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Management and outcomes of surgical patients with intestinal Behçet’s disease and Crohn’s disease in southwest China

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World Journal of Clinical Cases 2021年第16期9卷 3858-3868页

作者： Li Zeng wen-Jian Meng zhong-hui wen Yi-Long Chen Yu-Fang Wang Cheng-Wei Tang Department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Gastrointestinal Surgery West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina West China Biomedical Big Data Center West China Hospital/West China School of MedicineSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Gastrointestinal involvement in Behçet's disease(GIBD)and Crohn’s disease(CD)are inflammatory diseases sharing a considerable number of ***,different from CD,the operative and postoperative management of GIBD remains largely empirical because of the lack of comprehensive treatment *** To compare surgical patients with GIBD and those with CD in a medical center and identify notable clinical features and effective postoperative treatment for surgical patients with *** We searched patients diagnosed with CD and GIBD who underwent operations for gastrointestinal complications from 2009 to 2015 at West China Hospital of Sichuan University.A total of 10 surgical patients with GIBD and 106 surgical patients with CD were *** including demographic data,medication,and operative and postoperative parameters were collected and *** the incidence of surgical GIBD is low,their detailed medical records were reviewed and compared to previous ***,the prognoses of CD and GIBD were evaluated respectively between groups treated with biological and non-biological *** Indication for first surgery was often acute intestinal perforation for GIBDpatients (7/10 vs 0/106, P went reoperations. Theaverage period of postoperative recurrence was 7.87 mo in patients with Behçet'sdisease (BD) and 10.43 mo in patients with CD, whereas the mean duration fromfirst surgery to reoperation was 5.75 mo in BD patients and 18.04 mo in CDpatients. Surgical patients with GIBD more often used cortic

关键词： Gastrointestinal involvement in Behçet's disease Crohn’s disease Surgery Postoperative treatment Biological agents Real-world study

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Corticostriatal Neurons in the Anterior Auditory Field Regulate Frequency Discrimination Behavior

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Neuroscience Bulletin 2023年第6期39卷 962-972页

作者： Zhao-Qun Wang hui-zhong wen Tian-Tian Luo Peng-hui Chen Yan-Dong Zhao Guang-Yan Wu Ying Xiong Department of Neurobiology Chongqing Key Laboratory of NeurobiologyArmy Medical UniversityChongqing400038China Experimental Center of Basic Medicine Army Medical UniversityChongqing400038China

The anterior auditory field(AAF)is a core region of the auditory cortex and plays a vital role in discrimination ***,the role of the AAF corticostriatal neurons in frequency discrimination remains ***,we used c-Fos staining,fiber photometry recording,and pharmacogenetic manipulation to investigate the function of the AAF corticostriatal neurons in a frequency discrimination task.c-Fos staining and fiber photometry recording revealed that the activity of AAF pyramidal neurons was significantly elevated during the frequency discrimination *** inhibition of AAF pyramidal neurons significantly impaired frequency *** addition,histological results revealed that AAF pyramidal neurons send strong projections to the ***,pharmacogenetic suppression of the striatal projections from pyramidal neurons in the AAF significantly disrupted the frequency ***,our findings show that AAF pyramidal neurons,particularly the AAF–striatum projections,play a crucial role in frequency discrimination behavior.

关键词： Anterior auditory field Corticostriatal neuron Frequency discrimination AAF-striatum projection

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Anodal transcranial direct current stimulation alleviates cognitive impairment in an APP/PS1 model of Alzheimer’s disease in the preclinical stage

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Neural Regeneration Research 2022年第10期17卷 2278-2285页

作者： Yin-Pei Luo Zhi Liu Cong Wang Xiu-Fang Yang Xiao-Ying Wu Xue-Long Tian hui-zhong wen Chongqing Key Laboratory of Neurobiology Department of NeurobiologySchool of Basic MedicineArmy Medical UniversityChongqingChina Chongqing Medical Electronics Engineering Technology Research Center Laboratory of Neural Regulation and Rehabilitation TechnologyCollege of BioengineeringChongqing UniversityChongqingChina Department of Histology and Embryology School of Basic MedicineArmy Medical UniversityChongqingChina

Anodal transcranial direct current stimulation(AtDCS)has been shown to alleviate cognitive impairment in an APP/PS1 model of Alzheimer’s disease in the preclinical ***,this enhancement was only observed immediately after AtDCS,and the long-term effect of AtDCS remains *** this study,we treated 26-week-old mouse models of Alzheimer’s disease in the preclinical stage with 10 AtDCS sessions or sham *** Morris water maze,novel object recognition task,and novel object location test were implemented to evaluate spatial learning memory and recognition memory of *** blotting was used to detect the relevant protein *** changes were observed using immunohistochemistry and immunofluorescence *** weeks after treatment,the mice subjected to AtDCS sessions had a shorter escape latency,a shorter path length,more platform area crossings,and spent more time in the target quadrant than sham-stimulated *** mice subjected to AtDCS sessions also performed better in the novel object recognition and novel object location tests than sham-stimulated ***,AtDCS reduced the levels of amyloid-β42 and glial fibrillary acidic protein,a marker of astrocyte activation,and increased the level of neuronal marker NeuN in hippocampal *** findings suggest that AtDCS can improve the spatial learning and memory abilities and pathological state of an APP/PS1 mouse model of Alzheimer’s disease in the preclinical stage,with improvements that last for at least 6 weeks.

关键词： Alzheimer’s disease amyloid-β anodal transcranial direct current stimulation cognitive function inflammation long-term effect neuron preclinical stage

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Chinese research into severe ulcerative colitis has increased in quantity and complexity

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World Journal of Clinical Cases 2018年第3期6卷 35-43页

作者： Cheng-Xin Luo zhong-hui wen Yu Zhen Zhu-Jun Wang Jing-Xi Mu Min Zhu Qin Ouyang Hu Zhang Department of Gastroenterology West China Hospital Sichuan University

AIM To investigate the current state of research output from Chinese studies into severe ulcerative colitis(SUC) using a bibliometric analysis of publications. METHODS The contents of the Chinese periodical databases WANFANG, VIP, and China National Knowledge Infrastructure were searched for all papers regarding UC or SUC published in last the 15 years (from 2001 to 2015). The number of publications in each year was recorded to assess the temporal trends of research output. All SUC related publications were downloaded and the complexity of this research was evaluated with methods described previously. The number of patients with SUC reported each year was recorded and their clinical characteristics were analyzed using information available in the relevant papers. RESULTS There were 13499 publications regarding UC published in Chinese medical journals between 2001 and 2015, of which 201 focused on SUC. The number of publications increased rapidly with more than half of all papers being published in the most recent 5-year period. There was a significant increase in analyticalstudies and clinical trials over the study period (P < 0.01), with research into the management of SUC, included pharmacotherapy, nutrition support as well as surgery, predominating. Almost half (46.2%) of the observational analytical studies and clinical trials focused on Traditional Chinese Medicine, with little research on the efficacy of cyclosporin and infliximab in disease management. About 6222 patients with SUC were reported in the 201 SUC relevant papers, with a ratio of male/female of 1.38. The number of patients reported in each 5-year period significantly increased. The colectomy rate and short-term mortality rate were 7.7% and 0.8% respectively. The most commonly employed operation was total proctocolectomy with ileal pouch-anal *** The output and complexity of research related to SUC in China increased significantly over the previous 15 years, however few of these

关键词： Bibliometric analysis Clinical trials Salvage therapy Complexity Severe ulcerative colitis Temporal trends Traditional Chinese Medicine

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Spontaneous remission of acromegaly or gigantism due to subclinical apoplexy of pituitary growth hormone adenoma

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Chinese Medical Journal 2011年第22期124卷 3820-3823页

作者： WANG Xian-ling DOU Jing-tao LU Zhao-hui zhong wen-wen BA Jian-ming JIN Du LU Ju-ming PAN Chang-yu MU Yi-ming Department of Endocrinology Chinese People＇s Liberation Army General Hospital Beijing 100853 China

Background Subclinical apoplexy of pituitary functional adenoma can cause spontaneous remission of hormone hypersecretion. The typical presence of pituitary growth hormone （GH） adenoma is gigantism and/or acromegaly. We investigated the clinical characteristics of patients with spontaneous partial remission of acromegaly or gigantism due to subclinical apoplexy of GH adenoma. Methods Six patients with spontaneous remission of acromegaly or gigantism were enrolled. The clinical characteristics, endocrinological evaluation and imageological characteristics were retrospectively analyzed. Results In these cases, the initial clinical presences were diabetes mellitus or hypogonadism. No abrupt headache, vomiting, visual function impairment, or conscious disturbance had ever been complained of. The base levels of GH and insulin growth factor-1 （IGF-1） were normal or higher, but nadir GH levels were all still 〉1 μg/L in 75 g oral glucose tolerance test. Magnetic resonance imaging detected enlarged sella, partial empty sella and compressed pituitary. The transsphenoidal surgery was performed in 2 cases, and the other patients were conservatively managed. All the patients were in clinical remission. Conclusions When the clinical presences, endocrine evaluation, biochemical examination and imageology indicate spontaneous remission of GH hypersecretion in patients with gigantism or acromegaly, the diagnosis of subclinical apoplexy of pituitary GH adenoma should be presumed. To these patients, conservative therapy may be appropriate.

关键词： growth hormone adenoma subclinical apoplexy of pituitary adenoma acromegaly

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Inhibition of mGluR1 alters the excitability of the commissural pyramidal neuron in the rat anterior cingulate cortex after chronic constriction injury to the sciatic nerve

Inhibition of mGluR1 alters the excitability of the commissu...

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中国神经科学学会第十二届全国学术会议

作者： Shi-Hao Gao Lin-Lin Shen hui-zhong wen Yan-Dong Zhao Huai-Zhen Ruan Department of Neurobiology College of Basic Medical Science Chongqing Key Laboratory of Neurobiology Third Military Medical University Department of Neurology Daping Hospital Third Military Medical University

Objective Our previous study has shown that inhibition of the metabotropic glutamate receptor subtype 1（mGluR1） in the output side of rat anterior cingulate cortex（ACC） has therapeutic implications for the sustained nociceptive hypersensitivity. However, it still remains unclear whether the ACC has different subtypes of output neurons. Furthermore, the specific changes in different subtypes of ACC layer 5 pyramidal neurons（L5 PNs） during chronic pain, as well as the distinct effect of mGluR1 inhibition on different neuronal subtypes, have not been well studied. Methods Retrograde labeling combined with immunofluorescence and whole-cell clamp recording were performed to characterize the alterations of commissural ACC L5 PNs in a rat model of chronic constriction injury（CCI） to the sciatic nerve. The specific agonist and antagonist were applied to evaluate the contribution of mGluR1 to these alterations and the underlying mechanisms. Behavioral tests combined with RNA interference were performed to test whether mGluR1 antagonist exerts analgesic effect via its action on the commissural neurons. Results Commissural L5 PNs（projecting to contralateral cortex） existed in the ACC and exhibited few hyperpolarization-activated/cyclic nucleotide-gated channels. The voltagegated potassium channel subunit 2（Kv2）-mediated current in these neurons were substantially reduced after CCI（current densities at +30 m V for the sham and CCI neurons were [mean ± SD] 10.22 ± 3.42 p A/p F vs. 5.58 ± 2.71 p A/p F, respectively;n = 11, p ＜ 0.01）, which increased the spike width and fast afterhyperpolarization potential, resulting in hyperexcitability. Activating mGluR1 in sham slices could mimic the downregulation of Kv2 currents, but inhibition of mGluR1 alleviated the downregulation of Kv2 currents（current density increased by 8.11 ± 3.22 p A/p F;n = 7, p ＜ 0.01） in CCI slices, thereby restoring the normal spike width and fast afterhyperpolarization potential. Protein kinase C mediated the

关键词： neuropathic pain anterior cingulate cortex commissural pyramidal neuron metabotropic glutamate receptor subtype 1 voltage-gated potassium channel subunit 2

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Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： wen Gao Jing-wen Li hui Ye Xue-Zhi Zhang Jian-Xiang Liu Hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

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矩形截面弹簧卷制机成形优化仿真研究

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计算机仿真 2018年第5期35卷 216-220,253页

作者：项辉宇魏景辉钟文胡晶北京工商大学材料与机械工程学院北京100048

矩形截面弹簧成形过程的本质是金属的弹塑性变形,成形过程复杂,影响因素多,根据材料力学以及弹性力学推导出来的理论公式很难制造出高精度的弹簧;针对当前矩形截面弹簧卷制过程中出现的褶皱以及断裂问题,在***环境下对矩形截面弹簧成形... 详细信息

矩形截面弹簧成形过程的本质是金属的弹塑性变形,成形过程复杂,影响因素多,根据材料力学以及弹性力学推导出来的理论公式很难制造出高精度的弹簧;针对当前矩形截面弹簧卷制过程中出现的褶皱以及断裂问题,在***环境下对矩形截面弹簧成形过程进行了有限元仿真模拟,采用正交试验法建立相应的试验方案,研究了成形过程中速度和温度两种参数对等效米塞斯应力的影响情况,并对分布情况进行了分析。研究结果表明:成形速度增大使弹簧所受应力增大,且距芯轴越远越明显;高温卷制加工时弹簧所受应力明显小于中低温卷制加工。

关键词：弹簧卷制数值模拟成形速度成形温度

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基于VB的液压支架辅助设计程序开发

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煤矿机械 2010年第9期31卷 205-206页

作者：周凯李刚惠忠文煤炭科学研究总院太原研究院山西太原030006

利用VB程序设计语言编写了液压支架辅助设计程序,能够对液压支架运动参数、机构受力等进行分析计算。合理的程序界面以及数据库结构设计,使程序适用于多种类型液压支架。计算结果以该文件的形式输出,便于查看和保存。通过程序的使用,可... 详细信息

利用VB程序设计语言编写了液压支架辅助设计程序,能够对液压支架运动参数、机构受力等进行分析计算。合理的程序界面以及数据库结构设计,使程序适用于多种类型液压支架。计算结果以该文件的形式输出,便于查看和保存。通过程序的使用,可以在一定程度上提高支架设计效率。

关键词：液压支架辅助设计程序

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The role of IL-6 in regeneration both in vitro and in vivo

The role of IL-6 in regeneration both in vitro and in vivo

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Ping YANG~*,hui-zhong wen,De-Hua FAN Department of Neurobiology,Chongqing Key Laboratory of Neurobiology,Third Military Medical University, Chongqing 400038,China

＜正＞The failure of mature CNS neurons to regenerate injured axons has been mainly attributed to the inhibitory signal associated with myelin and a lower intrinsic growth state of *** IL-6 is the highest increase one among the 11 molecules in DRG neurons after conditioning lesion or dbcAMP injection,it is postulated that IL-6 could alter neuron gene expression profile and switch into a strong growth state and then promote neurite *** this study we investigated whether IL-6 could increase the intrinsic growth capacity of adult rat dissociated DRG neurons as result in promoting neurite outgrowth by administration of exogenous IL-6 in the medium in vitro,and promote cortical spinal tract regeneration and functional recovery by intratheral delivery IL-6 for 7 days after spinal cord injury in *** Primary DRG neurons culture,RT-PCR,immunohistochemical staining,Western blot,dorsal column transection,intratheral cannal,BDA anterograde tracing,confocal image,BBB functional test,*** We found that addition of exogenous IL-6 to the culture medium resulted in an IL-6 dose-dependent enhancement of neurite outgrowth and a higher expression of growth-associated genes,such as GAP-43,SPRRL and Arginase ***-6 also could promote neurite outgrowth in mimick CNS injury *** vivo,intratheral delivery of IL-6 for 7 days after dorsal column transection resulted in a promoting regeneration and functional *** IL-6 increased the expression of mTOR（mammalian target of rapamycin）in neuron while decreased the expression of mTOR in astrocyte which inhibited glia scar *** also observed that the SOCS3 expression both in neuron and astrocytes while the STAT3 expression only observed in IL-6 treatment *** IL-6 reactivates the growth-associated gene and increases the expression of mTOR in neuron result in reactivating the regeneration program and intrinsic growth state of *** intratheral delivery of IL-6 downregulates

关键词： DRG regeneration-associated gene IL-6 mTOR SOCS3 STAT3 neurite outgrowth regeneration SCI

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