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Investigation of the infection route of HIV-associated cytomegalovirus retinitis

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International Journal of Ophthalmology(English edition) 2025年第3期18卷 478-486页

作者： Jie Cai Zi-Kang Xie Dong-Yong Tang hui-yi Zuo Hao Liang Department of Ophthalmology the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

AIM:To investigate the etiology of ocular pathogens and to establish the various pathogens present in human immunodeficiency virus(HIV)patients with cytomegalovirus retinitis(CMVR).METHODS:A total of 17 HIV-infected patients with concomitant eye disorders were *** were divided into CMVR group(10 patients,18 eyes)and non-CMVR group(7 patients,9 eyes)based on clinical manifestations and the presence of cytomegalovirus(CMV)-DNA in ocular *** viral load of CMV was assessed using polymerase chain reaction in aqueous humor,vitreous fluid,and peripheral blood samples of patients in the CMVR ***,peripheral blood CD4+T cell counts were measured in both ***:In the CMVR group,the CMV-DNA load in the vitreous and aqueous humor samples was substantially higher than in the peripheral blood samples(P<0.01).CMVDNA load in the aqueous humor and vitreous samples of the two eyes in the CMVR group was determined to be statistically significant(10 patients,16 eyes,P=0.018,0.012).Peripheral blood CD4+T cell counts in the CMVR group were adversely linked with the CMV-DNA load in both the aqueous humor and peripheral blood(P=0.005,0.048).Compared with the non-CMVR group,the peripheral blood CD4+T cell count in the CMVR group decreased significantly(P=0.014).The peripheral blood CD4+T cell count exceeded 300 cells/μL in 85.71%of non-CMVR patients,whereas it was below 100 cells/μL in 90.00%of the CMVR *** intraocular specimens of the patients who underwent CMVR testing did not include any additional ***:In HIV-associated CMVR patients,there may exist alternative,yet unidentified,infection pathways for intraocular CMV in addition to the conventional *** substantial difference in CMV-DNA load between the eyes of most CMVR patients suggests that CMV may originate from different sources in each *** proportion of peripheral blood CD4+T cells in HIV patients is negatively correlated with the quantity of CMV viruses

关键词： cytomegalovirus retinitis acquired immunodeficiency syndrome human immunodeficiency virus

中国主流新闻媒体走向系统性变革的道路及挑战

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编辑之友 2025年第1期 5-10页

作者：蔡雯汪惠怡中国人民大学新闻与社会发展研究中心北京100872 中国人民大学新闻学院北京100872

文章基于系统论的理论视角,在主流媒体、中国新闻业、中国式现代化社会这三个由微观到宏观的层面,从行动主体、以资源配置为纲的行动策略两个方面,分析主流媒体系统性变革的经验与对策。中国主流新闻媒体在通过优化内部资源的配置而走... 详细信息

文章基于系统论的理论视角,在主流媒体、中国新闻业、中国式现代化社会这三个由微观到宏观的层面,从行动主体、以资源配置为纲的行动策略两个方面,分析主流媒体系统性变革的经验与对策。中国主流新闻媒体在通过优化内部资源的配置而走向繁荣、突破行业边界实现资源整合的基础上,进一步推进系统性变革,在微观层面应处理好新闻舆论“四力”之间的关系,中观层面应处理好四级媒体之间的关系、行政扶持与市场竞争力之间的关系,宏观层面应处理好党和政府对媒体的治理和媒体参与国家治理之间的关系。

关键词：主流新闻媒体系统性变革资源配置

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基于循环一致对抗学习的段码液晶仪表读数识别方法

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武汉科技大学学报 2025年第1期48卷 59-69页

作者：惠毅徐望明叶胜武汉科技大学信息科学与工程学院湖北武汉430081 武汉科技大学冶金自动化与检测技术教育部工程研究中心湖北武汉430081

为解决自然场景中仪表图像受复杂光照、背景及其他随机干扰所造成的读数识别难题,提出一种基于循环一致对抗学习的段码液晶仪表读数识别方法。该方法使用M-CRAFT作为字符检测网络,获取段码读数区域和段码字符位置,通过后处理算法分割得... 详细信息

为解决自然场景中仪表图像受复杂光照、背景及其他随机干扰所造成的读数识别难题,提出一种基于循环一致对抗学习的段码液晶仪表读数识别方法。该方法使用M-CRAFT作为字符检测网络,获取段码读数区域和段码字符位置,通过后处理算法分割得到段码字符子图像,然后以循环一致对抗域自适应网络CYCADA为基础,增加感知损失和重构损失并设计分类器,构建了一种改进的字符背景分离与识别网络I-CYCADA,用于将具有复杂背景的段码字符图像转换为清晰直观的二值图像,从而使读数识别变得更为简单和准确。为了验证该方法的有效性,构建了由多种复杂场景下的液晶段码仪表图像组成的数据集。实验结果表明,I-CYCADA可与不同CNN分类网络结合使用,均能提升转换后的段码字符图像的识别准确率,本文方法在自建数据集上的字符级识别准确率达95.39%,完整读数识别准确率达86.65%,有效改善了对困难样本的识别效果,且轻量级设计可满足实时性要求。

关键词：液晶仪表读数识别对抗学习域自适应感知损失重构损失

长循环双靶向重组蛋白药物偶联体用于抗肿瘤治疗

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高分子学报 2025年第2期56卷 266-277页

作者：袁洋蒋惠忆陈伟芝蒋锡群南京大学化学化工学院、高性能高分子材料与技术教育部重点实验室南京210023

药物的靶向性以及体内长效循环特性对于药物在病灶部位的累积和疗效发挥着至关重要的作用.本研究设计合成了长循环双靶向重组蛋白药物偶联体RPDC-L(long-circulated dualtargeted recombinant protein drug conjugate),用于抗肿瘤治疗.R... 详细信息

药物的靶向性以及体内长效循环特性对于药物在病灶部位的累积和疗效发挥着至关重要的作用.本研究设计合成了长循环双靶向重组蛋白药物偶联体RPDC-L(long-circulated dualtargeted recombinant protein drug conjugate),用于抗肿瘤治疗.RPDC-L包含4个部分,分别是靶向人表皮生长因子受体2(HER2)的anti-HER2纳米抗体、整合素受体αvβ_(3)的多肽配体RGD、白蛋白结合域以及小分子化疗药物阿霉素.其中,anti-HER2纳米抗体和RGD多肽提供肿瘤靶向功能;白蛋白结合域通过结合血液中的白蛋白,赋予药物较长的体内循环时间;化疗药物阿霉素通过酸响应聚乙二醇-腙键连接子与重组蛋白偶联,在微酸性的肿瘤微环境中通过pH响应性释放,进行肿瘤杀伤.与非长循环双靶向重组蛋白相比,融合表达白蛋白结合单元后,长循环双靶向重组蛋白在小鼠体内的半衰期时间提升到了1.51倍.与抗肿瘤药物阿霉素偶联后,药物在肿瘤组织中的累积提升到了1.6倍.体内抗肿瘤试验表明,RPDC-L实现安全高效的抗肿瘤效果,肿瘤抑制率达到78.4%,是非长循环双靶向重组蛋白药物偶联体的1.50倍.

关键词：药物递送大分子药物双靶向重组蛋白药物偶联体长循环

Vibration attenuation performance of wind turbine tower using a prestressed tuned mass damper under seismic excitation

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 511-524页

作者： Lei Zhenbo Liu Gang Wang hui hui yi School of Civil Engineering Chongqing UniversityChongqing 400045China Key Laboratory of New Technology for Construction of Cities in Mountain Area Chongqing UniversityMinistry of EducationChongqing 400045China

With the rapid development of large megawatt wind turbines,the operation environment of wind turbine towers(WTTs)has become increasingly *** particular,seismic excitation can create a resonance response and cause excessive vibration of the *** investigate the vibration attenuation performance of the WTT under seismic excitations,a novel passive vibration control device,called a prestressed tuned mass damper(PS-TMD),is presented in this ***,a mathematical model is established based on structural dynamics under seismic ***,the mathematical analytical expression of the dynamic coefficient is deduced,and the parameter design method is obtained by system tuning ***,based on a theoretical analysis and parameter design,the numerical results showed that the PS-TMD was able to effectively mitigate the resonance under the harmonic basal ***,the time-history analysis method is used to verify the effectiveness of the traditional pendulum tuned mass damper(PTMD)and the novel PS-TMD device,and the results indicate that the vibration attenuation performance of the PS-TMD is better than the *** addition,the PS-TMD avoids the nonlinear effect due to the large oscillation angle,and has the potential to dissipate hysteretic energy under seismic excitation.

关键词： wind turbine tower prestressed tuned mass damper vibration control seismic excitation numerical simulation

Anomalous Optical and Electronic Properties of CaTiO3 Perovskites

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Communications in Theoretical Physics 2007年第3X期48卷 563-570页

作者： LIU hui-Ping DUAN yi-Feng yi Lin Department of Physics and State Key Laboratory of Laser Technology Huazhong University of Science and TechnologyWuhan 430074 China

With the help of the first-prlnciples full potential linearized augmented plane wave method, absorption coefficients, reflect/vity, dielectric behavior and electronic properties, including electronic energy bands, density of states and charge density distributions, are studied for the tetragonal and cubic CaTiO3. By considering the thermal expansion effects, an approximate method is proposed for the study of the stability of ground state and a tendency of phase transition, based on the minimum free energy principle. Subsequently, numerical calculations are carried out by using the first-principles perturbation method. We demonstrate that the high-temperature phase is cubic. It is shown that optical spectra in tetragonal phase exhibit single-peak feature and differ from multi-peak character in cubic. We find that strong orbital hybridization results in the co-valent bonds between Ti 3d and O 2p electrons and forms two-type dipoles （Ti-Ol and Ti-02） in tetragonal, while the Ti-O dipoles are identical in cubic. It is argued that crystal structure determines the dipole distributions and leads to some electron states among which the dipole-dipole transit/on forbidden is a key, causing such anomalous optical phenomena with the insulator characteristics. The predicted charge density distribution and the tendency of phase transition from tetragonal to cubic are in good agreement with experimental observations.

关键词： first-principles calculations CaTiO3 perovskites optical and electronic properties

STOCHASTIC COMPARISONS IN A PRICE-QUANTITY SETTING FIRM WITH UNCERTAIN DEMAND AND EMERGENCY PROCUREMENT

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Journal of Systems Science and Systems Engineering 2013年第4期22卷 401-420页

作者： Minghui XU Xiaolin XU yi-hui ZHOU School of Economics and Management Wuhan University School of Business Nanjing University Department of Biostatistics University of North Carolina

We consider a newsvendor problem with price-dependent demand, in either additive or multiplicative format. The newsvendor has two modes of purchasing： regular ordering at the beginning of the selling season and emergency ordering （if the realized demand exceeds the initial order quantity） at the end of the selling season. By stochastic comparisons, we systematically investigate the effects of demand magnitude and demand randomness on pricing and ordering quantity decisions as well as expected profit of the newsvendor, under both usual stochastic order （first order stochastic dominance） and convex order （less variable）. Our key findings include：（i） in contrary to the case where price is exogenous, a stochastically larger demand shock may even lead to a lower order quantity; （ii） a stochastically larger demand shock leads to a higher price for the additive demand case, but may lead to a lower price for the multiplicative demand case; （iii） a stochastically larger demand shock leads to a higher expected profit for both demand models; （iv） in general, a less variable demand leads to a higher expected profit for both demand models; and furthermore, a less variable demand shock has no effect on price for the additive demand model, but leads to a higher price for the multiplicative demand model. The implications of all these findings for pricing and order quantity are discussed in detail.

关键词： Price-dependent newsvendor stochastic comparison demand uncertainty pricing emergency supply option

Palladium-catalyzed 3,4-hydroaminocarbonylation of conjugated dienes for formation ofβ,γ-unsaturated amides

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Science China Chemistry 2023年第5期66卷 1474-1481页

作者： hui-yi Yang Liang-Quan Lin Na-Qi Li Zhi-hui Ren Zheng-hui Guan Key Laboratory of Synthetic and Nature Molecule of Ministry of Education Department of Chemistry&Materials ScienceNorthwest UniversityXi’an 710127China

Hydrocarbonylation of conjugated dienes is one of the most promising yet challenging methods for the synthesis of carbonyl ***,we reported the development of an unprecedented palladium-catalyzed branched selective 3,4-hydroaminocarbonylation of 1,3-dienes with CO and amines hydrochloride to affordβ,γ-unsaturated *** reaction employs readily available starting materials(including anilines,amines,amino acids,peptides,aryl-1,3-dienes,alyl-1,3-dienes)and tolerates a wide range of functional groups,thus providing a facile and effective approach to access a diverse array ofα-substitutedβ,γ-unsaturated *** investigations suggested that the hydropalladation of dienes is irreversible,and the insertion of CO into the allyl-Pd species is probably the rate-limiting step.

关键词： palladium-catalyzed carbonylation reaction regioselectivity conjugated diene amides synthesis

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新质生产力引领现代海洋城市高质量发展研究

北方论丛 2025年第1期 119-128页

作者：王举颖苏慧怡中国海洋大学管理学院青岛266100

新质生产力是推动现代海洋城市高质量发展的关键动力。本研究聚焦于新质生产力对现代海洋城市高质量发展的推动作用,通过扎根理论方法明确了创新驱动发展、产业转型升级、深化改革创新、区域协同发展和绿色生态发展五大核心要素及其相... 详细信息

新质生产力是推动现代海洋城市高质量发展的关键动力。本研究聚焦于新质生产力对现代海洋城市高质量发展的推动作用,通过扎根理论方法明确了创新驱动发展、产业转型升级、深化改革创新、区域协同发展和绿色生态发展五大核心要素及其相互作用,深入分析了新质生产力通过高科技赋能、高水平支撑和高效能变革三大特征,有效促进了海洋城市的动能转换和形态升级,构建了新质生产力引领海洋城市高质量发展的理论模型,提出了数智化赋能海洋科技创新驱动发展、海洋产业转型升级与协同体系构建等五大策略建议,为相关政策制定与实践提供了科学依据。

关键词：新质生产力现代海洋城市高质量发展扎根理论