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Multimodal imaging diagnosis and analysis of prognostic factors in patients with adult-onset Coats disease

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1469-1476页

作者： Wei Zhou hui Zhou Yuan-Yuan Liu Meng-Xuan Li Xiao-Han Wu Jiao liang Jing Hao Sheng-Nan Liu Chun-Jie Jin Department of Ophthalmology Tianjin Medical University General HospitalTianjin 300052China Department of Ophthalmology Shanxi Yuncheng Tongde HospitalYuncheng 044000Shanxi ProvinceChina Department of Information Tianjin Medical University General HospitalTianjin 300052China

AIM:To describe the multimodal imaging features,treatment,and outcomes of patients diagnosed with adultonset Coats ***:This retrospective study included patients first diagnosed with Coats disease at≥18 years of age between September 2017 and September *** patients received anti-vascular endothelial growth factor(VEGF)therapy(conbercept,0.5 mg)as the initial treatment,which was combined with laser photocoagulation as *** the patients underwent best corrected visual acuity(BCVA)and intraocular pressure examinations,fundus color photography,spontaneous fluorescence tests,fundus fluorescein angiography,optical coherence tomography(OCT),OCT angiography,and other *** alterations and multimodal image findings in the affected eyes following treatment were compared and the prognostic factors were ***:The study included 15 patients who were aged 24-72(57.33±12.61)y at *** hypertension was the most common associated systemic condition,occurring in 13(86.7%)*** BCVA ranged from 2.0 to 5.0(4.0±1.1),which showed improvement following treatment(4.2±1.0).Multimodal imaging revealed retinal telangiectasis in 13 patients(86.7%),patchy hemorrhage in 5 patients(33.3%),and stage 2B disease(Shield’s staging criteria)in 11 patients(73.3%).OCT revealed that the baseline central macular thickness(CMT)ranged from 129 to 964μm(473.0±230.1μm),with 13 patients(86.7%)exhibiting a baseline CMT exceeding 250μ***,8 patients(53.3%)presented with an epiretinal membrane at baseline or during ***-reflective scars were observed on OCT in five patients(33.3%)with poor visual *** deteriorated in one patient who did not receive *** vision was stable in three patients who received laser treatment,whereas improvement was observed in one of two patients who received anti-VEGF therapy *** addition,8 of 9 patients(88.9%)who received laser treatment and conbercept exhibited sta

关键词： adult-onset Coats disease multimodal imaging anti-vascular endothelial growth factor conbercept

Helicobacter pylori plays a key role in gastric adenocarcinoma induced by spasmolytic polypeptide-expressing metaplasia

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World Journal of Clinical Cases 2023年第16期11卷 3714-3724页

作者： Mian-Li Li Xin-Xin Hong Wei-jian Zhang Yi-Zhong liang Tian-Tian Cai Yi-Fei Xu Hua-Feng Pan jian-Yuan Kang Shao-Ju Guo Hai-Wen Li Department of Gastroenterology Shenzhen Hospital of IntegratedTraditional Chinese and Western MedicineShenzhen 518033Guangdong ProvinceChina Department of Gastroenterology Shenzhen Traditional Chinese Medicine HospitalShenzhen 518033Guangdong ProvinceChina Science and Technology Innovation Center Guangzhou University of Traditional Chinese MedicineGuangzhou 510405Guangdong ProvinceChina

Heliobacter pylori(H. pylori), a group 1 human gastric carcinogen, is significantly associated with chronic gastritis, gastric mucosal atrophy, and gastric *** 20% of patients infected with H. pylori develop precancerous lesions, among which metaplasia is the most critical. Except for intestinal metaplasia(IM), which is characterized by goblet cells appearing in the stomach glands, one type of mucous cell metaplasia, spasmolytic polypeptide-expressing metaplasia(SPEM), has attracted much attention. Epidemiological and clinicopathological studies suggest that SPEM may be more strongly linked to gastric adenocarcinoma than IM. SPEM, characterized by abnormal expression of trefoil factor 2, mucin 6, and Griffonia simplicifolia lectin II in the deep glands of the stomach, is caused by acute injury or inflammation. Although it is generally believed that the loss of parietal cells alone is a sufficient and direct cause of SPEM, further in-depth studies have revealed the critical role of *** is controversy regarding whether SPEM cells originate from the transdifferentiation of mature chief cells or professional progenitors. SPEM plays a functional role in the repair of gastric epithelial injury. However, chronic inflammation and immune responses caused by H. pylori infection can induce further progression of SPEM to IM, dysplasia, and adenocarcinoma. SPEM cells upregulate the expression of whey acidic protein 4-disulfide core domain protein 2 and CD44 variant 9, which recruit M2 macrophages to the wound. Studies have revealed that interleukin-33, the most significantly upregulated cytokine in macrophages, promotes SPEM toward more advanced metaplasia. Overall, more effort is needed to reveal the specific mechanism of SPEM malignant progression driven by *** infection.

关键词： Gastric cancers Helicobacter pylori Intestinal metaplasia Macrophages Spasmolytic polypeptide-expressing metaplasia

Magnetoresistance Behavior of La_((2-x))/3Bi_(x/3)Ca_(l/3)MnO_(3) (x = 0.4)

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Chinese Physics Letters 1997年第6期14卷 453-456页

作者： TANG Wei-hua liang Jing-kui liang Chang-lin SUN Ji-rong RAO Guang-hui Institute of Physics&Center for Condensed Matter Physics Chinese Academy of SciencesBeijing 100080 International Center for Materials Physics Chinese Academy of SciencesShenyang 110015 Department of Physics Beijing Normal UniversityBeijing 100875

The magnetoresistance(MR)behavior of La_((2-x)/3)Bi_(x/3)Ca_(l/3)MnO_(3)(x=0.4)compound was *** compound exhibits complex magnetic transitions,i.e.,paramagnetic-canted ferromagnetic-ferromagnetic-spin glass *** temperature dependence of resistivity of the compound indicates a semiconducting behavior,and no semiconductor-metal transition was associated with these magnetic *** magnetoresistance ratio exhibits a critical maximum corresponding to the canted ferromagnetic transition.A MR ratio as large as 86%was observed at 85 *** temperature dependence of MR ratio is well described by the relation of(ρo-ρH)/ρo=A(M/M_(s))^(2).

关键词： transition. resistance ferromagnetic

Characterization of somatic mutations of colorectal tumor in a patient with concurrent APC and MLH1 germline mutations

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Genes & Diseases 2023年第6期10卷 2245-2247页

作者： Yunsheng Cheng Yanyan Xu Xiaopeng Zhang jian Qi Jialiang Wang Yanzhe Liu Kun Wan YanWei Liu liang Yu Hongzhi Wang Jinfu Nie Bo Hong Yong Wang Department of General Surgery The Second Hospital of Anhui Medical UniversityHefeiAnhui 230601China Anhui Province Key Laboratory of Medical Physics and Technology Institute of Health and Medical TechnologyHefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhui 230031China University of Science and Technology of China HefeiAnhui 230026China School of Basic Medical Sciences Anhui Medical UniversityHefeiAnhui 230032China Casgenome Medicine(Hefei)Ltd HefeiAnhui 230031China Hefei Cancer Hospital Chinese Academy of SciencesHefeiAnhui 230031China

The two most common inherited forms of colorectal cancer(CRC)are familial adenomatous polyposis and hereditary nonpolyposis colorectal *** are caused by germline mutations in the APC and mismatch repair genes,respectively.1 The simultaneous inheritance of both an APC gene mutation and a mismatch repair gene mutation is very *** this study,we reported a coinheritance of mutations in the APC and MLH1 genes in a 20-year-old patient with CRC and multiple *** described for the first time the somatic mutational profile of a colorectal tumor harboring concurrent germline mutations in the APC and MLH1 genes.

关键词： MLH1 colorectal patient

Standardizing the classification of gastric cancer patients with limited and adequate number of retrieved lymph nodes:an externally validated approach using real-world data

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Military Medical Research 2022年第5期9卷 565-575页

作者： Wei Wang Yu-Jie Yang Ri-Hong Zhang Jing-Yu Deng Zhe Sun Sharvesh Raj Seeruttun Zhen-Ning Wang hui-Mian Xu Han liang Zhi-Wei Zhou Department of Gastric Surgery Sun Yat-sen University Cancer CenterGuangzhou 510060China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangzhou 510060China Department of Gastric Cancer Surgery Tianjin Medical University Cancer Institute and HospitalTianjin 300000China Department of Surgical Oncology the First Hospital of China Medical UniversityShenyang 110000China

Background:Currently,there is no formal consensus regarding a standard classification for gastric cancer(GC)patients with<16 retrieved lymph nodes(rLNs).Here,this study aimed to validate a practical lymph node(LN)staging strategy to homogenize the nodal classification of GC cohorts comprising of both<16(Limited set)and≥16(Adequate set)***:All patients in this study underwent R0 *** overall survival(OS)difference between the Limited and Adequate set from a large Chinese multicenter dataset was *** the 8th American Joint Committee on Cancer(AJCC)pathological nodal classification(pN)for GC as base,a modified nodal classification(N’)resembling similar analogy as the 8th AJCC pN classification was *** performance of the proposed and 8th AJCC GC subgroups was compared and validated using the Surveillance,Epidemiology,and End Results(SEER)dataset comprising of 10,208 multi-ethnic GC ***:Significant difference in OS between the Limited and Adequate set(corresponding N0–N3a)using the 8th AJCC system was observed but the OS of N0_(limited)vs.N1_(adequate),N1_(limited)vs.N2_(adequate),N2_(limited)vs.N3_(aadequate),and N3_(alimited)vs.N3_(badequate)subgroups was almost similar in the Chinese ***,we formulated an N’classification whereby only the nodal subgroups of the Limited set,except for pT1N0M0 cases as they underwent less extensive surgeries(D1 or D1+gastrectomy),were re-classified to one higher nodal subgroup,while those of the Adequate set remained unchanged(N’0=N0_(adequate)+pT1N0M0_(limited),N’1=N1_(adequate)+N0_(limited)(excluding pT1N0M0_(limited)),N’2=N2_(adequate)+N1_(limited),N’3a=N3_(aadequate)+N2_(limited),and N’3b=N3_(badequate)+N3_(alimited)).This N’classification demonstrated less heterogeneity in OS between the Limited and Adequate *** analyses demonstrated superior statistical performance of the pTN’M system over the 8th AJCC edition and was successfully validated using the SEER

关键词： Lymph nodes Limited Adequate Gastric cancer American Joint Committee on Cancer Tumor-node-metastasis Staging system Overall survival

TiO_2-ZrO_2的表征及其异丙醇催化转化性能

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物理化学学报 2006年第8期22卷 993-998页

作者：韩承辉刘炳华张惠良沈俭一南京大学化学化工学院

用共沉淀法制备了TiO2-ZrO2复合氧化物.采用N2吸附、XRD、TEM、NH3和CO2吸附量热、NH3吸附红外对TiO2-ZrO2体系的结构及酸碱性等进行了表征.结果表明:与单纯的氧化物相比,形成的复合氧化物为无定形物相,有介孔结构,表面积明显提高,可达2... 详细信息

用共沉淀法制备了TiO2-ZrO2复合氧化物.采用N2吸附、XRD、TEM、NH3和CO2吸附量热、NH3吸附红外对TiO2-ZrO2体系的结构及酸碱性等进行了表征.结果表明:与单纯的氧化物相比,形成的复合氧化物为无定形物相,有介孔结构,表面积明显提高,可达218m2·g-1;初始吸附热差别不大,但具有更多的表面B酸位;随着TiO2掺入量的增大,复合氧化物表面碱位减少.异丙醇催化转化,在无氧条件下,ZrO2、TiO2和TiO2-ZrO2复合氧化物上丙烯的选择性大于90%,说明这些氧化物具有强的表面酸性;在有氧条件下,ZrO2和TiO2丙酮的选择性达到70%～85%,主要体现为氧化还原性;而在复合氧化物上丙烯选择性增大到70%左右,丙酮的选择性下降为30%左右,表明生成的复合氧化物表面上的氧化还原性削弱,酸性增强.

关键词： TiO2-ZrO2 异丙醇催化表面酸碱性氧化还原性

基于GL0816传感器的高速线阵CMOS相机系统设计

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液晶与显示 2019年第1期34卷 24-32页

作者：张军亮戚涛李晖乔健凌云光技术集团有限责任公司相机开发部北京100094

为了满足印刷等高端工业检测中物体快速运动,需要大幅面、高行频、高分辨率图像采集等要求,研发了一款微米级高分辨率、高速线阵工业相机。首先,介绍了高行频、高分辨率国产CMOS图像传感器GL0816的功能与特点。然后,基于该芯片设计了一... 详细信息

为了满足印刷等高端工业检测中物体快速运动,需要大幅面、高行频、高分辨率图像采集等要求,研发了一款微米级高分辨率、高速线阵工业相机。首先,介绍了高行频、高分辨率国产CMOS图像传感器GL0816的功能与特点。然后,基于该芯片设计了一套高速大幅面高分辨率线阵工业相机系统,该系统采用FPGA作为整个系统的控制核心,以DDR3LSDRAM作为图像缓存器,以GigE vision2.0协议为输出标准,以SFP+作为高速图像输出接口。最后,搭建相机系统测试环境,对所设计的相机进行系统测试。结果表明:该相机系统行分辨率为8 192,可连续采集2 000行作为一帧图像输出,行频为50kHz,动态范围为57.32dB,信噪比为40.95dB,具有实时图像采集功能。该相机系统具有大幅面、高帧频、高分辨率、高信噪比、宽动态范围等优点,适用于印刷检测行业快速运动目标捕获成像及图像实时显示。

关键词： CMOS图像传感器高分辨率线阵 FPGA GigE vision2.0

Numerical method and model for calculating thermal storage time for an annular tube with phase change material

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Journal of Central South University 2017年第1期24卷 217-226页

作者：刘泛函徐建新王辉涛王华 State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Kunming University of Science and TechnologyKunming 650093China Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650093China Quality Development Institure Kunming University of Science and TechnologyKunming 650093China

For calculating the thermal storage time for an annular tube with phase change material （PCM）, a novel method is proposed. The method is suitable for either low-temperature PCM or high-temperature PCM whose initial temperature is near the melting point. The deviation fit is smaller than 8% when the time is below 2x104 s. Comparison between the predictions and the reported experimental data of thermal storage time at same conditions is investigated and good agreements have been got. Based on this method, the performance of the thermal storage unit and the role of natural convection are also investigated. Results show a linear relation between the maximum amount of stored heat and thermal storage time, and their ratio increases with the height of the thermal storage unit. As the thickness of the cavity increases, natural convection plays an increasingly important role in promoting the melting behavior of paraffin. When the thickness of the cavity is small, natural convection restrains the melting behavior of paraffin.

关键词： natural convection energy storage modeling heat transfer mass transfer

Microstructures and phase transformation in directionally solidified TiAl-Nb alloys

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China Foundry 2020年第6期17卷 402-408页

作者： Fu-qiang Zhang Xian-fei Ding Hai Nan Ru-yue You Qiang Wang jian-ping He Yan-qing Su Yong-feng liang Jun-pin Lin State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Cast Titanium Alloy R&D Center Beijing Institute of Aeronautical MaterialsBeijing 100095China AECC Hunan Aviation Powerplant Research Institute Harbin 150001China National Key Laboratory for Precision Hot Processing of Metals Harbin Institute of TechnologyZhuzhou 412002China

Intermetallic Ti-45Al-8Nb-(W,B,Y)(at.%)and Ti-46Al-5Nb alloys are directionally solidified at a constant growth rate of 30μm·s-1 using a Bridgman type *** quenched microstructures and lengths of different phase regions were observed and measured after various growing times of 0-30 *** show that the phase transformations in different phase regions are mainly depending on the high temperature microstructure and the supercooling degree during quenching *** isothermal holding,the primary phase grows into the liquid phase,the dendrites change from equiaxed to columnar grains,and the length of the L+βphase region,L+β+αphase region and mushy zone varies,indicating that the entire directional solidification process can be described by a static equilibrium-nonequilibrium-dynamic equilibrium evolution *** addition,the gap between the original growth interface and front interface shows that the actual crystal growth rate is not equal to the drawing velocity during directional solidification.

关键词： TiAl alloys directional solidification quenched microstructure phase transformation