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Chinese Chemical Letters 2007年第1期18卷 89-90页

作者： Ming hui xiang xian Bo Shi Na Li Ke An Li College of Chemistry and Molecular Engineering Peking University Beijing 100871 China

Tris （2, 2′-bipyridine） ruthenium （Ⅱ）（Ru（bpy）3^2＋） dichloride was successfully immobilized into the galleria of layered gamma zirconium phosphate （γ-ZrP） preintercalated by butyl amine（BA）. The compou... 详细信息

关键词： Tris (2, 2′-bipyridine) ruthenium Zirconium phosphate Immobilization Luminescence

Liver Dysfunction and Its Association with the Risk of Death in COVID-19 Patients:A Prospective Cohort Study

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Journal of Clinical and Translational Hepatology 2020年第3期8卷 246-254页

作者： Lin Fu Jun Fei Shen Xu hui-xian xiang Ying xiang Biao Hu Meng-Die Li Fang-Fang Liu Ying Li Xiu-Yong Li hui Zhao De-xiang Xu Second Affiliated Hospital Anhui Medical UniversityHefeiAnhuiChina School of Public Health Anhui Medical UniversityHefeiAnhuiChina Union Hospital Huazhong University of Science and TechnologyWuhanHubeiChina The Second People’s Hospital of Fuyang City FuyangAnhuiChina

Background and Aims:Coronavirus disease 2019(COVID-19)is a new respiratory infectious disease caused by severe acute respiratory syndrome coronavirus-2(commonly known as SARS-CoV-2)with multiple organ *** aim of this study was to analyze COVID-19-associated liver dysfunction(LD),its association with the risk of death and prognosis after ***:Three-hundred and fifty-five COVID-19 patients were *** data were collected from electronic medical *** was evaluated and its prognosis was *** association between LD and the risk of death was ***:Of the 355 COVID-19 patients,211 had mild disease,88 had severe disease,and 51 had critically ill *** admission,223(62.8%)patients presented with hypoproteinemia,151(42.5%)with cholestasis,and 101(28.5%)with hepatocellular *** expected,LD was more common in critically ill *** multivariate logistic regression,male sex,older age and lymphopenia were three important independent risk factors predicting LD among COVID-19 *** of death analysis showed that the fatality rate was higher in patients with hypoproteinemia than in those without hypoproteinemia(relative risk=9.471,p<0.01).Moreover,the fatality rate was higher in patients with cholestasis than those without cholestasis(relative risk=2.182,p<0.05).Follow-up observation found that more than one hepatic functional index of two-third patients remained abnormal at 14 days after ***:LD at early disease stage elevates the risk of death of COVID-19 ***-19-associated LD does not recover completely by 14 days after discharge.

关键词： Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2) Coronavirus disease 2019(COVID-19) liver dysfunction(LD) Hepatocellular Hypoproteinemia

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期68卷 300-302页

作者： Ze-Min Lin Mai xiang Wen-hui Wei Shu-hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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Tectonic modes of mantle convection and their implications for Earth's tectonic evolution based on three-dimensional numerical simulations

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Science China Earth Sciences 2025年第1期68卷 270-296页

作者： Song xiang Jinshui HUANG Bingcheng WU School of Earth and Space Sciences University of Science and Technology of China CAS Center of Excellence in Comparative Planetary Studies

Five tectonic modes of mantle convection are obtained and analyzed with three-dimensional numerical models in a spherical shell domain. The five tectonic convective modes are non-plate mobile-lid, plate-like mobile-lid, episodic plate-like mobile-lid, episodic stagnant-lid, and stagnant-lid convective modes, respectively. The typical characteristics of these five tectonic modes and their numerical classification criteria based on plateness, mobility, and their standard deviations are presented and discussed. The results show that the yield stress of the lithosphere has profound effects on the tectonic convective *** the gradual increase of yield stress, the tectonic mode of mantle convection changes from one to another sequentially through the aforementioned five modes. Additionally, as the Rayleigh number increases, the range of yield stress for the platelike mobile-lid convective mode decreases, and the dimensionless transition stress between different tectonic modes ***, the dimensional transition stress between the non-plate mobile-lid convective mode and plate-like mobile-lid convective mode increases with the increase of Rayleigh number, but decreases between other tectonic modes. Furthermore, we find that the transition stress between different tectonic modes is inversely proportional to the internal heating rate, with the transition stress decreasing as the internal heating rate increases. The fitting analysis of the transition stress between tectonic modes shows that Earth's current plate tectonics correspond to a lithospheric yield stress of 150–250 MPa, which aligns with the strength of serpentinized mantle rock determined by experimental petrography. If the Archean mantle was 300°C warmer than it is today, then the Earth was in an episodic stagnant-lid convective mode. The tectonic evolution of the Earth's surface is closely related to the lithospheric strength and the process of thermal evolution. If the lithospheric strength w

关键词： Tectonic mode of mantle convection Plate-like mobile-lid convection Episodic plate-like mobile-lid convection Episodic stagnant-lid convection Plate tectonics and tectonic evolution of the Earth

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钼钨纳米合金膜的制备及其微结构研究

西南师范大学学报（自然科学版） 2003年第5期28卷 762-765页

作者：章娴君郑慧雯王显祥西南师范大学化学化工学院重庆400715

利用羰基金属气相沉积方法,在Al2O3陶瓷基片上,以Mo(CO)6+W(CO)6为源,制备了MoW纳米合金晶膜.采用XRD和SEM技术,并与相同条件制备的Mo膜比较,研究了MoW合金晶膜的微结构.结果表明:该法制备的薄膜是以纳米粒子状态存在、具有超微结构的... 详细信息

利用羰基金属气相沉积方法,在Al2O3陶瓷基片上,以Mo(CO)6+W(CO)6为源,制备了MoW纳米合金晶膜.采用XRD和SEM技术,并与相同条件制备的Mo膜比较,研究了MoW合金晶膜的微结构.结果表明:该法制备的薄膜是以纳米粒子状态存在、具有超微结构的多晶膜材料.

关键词：钼钨纳米合金膜制备方法微结构羰基金属气相沉积方法纳米结构多晶膜材料

Contribution of fungal biomass to persistent soil carbon across natural ecosystems

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Science China Earth Sciences 2025年

作者： xiang WANG Guang-hui YU Yakov KUZYAKOV Bo-Hao YIN Andreas KAPPLER Cong-Qiang LIU Bohai Coastal Critical Zone National Observation and Research Station Institute of Surface-Earth System Science School of Earth System Science Tianjin Key Laboratory of Earth Critical Zone Science and Sustainable Development in Bohai Rim Tianjin University Department of Soil Science of Temperate Ecosystems Department of Agricultural Soil Science University of G?ttingen Agro-Technological Institute Peoples Friendship University of Russia (RUDN University) Geomicrobiology Center for Applied Geosciences University of Tübingen Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infection University of Tübingen

Fungi are known to be crucial in the formation and stabilization of soil organic matter through their exudates and dead residues (necromass). Yet, it remains unclear how fungi contribute to the persistence of carbon in soils over millennial scales across biomes. Here, this study fills the knowledge gap by linking fungal carbon stocks with minerals-associated carbon stocks across major biomes. A strong correlation between fungal biomass and reactive mineral-associated carbon stocks in soils across six biomes supports the substantial role of fungi in soil carbon persistence at the global level. High spatial resolution nanoscale secondary ion mass spectrometry revealed that fungi may stabilize carbon by forming organo-mineral associations through their close physical connection to reactive minerals and weathered nanoparticles. We propose a conceptual model that emphasizes the dualistic role of hypha-mineral interactions:(i) fungi accelerate organic matter decomposition by producing reactive oxygen species on the hypha-mineral interfaces, and (ii) fungi stabilize their residues on mineral surfaces, leading to millennial scale persistence of soil C. Concluding, fungi play a fundamental role in ecosystems that extends beyond the decomposition of persistent carbon. They are crucial in stabilizing carbon on mineral surfaces, thereby facilitating the long-term removal of carbon from rapid biotic cycling.

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Multivariate synergy for heightening ionic HOF robustness and proton conductivity

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Science China Chemistry 2025年

作者： xiang-Tian Bai Li-hui Cao Xu-Yong Chen Jia-Yu Wang Zi-Ye Zhou Shaanxi Key Laboratory of Chemical Additives for Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and Technology

Multicomponent crystalline materials construct more complex and diversified structures with different combinations and modes,which expands the material structure space and application *** this work,we have successfully synthesized two twocomponent ionic hydrogen-bonded organic frameworks （iHOF-32 and iHOF-33） and a three-component iHOF （iHOF-34）.Guanidine hydrochloride which is rich in N and H and has a short chain length strengthens the hydrogen bonding network of iHOF,thereby aiding in the efficient migration of *** rigid architecture of 1,1'-diamino-4,4'-bipyridine diiodide furnishes additional scaffolding for the iHOFs and enhances its robustness under harsh ***-34 accomplishes the combination of the ultra-high proton conductivity of iHOF-32 and the robustness of iHOF-33 by the synergistic interaction among the three components of *** addition,iHOF-34 was fabricated as a composite membrane with a peak proton conductivity of 1.55×10-1S cm-1,which is 3.8 times higher than that of recast Nafion,and has extensive potential in fuel *** self-assembly strategy of multicomponent HOFs opens up new avenues for constructing diverse structures while promising new opportunities for applications in the fields of proton conduction and energy storage.

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缬沙坦对高血压病的疗效及其对肱动脉内皮功能的影响

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中国新药与临床杂志 2004年第10期23卷 661-663页

作者：龚辉张象贤王亚芬复旦大学附属金山医院心内科上海200540

目的 :观察缬沙坦对原发性高血压病人的降压疗效及其对肱动脉内皮功能的影响。方法 :35例高血压病病人 (治疗组 )应用缬沙坦 80mg ,po ,qd× 30wk。 2 2例健康志愿者为对照组。采用多普勒超声血管显象法测定 2组肱动脉血流调节的扩血管... 详细信息

目的 :观察缬沙坦对原发性高血压病人的降压疗效及其对肱动脉内皮功能的影响。方法 :35例高血压病病人 (治疗组 )应用缬沙坦 80mg ,po ,qd× 30wk。 2 2例健康志愿者为对照组。采用多普勒超声血管显象法测定 2组肱动脉血流调节的扩血管反应 (FMD)和硝酸甘油诱发的扩血管反应 (NMD)。结果 :治疗组应用缬沙坦后 2wk显著降压 (P <0 .0 1) ,4～ 6wk进一步降压 ,至 30wk持续平稳降压 (P <0 .0 1) ,降压总有效率 2wk为 5 1% ,30wk达 80 % ;治疗组FMD和NMD显著低于对照组[(6±s 5 ) %vs(18± 7) % ,(17± 9) %vs (2 8±11) % ,P <0 .0 1],治疗组应用缬沙坦后FMD与用药前比较显著提高 (P <0 .0 1) ,但仍低于对照组(P <0 .0 1)。结论 :缬沙坦具有降压和改善FMD ,恢复动脉内皮功能。

关键词：高血压超声检查多普勒彩色内皮血管缬沙坦血管内皮功能

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基于随钻资料的地层岩性实时识别方法

石油学报 2004年第2期25卷 51-54页

作者：夏宏泉陈平石晓兵张贤辉范翔宇西南石油学院石油工程学院四川成都610500

实时确定地层岩性是水平井地质导向钻井中的一个重要问题。介绍了一种基于随钻测井 (LWD)和录井资料实时识别钻井近钻头处的地层岩性的实用方法。该方法从测井相分析的角度出发 ,充分利用随钻资料 ,并从中提取反映岩性的一些特征参数 ,... 详细信息

实时确定地层岩性是水平井地质导向钻井中的一个重要问题。介绍了一种基于随钻测井 (LWD)和录井资料实时识别钻井近钻头处的地层岩性的实用方法。该方法从测井相分析的角度出发 ,充分利用随钻资料 ,并从中提取反映岩性的一些特征参数 ,建立随钻岩性统计模式 ,采用灰色关联分析法实时处理随钻资料 ,进而识别近钻头处的地层岩性。将其应用于新疆莫北油田 3口水平井的地质导向钻井中 ,及时地提供了较为准确的岩性剖面。

关键词：随钻测井录井水平井钻井岩性实时识别灰色关联分析地质导向

Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu Jia Rui Mao xiang Cao Yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury