERGED IN INCOMPRESSIBLE VISCOUS FLUID BY COUPLING FINITE ELEMENT METHOD

引用

Acta Mechanica Solida Sinica 1998年第1期11卷 1-12页

作者： Wang hui pan Qingyu Cen Zhangzhi Tsing Hua Univ Dept Engn Mech Beijing 100084 Peoples R China

The interaction problem of an elastic structure and anincompressible viscous fluid is solved through a computationalprocedure proposed in this paper. The fluid region is considered tobe bounded though without free surface boundary. The discrete fluiddomain is described by the stream- line upwind/Petrov-Galerkin finiteelement method. The arbitrary Lagrangian-Eulerian description isemployed to treat the moving interface between the structure and thefluid. The predictor-multicorrec- tor method is adopted to solve thecoupling finite element equations. The results of three numerical ex-amples show the effectiveness of the procedure.

关键词： plate vibration fluid-structure interaction SU/PG method

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evolutionary and functional analyses of the interaction between the Bombyx mori inhibitor of apoptosis(IAP)and nucleopolyhedrovirus IAPs

引用

Insect Science 2020年第3期27卷 463-474页

作者： Peng Chen Tao-Tao Kang Xi-Yan Bao Zhan-Qi Dong Yan Zhu wen-Fu Xiao Min-hui pan Cheng Lu State Key Laboratory of Silkworm Genome Biology Southwest UniversityChongqingChina Key Laboratory of Sericultural Biology and Genetic Breeding Ministry of AgricultureSouthwest UniversityChongqingChina

As an important insect immune response,apoptosis plays a critical role in the interaction between baculoviruses and insect *** reports have identified inhibitor of apoptosis(IAP)proteins in both insects and baculoviruses,but the relationship between these proteins is still not clearly ***,we found that insect IAP proteins were clustered with baculovirus IAP3,suggesting that the baculovirus iap3 gene might be derived from the Lepidoptera or *** demonstrated that Bombyx mori inhibitor of apoptosis(Bmiap)gene had an inhibitory effect on apoptosis in silkworm *** analysis of the effects of Bmiap genes on the proliferation of *** nucleopolyhedrovirus(BmNPV)showed that both the Bmiap and BmNPV iap genes increased BmNPV proliferation after BmNPV infected silkworm *** results also indicated that BmNPV IAP1 and IAP2 directly interacted with BmIAP in silkworm cells,implying that the Bmiap gene might be hijacked by BmNPV iap genes during BmNPV *** together,our results provide important insights into the functional relationships of iap genes,and improve our knowledge of apoptosis in baculoviruses and insect hosts.

关键词： baculovirus baculovirus-host interaction BmNPV Bombyx mori evolution inhibitor of apoptosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：