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Microsystems & Nanoengineering 2024年第2期10卷 91-99页

作者： Zhixian zhu hui Ren Dan Wu Zhonghua Ni Nan Xiang School of Mechanical Engineering and Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical InstrumentsSoutheast University211189NanjingChina School of Mechanical Technology Wuxi Institute of TechnologyNo.1600 Gaolang West Road214129WuxiChina Department of Oncology Jiangyin People’s Hospital214400JiangyinChina

Tumor cell clusters are regarded as critical factors in cancer pathophysiology,and increasing evidence of their higher treatment resistance and metastasis compared to single tumor cells has been ***,existing cell separation methods that are designed for single tumor cells cannot be used to simultaneously purify tumor cell *** address this problem,we demonstrated a microfluidic approach for the high-throughput,continuous-flow ternary separation of single tumor cells,tumor cell clusters,and WBCs from clinical pleural or abdominal effusions by coupling slanted spiral channels and periodic contraction-expansion *** first systematically explored the influence of particle size and flow rate on particle *** separation performance indicated that 94.0%of WBCs were removed and more than 97%of MDA-MB-231 tumor cells were recovered at a high flow rate of 3500µL/***,more than 90%of tumor cell clusters were effectively preserved after ***,we successfully applied our device for the ternary separation of single tumor cells,tumor cell clusters,and WBCs from different malignant effusions collected from patients with metastatic ***,our spiral-contraction-expansion device has potential as a sample pretreatment tool for the cytological diagnosis of malignant effusions.

关键词： separation contraction removed

Molecular Chain Flexibility and Dielectric Loss at High-Frequency:Impact of Ester Bond Arrangement in Poly(ester imide)s

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Chinese Journal of Polymer Science 2024年第8期42卷 1122-1133页

作者： Ya-dong Li Hong Li Lu-Kun Feng Feng Bao Ming-Liang Wang Cai-Zhen zhu Zhao-hui Zheng Xiao-Bin Ding Jian Xu Chengdu Institute of Organic Chemistry Chinese Academy of SciencesChengdu 610041China University of Chinese Academy of Sciences Beijing 100081China Institute of Low-Dimensional Materials Genome Initiative College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060China

The evolution of high-frequency communication has accentuated the significance of controlling dielectric properties in polymer ***,it has been theorized that rigid molecular chains lead to lower dielectric ***,the validity of this proposition at high frequencies remains *** scrutinize the correlation between chain flexibility and dielectric properties,we synthesized six poly(ester imide)s(PEIs)with systematically varied molecular chain flexibilities by modifying the ester's substitution on the aromatic *** introduction of ester bonds bestowed all PEI films with a low dielectric dissipation factor(D_(f)),ranging from 0.0021 to 0.0038 at 10 GHz in dry *** dry D_(f)displayed a pattern consistent with volume polarizability(P/V).Unexpectedly,PI-mmm-T,featu ring the most flexible molecular chain,exhibited the lowest dielectric loss under both dry(0.0021@10 GHz)and hygroscopic(0.0029@10 GHz)***,the observed increase in D_(f)after humidity absorption suggests that the high dielectric loss of PEI in applications may be attributed to its hygroscopic *** simulations and characterization of the aggregation structure revealed that the smaller cavities within flexible molecular chains,after close stacking,impede the entry of water *** sacrificing high-temperature resistance,the precursor exhibited enhanced solubility properties and could be processed into high-quality *** research unveils new insights into the relationship between flexibility and highfrequency dielectric loss,offering innovative perspectives on synthesizing aromatic polymers with exceptional dielectric properties.

关键词： 5G communications Poly(ester imide)s Molecular chain flexibility Dielectric properties Humidity absorption

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Comparison efficacy and safety of total laparoscopic gastrectomy and laparoscopically assisted total gastrectomy in treatment of gastric cancer

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1871-1882页

作者： Long Li dong-Yuan Liu Jing Leng Xue-Mei Tao hui-Qin Wu Yan-Peng zhu Department of General Surgery The 971^(st)Hospital of Chinese People's Liberation ArmyQingdao 266071Shandong ProvinceChina Department of Surgery Qingdao Municipal HospitalQingdao 266071Shandong ProvinceChina Hyperbaric Oxygen Department The Eighth Peoples Hospital of QingdaoQingdao 266121Shandong ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Naval Medical UniversityShanghai 200433China

BACKGROUND The development of laparoscopic technology has provided a new choice for surgery of gastric cancer(GC),but the advantages and disadvantages of laparoscopic total gastrectomy(LTG)and laparoscopic-assisted total gastrectomy(LATG)in treatment effect and safety are still *** purpose of this study is to compare the efficacy and safety of the two methods in the treatment of GC,and to provide a basis for clinical *** To compare the efficacy of totally LTG(TLTG)and LATG in the context of radical gastrectomy for ***,we investigated the safety and feasibility of the total laparoscopic esophagojejunostomy *** Literature on comparative studies of the above two surgical methods for GC(TLTG group and LATG group)published before September 2022 were searched in the PubMed,Web of Science,Wanfang Database,CNKI,and other Chinese and English *** addition,the following search keywords were used:Gastric cancer,total gastrectomy,total laparoscopy,laparoscopy-assisted,esophagojejunal anastomosis,gastric/stomach cancer,total gastrectomy,totally/completely laparoscopic,laparoscopic assisted/laparoscopy assisted/laparoscopically assisted,and esophagojejunostomy/esophagojejunal *** Manager 5.3 software was used for the meta-analysis after two researchers independently screened the literature,extracted the data,and evaluated the risk of bias in the included *** After layer-by-layer screening,258 pieces of literature were recovered,and 11 of those pieces were eventually *** resulted in a sample size of 2421 instances,with 1115 cases falling into the TLTG group and 1306 cases into the LATG *** or sex differences between the two groups were not statistically significant,according to the meta-analysis,however the average body mass index of the TLTG group was considerably higher than that of the LATG group(P=0.01).Compared with those in the LATG group,the incision length in the TLTG

关键词： Total laparoscopic gastrectomy Laparoscopically assisted total gastrectomy Gastric cancer Meta-analysis

Adverse Effects of Opioid Analgesics in Osteoarthritis Treatment:A Global Meta-Analysis,2000-2022

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China CDC weekly 2024年第25期6卷 589-596,I0001-I0012页

作者： Heng Jiang Xing Xing He zhu Tuo dong School of Public Health Harbin Medical UniversityHarbin CityHeilongjiang ProvinceChina School of Public Health Peking UniversityBeijingChina

Osteoarthritis(OA)treatment commonly depends on nonsteroidal anti-inflammatory drugs and opioid ***,the clinical use of opioids is controversial due to their adverse effects and addiction *** study,drawing on 24 randomized controlled trials(RCTs)with a total of 9,586 patients,thoroughly explored the various side effects associated with opioid use in OA *** results provide additional insight into the non-addictive risks of opioids and may assist clinicians in their judicious use,potentially fostering the advancement of safer treatment *** reducing the risks of misuse and addiction,public health and safety can be enhanced.

关键词： potential thoroughly insight

Topological non-reciprocal robust waveguide transport

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 39-45页

作者： Ruizhi dong Yihuan zhu dongxing Mao Xu Wang Yong Li Institute of Acoustics Tongji UniversityShanghai 200092China

Devices that surpass the restriction of reciprocity of classical physical waves have brought intriguing possibilities for wave ***-reciprocal acoustic devices that rely on the viscosity of the medium or nonlinear effect have low efficiency and distortion problems respectively,and poor immunity to *** appearance of acoustic topological insulators achieves nonreciprocal transport with high ***,the local nature of topological states means that their appearance depends on a system with a larger *** is,most of the area of a topological device is occupied by useless lattices that do not directly contribute to non-reciprocal *** extra cost of topology protection severely limits the application scenarios of topology states,decreases the cost-effectiveness of topology devices,and is not conducive to device miniaturization and *** this work,we construct an acoustic three-layer heterojunction by introducing two types of domain walls into a conventional quantum Hall effect acoustic topological insulator,and successfully construct a non-reciprocal scattering network that forms topological modes spanning the interlayer *** extended states are still protected by bulk-band topology,making their non-reciprocity robust against *** structure flawlessly realizes the path broadening in a two-dimensional topological system and can accomplish functions such as non-reciprocal acoustic splitting and multichannel *** work opens up opportunities for developing topological-insulator-based non-reciprocal devices in acoustics.

关键词： reciprocal topological topology

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Predicting the evolution of electrochemical trepanning for inner blisks with a chamfer structure at blade tip

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Chinese Journal of Aeronautics 2024年第9期37卷 560-576页

作者： Erhao JIAO dong zhu Penghui WANG Hang ZUO Liyong CHEN College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Electrochemical trepanning(ECTr)is an effective electrochemical machining(ECM)technique that can be used to manufacture the integral components of aero-engine *** study focused on the dynamic evolution of ECTr for production of inner blisks(bladed disks)with a special chamfer structure at blade *** to the existence of chamfer,the ECTr process of inner blades is in a non-equilibrium state during the early stages,and the physical field changes in the machining gap are complex,making it difficult to predict the forming *** this paper,a dynamic evolution model(DEM)of inner blade ECTr with a special chamfer at blade tip structure is proposed,and an ECTr multi-physical fields simulation study was carried *** evolution of the chamfer at blade tip was analyzed and data related to chamfer were predicted based on the dependence of anode boundary properties with machining time and feed *** addition,the dis-tributions of current density,electrolyte flow rate,bubble volume fraction,temperature rise,and electrolyte conductivity in the machining area at different times were obtained by combining them with the multi-physical fields simulation ***,a series of ECTr experiments were conducted,in which,as the feed rate increased,the surface quality and machining accuracy of the inner blades were *** with the simulation results,the error in machining accu-racy of the chamfer profile is controlled within±2%,and the machining accuracy of the blade full profile was controlled within±0.2 mm,indicating that the model proposed in this study was effec-tive in predicting the evolution of inner blades ECTr with chamfer structures at blade tip.

关键词： Chamfer structure Inner blisk Electrochemical trepanning(ECTr) Dynamic evolution model Forming prediction Multiphysics Machining quality

Field-based evidence for the enrichment of intrinsic antibiotic resistome stimulated by plant-derived fertilizer in agricultural soil

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Journal of Environmental Sciences 2024年第1期135卷 728-740页

作者： Shihai Liu Ziming Han dong zhu Xiao Luan Liujie Deng Liping dong Min Yang Yu Zhang State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Environmental Protection Engineering Center for Harmless Treatment and Resource Utilization of Antibiotic Residues Khorgos 835007China University of Chinese Academy of Sciences Beijing 100049China

Animal manures have been demonstrated to enhance antibiotic resistance in agricultural ***,little is known about the effects of plant-derived fertilizer on soil antibiotic ***,metagenomic sequencing was used to investigate the effects of a plantderived fertilizer processed from sugarcane and beet on soil antibiotic resistance genes(ARGs)in a soybean field along crop growth *** profiles in the soils amended by plant-derived fertilizer were compared with those in the soils amended by chicken *** abundance and diversity of total ARGs in the soils amended by plant-derived fertilizer were significantly(P<0.05)elevated at the sprout stage,to a level comparable to that in the manured ***,unlike chicken manure mainly introducing manure-borne ARGs to soil,the plant-derived fertilizer was indicated to mainly enrich multidrug resistance genes in soil by nourishing indigenous *** with abundances in amended soils significantly(P<0.05)higher than in unamended soils at the sprout stage of soybean were considered as enriched *** in the abundance of the enriched ARGs was observed in both the amended soils from the sprout to the *** analysis further identified Proteobacteria and Bacteroidetes as the primary bacterial taxa involved in the temporal variation of the enriched ARGs in the soils amended by plant-derived fertilizer,while in manured soils were Firmicutes and *** revealed by multivariate statistical analyses,variation of the enriched ARGs in the soils amended by plant-derived fertilizer was majorly attributed to the response of co-occurred bacteria to depleting nutrients,which was different from the failed establishment of manure-borne bacteria in the manured *** study provided field-based evidence that plant-derived fertilizer stimulated the intrinsic antibiotic resistome,and proposed attention to the un-perceived risk since some clinically relevant ARGs originate and evolve fr

关键词： Organic fertilizer Intrinsic antibiotic resistance Indigenous bacteria Metagenomic sequencing

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Transient synthesis of carbon-supported high-entropy alloy sulfide nanoparticles via flash Joule heating for efficient electrocatalytic hydrogen evolution

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Nano Research 2024年第4期17卷 3379-3389页

作者： Yuntian Liao Rongtao zhu Wenjun Zhang Haiyang zhu Yang Sun Jiale Chen Zhenhua dong Ronghuan Lv School of Chemical Engineering and Technology China University of Mining and TechnologyXuzhou 221116China

High entropy alloys(HEA)are frequently employed as catalysts in electrocatalytic hydrogen ***,the traditional high entropy alloy synthesis methods are time-consuming,energy-intensive,and environmentally polluting,which limits their application in the hydrogen evolution reaction(HER).This study leveraged the capabilities of flash Joule heating(FJH)to synthesize carbon-supported high-entropy alloy sulfide nanoparticles(CC-S-HEA)on carbon cloth(CC)with good self-standing properties within 300 *** carbon thermal shock generated by the Joule heating could pyrolyze the sulfur source into gas,resulting in numerous pore structures and defects on CC,forming an S-doped carbon substrate(CC-S).Then the S atoms were used to stably anchor the metal atoms on CC-S to form high-density uniformly dispersed HEA *** electrochemical test results demonstrated that CC-S-HEA prepared at 60 V flash voltage had HER performance comparable to Pt/*** density functional theory(DFT)calculation indicated that the S atoms on CC-S accelerated the electron transfer between the carbon substrate and HEA ***,the unique electronic structure of CC-S-HEA was beneficial to H*adsorption and promoted catalytic *** simplicity and versatility of FJH synthesis are of great significance for optimizing the synthesis of HEA and improving the quality of HEA products,which provides a broad application prospect for the synthesis of nanocatalysts with efficient HER performance.

关键词： high entropy alloy flash Joule heating carbon thermal shock hydrogen evolution reaction density functional theory

PCA-Net: a heart segmentation model based on the meta-learning method

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Optoelectronics Letters 2024年第11期20卷 697-704页

作者： YANG Mengzhu zhu dong dong Hao HU Shunbo WANG Yongfang School of Information Science and Engineering Linyi University

In order to effectively prevent and treat heart-based diseases, the study of precise segmentation of heart parts is particularly important. The heart is divided into four parts: the left and right ventricles and the left and right atria, and the left main trunk is more important, thus the left ventricular muscle(LV-MYO), which is located in the middle part of the heart, has become the object of many researches.

关键词： A

Proactive Caching at the Wireless Edge:A Novel Predictive User Popularity-Aware Approach

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1997-2017页

作者： Yunye Wan Peng Chen Yunni Xia Yong Ma dongge zhu Xu Wang hui Liu Weiling Li Xianhua Niu Lei Xu Yumin dong College of Computer Science Chongqing UniversityChongqing400044China School of Computer and Software Engineering Xihua UniversityChengdu610039China School of Computer and Information Engineering Jiangxi Normal UniversityNanchang330022China Electric Power Research Institute of State Grid Ningxia Electric Power Co. Ltd.Yinchuan750002China College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing400030China School of Computer Science and Technology Beijing Institute of TechnologyBeijing100083China School of Computer Science and Technology Dongguan University of TechnologyDongguan523808China School of Emergency Management Xihua UniversityChengdu610039China College of Computer and Information Science Chongqing Normal UniversityChongqing401331China

Mobile Edge Computing(MEC)is a promising technology that provides on-demand computing and efficient storage services as close to end users as *** an MEC environment,servers are deployed closer to mobile terminals to exploit storage infrastructure,improve content delivery efficiency,and enhance user ***,due to the limited capacity of edge servers,it remains a significant challenge to meet the changing,time-varying,and customized needs for highly diversified content of ***,techniques for caching content at the edge are becoming popular for addressing the above *** is capable of filling the communication gap between the users and content providers while relieving pressure on remote cloud ***,existing static caching strategies are still inefficient in handling the dynamics of the time-varying popularity of content and meeting users’demands for highly diversified entity *** address this challenge,we introduce a novel method for content caching over MEC,i.e.,*** synthesizes a content popularity prediction model,which takes users’stay time and their request traces as inputs,and a deep reinforcement learning model for yielding dynamic caching *** results demonstrate that PRIME,when tested upon the MovieLens 1M dataset for user request patterns and the Shanghai Telecom dataset for user mobility,outperforms its peers in terms of cache hit rates,transmission latency,and system cost.

关键词： Mobile edge computing content caching system average cost deep reinforcement learning collaborative mechanism