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Three-year follow-up of Coats disease treated with conbercept and 532-nm laser photocoagulation

World Journal of Clinical Cases 2020年第24期8卷 6243-6251页

作者： Li Jiang Bo qin Xiao-Ling Luo He Cao Ting-Ming Deng Ming-Ming yang Ting Meng hui-qin yang Department of Ophthalmology Shenzhen People’s HospitalSecond Clinical Medical College of Jinan UniversityShenzhen 518020Guangdong ProvinceChina Department of Ophthalmology Shenzhen Aier Eye Hospital Affiliated to Jinan UniversityShenzhen 518032Guangdong ProvinceChina

BACKGROUND Coats disease is an idiopathic exudative outer retinopathy caused by abnormalretinal vascular *** To evaluate the long-term outcomes of intravitreal conbercept injection with laserphotocoagulation as a treatment for Coats disease in *** This retrospective case series study included patients diagnosed with Coatsdisease and treated with intravitreal conbercept injection and 532-nm laserphotocoagulation at the Ophthalmology Department of Shenzhen People’sHospital between January 2016 and January 2017. Best-corrected visual acuity(BCVA) measurements, noncontact tonometry, ophthalmoscopy, fundusphotography, fundus fluorescein angiography and optical coherence tomographywere performed before treatment and at 1 wk, 1 mo, 3 mo, 6 mo, 9 mo, 12 mo, 24mo and 36 mo after therapy. Best-corrected visual acuity was measured using theearly treatment of diabetic retinopathy study *** The study included eight eyes of 8 patients (7 men) aged 36.10 ± 6.65 years. Theaverage BCVA of the affected eye before treatment was 51.17 ± 15.15 letters(range, 28–70 letters), and the average central macular thickness was 303.30 ±107.87 μm (range, 221–673 μm). Four eyes were injected once, three were injectedtwice, and one was injected three times. Average follow-up duration was 37.33 ±2.26 mo. Average BCVA of the affected eye was 51.17 ± 15.15 letters before treatment and was increased by 13.50 ± 3.20, 16.25 ± 7.73, 18.25 ± 8.96, 18.03 ± 5.27,18.63 ± 3.35, 19.75 ± 6.96, 18.05 ± 5.36 and 17.88 ± 3.45 letters at 1 wk, 1 mo, 3 mo, 6mo, 9 mo, 12 mo, 24 mo and 36 mo after treatment, respectively (P < 0.01). Thepatients showed varying degrees of subretinal fluid resorption after *** of the patients had serious complications such as increased intraocularpressure, development/progression of cataracts, endophthalmitis or *** Intravitreal injection of conbercept combined with 532-nm laser photocoagulationmay be a feasible treatmen

关键词： Coats disease Adults Retinal telangiectasis Conbercept Laser therapy Retrospective study

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Stellar activity cycles as revealed by long-term beat-like patterns from light curves of Kepler

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Research in Astronomy and Astrophysics 2021年第6期21卷 301-313页

作者： Heng-Geng Han Kai-Ming Cui Ji-Feng Liu hui-qin yang Xuan Fang Rui-Ning Zhao CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China WHU-NAOC Joint Center for Astronomy Wuhan UniversityWuhan 430072China Department of Physics&Laboratory for Space Research Faculty of Sciencethe University of Hong KongHong KongChina

Stellar activity cycles have been found on many stars through different *** in debate,an empirical relation has been found where a period of stellar activity cycle Pcyc is positively correlated with rotation period Prot along some segregated *** this work,we built a systematic process to search for the Kepler objects that are analogous to the long-term solar brightness variations and investigate their possible *** a rigorous selection,we obtained 43 objects that all exhibit clear long-term beat-like patterns and their variability(amplitude of rotational modulation)periods and rotation periods were *** to the 4-year duration of the Kepler mission,our targets are located in the region where the cycle periods are longer than~1 yr and shorter than~2.5 ***,all of our targets exhibit clear and notable quasi-periodic variations in variability,yet we cannot confirm any linear trends that were predicted by previous research *** may suggest that in the Kepler realm of the Pcyc-Prot diagram,these relations would mix with each other or the beat-like patterns may not be related to the stellar cycle unless other evidence is provided.

关键词： stars:activity starspots stars:rotation

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Sky subtraction for LAMOST

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Research in Astronomy and Astrophysics 2017年第9期17卷 25-38页

作者： Zhong-Rui Bai Hao-Tong Zhang Hai-Long Yuan Guang-Wei Li Jian-Jun Chen Ya-Juan Lei hui-qin yang Yi-Qiao Dong Gang Wang Yong-Heng Zhao 1 University of Chinese Academy of Sciences Beijing 100049China Key Lab for Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100012China

Sky subtraction is a key technique in data reduction of multi-fiber spectra. Knowledge of characteristics related to the instrument is necessary to determine the method adopted in sky subtraction. In this study, we describe the sky subtraction method designed for the Large sky Area Multi-Object fiber Spectroscopic Telescope （LAMOST） survey. The method has been integrated into the LAMOST 2D Pipeline v2.6 and applied to data from LAMOST DR3 and later. For LAMOST, calibration using sky emission lines is used to alleviate the position-dependent （and thus time-dependent） ,-~ 4% fiber throughput uncertainty and small wavelength instability （0.1/~） during observation. Sky subtraction using principal component analysis （PCA） further reduces 25% of the sky line residual from OH fines in the red part of LAMOST spectra after the master sky spectrum, which is derived from a B-spline fit of 20 sky fibers in each spectrograph. Using this approach, values are adjusted by a sky emission line and subtracted from each fiber. Further analysis shows that our wavelength calibration accuracy is about 4.5 km s-1, and the averages of residuals after sky subtraction are about 3% for sky emission lines and 3% for the continuum region. The relative sky subtraction residuals vary with moonlight background brightness, and can reach as low as 1.5% for regions that have sky emission lines during a dark night. Tests on F stars with both similar sky emission line strength and similar object continuum intensity show that the sky emission line residual of LAMOST is smaller than that of the SDSS survey.

关键词： techniques: spectroscopic -- methods data analysis -- instrumentation spectrographs

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青藤碱对膝骨性关节炎兔关节液及血清白细胞介素1β含量的影响

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中西医结合学报 2008年第12期6卷 1275-1279页

作者：杨惠琴陈礼荣武汉市第一医院风湿免疫科湖北武汉430022

目的:探讨关节腔内注射青藤碱对膝骨关节炎兔关节液及血清中白细胞介素1β(interleukin-1β,IL-1β)含量的影响。方法:除正常对照组(n=4)外,36只兔采用左后肢膝关节伸直位石膏管型制动法建立兔骨关节炎模型。造模6周后青藤碱组兔关节腔... 详细信息

目的:探讨关节腔内注射青藤碱对膝骨关节炎兔关节液及血清中白细胞介素1β(interleukin-1β,IL-1β)含量的影响。方法:除正常对照组(n=4)外,36只兔采用左后肢膝关节伸直位石膏管型制动法建立兔骨关节炎模型。造模6周后青藤碱组兔关节腔内注射青藤碱,1次/周,连续5周,透明质酸组关节腔内注射透明质酸,模型组关节腔内注射生理盐水,正常组不治疗。分别于治疗前及治疗后采用酶联免疫吸附测定法检测关节液及血清IL-1β含量,并对软骨组织进行Mankin评分。结果:与模型组比较,青藤碱组骨性关节炎兔血清及关节液中IL-1β含量下降(P<0.01),且青藤碱组低于透明质酸组(P<0.05)。青藤碱组的软骨Mankin评分明显低于透明质酸组(P<0.05)。结论:青藤碱可能通过抑制关节液及血清中IL-1β表达降低兔骨性关节炎模型的关节退变程度。

关键词：骨性关节炎青藤碱白细胞介素1β 兔

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新型高密度发酵基因工程菌G830

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生物化学与生物物理学报 2001年第3期33卷 296-302页

作者：杨运桂张惠堂童芹杨艳华王又杨胜利龚毅中国科学院上海生命科学研究院生物工程研究中心!上海200233 中国科学院上海生命科学研究院生?

运用PCR方法 ,从磷酸乙酰转移酶 (Pta) 乙酸激酶 (Ack)代谢途径缺失菌株E .coliPA1染色体上 ,扩增出天冬氨酸激酶 I 高丝氨酸脱氢酶 I(thrA)和高丝氨酸激酶 (thrB)基因部分序列 ,构建了整合型重组质粒 pVHb Kan ;应用染色体质粒同源重... 详细信息

运用PCR方法 ,从磷酸乙酰转移酶 (Pta) 乙酸激酶 (Ack)代谢途径缺失菌株E .coliPA1染色体上 ,扩增出天冬氨酸激酶 I 高丝氨酸脱氢酶 I(thrA)和高丝氨酸激酶 (thrB)基因部分序列 ,构建了整合型重组质粒 pVHb Kan ;应用染色体质粒同源重组的方法 ,将透明颤菌血红蛋白 (Vitreoscillahaemoglobin ,VHb)基因整合到大肠杆菌PA1染色体上的thr操纵子 ,构建了新型整合工程菌G830。在高密度发酵条件下 ,G830的细胞呼吸强度、能量代谢、最高菌密度和细胞干重 ,均明显优于对照菌株PA1和BL2 1;重组蛋白脯氨酰内肽酶在G830和PA1中获得稳定高表达 ;重组菌生长状况及发酵指标均与空宿主菌基本一致且表达质粒能维持较好的稳定性。整合型vhb的表达及乙酸代谢途径 (Pta Ack)的缺陷 ,改善了宿主在贫氧条件下的生长 ,且促进了重组蛋白的表达。该工程菌具有良好的氧耐受力 ,且乙酸积累得到大幅度降低 ,可作为适于高密度发酵的基因工程菌

关键词：高密度发酵透明颤菌血红蛋白苏氨酸操纵子乙酸代谢途径脯氨酰内肽酶

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草菇子实体GC-MS分析及不同极性部位体外抗氧化活性研究

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食品工业科技 2016年第21期37卷 318-322,328页

作者：秦惠娟杨健华陈屏张晶王琦吉林农业大学中药材学院吉林长春130118 吉林农业大学食药用菌教育部工程研究中心吉林长春130118

目的:研究草菇乙醇提取物不同极性部分的抗氧化活性及子实体GC-MS分析。方法:用95%的乙醇回流提取草菇,依次用有机溶剂萃取获得石油醚层、氯仿层、乙酸乙酯层、正丁醇层4个不同极性部位。以2,6-二叔丁基对甲酚(BHT)为对照,分别考察其总... 详细信息

目的:研究草菇乙醇提取物不同极性部分的抗氧化活性及子实体GC-MS分析。方法:用95%的乙醇回流提取草菇,依次用有机溶剂萃取获得石油醚层、氯仿层、乙酸乙酯层、正丁醇层4个不同极性部位。以2,6-二叔丁基对甲酚(BHT)为对照,分别考察其总抗氧化能力、DPPH自由基清除活性、铁离子还原能力、ABTS自由基清除活性,比较草菇乙醇提取物不同极性部位的抗氧化作用。结果:通过GC-MS分析,分析出49个化合物,以烷烃类、脂肪酸类、醛类、酯类、酮类为主,含量分别为22.54%、19.94%、15.38%、13.08%、7.33%。通过四种体外抗氧化能力的测定,草菇乙醇提取物的不同极性部位均有抗氧化活性,其中乙酸乙酯层和正丁醇层表现出较好的抗氧化活性,氯仿层的抗氧化活性最弱。在所设定浓度范围内,其乙酸乙酯层的总抗氧化能力、DPPH自由基清除率、铁离子还原能力明显高于其它层(p0.05)。结论:通过对草菇子实体GC-MS分析及抗氧化活性测试,草菇提取物的乙酸乙酯层和正丁醇层的抗氧化作用强,是天然抗氧化剂的良好来源,应对其进一步分离纯化。

关键词：草菇总抗氧化能力 DPPH 铁离子还原能力 ABTS

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Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang hui-Na Liu Yu-Fan yang Zhi-Cheng Zhang Qi Dai Xiao-Yan Bao Lin-Jie Wu Ya-Xin qin Xin Tan Xiao-Yan Sun Xu-Fang Ying Zhi-qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

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肠道真菌菌群和炎症性肠病

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世界华人消化杂志 2017年第17期25卷 1528-1535页

作者：李亚周江慧琴秦阳华上海长海医院实验诊断科上海市200433

炎症性肠病(inflammatory bowel disease,IBD)的发生受到遗传、环境、免疫、肠道内微生物群的影响.研究发现IBD与真菌微生物群存在密切关系:(1)真菌在肠道中正常定植,是肠道微生物的重要组成成员;(2)IBD患者存在微生物群失调,真菌分布... 详细信息

炎症性肠病(inflammatory bowel disease,IBD)的发生受到遗传、环境、免疫、肠道内微生物群的影响.研究发现IBD与真菌微生物群存在密切关系:(1)真菌在肠道中正常定植,是肠道微生物的重要组成成员;(2)IBD患者存在微生物群失调,真菌分布异常可能参与IBD发生或者进展;(3)粪便微生物移植、微生态制剂等在IBD治疗中已有初步疗效;(4)IBD患者肠道内真菌群落的改变是继发于肠道细菌群落的失衡还是IBD的独立病原学因素,有待进一步的研究.本文就近年来人们对真菌菌群在IBD进展中的作用的研究性进展与微生态制剂在IBD治疗进展中的潜在应用价值进行简要的综述.

关键词：真菌菌群炎症性肠病微生物群失调微生态制剂

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MicroRNA-126对类风湿性关节炎滑膜成纤维细胞增殖、侵袭、凋亡的作用及其机制研究

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中国现代医学杂志 2022年第12期32卷 33-38页

作者：万彬彬杨惠琴胡刚明邹荣武汉市第一医院风湿免疫科湖北武汉430022 汉川市人民医院肾内科湖北汉川431600 武汉市第一医院肾病科湖北武汉430022

目的探究microRNA-126(miR-126)通过靶向Dickkopf-1(DKK1)参与类风湿性关节炎滑膜成纤维细胞(RASFs)增殖、侵袭、凋亡的机制研究。方法选取2018年6月—2019年9月在武汉市第一医院就诊的25例类风湿性关节炎(RA)患者的滑膜组织(RA组),同... 详细信息

目的探究microRNA-126(miR-126)通过靶向Dickkopf-1(DKK1)参与类风湿性关节炎滑膜成纤维细胞(RASFs)增殖、侵袭、凋亡的机制研究。方法选取2018年6月—2019年9月在武汉市第一医院就诊的25例类风湿性关节炎(RA)患者的滑膜组织(RA组),同时收集在该院同期接受膝关节十字韧带断裂重建手术的21例非类风湿关节炎患者的滑膜组织作为健康组,检测其miR-126和DKK1蛋白。利用RA组织构建原代RASFs,通过双萤光素酶报告验证miR-126与DKK1的靶向关系。将RASFs分为对照组、miR-126组、DKK1组、miR-126+DKK1组。采用CCK-8、Transwell及流式细胞术检测过表达miR-126和/或DKK1对RASFs增殖、侵袭和凋亡的影响。结果RA组滑膜组织miR-126相对表达量低于健康组(P<0.05),而DKK1蛋白相对表达量高于健康组(P<0.05)。miR-126 mimic与DKK1 Wt共转染后的相对萤光素酶活性低于miR-126 NC质粒与DKK1 Wt共转染(P<0.05),证明miR-126与DKK1靶向结合。miR-126组RASFs增殖力和侵袭细胞数低于对照组(P<0.05),而凋亡率高于对照组(P<0.05)。DKK1组RASFs增殖力和侵袭细胞数高于对照组(P<0.05),而凋亡率低于对照组(P<0.05)。miR-126+DKK1组增殖力和侵袭细胞数高于miR-126组(P<0.05),而低于DKK1组(P<0.05);miR-126+DKK1组凋亡率低于miR-126组(P<0.05),而高于DKK1组(P<0.05)。结论miR-126在RA滑膜组织中低表达,miR-126可通过靶向DKK1抑制RASFs增殖、侵袭及凋亡。

关键词：类风湿性关节炎滑膜组织滑膜成纤维细胞 microRNA-126 Dickkopf-1

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ANALYTICAL SOLUTIONS FOR A ONE-DIMENSIONAL CHEMO-MECHANICAL COUPLING PROBLEM

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Acta Mechanica Solida Sinica 2014年第2期27卷 137-145页

作者： qingsheng yang hui Tian qinghua qin Department of Engineering Mechanics Beijing University of Technology Research School of Engineering Australian National University

Chemo-mechanical coupling exists in a lot of intelligent materials including hy- drogels, biological tissues and other soft materials. These materials are able to respond to ex- ternal stimulus, such as temperature, chemical concentration, and pH value. In this paper, a one-dimensional theoretical model for chemo-mechanical coupling is proposed for analyzing the uniaxial stress/strain state of coupling materials. Based on the chemo-mechanical coupled gov- erning equation, the displacement function and concentration function are derived and the stress and chemical potential are obtained. It is shown that the present chemo-mechanical theory can characterize the chemo-mechanical coupling behavior of intelligent materials.

关键词： intelligent materials chemo-mechanical coupling analytical solution theoretical model constitutive equations hydrogel

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