检索结果-南通市图书馆

Science China Chemistry 2024年第7期67卷 2306-2313页

作者： dong-Yue Cai Weiming Shi Zhao-hui jin Zhi-Xiang Yu jin-Xin Zhao Jian-Min Yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Beijing National Laboratory for Molecular Sciences(BNLMS) Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of ChemistryPeking UniversityBeijing 100871China

Mimicking biosynthetic pathways of hongkonoids led to the development of a new Cu(Ⅰ)-catalyzed[3+2]cycloaddition ofα-hydroxyketone andβ-keto enol ethers,affording tetrahydrofuran acetals in a highly diastereoselective manner and 100%atom *** studies on the mechanism disclosed a concerted but asynchronous Michael addition/aldol *** the same importance,this methodology provides a practical biomimetic approach for one-step construction of the dibenzylbutyrolactol lignan backbone starting from two phenyl propane derivatives,opening up a powerful new approach for lignan synthesis,which is showcased by succinct total syntheses of two biologically important aryltetralin-type lignans,β-apopicropodophyllin and *** the mild and operationally simple conditions,the developed chemistry might have a promising prospect in potential industrial applications.

关键词： [3+2]cycloaddition transition-metal catalysis tetrahydrofuran lignans natural products

Molecular epidemiology of coxsackievirus A16 circulating in children in Beijing, China from 2010 to 2019

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2021年第5期17卷 508-516页

作者： Ya-Fang Hu Li-Ping Jia Fang-Yuan Yu Li-Ying Liu Qin-Wei Song hui-jin dong Jie Deng Yuan Qian Lin-Qing Zhao Li Deng hui Huang Ru-Nan Zhu Laboratory of Virology.Beijing Key Laboratory of Etiology of Viral Diseases in Children Capital Institute of Pediatrics2 Yabao RoadChaoyang DistrictBeijing 100020China Department of Clinical Laboratory Shanghai Children's HospitalShanghai Jiaotong UniversityLuding Road 355Putuo DistrictShanghai 200040China Department of Clinical Laboratory Children's Hospital of Capital Institute of Pediatrics2 Yabao RoadBeijing 100020China Department of Infectious Diseases Children's Hospital of Capital Institute of Pediatrics2 Yabao RoadBeijing 100020China

Background Coxsackievirus A16(CVA16)is one of the major etiological agents of hand,foot and mouth discase(HFMD).This study aimed to investigate the molecular epidemiology and evolutionary characteristics of *** Throat swabs were collected from children with HFMD and suspected HFMD during ***(EVs)were detected and typed by real-ime reverse transcription-polymerase chain reaction(RT-PCR)and *** genotype,evolutionary rate,the most recent common ancestor,population dynamics and selection pressure of CVA16 were analyzed based on viral protein gene(VPI)by bioinformatics *** A total of 4709 throat swabs were *** were detected in 3180 samples and 814 were CVA16 *** than 81%of CVA 16-positive children were under 5 years *** prevalence of CVA 16 showed obvious periodic fluctuations with a high level during 2010--2012 followed by an apparent decline during ***,the activities of CVA16 increased gradually during *** the Beijing CVA16 strains belonged to sub-genotype BI,and B Ib was the dominant *** B Ic strain was detected in Bejing for the first time in *** estimated mean evolutionary rate of VPI gene was 4.49x 103 substitution/site/*** gradually fixed at site-23 of VP1 since *** sites were detected under episodic positive selection,one of which(site-223)located in neutralizing linear epitope *** The dominant strains of CVA 16 belonged to clade B lb and evolved in a fast evolutionary rate during 2010-2019 in *** provide more favorable data for HFMD prevention and control,it is necessary to keep attention on molecular epidemiological and evolutionary characteristics of CVA16.

关键词： Coxsackievirus A16 Genetic evolution Molecular epidemiology Phylogenetic analysis

Radiofrequency ablation combined with transcatheter arterial chemoembolization for recurrent liver cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第6期16卷 1756-1764页

作者： jin-You Guo Li-Li Zhao hui-Jun Cai hui Zeng Wei-dong Mei Department of Oncology The Second People's Hospital of Zhejiang Province Taizhou Yuhuan CityTaizhou 317605Zhejiang ProvinceChina Department of Interventional China's Zhejiang Province Tumor HospitalHangzhou 310000Zhejiang ProvinceChina

BACKGROUND The recurrence rate of liver cancer after surgery is *** ablation(RFA)combined with transcatheter arterial chemoembolization(TACE)is an effective treatment for liver cancer;however,its efficacy in recurrent liver cancer remains *** To investigate the clinical effect of TACE combined with RFA in the treatment of recurrent liver *** Ninety patients with recurrent liver cancer were divided into 2 groups according to treatment plan:Control(RFA alone);and experimental[TACE combined with RFA(TACE+RFA)].The incidence of increased alanine aminotransferase levels,complications,and other indices were compared between the two groups before and after the *** One month after the procedures,the short-term efficacy rate and Karnofsky Performance Status scores of the experimental group were significantly higher than those of the control group(P0.05).CONCLUSION TACE+RFA was effective for the treatment of recurrent liver cancer and significantly reduced AFP levels and improved various indices of liver function.

关键词： Transcatheter arterial chemoembolization Radiofrequency ablation Recurrent liver cancer Clinical efficacy Overall response rate Disease control rate

Recent Progress in Fabrication and Structural Design of Thermal Conductive Polymer Composites

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第3期42卷 277-291,I0004页

作者： Yuan-Kai Du Zheng-Xue Shi Shan dong hui jin Xue Ke Pei Zhao Bing-Bing Jiang Feng You Hubei Key Laboratory of Plasma Chemistry and Advanced Materials School of Material Science and EngineeringWuhan Institute of TechnologyWuhan 430205China Key Laboratory of Green Preparation and Application of Functional Materials Ministry of EducationHubei UniversityWuhan 430062China Institute of Molecular Aggregation Science Tianjin UniversityTianjin 300072China

In recent years, the demand direction for electronic equipment has expanded into embedded and miniaturized devices. The heat radiation problem has become one of the most significant factors for hindering the development of electronic devices. Since heat radiation material is one of the important components in electronic devices, the demand for enhancing thermal conductivity is also increasingly urgent. Research on thermal conductive polymer composites has become a major direction for developing functional composites. This work reviewed the recent progress in the fabrication of thermal conductive polymer composites. Five different structures are presented, including the using of single fillers,hybrid fillers, double threshold percolation structure, segregated structure and other complex multiphase structures. Specifically, the preparation of high-performance thermal conductive polymer composites was introduced through the combination of various thermal conductive ***, the development direction of high thermal conductive polymer composites was briefly explored.

关键词： Thermal conductive polymer Hybrid fillers Polymer composite Thermal resistance

Machine learning for carbonate formation drilling: Mud loss prediction using seismic attributes and mud loss records

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2024年第2期21卷 1241-1256页

作者： hui-Wen Pang Han-Qing Wang Yi-Tian Xiao Yan jin Yun-Hu Lu Yong-dong Fan Zhen Nie National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China College of Science China University of Petroleum-BeijingBeijing102249China Petroleum Exploration and Production Research Institute SINOPECBeijing102206China College of Petroleum Engineering China University of Petroleum-BeijingBeijing102249China Research Institute of Petroleum Exploration and Development CNPCBeijing100083China

Due to the complexity and variability of carbonate formation leakage zones, lost circulation prediction and control is one of the major challenges of carbonate drilling. It raises well-control risks and production expenses. This research utilizes the H oilfield as an example, employs seismic features to analyze mud loss prediction, and produces a complete set of pre-drilling mud loss prediction solutions. Firstly, 16seismic attributes are calculated based on the post-stack seismic data, and the mud loss rate per unit footage is specified. The sample set is constructed by extracting each attribute from the seismic trace surrounding 15 typical wells, with a ratio of 8:2 between the training set and the test set. With the calibration results for mud loss rate per unit footage, the nonlinear mapping relationship between seismic attributes and mud loss rate per unit size is established using the mixed density network ***, the influence of the number of sub-Gausses and the uncertainty coefficient on the model's prediction is evaluated. Finally, the model is used in conjunction with downhole drilling conditions to assess the risk of mud loss in various layers and along the wellbore trajectory. The study demonstrates that the mean relative errors of the model for training data and test data are 6.9% and 7.5%, respectively, and that R2is 90% and 88%, respectively, for training data and test data. The accuracy and efficacy of mud loss prediction may be greatly enhanced by combining 16 seismic attributes with the mud loss rate per unit footage and applying machine learning methods. The mud loss prediction model based on the MDN model can not only predict the mud loss rate but also objectively evaluate the prediction based on the quality of the data and the model.

关键词： Lost circulation Risk prediction Machine learning Seismic attributes Mud loss records

Human bocavirus 1 and 2 genotype-specific antibodies for rapid antigen testing in pediatric patients with acute respiratory infections

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2023年第10期19卷 1009-1016页

作者： Ri De Yan-Peng Xu Fang Wang Yu-Tong Zhou Pan-Deng Shi Ru-Nan Zhu Yu Sun Li-Ying Liu Li-Ping Jia hui-jin dong hui Zhao Cheng-Feng Qin Lin-Qing Zhao Laboratory of Virology Beijing Key Laboratory of Etiology of Viral Diseases in ChildrenCapital Institute of PediatricsBeijing 100020China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAcademy of Military Medical SciencesBeijing100071China

Background Previous serological studies of human bocavirus(HBoV)1 could not exclude cross-reactivity with the other three HBoVs,particularly *** To search for genotype-specific antibodies against HBoV1 and HBoV2,the divergent regions(DRs)located on the major capsid protein VP3 were defined through viral amino acid alignment and structure ***-deduced peptides were used as antigens to harvest corresponding anti-DR rabbit *** determine their genotype specificities for HBoV1 and HBoV2,these sera samples were used as antibodies against the antigens VP3 of HBoV1 and HBoV2(expressed in Escherichia coli)in western blotting(WB),enzyme-linked immunosorbent assay(ELISA),and bio-layer interferometry(BLI)***,the antibodies were evaluated with clinical specimens from pediatric patients with acute respiratory tract infection by indirect immunofluorescence assay(IFA).Results There were four DRs(DR1–4)located on VP3 with different secondary and tertiary structures between HBoV1 and *** the reactivity with VP3 of HBoV1 or HBoV2 in WB and ELISA,high intra-genotype cross-reactivity of anti-HBoV1 or HBoV2 DR1,DR3,and DR4,but not anti-DR2,was ***-specific binding capacity of anti-DR2 sera was confirmed by BLI and IFA,in which only anti-HBoV1 DR2 antibody reacted with HBoV1-positive respiratory *** Antibodies against DR2,located on VP3 of HBoV1 or HBoV2,were genotype specific for HBoV1 and HBoV2,respectively.

关键词： Divergent regions Genotype-specific antibody Human bocavirus 1 and 2 Major capsid protein VP3

On hypersurfaces of H2×H2

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Mathematics 2024年第2期67卷 339-366页

作者： dong Gao hui Ma Zeke Yao School of Science Beijing University of Civil Engineering and Architecture Department of Mathematical Sciences Tsinghua University

In this paper, we study hypersurfaces of H2× H2. We first classify the hypersurfaces with constant principal curvatures and constant product angle functions. Then we classify homogeneous hypersurfaces and isoparametric hypersurfaces, respectively. Finally, we classify the hypersurfaces with at most two distinct constant principal curvatures, as well as those with three distinct constant principal curvatures under some additional conditions.

关键词： constant principal curvature homogeneous hypersurface isoparametric hypersurface 53C42 53B25 53C40

Neg-Entropy Mechanism as a Target for Natural Medicines

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Engineering 2024年第7期38卷 11-12页

作者： Tian-Le Gao hui-hui Guo Jian-dong Jiang Institute of Materia Medica Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Current strategies for drug discovery research mainly focus on molecular targets,in which structure biology plays a central role,such as the detailed mechanism of a drug-target *** principle of this approach is the presumed molecular mechanism or genetic background of the disease being *** this approach has brought progress in understanding the mode of action for some drugs,most prevalent illnesses-especially chronic diseases-are multifactorial and present with a group of symptoms,as is often the case in cardiovascular diseases,metabolic disorders,cancers,and so *** newly emerging term“multi-morbidity”(i.e.,multiple co-occurring diseases)describes a grand challenge for this strategy,and successful drug intervention for multimorbidity should be multifaceted[1].So,our research team has shifted its attention to a new direction that views the disease as a whole instead of a single-molecule abnormality,and focusing on drugs with multiple targets.

关键词： drugs diseases cardiovascular

Insight into vertical piezoelectric characteristics regulated thermal transport in van der Waals two-dimensional materials

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第2期43卷 770-779页

作者： dong-Hai Wei E Zhou jin-Yuan Xu hui-Min Wang Chen Shen Hong-Bin Zhang Zhen-Zhen Qin Guang-Zhao Qin State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha410082China Hunan Key Laboratory for Micro-Nano Energy Materials and Device and School of Physics and Optoelectronics Xiangtan UniversityXiangtan411105China Institute of Materials Science Technical University of DarmstadtAlarich-Weiss-Str.264287DarmstadtGermany School of Physics and Microelectronics Zhengzhou UniversityZhengzhou450001China

The urgent demand of extreme(ultra-high/low)thermal conductivity materials is triggered by the high-power device,where exploring the theories and mechanisms of regulating thermal transport properties plays a key ***,we elaborately investigate the effect of vertical(out-of-plane)piezoelectric characteristics on thermal transport,which is historically *** different stacking-order(AA and AB)bilayer boron nitride(Bi-BN)in two-dimensional(2D)materials are selected as study *** performing state-of-the-art first-principles calculations,it is found that the polarization charge along the out-of-plane orientation ascends significantly with the increasing piezoelectric response in AB stacked Bi-BN(Bi-BN-AB)followed by the enhanced interlayer B–N atomic ***,the amplitude of phonon anharmonicity in Bi-BN-AB increases larger than that in the AA stacked Bi-BN(Bi-BN-AA),resulting in the dramatic weakening of the thermal conductivity by 20.34%under 18%*** research reveals the significant role of the vertical(out-of-plane)piezoelectric characteristic in regulating thermal transport and provides new insight into accurately exploring the thermal transport performance of 2D van der Waals materials.

关键词： Thermal conductivity Piezoelectric effect 2D materials Bilayer BN Strain engineering

Research on Bast Fiber Extracted from the White Bark of Three Species in the Genus Broussonetia

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第6期42卷 729-738页

作者： Shan-Shan jin Si-Nong Wang Yan-Yan Huang jing-Yu Zhang Peng Liu hui Yu Hong-dong Zhang Yu-Liang Yang Institute for Preservation and Conservation of Chinese Ancient Books Fudan University LibraryFudan UniversityShanghai200433China State key laboratory of Molecular Engineering of polymers Department of Macromolecular ScienceFudan UniversityShanghai200433China

Against the backdrop of a global paper resource shortage,there is a growing need to identify fast-growing tree species capable of producing long-lasting *** plant species namely Broussonetia kazinoki,Broussonetia papyrifera and hybrid paper mulberry,belong to the Broussonetia genus,were collected from China to study their white bark suitability for pulp and *** chemical composition revealed that the holocellulose content in Broussonetia kazinoki and Broussonetia papyrifera was more than 80%.The molecular weight distribution of several holocellulose/α-cellulose is observed by GPC,which allows us to better observe the changes of various components on the molecular *** yield,lignin,whiteness,and molecular weight of the pulps obtained by NaOH treatment were *** microscope was used to characterize the fiber length-width ratio and ***,the improvement of the fiber rigidity method based on the Kratky-Porod chain model makes it more theoretical and further reveals the influencing factors of fiber *** study demonstrates the high potentiality of these three species for papermaking applications.

关键词： Broussonetia genus Cellulose Alkaline pulping Kratky-Porod chain model Fiber rigidity