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数字服务贸易网络与企业技术持续创新——基于我国沪深A股上市公司的经验证据

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技术经济与管理研究 2024年第4期 21-26页

作者：徐向慧对外经济贸易大学国际经济与贸易学院北京100029 郑州科技学院财经学院河南郑州450064

选取2012—2022年沪深A股上市公司数据,对数字服务贸易网络与企业技术持续创新的关系进行研究。同时,采用基准回归模型、中介模型、门槛模型的方法进行实证,研究表明,数字服务贸易网络对企业技术持续创新具有正向推动作用,且知识产权保... 详细信息

选取2012—2022年沪深A股上市公司数据,对数字服务贸易网络与企业技术持续创新的关系进行研究。同时,采用基准回归模型、中介模型、门槛模型的方法进行实证,研究表明,数字服务贸易网络对企业技术持续创新具有正向推动作用,且知识产权保护与研发要素流动在二者间发挥中介作用;受知识产权保护与研发要素流动影响,数字服务贸易网络对企业技术持续创新的推动作用呈现非线性特征。基于此,提出提高数字服务贸易领域对外开放水平、建立健全知识产权保护体制机制、发挥研发要素协同配置效应的政策建议,以期为企业技术持续创新注入新动能。

关键词：数字服务贸易网络企业技术持续创新知识产权保护

The value of trans esophageal echocardiography in patients with atrial fibrillation or atrial flutter before radiofrequency ablation or cardioversion

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中国循环杂志 2016年第Z1期31卷 -页

作者： Qiyin zhang jie hui First Hospital Af iliated to Suzhou University Zhejiang China

Background Transesophageal echocardiography before radiofrequency catheter ablation and cardioversion gradually become complex in patients with atrial fibrillation or atrial flutter[第一段]

关键词：超声心动描记术超声心动描记术经食管导管消融术电抗休克心房颤动心房扑动

Mechanism underlying treatment of ischemic stroke using acupuncture:transmission and regulation

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Neural Regeneration Research 2021年第5期16卷 944-954页

作者： Bing-Qian Cao Feng Tan jie zhan Peng-hui Lai Department of Neurology Foshan Hospital of Traditional Chinese MedicineGuangzhou University of Chinese MedicineFoshanGuangdong ProvinceChina Department of Rehabilitation Guangdong Provincial Hospital of Chinese MedicineGuangzhouGuangdong ProvinceChina Department of Rehabilitation Nan’ao People’s Hospital Dapeng New DistrictShenzhenGuangdong ProvinceChina

The inflammatory response after cerebral ischemia/reperfusion is an important cause of neurological damage and *** cerebral ischemia/reperfusion,microglia are activated,and a large number of circulating inflammatory cells infiltrate the affected *** leads to the secretion of inflammatory mediators and an inflammatory cascade that eventually causes secondary brain damage,including neuron necrosis,blood-brain barrier destruction,cerebral edema,and an oxidative stress *** of inflammatory signaling pathways plays a key role in the pathological process of ischemic *** evidence suggests that acupuncture can reduce the inflammatory response after cerebral ischemia/reperfusion and promote repair of the injured nervous *** can not only inhibit the activation and infiltration of inflammatory cells,but can also regulate the expression of inflammation-related cytokines,balance the effects of pro-inflammatory and anti-inflammatory factors,and interfere with inflammatory signaling ***,it is important to study the transmission and regulatory mechanism of inflammatory signaling pathways after acupuncture treatment for cerebral ischemia/reperfusion injury to provide a theoretical basis for clinical treatment of this type of injury using *** review summarizes the overall conditions of inflammatory cells,mediators,and pathways after cerebral ischemia/reperfusion,and discusses the possible synergistic intervention of acupuncture in the inflammatory signaling pathway network to provide a foundation to explore the multiple molecular mechanisms by which acupuncture promotes nerve function restoration.

关键词： acupuncture central nervous system factor inflammation ischemic stroke pathways protein stroke

On capped Higgs positivity cone

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中国科学技术大学学报 2024年第7期54卷 44-54,43,I0003页

作者： Dong-Yu Hong zhuo-hui Wang Shuang-Yong zhou Interdisciplinary Center for Theoretical Study University of Science and Technology of ChinaHefei 230026China Peng Huanwu Center for Fundamental Theory Hefei 230026China

The Wilson coefficients of the standard model effective field theory are subject to a series of positivity *** has been shown that while the positivity part of the ultraviolet(UV)partial wave unitarity leads to the Wilson coefficients living in a convex cone,further including the nonpositivity part caps the cone from *** Higgs scattering,a capped positivity cone was obtained using a simplified,linear unitarity condition without utilizing the full internal symmetries of Higgs ***,we further implement stronger nonlinear unitarity conditions from the UV,which generically gives rise to better *** show that,for the Higgs case in particular,while the nonlinear unitarity conditions per se do not enhance the bounds,the fuller use of the internal symmetries do shrink the capped positivity cone significantly.

关键词： positivity bounds standard model effective field theory(SMEFT) Higgs

Immunosuppression and phenotypic plasticity in an atlas of human hepatocholangiocarcinoma

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 586-603,I0002-I0014页

作者： Yiran Li ziyu Xun Junyu Long huishan Sun Xu Yang Yanyu Wang Yunchao Wang Jingnan Xue Nan zhang Junwei zhang Jin Bian jie Shi Xiaobo Yang Hanping Wang Haitao zhao State Key Laboratory of Complex Severe and Rare Diseases Department of Liver SurgeryPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College(CAMS&PUMC)BeijingChina Division of Pulmonary and Critical Care Medicine State Key Laboratory of Complex Severe and Rare DiseasesChinese Academy of Medical Sciences and Peking Union Medical College(CAMS&PUMC)BeijingChina

Background:Hepatocholangiocarcinoma(H-ChC)has the clinicopathological features of both hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(iCCA)and is a more aggressive subtype of primary hepatic carcinoma than HCC or ***:We sequenced 91,112 single-cell transcriptomes from 16 human samples to elucidate the molecular mechanisms underlying the coexistence of HCC and iCCA components in ***:We observed two molecular subtypes of H-ChC at the whole-transcriptome level(CHP and CIP),where a metabolically active tumour cell subpopulation enriched in CHP was characterized by a cellular pre-differentiation *** define the heterogeneity of tumours and their associated microenvironments,we observe greater tumour diversity in H-ChC than HCC and iCCA.H-ChC exhibits weaker immune cell infiltration and greater CD8+exhausted T cell(Tex)dysfunction than HCC and *** we defined two broad cell states of 6,852 CD8+Tex cells:gzMK+CD8+Tex cells and terminal CD8+Tex ***+CD8+Tex cells exhibited higher infiltration of after treatment in H-ChC,the effector scores and expression of the immune checkpoints of them greatly increased after immunotherapy,which indicated that H-ChC might be more sensitive than HCC or iCCA to ***:In this paper,H-ChC was explored,hoping to contribute to the study of mixed tumours in other cancers.

关键词： Hepatocholangiocarcinoma(H-ChC) biphenotypic plasticity CD8+Tex cells immunosuppression

改良T组合复苏器与鼻导管吸氧用于婴儿电子支气管镜检查的安全性比较:一项前瞻性随机对照研究

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中国当代儿科杂志 2024年第1期26卷 37-41页

作者：宁俊杰左智惠喻志东李雪梅乔莉娜自贡市第一人民医院儿科四川自贡643000 四川大学华西第二医院儿童重症医学科四川成都610041 国家卫生健康委员会时间生物学重点实验室(四川大学) 四川成都610041 出生缺陷与相关妇儿疾病教育部重点实验室四川成都610041

目的优化肺部疾病婴儿接受支气管镜检查时的氧疗方案。方法该研究是一项前瞻性随机、对照的单中心临床试验。前瞻性选择2019年7月—2021年7月42例接受电子支气管镜检查的婴儿为研究对象。按照随机数字表法分为鼻导管吸氧(nasal cannula ... 详细信息

目的优化肺部疾病婴儿接受支气管镜检查时的氧疗方案。方法该研究是一项前瞻性随机、对照的单中心临床试验。前瞻性选择2019年7月—2021年7月42例接受电子支气管镜检查的婴儿为研究对象。按照随机数字表法分为鼻导管吸氧(nasal cannula oxygen,NC)组及改良T组合复苏器(T-piece resuscitator,TPR)组。记录两组术中最低血氧饱和度结果作为主要指标,术中心率及呼吸结果作为次要指标。结果改良TPR组术中最低血氧饱和度高于NC组,低氧血症发生率低于NC组(P0.05)。结论改良TPR可以显著减少肺部疾病婴儿接受电子支气管镜时发生低氧血症的风险;与传统NC相比,TPR可明显改善低氧血症的严重程度,且减少呼吸节律异常的发生率。

关键词： T组合复苏器鼻导管吸氧电子支气管镜临床效果婴儿

L-theanine/α-Ketoglutarate/Nrf2 axis promotes exercise-mediated amelioration of NASH in mice

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Food Science and Human Wellness 2024年

作者： Wang-Jing Mu Min Chen jie-Ying zhu Hong-Yang Luo Yang Li Shan Li Lin-jing Yan Ruo-ying Li Liang guo School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health， Shanghai University of Sport Shanghai Frontiers Science Research Base of Exercise and Metabolic Health， Shanghai University of Sport Key Laboratory of Exercise and Health Sciences of the Ministry of Education， Shanghai University of Sport

L-Theanine (LTA) is a non-protein amino acid mainly found in tea plants with many beneficial effects. Exercise exerts a wide range of benefits in metabolic health. Here， we show that exercise or gastric lavage intervention on mice with LTA improves diet-induced NASH in mice. Meanwhile， combinatory therapy shows that exercise and LTA synergistically improve obesity-related metabolic disorders and NASH phenotypes， including hepatic steatosis， inflammation， cell death and oxidative stress. In vivo studies indicate that LTA inhibits free fatty acid (FFA)-induced hepatocyte injury， including steatosis， oxidative stress and apoptosis. Knockdown of Nrf2 blunts the role of LTA in inhibiting FFA-induced hepatocyte oxidative stress and dysfunction. Mechanistically， LTA increases the α-ketoglutarate (α-Kg) level in hepatocytes， which increases the transcription of Nrf2 by inducing active DNA demethylation on its promoter. Moreover， LTA promote the above α-Kg/Nrf2 axis in synergy with exercise， thereby more efficiently inhibiting hepatic oxidative stress and ameliorating diet-induced NASH in mice. Our results suggest that， through promoting the α-Kg/Nrf2 axis-mediated anti-oxidative pathway， the combination of LTA and exercise may provide an effective measure for the prevention and control of NASH.

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中国基础研究投入不足的内因分析——基于地方政府间经济赶超的视角

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技术经济与管理研究 2024年第7期 18-23页

作者：张煜晖北京银行博士后科研工作站北京100033

选取2005—2022年省级面板数据,检验地方政府横向竞争对基础研究投入的影响。研究发现,地方政府经济赶超行为会减少地方政府对基础研究的投入,并且这种行为会在地方政府间呈现出“竞而向下”的特征。机制检验表明,地方政府的经济赶超行... 详细信息

选取2005—2022年省级面板数据,检验地方政府横向竞争对基础研究投入的影响。研究发现,地方政府经济赶超行为会减少地方政府对基础研究的投入,并且这种行为会在地方政府间呈现出“竞而向下”的特征。机制检验表明,地方政府的经济赶超行为通过降低市场化程度和政府创新投资意愿降低了基础研究投入。异质性分析表明,在经济落后地区这一现象更为严重。同时,优化考核体系后赶超行为会提升基础研究投入。鉴于此,应优化地方政府考核体系,充分调动地方政府积极性,推动核心技术突破。

关键词：经济赶超基础研究创新意愿市场化财政支出财政分权

从“人类世”到“人机世”:后人类时代教育变革路径探析

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科学技术哲学研究 2024年第1期41卷 67-73页

作者：苏慧丽东北师范大学教育学部长春130024

伴随着生物技术与信息技术的急速发展,人与技术的互构性不断增强,后人类时代从“人类世”过渡到“人机世”的特征与影响开始逐渐凸显。后人类理论强调打破“人文主义”对规范的大写的“人”的限定,技术的发展与文化境况的转变对教育提... 详细信息

伴随着生物技术与信息技术的急速发展,人与技术的互构性不断增强,后人类时代从“人类世”过渡到“人机世”的特征与影响开始逐渐凸显。后人类理论强调打破“人文主义”对规范的大写的“人”的限定,技术的发展与文化境况的转变对教育提出了激进的挑战。在后人类时代下,教育主体形态将趋向于人的“机器化”与机器的“人化”,知识生产方式可能造成路途与景深的消解,人工智能对人类思维的替代可能导致人类创造力的萎缩。为应对技术带来的挑战,教育应重新审视并建构后人类时代的人机关系,以创变性作为人机相区别的奇点指向人类智慧培养,打破人类中心主义构建人机交互教育网络,基于“善恶对价法则”划定教育技术伦理红线,坚守“人是目的”这一原则推动教育变革。

关键词： “人类世” “人机世” 后人类教育变革