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BGP-Reflection Functors and Lusztig＇s Symmetries of Modified Quantized Enveloping Algebras

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数学学报（中文版） 2013年第6期56卷 I0005-I0008页

作者： Jie XIAO ming hui zhao Department of Mathematical Sciences Tsinghua University College of Science Beijing Forestry University

Let U be a quantized enveloping algebra and  its modified *** gives some symmetries on U and.In view of the realization of U by the reduced Drinfeld double of the Ringel-Hall algebra,one can apply the BGP-reflection functors to the double Ringel-Hall algebra to obtain Lusztig's symmetries on U and their important properties,for instance,the braid *** this paper,we define a modified form ■ of the Ringel-Hall algebra and realize the Lusztig's symmetries on  by applying the BGP-reflection functors to ■.

关键词：《数学学报》期刊编辑部论文摘要

Biofilm effects on size gradation,drag coefficient and settling velocity of sediment particles

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International Journal of Sediment Research 2014年第4期29卷 471-480页

作者： Qian-qian SHANG Hong-wei FANG hui-ming zhao Guo-jian HE Zheng-hui CUI Department of Hydraulic Engineering State Key Laboratory of Hydroscience and EngineeringTsinghua University Nanjing Hydraulic Research Institute China Institute of Water Resources and Hydropower Research

Sediment particles are often colonized by biofilm in a natural aquatic ecological system,especially in eutrophic water body.A series of laboratory experiments on particle size gradation,drag coefficient and settling velocity were conducted after natural sediment was colonized by biofilm for 5,10,15 and 20 *** image acquisition,particle tracking techniques of Particle Image Velocimetry and Particle Tracking Velocimetry were utilized to analyze the changes of these *** experimental results indicate that the size gradation,the drag force exerted on bio-particles,and the settling velocity of bio-particles underwent significant change due to the growth of biofilm onto the sediment *** study proposes a characteristic particle size formula and a bio-particle settling velocity formula based on the regression of experiment results,that the settling velocity is only 50%to 60%as the single particle which has the same diameter and ***,biofilm growth causes large particle which the settling velocities are approximately 10 times larger than that of primary *** results may be specifically used in the low energy reservoir or lake environment.

关键词： Sediment particle Biofilm Size gradation Drag coefficient Settling velocity

Effects of sediment particle morphology on adsorption of phosphorus elements

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International Journal of Sediment Research 2013年第2期28卷 246-253页

作者： Hong-wei FANG ming-hong CHEN Zhi-he CHEN hui-ming zhao Guo-jian HE Department of Hydraulic Engineering the State Key Laboratory of Hydro Science and EngineeringTsinghua University College of Water Resources and Civil Engineering China Agricultural University Department of Water Resources and Environment Sun Yat-sen University

Sediment particle surface morphology affects phosphorus *** paper studied the phosphorus adsorption on sediment particle by using a Scanning Electron Microscope(SEM) and an Energy Dispersive X-ray Spectroscopy (EDS).Sediment samples from the Yangtze,Yellow and Yongding rivers in China were chosen to measure the particle surface morphology,surface gray scale and element distribution *** samples were firstly cleaned and put into phosphate solution for *** the Langmuir equation and Freundlich equation were used for descriptions of adsorption-desorption isotherms for *** were then dried and *** results show that the adsorption of phosphorus depends on the surface morphology of *** exists mostly in the ridges and channels,while a few exist in the slopes,and casually in the peaks,passes and pits.

关键词： Surface morphology Scanning electron microscope Adsorption Element distribution

Expert consensus on the diagnosis and management of diabetic kidney disease

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Chinese Medical Journal 2020年第19期133卷 2333-2334页

作者：无 ming-hui zhao Diabetic Kidney Disease Cooperative Group of Peking University Health Science Center Renal Division Department of MedicinePeking University First HospitalPeking University Institute of NephrologyKey Laboratory of Renal DiseaseMinistry of Health of China Research Units of Diagnosis and Treatment of Immune-mediated Kidney Diseases Chinese Academy of Medical Sciencesand Key Laboratory of Chronic Kidney Disease Prevention and Treatment(Peking University)Ministry of EducationBeijing 100034China.

For the past decades,the rapid growth of economy and transition of lifestyles have led to a rapid rise in the prevalence of diabetes in *** to the lack of standard process in prevention and management of diabetic kidney disease(DKD)in China,the Peking University Health Science Center organized experts in fields of nephrology and endocrinology to develop the Chinese consensus statement of *** consensus emphasizes on evidence-based inquiry,and focuses on the following three topics:(1)risk factors of the incidence and progression of DKD;(2)the diagnosis of DKD and indication of renal biopsy;(3)the overall management of DKD.

关键词： diagnosis prevention statement

Activation of Growth-associated Protein by Intragastric Brazilein in Motor Neuron of Spinal Cord Connected with Injured Sciatic Nerve in Mice

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Chemical Research in Chinese Universities 2011年第2期27卷 254-257页

作者： CAO Jian LI Li-sen LIU Biao LIU Hao-yu ZHANG hui zhao ming-ming YIN Wei-tian China-Japan Union Hospital of Jilin University Changchun 130033 P. R. China

The purpose of this study is to explore the expression of growth-associated protein（GAP-43） in spinal cord segments connected with injured sciatic nerve by the treatment with brazilein in mice. Unilateral sciatic nerve interruption and anastomosis were performed. Physiological saline（blank group）, high dose, middle dose and low dose of brazilein were administrated intragastrically to healthy adult BALB/c mice in separate groups. L4―6 spinal segments connected with the sciatic nerve were harvested. Real-time PCR（Polymerase chain reaction） and Western blot analysis were performed to detect the expression of GAP-43 in spinal segments. Histological staining on myelin and the electrophysiology were performed to examine the sciatic nerve recovery. GAP-43 was activated in spinal cord L4―6 connected with injured sciatic nerve. In the survival time of 12 h, 24 h, 3 d, 5 d, 7 d and 14 d, GAP-43 expression in the motor neurons of spinal cord of the high dose group and that in the middle dose group were significantly higher than those on the low dose and blank groups. Myelin in the high dose group and that in the middle dose group were more mature and the potential amplitude and MNCV（motor nerve conduction velocity） in the high and middle dose groups were obviously higher than those in the low dose group and blank group. Brazilein facilitates the expression of GAP-43 in neurons in spinal cord L4―6 segments connected with injured sciatic nerve, which promotes nerve regeneration.

关键词： Brazilein Growth-associated protein(GAP-43) Injury of sciatic nerve Regeneration

T cell infiltration is associated with kidney injury in patients with anti-glomerular basement membrane disease

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Science China(Life Sciences) 2016年第12期59卷 1282-1289页

作者： Shui-Yi Hu Xiao-Yu Jia Jian-Nan Li Xin Zheng Jie Ao Gang Liu zhao Cui ming-hui zhao Renal Division Department of Medicine Peking University First HospitalInstitute of Nephrology Peking UniversityKey Laboratory of Renal Disease Ministry of Health of China Key Laboratory of CKD Prevention and Treatment Ministry of Education of China Beijing 100034 China Peking-Tsinghua Center for Life Sciences Beijing 100871 China Department of Nephrology Tianjin Medical University General Hospital Tianjin 300052 China

Cell-mediated autoimmunity, particularly that involving autoreactive T cells, participates in mediating anti-glomerular basement membrane(GBM) disease. However, direct kidney injury mediated by renal infiltrated T cells has not been clearly elucidated in humans. The T cell profile(CD3, CD4, CD8, IL-17, and foxp3) and macrophage(CD68) were examined by immunohistochemistry on renal biopsy tissues from 13 patients with anti-GBM disease. The correlation between cell infiltration and clinical data was also analyzed. We found that the distribution of T cell infiltration was predominant in the peri-glomerular and interstitial areas. CD3^+ T cell infiltratrion around the glomeruli with cellular crescent formations was significantly higher than that around the glomeruli with mild mesangial proliferation. CD8^+ T cells significantly accumulated around the glomeruli with cellular crescents without Ig G deposits compared to those with Ig G deposits. The prevalence of infiltrating CD8^+ T cells was correlated with the percentage of ruptured Bowman's capsules. In conclusion, cellular immunity may play a crucial role in the inflammatory kidney injury in anti-GBM patients. The periglomerular infiltration of T cells, especially CD8^+ T cells, may participate in the pathogenic mechanism of glomerular damage.

关键词： anti-GBM disease T cell IL-17 CD8 kidney injury

3D laser scanning strategy based on cascaded deep neural network

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Defence Technology（防务技术） 2022年第9期18卷 1727-1739页

作者： Xiao-bin Xu ming-hui zhao Jian Yang Yi-yang Xiong Feng-lin Pang Zhi-ying Tan Min-zhou Luo College of Mechanical&Electrical Engineering Hohai UniversityChangzhou213022China Jiangsu Key Laboratory of Special Robot Technology Hohai UniversityChangzhou213022China College of Mechanical Engineering Yangzhou UniversityYangzhou225127China

A 3D laser scanning strategy based on cascaded deep neural network is proposed for the scanning system converted from 2D Lidar with a pitching motion device. The strategy is aimed at moving target detection and monitoring. Combining the device characteristics, the strategy first proposes a cascaded deep neural network, which inputs 2D point cloud, color image and pitching angle. The outputs are target distance and speed classification. And the cross-entropy loss function of network is modified by using focal loss and uniform distribution to improve the recognition accuracy. Then a pitching range and speed model are proposed to determine pitching motion parameters. Finally, the adaptive scanning is realized by integral separate speed PID. The experimental results show that the accuracies of the improved network target detection box, distance and speed classification are 90.17%, 96.87% and 96.97%, respectively. The average speed error of the improved PID is 0.4239°/s, and the average strategy execution time is 0.1521 *** range and speed model can effectively reduce the collection of useless information and the deformation of the target point cloud. Conclusively, the experimental of overall scanning strategy show that it can improve target point cloud integrity and density while ensuring the capture of target.

关键词： Scanning strategy Cascaded deep neural network Improved cross entropy loss function Pitching range and speed model Integral separate speed PID

Analysis of Synonymous Codon Usage Bias in Chlamydia

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Acta Biochimica et Biophysica Sinica 2005年第1期37卷 1-10页

作者： hui L(?) Wei-ming zhao~* Yan ZHENG Hong WANG Mei QI Xiu-Ping YU Department of Medical Microbiology,School of Medicine,Shangdong University,Jinan 250012,China Department of Medical Microbiology School of Medicine Shandong University Jinan 250012 China.

Chlamydiae are obligate intracellular bacterial pathogens that cause ocular and sexuallytransmitted diseases,and are associated with cardiovascular *** analysis of codon usage mayimprove our understanding of the evolution and pathogenesis of Chlamydia and allow reengineering of targetgenes to improve their expression for gene ***,we analyzed the codon usage of ***,***(here indicating biovar trachoma and LGV),***,and *** using the codonusage database and the CUSP(Create a codon usage table)program of EMBOSS(The European MolecularBiology Open Software Suite).The results show that the four genomes have similar codon usage patterns,with a strong bias towards the codons with A and T at the third codon *** with Homosapiens,the four chlamydial species show discordant seven or eight preferred *** ENC(effectivenumber of codons used in a gene)-plot reveals that the genetic heterogeneity in Chlamydia is constrained bythe G+C content,while translational selection and gene length exert relatively weaker ***,mutational pressure appears to be the major determinant of the codon usage variation among the *** addition,we compared the codon preferences of *** with those of ***,yeast,adenovirus and Homo *** are 23 codons showing distinct usage differences between *** ***,24 between *** and adenovirus,21 between *** and Homo sapiens,butonly six codons between *** and ***,the yeast system may be more suitable for theexpression of chlamydial ***,we compared the codon preferences of *** with those ofsix eukaryotes,eight prokaryotes and 23 *** is a strong positive correlation between the differ-ences in coding GC content and the variations in codon bias(r=0.905,P<0,001).We conclude that thevariation of codon bias between *** and other organisms is much less influenced b

关键词： Chlamydia codon usage bias GC content gene expression

Suppression of bcl-2 Gene by RNA Interference Increases Chemosensitivity to Cisplatin in Nasopharyngeal Carcinoma Cell Line CNE1

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Acta Biochimica et Biophysica Sinica 2004年第11期36卷 749-753页

作者： Zhi-Hua YIN, Cai-Ping REN, Feng LI, Xu-Yu YANG, hui LI, ming zhao, and Kai-Tai YAOCancer Research Institute, Central South University, Changsha 410078, China Cancer Research Institute Central South UniversityChangsha 410078 China

To explore the effect of suppressing BCL-2 expression using RNA interference (RNAi) technique in nasopharyngeal carcinoma cell line CNE1. CNE1 cell lines stably expressing shRNAs targeted bcl-2 and GL3 gene were established and gene expression inhibition was assessed by Western blotting analysis. The effect of suppressing bcl-2 by RNAi on cell growth was studied, the apoptosis induction and the sensitization of CNE1 cells to cisplatin were quantified by MTT assay and flow cytometry. The results showed that: stable transfection of CNE1

关键词： RNA interference nasopharyngeal carcinoma bcl-2 cisplatin