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Physiotherapy for patients with depression:Recent research progress

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World Journal of Psychiatry 2024年第5期14卷 635-643页

作者： hui-ling liu Jing Sun Shi-Feng Meng Ning Sun Department of Mental Health First Clinical Medical College of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Rehabilitation First Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Mental Health First Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina

Depression,a common mental illness,seriously affects the health of individuals and has deleterious effects on *** prevention and treatment of depression has drawn the attention of many researchers and has become an important social *** treatment strategies for depression include drugs,psychotherapy,and *** therapy is ineffective in some patients and psychotherapy has treatment *** a reliable adjuvant therapy,physiotherapy compensates for the shortcomings of drug and psychotherapy and effectively reduces the disease recurrence *** is more scientific and rigorous,its methods are diverse,and to a certain extent,provides more choices for the treatment of *** can relieve symptoms in many ways,such as by improving the levels of neurobiochemical molecules,inhibiting the inflammatory response,regulating the neuroendocrine system,and increasing *** has biological effects similar to those of antidepressants and may produce a superimposed impact when combined with other *** article summarizes the findings on the use of physiotherapy to treat patients with depression over the past five *** also discusses several methods of physiotherapy for treating depression from the aspects of clinical effect,mechanism of action,and disadvantages,thereby serving as a reference for the in-depth development of physiotherapy research.

关键词： Depression Physiotherapy Non-pharmacological Rehabilitation therapy Recent advances

Effect of electro-acupuncture on substance P, its receptor and corticotropin-releasing hormone in rats with irritable bowel syndrome

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World Journal of Gastroenterology 2009年第41期15卷 5211-5217页

作者： Xiao-Peng Ma Lin-Ying Tan Yun Yang Huan-Gan Wu Bin Jiang hui-Rong liu ling Yang Shanghai Institute of Acupuncture-Moxibustion and Meridian Shanghai 200030 China

AIM： To investigate the effect and mechanism of electro-acupuncture lEA） at ST25 and ST37 on irritable bowel syndrome （IBS） of rats. METHODS： A total of 21 male Sprague-Dawley rats were randomly divided into normal group, model group and EA group. A rat model of IBS was established by constraining the limbs and distending the colorectum of rats. Rats in EA group received bilateral EA at ST25 and ST37 with a sparse and intense waveform at a frequency of 2/50 Hz for 15 min, once a day for 7 d as a course. Rats in normal and model groups were stimulated by distending colorectum （CR）. An abdominal withdrawal reflex （AWR） scoring system was used to evaluate improvements in visceral hypersensitivity. Toluidine blue-improved method, immunohistochemistry and radioimmunoassay were used to observe mucosal mast cells （MC）, changes of substance P （SP） and substance P receptor （SPR） in colon and change of corticotropin-releasing hormone （CRH） in hypothalamus. RESULTS： The threshold of visceral sense was significantly lower in model group than in normal group,and significantly higher in EA group than in model group. The number of mucosal MC was greater in model group than in normal group and significantly smaller in EA group than in model group. The CRH level in hypothalamus of rats was significantly higher in model group than in normal group, which was remarkably decreased after electro-acupuncture treatment. The SP and SPR expression in colon of rats in model group was decreased after electro-acupuncture treatment. CONCLUSION： EA at ST25 and ST37 can decrease the number of mucosal MC and down-regulate the expression of CRH in hypothalamus, and the expression of SP and SPR in colon of rats with IBS.

关键词： Electro-acupuncture Corticotropin-releasing hormone Irritable bowel syndrome Substance P Substance P receptor

Tumor necrosis factor-α mediates JNK activation response to intestinal ischemia-reperfusion injury

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World Journal of Gastroenterology 2013年第30期19卷 4925-4934页

作者： Qi Yang Feng-Ping Zheng Ya-Shi Zhan Jin Tao Si-Wei Tan hui-ling liu Bin Wu Department of Gastroenterology the Third Affiliated Hospital of Sun Yat-Sen University

AIM:To investigate whether tumor necrosis factor-α(TNF-α)mediates ischemia-reperfusion(I/R)-induced intestinal mucosal injury through c-Jun N-terminal kinase(JNK)***:In this study,intestinal I/R was induced by 60-min occlusion of the superior mesenteric artery in rats followed by 60-min reperfusion,and the rats were pretreated with a TNF-α inhibitor,pentoxifylline,or the TNF-α antibody *** surgery,part of the intestine was collected for histological *** mucosal layer was harvested for RNA and protein extraction,which were used for further real-time polymerase chain reaction,enzyme-linked immunosorbent assay and Western blotting *** TNF-α expression,intestinal mucosal injury,cell apoptosis,activation of apoptotic protein and JNK signaling pathway were ***:I/R significantly enhanced expression of mucosal TNF-α at both the mRNA and protein levels,induced severe mucosal injury and cell apoptosis,activated caspase-9/caspase-3,and activated the JNK signaling *** with pentoxifylline markedly downregulated TNF-α at both the mRNA and protein levels,whereas infliximab pretreatment did not affect the expression of TNF-α induced by I/***,pretreatment with pentoxifylline or infliximab dramatically suppressed I/R-induced mucosal injury and cell apoptosis and significantly inhibited the activation of caspase-9/3 and JNK ***:The results indicate there was a TNFα-mediated JNK activation response to intestinal I/R injury.

关键词： Tumor necrosis factor-α Intestine Mucosa Apoptosis c-Jun N-terminal kinase

β-arrestin 2 attenuates lipopolysaccharide-induced liver injury via inhibition of TLR4/NF-κB signaling pathwaymediated inflammation in mice

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World Journal of Gastroenterology 2018年第2期24卷 216-225页

作者： Meng-Ping Jiang Chun Xu Yun-Wei Guo Qian-Jiang Luo Lin Li hui-ling liu Jie Jiang hui-Xin Chen Xiu-Qing Wei Department of Digestive Diseases The Third Affiliated Hospital of Sun Yat-sen University Department of Digestive Diseases Huizhou Municipal Center Hospital

AIM To study the role and the possible mechanism of β-arrestin 2 in lipopolysaccharide(LPS)-induced liver injury in vivo and in *** Male β-arrestin 2^(+/+) and β-arrestin 2^(-/-)C57 BL/6 J mice were used for in vivo experiments, and the mouse macrophage cell line RAW264.7 was used for in vitro experiments. The animal model was established via intraperitoneal injection of LPS or physiological sodium chloride solution. Blood samples and liver tissues were collected to analyze liver injury and levels of pro-inflammatory cytokines. Cultured cell extracts were collected to analyze the production of pro-inflammatory cytokines and expression of key molecules involved in the TLR4/NF-κB signaling *** Compared with wild-type mice, the β-arrestin 2 knockout mice displayed more severe LPS-induced liver injury and significantly higher levels of proinflammatory cytokines, including interleukin(IL)-1β, IL-6, tumor necrosis factor(TNF)-α, and IL-10. Compared with the control group, pro-inflammatory cytokines(including IL-1β, IL-6, TNF-α, and IL-10) produced by RAW264.7 cells in the β-arrestin 2 si RNA group were significantly increased at 6 h after treatment with LPS. Further, key molecules involved in the TLR4/NF-κB signaling pathway, including phosphoIκBα and phosho-p65, were *** β-arrestin 2 can protect liver tissue from LPS-induced injury via inhibition of TLR4/NF-κB signaling pathwaymediated inflammation.

关键词： Lipopolysaccharide Liver injury β-arrestin 2 TLR4/NF-κB signaling pathway Pro-inflammatory cytokines

Sodium butyrate protects against lipopolysaccharideinduced liver injury partially via the GPR43/b-arrestin-2/NF-кB network

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Gastroenterology Report 2021年第2期9卷 154-165,I0002页

作者： Qian-Jiang Luo Mei-Xing Sun Yun-Wei Guo Si-Wei Tan Xiao-Ying Wu Kodjo-Kunale Abassa Li Lin hui-ling liu Jie Jiang Xiu-Qing Wei Department of Gastroenterology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Gastroenterology The Eighth Affiliated Hospital of Sun Yat-sen University(Shenzhen Futian Hospital)ShenzhenGuangdongP.R.China

Background Butyrate acts as a regulator in multiple inflammatory organ ***,the role of butyrate in acute liver injury has not yet been fully *** the present study,we aimed to investigate the association between butyrate and lipopolysaccharide(LPS)-induced acute liver injury and the signaling pathways *** LPS-induced acute liver injury was induced by intraperitoneal injection of LPS(5 mg/kg)in G-protein-coupled receptor 43(GPR43)-knockout(KO)and wild-type female C57BL/6 *** butyrate(500mg/kg)was administered intraperitoneally 30min prior to LPS *** injury was detected by serum markers,tissue morphology,and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling(TUNEL).Pro-inflammatory-factor levels were detected by enzyme-linked immunosorbent assay and real-time polymerase chain reaction(RT-PCR).Cell models were first treated with sodium butyrate(4μmol/mL),followed by LPS(1μg/mL)half an hour later in GPR43 small interfering RNA(siRNA)-transfected or control RAW264.7 ***-inflammation status was evaluated through detecting pro-inflammatory-factor expression by RT-PCR and also through checking toll-like receptor 4/nuclear factor-кB(TLR4/NF-кB)-element levels including TLR4,TRAF6,IKKb,IкBα,phospho-IкBα,p65,and phospho-p65 by Western *** interaction between GPR43 and barrestin-2 was tested by *** Sodium butyrate reversed the LPS-induced tissue-morphology changes and high levels of serum alanine aminotransferase,aspartate transaminase,myeloperoxidase,TUNEL,and pro-inflammatory cytokines such as tumor necrosis factor-a and *** ameliorating effect of sodium butyrate was weakened in GPR43-KO mice and GPR43 siRNA RAW264.7 cells,compared with those of GPR43-positive *** butyrate downregulated some elements of the TLR4/NF-кB pathway,including phospho-IкBαand phospho-p65,in RAW264.7 *** interactions between GPR43 and b-arrestin-2,and betw

关键词： sodium butyrate short-chain fatty acids lipopolysaccharide-induced liver injury G-protein-coupled receptor 43 b-arrestin-2 NF-кB

Lnc-TCL6 is a potential biomarker for early diagnosis and grade in liver-cirrhosis patients

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Gastroenterology Report 2019年第6期7卷 434-443,I0002页

作者： Lei-Jia Li Xiao-Ying Wu Si-Wei Tan Zi-Jun Xie Xue-Mei Pan Shun-Wen Pan Wu-Ri-Na Bai Hai-Jiao Li hui-ling liu Jie Jiang Bin Wu Department of Gastroenterology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Guangdong Provincial Key Laboratory of Liver Disease Research GuangzhouGuangdongP.R.China Department of Laboratory Medicine The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:Long non-coding RNAs(lncRNAs)have been applied as biomarkers in many ***,scarce biomarkers are available in single lncRNA differential expression associated with different clinical stages of liver cirrhosis(LC).The aim of the study is to identify some lncRNAs that can serve as non-invasive sensitive biomarkers for early diagnosis and grade of ***:Blood lncRNA expression was evaluated in three independent cohorts with 305 participants including healthy controls,hepatitis B virus(HBV)carriers,and patients with chronic hepatitis B(CHB)or ***,candidate lncRNAs were screened by CapitalBiotech microarray to diagnose *** reverse-transcriptase polymerase chain reaction was then used to investigate the expression of selected lncRNAs in the whole group of cirrhosis and different Child–Pugh ***,the diagnostic accuracy of the promising biomarker was examined and validated via Mann–Whitney test and receiver-operating characteristics ***:Lnc-TCL6 was identified as a sensitive biomarker for early diagnosis of LC(Child–Pugh A)compared with healthy controls(area under the ROC curve[AUC]=0.636),HBV carriers(AUC=0.671),and CHB patients(AUC=0.672).Furthermore,lnc-TCL6 showed a favourable capacity in discriminating among different Child–Pugh classes(AUC:0.711–0.837).Compared with healthy controls,HBV carriers,and CHB patients,the expression of lnc-TCL6 was obviously up-regulated in Child–Pugh A patients and,conversely,significantly down-regulated in Child–Pugh C ***:Lnc-TCL6 is a novel potential biomarker for early diagnosis of LC and is a possible predictor of disease progression.

关键词： long non-coding RNAs Lnc-TCL6 biomarker liver cirrhosis Child–Pugh classification

Rational modulation of fluorophosphate cathode by anionic groups to reduce the polarization behavior for fast-charging sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 509-521页

作者： Xinyuan Wang Fan Zhang Xingyu Zhou Qian Wang Changyu liu Yangyang liu hui Wang Xiaojie liu Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry & Materials Science Northwest University

Na3V2（PO4）2O2F （VP） is recognized as a promising cathode material for sodium-ion batteries due to its stable structural framework and high specific *** functional theory （DFT） and finite element simulations show that incorporating SO42-into VP decreases its band gap,lowers the migration energy barrier,and ensures a uniform Na+concentration gradient and stress distribution during charge and discharge ***,the average Na+diffusion coefficient of Na3V2（PO4）1.95（SO4）0.05O2F（VPS-1） is roughly double that of VP,leading to enhanced rate capability (80 C,75.5 mAh g-1) and cycling stability (111.0 mAh g-1capacity after 1000 cycles at 10 C current density) for ***-1 exhibits outstanding fast-charging capabilities,achieving an 80%state of charge in just 8.1 *** assembled VPS-1//SbSn/NPC full cell demonstrated stable cycling over 200 cycles at a high 5 C current,maintaining an average coulombic efficiency of 95.35%.

关键词： Anionic group modulation Polarization behavior Fast-charging Sodium-ion battery Fluorophosphate Cathode

RF Optimizer Model for Predicting Compressive Strength of Recycled Concrete

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 215-223页

作者： liu Lin WANG liuyan WANG hui SUN Huayue School of Civil Engineering and Architecture Shenyang UniversityShenyang 110000China

Traditional machine learning(ML)encounters the challenge of parameter adjustment when predicting the compressive strength of reclaimed *** address this issue,we introduce two optimized hybrid models:the Bayesian optimization model(B-RF)and the optimal model(Stacking model).These models are applied to a data set comprising 438 observations with five input variables,with the aim of predicting the compressive strength of reclaimed ***,we evaluate the performance of the optimized models in comparison to traditional machine learning models,such as support vector regression(SVR),decision tree(DT),and random forest(RF).The results reveal that the Stacking model exhibits superior predictive performance,with evaluation indices including R2=0.825,MAE=2.818 and MSE=14.265,surpassing the traditional ***,we also performed a characteristic importance analysis on the input variables,and we concluded that cement had the greatest influence on the compressive strength of reclaimed concrete,followed by ***,the Stacking model can be recommended as a compressive strength prediction tool to partially replace laboratory compressive strength testing,resulting in time and cost savings.

关键词： machine learning recycled concrete compressive strength

A Review of Root Lesion Nematode: Identification and Plant Resistance

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Advances in Microbiology 2012年第4期2卷 411-416页

作者： Yong-Ting Yu hui-ling liu Ai-Guo Zhu Gang Zhang Liang-Bin Zeng Shao-Dong Xue College of Graduate Chinese Academy of Agricultural Sciences Peking China College of Pharmacy Shaanxi University of Chinese Medicine Xianyang China Institute of Bast Fiber Crops Chinese Academy of Agricultural Sciences Changsha China

Root lesion nematode, one of the three most devastated plant parasitic nematodes, is widespread in the world. They can invade various food and cash crops, and cause great agriculture loss. Recognition and identification of root lesion nematode are important joint of nematode management, as well as the mechanism research of plant anti-nematode, which is of great benefit to breed resistance varieties. In this review, the recent advances in nematode identification and research of plant anti-nematode are presented, and the importance of non-inaccuracy identification of nematode was emphasized. The mechanism of resistance to root lesion nematode was also discussed.

关键词： Pratylenchus Isoenzyme ITS Resistance Related Protein Secondary Metabolite