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Regulations of m^(6)A and other RNA modifications and their roles in cancer

Frontiers of Medicine 2024年第4期18卷 622-648页

作者： Xin-hui chen Kun-Xiong Guo Jing Li Shu-hui Xu huifang Zhu Guang-Rong Yan Biomedicine Research Center Guangdong Provincial Key Laboratory of Major Obstetric DiseaseGuangdong Provincial Clinical Research Center for Obstetrics and GynecologyState Key Laboratory of Respiratory Diseasethe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150China

RNA modification is an essential component of the epitranscriptome,regulating RNA metabolism and cellular *** types of RNA modifications have been identified to date;they include N^(6)-methyladenosine(m^(6)A),N^(1)-methyladenosine(m1A),5-methylcytosine(m5C),N^(7)-methylguanosine(m^(7)G),N^(6),2′-O-dimethyladenosine(m^(6)Am),N4-acetylcytidine(ac^(4)C),*** modifications,mediated by regulators including writers,erasers,and readers,are associated with carcinogenesis,tumor microenvironment,metabolic reprogramming,immunosuppression,immunotherapy,chemotherapy,etc.A novel perspective indicates that regulatory subunits and post-translational modifications(PTMs)are involved in the regulation of writer,eraser,and reader functions in mediating RNA modifications,tumorigenesis,and anticancer *** this review,we summarize the advances made in the knowledge of different RNA modifications(especially m^(6)A)and focus on RNA modification regulators with functions modulated by a series of factors in cancer,including regulatory subunits(proteins,noncoding RNA or peptides encoded by long noncoding RNA)and PTMs(acetylation,SUMOylation,lactylation,phosphorylation,etc.).We also delineate the relationship between RNA modification regulator functions and carcinogenesis or cancer ***,inhibitors that target RNA modification regulators for anticancer therapy and their synergistic effect combined with immunotherapy or chemotherapy are discussed.

关键词： RNA modification writers erasers readers regulatory subunits PTMs cancer

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Visible light-driven oxidation of non-native substrate by laccase attached on Ru-based metal-organic frameworks

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Journal of Environmental Sciences 2024年第3期137卷 741-753页

作者： Wenguang Huang Wentao Zhang Guantongyi chen Yun chen jun Ma Dawei Huang Qinzheng Zhaoc Bingdang Wu State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment South China Institute of Environmental SciencesMinistry of Ecology and Environment of PRCGuangzhou 510655China Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China School of Environmental Science and Engineering Suzhou University of Science and TechnologySuzhou 215002China Key Laboratory of Suzhou Sponge City Technology Suzhou 215002China

Light-induced electron transfer can broaden the substrate range of ***,the efficiency of photo-enzyme coupling is limited by the poor combination of photosensitizer or photocatalyst with ***,we prepared the nano-photocatalyst MIL-125-NH_(2)@Ru(bpy)by in site embedding ruthenium pyridine-diimine complex[Ru(bpy)_(3)^(2+)into metal organic frameworks MIL-125-NH_(2)and associated it with multicopper oxidase(MCO)*** to[Ru(bpy)_(3)]^(2+),the coupling efficiency of MIL-125-NH_(2)@Ru(bpy)_(3)for enzymatic oxygen reduction increased by 35.7%.A series of characterizations confirmed that the amino group of laccase formed chemical bonds with the surface defects or hydrophobic groups of MIL-125-NH_(2)@Ru(bpy)_(3).Consequently,the tight binding accelerated the quenching process and electron transfer between laccase and the immobilized ruthenium pyridine-diimine *** work would open an avenue for the synthesis of MOFs photocatalyst towards photo-enzyme coupling.

关键词： Laccase Light-driven biocatalysis Ruthenium photocatalyst Metal-organic frameworks Enzyme immobilization

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Simultaneously Improved Curing,Mechanical,Antioxidative Properties and Reduced ZnO Loading of Silica Filled NR Composites by Incorporation of Low-cost Crude Carbon Dots via Conventional Melt-milling Method

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Chinese Journal of Polymer Science 2024年第6期42卷 815-825页

作者： Chao-Ying Sun Hai-jun Ji Li-Wei Li hui Yang Xiao-Peng An Yi-Ping chen Ming-Jian Han Can Jiang Li-Qun Zhang Peng Yu Run-Guo Wang State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing100029China School of Materials Science and Engineering Wuhan Institute of TechnologyWuhan430205China

Rubbers or elastomers play an important role in hi-tech technology and civilian daily life because of their unique and strategical ***,the rubber additives are essential components for rubbers’practical ***,developing novel multifunctional additives has attracted increasing research *** this work,low-cost crude carbon dots(CCDs)were used as multifunctional additives for natural rubber/silica system(without any additional modification)through industrial compatible melt-mixing *** results revealed that the CCDs could disperse well in the NR/silica system,and they could not only endow the rubber compound with excellent anti-aging capability due to CCDs’radical scavenging activity because of their plenty of nitrogen-containing species,but also improve the curing rate and mechanical performance of the rubber ***,the CCDs could reduce the rolling resistance of the rubber composites(tanδvalue at 7%strain of the rubber composite could be decreased by 34%),which is promising for the application of energy-saving tire ***,the addition of CCDs could effectively reduce the ZnO dosage by at least 40%in the rubber composite without deteriorating its ***,this work provides valuable guidance to develop novel cheap yet effective additives for the elastomer.

关键词： Natural rubber Crude carbon dots Antioxidant ZnO reduction Vulcanization

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Injectable chitosan hydrogels loaded with antioxidant agent as first-aid dressings for second-degree burn wounds

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Science China(Technological Sciences) 2024年第3期67卷 891-901页

作者： REN hui ZHANG Zhen LU KaiLun SHEN YuanYuan HE ChaoLiang chen XueSi CAS Key Laboratoryof Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China

Burn wounds are destructive skin traumas typically of irregular shape and large area. Prone to infection, they require frequent dressing replacement, and painless removal of dressings from burn wounds remains a major challenge. This study focuses on the dynamic characteristics and treatment difficulty of burn wounds. Hydrogel dressings based on glycol chitosan and propionaldehyde-or benzaldehyde-terminated 4-arm poly(ethylene glycol) were designed on the basis of Schiff base cross-linking networks. The hydrogels exhibited shape-adaptability, self-healing and fast-degradation properties, which makes these hydrogels suitable for burn wounds. Salvianolic acid B(SaB)-loaded hydrogel exhibited good antioxidant properties in vitro. In a rat model of deep second-degree burn wounds, the SaB-loaded hydrogel could quickly reduce wound temperature, regulate wound oxidant microenvironment, promote angiogenesis, and accelerate wound healing. Thus, the drug-loaded hydrogel shows significant potential as a first-aid dressing for treatment of burn wounds.

关键词： hydrogel dressing fast-degradation shape-adaptability stress relaxation burn wound treatment

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Neuroimmune interactions and their roles in neurodegenerative diseases

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Fundamental Research 2024年第2期4卷 251-261页

作者： Bai-Rong chen Ting Wu Ting-hui chen Yun Wang Neuroscience Research Institute and Department of Neurobiology School of Basic Medical SciencesKey Laboratory for NeuroscienceMinistry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic DrugsPeking UniversityBeijing 100083China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China

The nervous system possesses bidirectional,sophisticated and delicate communications with the immune *** neuroimmune interactions play a vitally important role in the initiation and development of many disorders,especially neurodegenerative *** scientific advancements have made tremendous progress in this field during the last few years,neuroimmune communications are still far from being *** organizing recent research,in this review,we discuss the local and intersystem neuroimmune interactions and their roles in Alzheimer’s disease,Parkinson’s disease and amyotrophic lateral *** these will help us gain a better understanding of the process of interplay inside the body and how the organism maintains *** will also facilitate a view of the diseases from a holistic,pluralistic and interconnected perspective,thus providing a basis of developing novel and effective methods to diagnose,intervene and treat diseases.

关键词： Nervous system Immune system Neuroimmune interactions Alzheimer’s disease Parkinson’s disease Amyotrophic lateral sclerosis

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Comparison of CWSI and T_(s)-T_(a)-VIs in moisture monitoring of dryland crops(sorghum and maize)based on UAV remote sensing

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Journal of Integrative Agriculture 2024年第7期23卷 2458-2475页

作者： hui chen Hongxing chen Song Zhang Shengxi chen Fulang Cen Quanzhi Zhao Xiaoyun Huang Tengbing He Zhenran Gao College of Agriculture Guizhou UniversityGuiyang 550025China Institute of New Rural Development Guizhou UniversityGuiyang 550025China Institute of Rice Industry Technology Research College of Agricultural SciencesGuizhou UniversityGuiyang 550025China

Monitoring agricultural drought using remote sensing data is crucial for precision irrigation in modern *** unmanned aerial vehicle(UAV)remote sensing,we explored the applicability of an empirical crop water stress index(CWSI)based on canopy temperature and three-dimensional drought indices(TDDI)constructed from surface temperature(T_(s)),air temperature(T_(a))and five vegetation indices(VIs)for monitoring the moisture status of dryland *** machine learning algorithms(random forest regression(RFR),support vector regression,and partial least squares regression)were used to compare the performance of the drought indices for vegetation moisture content(VMC)estimation in sorghum and *** main results of the study were as follows:(1)Comparative analysis of the drought indices revealed that T_(s)-T_(a)-normalized difference vegetation index(TDDIn)and T_(s)-T_(a)-enhanced vegetation index(TDDIe)were more strongly correlated with VMC compared with the other *** indices exhibited varying sensitivities to VMC under different irrigation regimes;the strongest correlation observed was for the TDDIe index with maize under the fully irrigated treatment(r=-0.93).(2)Regarding spatial and temporal characteristics,the TDDIn,TDDIe and CWSI indices showed minimal differences Over the experimental period,with coefficients of variation were 0.25,0.18 and 0.24,*** three indices were capable of effectively characterizing the moisture distribution in dryland maize and sorghum crops,but the TDDI indices more accurately monitored the spatial distribution of crop moisture after a rainfall or irrigation event.(3)For prediction of the moisture content of single crops,RFR models based on TDDIn and TDDIe estimated VMC most accurately(R^(2)>0.7),and the TDDIn-based model predicted VMC with the highest accuracy when considering multiple-crop samples,with R^(2)and RMSE of 0.62 and 14.26%,***,TDDI proved more effective than the CWSI in e

关键词： maize sorghum T_(s)-T_(a)-VIs CWSI UAV machine learning crop moisture monitoring

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Harness High-Temperature Thermal Energy via Elastic Thermoelectric Aerogels

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Nano-Micro Letters 2024年第8期16卷 196-210页

作者： Hongxiong Li Zhaofu Ding Quan Zhou jun chen Zhuoxin Liu Chunyu Du Lirong Liang Guangming chen College of Materials Science and Engineering Shenzhen UniversityShenzhen 518055People’s Republic of China Department of Bioengineering University of CaliforniaLos AngelesCA 90095USA

Despite notable progress in thermoelectric(TE)materials and devices,developing TE aerogels with high-temperature resistance,superior TE performance and excellent elasticity to enable self-powered high-temperature monitoring/warning in industrial and wearable applications remains a great ***,a highly elastic,flame-retardant and high-temperature-resistant TE aerogel,made of poly(3,4-ethylene dioxythiophene):poly(styrenesulfonate)/single-walled carbon nanotube(PEDOT:PSS/SWCNT)composites,has been fabricated,displaying attractive compression-induced power factor *** as-fabricated sensors with the aerogel can achieve accurately pressure stimuli detection and wide temperature range ***,a flexible TE generator is assembled,consisting of 25 aerogels connected in series,capable of delivering a maximum output power of 400μW when subjected to a temperature difference of 300 *** demonstrates its outstanding high-temperature heat harvesting capability and promising application prospects for real-time temperature monitoring on industrial high-temperature ***,the designed self-powered wearable sensing glove can realize precise wide-range temperature detection,high-temperature warning and accurate recognition of human hand *** aerogel-based intelligent wearable sensing system developed for firefighters demonstrates the desired self-powered and highly sensitive high-temperature fire warning *** from these desirable properties,the elastic and high-temperature-resistant aerogels present various promising applications including self-powered high-temperature monitoring,industrial overheat warning,waste heat energy recycling and even wearable healthcare.

关键词： Thermoelectrics Aerogel Self-powered High-temperature monitoring High-temperature warning

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All-trans retinoic acid alleviates transmissible gastroenteritis virus-induced intestinal inflammation and barrier dysfunction in weaned piglets

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1131-1144页

作者： junning Pu Daiwen chen Gang Tian jun He Ping Zheng Zhiqing Huang Xiangbing Mao Jie Yu Yuheng Luo junqiu Luo hui Yan Aimin Wu Bing Yu Institute of Animal Nutrition Sichuan Agricultural UniversityChengdu 611130SichuanPeople’s Republic of China Key Laboratory of Animal Disease-Resistance Nutrition Ministry of EducationMinistry of Agriculture and Rural AffairsKey Laboratory of Sichuan Province611130 ChengduSichuanPeople’s Republic of China

Background Transmissible gastroenteritis virus(TGEV)is one of the main pathogens causing severe diarrhea of *** pathogenesis of TGEV is closely related to intestinal ***-trans retinoic acid(ATRA)is the main active metabolite of vitamin A,which has immunomodulatory and anti-inflammatory ***,it is unclear whether ATRA can alleviate TGEV-induced intestinal inflammation and barrier dysfunction in *** study aimed to investigate the effects of ATRA on growth performance,diarrhea,intestinal inflammation and intesti-nal barrier integrity of TGEV-challenged *** In a 19-d study,32 weaned piglets were randomly divided into 4 treatments:Control group(basal diet),TGEV group(basal diet+TGEV challenge),TGEV+ATRA5 group(basal diet+5 mg/d ATRA+TGEV challenge)and TGEV+ATRA15 group(basal diet+15 mg/d ATRA+TGEV challenge).On d 14,piglets were orally administered TGEV or the sterile *** Feeding piglets with 5 and 15 mg/d ATRA alleviated the growth inhibition and diarrhea induced by TGEV(Pjunal mucosa induced by TGEV,and maintained intestinal barrier integrity(Pjunal mucosa of TGEV-challenged piglets(P<0.05).Furthermore,5 mg/d ATRA feeding attenuated TGEV-induced intestinal inflammatory response by inhibit-ing the release of interleukin(IL)-1β,IL-8 and tumor necrosis factor-α(TNF-α),and promoting the secretion of IL-10 and secretory immunoglobulin A(sIgA)(P<0.05).Feeding 5 mg/d ATRA also down-regulated the expressions of Toll-like receptors and RIG-I like receptors signaling pathway related genes(TLR3,TLR4,RIG-I,MyD88,TRIF and MAVS)and the phosphorylation level of nuclear factor-κB-p65(NF-κB p65),and

关键词： All-trans retinoic acid Inflammation Intestinal barrier Piglets Transmissible gastroenteritis virus

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Interfacial friction effects on sealing performances of elastomer packer

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Petroleum Science 2024年第3期21卷 2037-2047页

作者： Peng-cheng Wang Ming-hui chen Jim Jenkinson Yong-Xin Song Li Sun Department of Mechanical Engineering University of HoustonHoustonTX77024USA Guren Nanomaterials Suzhou215127JiangsuChina Department of Marine Engineering Dalian Maritime UniversityDalian116026LiaoningChina

Elastomer sealing performance is of critical importance for downhole tools application including the use of fracturing(Frac)plugs during multi-stage hydraulic *** practice sealing performances of such plugs are normally evaluated through pressure tests,and in numerical simulation studies,maximum contact stress,average contact stress and contact length data are used to determine sealing quality between a packer and *** previous studies,the impact of friction forces on sealing performance is often *** work aims to fill this knowledge gap in determining the influence of friction forces on elastomer packer sealing *** first determined the most appropriate constitutive hyperelastic model for the elastomers used in frac *** we compared analytical calculation results with Finite Element Analysis simulation using a simplified tubular geometry and showed the significant influences on interfacial friction on elastomer packer stress distribution,deformation,and contact stress after *** the demonstration of validity of FEA method,we conducted systematic numerical simulation studies to show how the interfacial friction coefficients can affect the maximum contact stress,average contact stress,contact stress distribution,and maximum mises stress for an actual packer used in plug *** addition,we also demonstrated how the groove in a packer can affect packer deformation and evolvement during setting with the consideration of interfacial *** study underscores the critical role that friction forces play in Frac plug performance and provides a new dimension for optimizing packer design by controlling interfacial interactions at the packer contact surfaces.

关键词： Elastomer seal Friction Sealing performance Contact stress

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Enhancing reversible hydrogen storage performance of 2LiBH_(4)–MgH_(2)via in-situ building heterogeneous nucleation sites

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Rare Metals 2024年第9期43卷 4367-4376页

作者： Wei chen Ya-hui Sun Tian Xu Xue-Bin Yu Guang-Lin Xia Department of Materials Science Fudan UniversityShanghai 200433China

2LiBH_(4)-MgH_(2)composite is one of the most attractive reactive hydride composites with a theoretic hydrogen capacity of 10.8 wt%.However,the large nucleation restriction of MgB_(2)during the second step of dehydrogenation results in sluggish hydrogen storage kinetics and high operating temperature,which hinders its practical application as on-board hydrogen storage ***,Al3Ti doped Al nanoparticles(AT NPs)are prepared by a facile chemical reduction reaction to improve the hydrogen storage performance of 2LiBH_(4)-MgH_(2)*** the initial H_(2)desorption process,MgAlB_(4)and TiB_(2)that have identical crystal structure and low d-value mismatch with MgB_(2)resulting from the reaction between AT NPs and 2LiBH_(4)-MgH_(2)composite serve as effective nucleation sites for the formation of MgB_(2).As a result,the apparent activation energy of the two-step H_(2)desorption of AT NPs doped 2LiBH_(4)-MgH_(2)composite are notably decreased to(110.0±5.9)and(119.6±1.4)kJ·mol^(-1),which is 55.5 and 33.5 kJ·mol^(-1)lower than that of the undoped *** importantly,a reversible hydrogen storage capacity of 9.2 wt%after 10cycles of H_(2)desorption and adsorption could be achieved,corresponding to a capacity retention rate of 99%.The building of reactive bimetallic catalyst towards in situ formation of heterogeneous nucleation sites provides a new strategy for improving the hydrogen storage performance of reactive hydride composites.

关键词： Reversible hydrogen storage Reactive hydride composites Catalytic effects Heterogeneous nucleation

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