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Visible Light-Induced Collapse of Molecular Microcrystals into Droplets by E-to-Z Photoisomerization and Melting Phase Transition

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CCS Chemistry 2024年第4期6卷 1071-1084页

作者： Tian-Yi Xu Min Cui Chengxi Zhao Shang-Wu Zhou Tian-Le Zhang hui-Yao lin Fei Tong Da-hui Qu Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237

Harnessing photoresponsive behavior in organic crystals,such as shape and morphology deformation,on multiple scales is intriguing with respect to precise spatiotemporal operation,because dynamic deformations are promising in fabricating future intelligent ***,we synthesized a new photoresponsive molecular crystal composed of dimethyl(E)-2-(3-(naphthalen-1-yl)allylidene)malonate((E)-DNAM)that undergoes E-to-Z photoisomerization accompanied by photoinduced crystal-to-liquid melting phase transition when exposed to visible *** of expanding in bulk polycrystals,single-crystal(E)-DNAM rectangular microplates in an aqueous solution rapidly collapsed into liquid droplets,showing a remarkable drastic reduction in surface area of more than 97%after light *** deduce that the unique microscopic morphology of microplates with high aspect ratios of length-tothickness reaching up to 1000 is mainly responsible for the photoinduced melting leading to drastic *** addition,the cohesive forces of liquid photoproduct facilitate the overall deformations and *** have shown a facile way to achieve the remarkable collapse of molecular crystals into droplets by photochemical reaction and phase transition.

关键词： molecular crystals crystal-to-liquid transition extreme deformations photochemistry crystal engineering flexible crystals

Nomogram prediction of vessels encapsulating tumor clusters in small hepatocellular carcinoma≤3 cm based on enhanced magnetic resonance imaging

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1808-1820页

作者： hui-lin Chen Rui-lin He Meng-Ting Gu Xing-Yu Zhao Kai-Rong Song Wen-Jie Zou Ning-Yang Jia Wan-Min Liu School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Radiology The Third Affiliated Hospital of Shanghai Naval Military Medical UniversityShanghai 200438China Department of Radiology Tongji University Affiliated Tongji HospitalShanghai 200065China

BACKGROUND Vessels encapsulating tumor clusters(VETC)represent a recently discovered vascular pattern associated with novel metastasis mechanisms in hepatocellular carcinoma(HCC).However,it seems that no one have focused on predicting VETC status in small HCC(sHCC).This study aimed to develop a new nomogram for predicting VETC positivity using preoperative clinical data and image features in sHCC(≤3 cm)*** To construct a nomogram that combines preoperative clinical parameters and image features to predict patterns of VETC and evaluate the prognosis of sHCC *** A total of 309 patients with sHCC,who underwent segmental resection and had their VETC status confirmed,were included in the *** patients were recruited from three different hospitals:Hospital 1 contributed 177 patients for the training set,Hospital 2 provided 78 patients for the test set,and Hospital 3 provided 54 patients for the validation *** predictors of VETC were identified through univariate and multivariate logistic *** independent predictors were then used to construct a VETC prediction model for *** model’s performance was evaluated using the area under the curve(AUC),calibration curve,and clinical decision ***,Kaplan-Meier survival analysis was performed to confirm whether the predicted VETC status by the model is associated with early recurrence,just as it is with the actual VETC status and early *** Alpha-fetoprotein_lg10,carbohydrate antigen 199,irregular shape,non-smooth margin,and arterial peritumoral enhancement were identified as independent predictors of *** model incorporating these predictors demonstrated strong predictive *** AUC was 0.811 for the training set,0.800 for the test set,and 0.791 for the validation *** calibration curve indicated that the predicted probability was consistent with the actual VETC status in all three ***,the decision curve analysis demonstr

关键词： Small hepatocellular carcinoma Vessels encapsulating tumor clusters Nomogram Magnetic resonance imaging Multicenter

Advancements of Macrophages Involvement in Pathological Progression of Colitis-Associated Colorectal Cancer and Associated Pharmacological Interventions

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Chinese Journal of Integrative Medicine 2024年第6期30卷 565-576页

作者： KE Jun-yu SONG Jin-bin LI Long HE Zhen-fan HUANG Zhuo-jian LIU Zheng-lin CHEN Gui-rong WANG Hai-yan WEN Su-ru ZHOU Heng-li MA hui-lin DU Qun WU Yong-qiang LI Yan-wu CHEN Xin-lin School of Basic Medical Sciences Guangzhou University of Chinese MedicineGuangzhou510006China Department of Surgery II Gaozhou Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese MedicineGaozhou525200China Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou510405China The First Clinical Medical College of Guangzhou University of Traditional Chinese Medicine Guangzhou510405China

Intestinal macrophages play crucial roles in both intestinal inflammation and immune homeostasis. They can adopt two distinct phenotypes, primarily determined by environmental cues. These phenotypes encompass the classically activated pro-inflammatory M1 phenotype, as well as the alternatively activated anti-inflammatory M2 phenotype. In regular conditions, intestinal macrophages serve to shield the gut from inflammatory harm. However, when a combination of genetic and environmental elements influences the polarization of these macrophages, it can result in an M1/M2 macrophage activation imbalance, subsequently leading to a loss of control over intestinal inflammation. This shift transforms normal inflammatory responses into pathological damage within the intestines. In patients with ulcerative colitis-associated colorectal cancer (UC-CRC), disorders related to intestinal inflammation are closely correlated with an imbalance in the polarization of intestinal M1/M2 macrophages. Therefore, reinstating the equilibrium in M1/M2 macrophage polarization could potentially serve as an effective approach to the prevention and treatment of UC-CRC. This paper aims to scrutinize the clinical evidence regarding Chinese medicine (CM) in the treatment of UC-CRC, the pivotal role of macrophage polarization in UC-CRC pathogenesis, and the potential mechanisms through which CM regulates macrophage polarization to address UC-CRC. Our objective is to offer fresh perspectives for clinical application, fundamental research, and pharmaceutical advancement in UC-CRC.

关键词： macrophage ulcerative colitis colon cancer Chinese medicine

Circulating glycated albumin levels and gestational diabetes mellitus

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World Journal of Diabetes 2024年第8期15卷 1802-1810页

作者： Wei Xiong Zhao-hui Zeng Yuan Xu hui Li hui lin Department of Medical Hunan Traditional Chinese Medical CollegeZhuzhou 412012Hunan ProvinceChina Department of Outpatient Zhuzhou Second HospitalZhuzhou 412012Hunan ProvinceChina

BACKGROUND Gestational diabetes mellitus(GDM)is characterized by glucose intolerance that is first diagnosed during pregnancy,making it the most common complication associated with this *** detection and targeted treatment of GDM can minimize foetal exposure to maternal hyperglycaemia and subsequently reduce the associated adverse pregnancy *** studies have inconsistently suggested that the level of glycated albumin(GA)might predict *** To review and synthesize existing evidence to evaluate the relationship between GA levels and the development of *** We sought to compare GA levels between GDM and control groups in this metaanalysis by systematically searching the Web of Science,PubMed,Cochrane Library,and Embase databases for articles published up to June *** analysis utilized the weighted mean difference(WMD)as the primary *** data were meticulously extracted,and the quality of the included studies was ***,we conducted a subgroup analysis based on study region and sample *** assessed heterogeneity using I2 statistics and evaluated publication bias through funnel ***,trim-and-fill analysis was employed to detect and address any potential publication *** The meta-analysis included a total of 11 studies involving 5477 participants,comprising 1900 patients with GDM and 3577 control *** synthesized results revealed a notable correlation between elevated GA levels and increased susceptibility to *** calculated WMD was 0.42,with a 95%confidence interval(95%CI)ranging from 0.11 to 0.74,yielding a P value less than *** specific GA levels,the mean GA level in the GDM group was 12.6,while for the control group,it was lower,at *** discrepancy underscores the potential of GA as a biomarker for assessing GDM ***,we explored the levels of glycated haemoglobin(HbA1c)in both *** WMD for HbA1c was 0.19,with a 95%CI ranging from 0.15 to 0.

关键词： Glycated albumin Gestational diabetes mellitus Diabetes mellitus Meta-analysis Weighted mean difference

Qingchang suppositry(清肠栓)induced remission in patients with mild-to-moderate ulcerative proctitis:a multicenter,prospective,randomized,parallel-controlled clinical trial

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Journal of Traditional Chinese Medicine 2024年第1期44卷 156-162页

作者： DAI Xiaoling ZHANG Anming lin hui SHI Bei REN Yi WEN Hongzhu FEI Xiaoyan lin Jiang Department of Gastroenterology Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200032China Department of Gastroenterology Shanghai Putuo Traditional Chinese Medicine hospitalShanghai 200063China Department of Protocology Shanghai Tianshan Traditional Chinese Medicine hospitalShanghai 200050China

OBJECTIVE:To evaluate the efficacy and safety of Qingchang suppository(清肠栓,QCS),a preparation of Chinese herbal medicine,in the induction of remission in patients with mild-to-moderate ulcerative proctitis(UP).METHODS:We performed a multicenter,prospective,randomized,parallel-controlled trial to evaluate the efficacy of QCS induction therapy in 140 adult patients with mild-to-moderate UP and TCM syndrome of dampness-heat in large *** patients were randomized to receive QCS(study group)or Salicylazosulfapyridine(SASP)suppository(control group)one piece each time,twice a day,per anum for 12 *** score and main symptoms score were evaluated at weeks 0,2,4,8 and 12,rectosigmoidscopy was taken at weeks 0,4,8 and 12,Geboes score,erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)and safety indexes were assessed at weeks 0 and *** primary efficacy endpoint is clinical remission rate,the secondary efficacy endpoints are clinical response rate,mucosa healing rate,Geboes score,the remission rates of the main symptoms,the median day to the remission of the symptom,***:There were no statistical difference in the clinical remission rates,the clinical response rates,the mucosa healing rates,Geboes score,ESR and CRP between the two *** remission rates of tenesmus and anal burning sensation of the study group were significantly higher than those of the control group(76.5%vs 25.0%,P=0.009;74.51%vs 29.63%,P=0.003).The median day to the remission of purulent bloody stool of the study group was significantly less than that of control group[11(1,64)vs 19(2,67),P=0.007].The patients receiving QCS had a significantly higher mucosa healing rate at week 4 than the patients receiving SASP suppository(71.42%vs 52.85%,P=0.023).No adverse event occurred in the study group while the adverse events incidence of the control group was 5.7%(P=0.049).CONCLUSIONS:QCS could induce the remission of UP as effectively and safely as SASP suppository,and was superio

关键词： ulcerative proctitis salicylazosulfapyridine suppository Qingchang suppositry randomized controlled trial

精神生活共同富裕内在逻辑、科学内涵与价值意蕴探赜

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贵州民族研究 2024年第2期45卷 56-62页

作者：惠春琳中央党校〔国家行政学院〕国际战略研究院北京100089

精神生活共同富裕是党的十八大以来,新一届党和国家领导人提出的全新命题。从其出场逻辑来讲,是实现人的自由全面发展的内在要求,是中国共产党长期奋斗的历史目标,是应对社会主要矛盾变化的现实需要。从其内涵来看,是以物质生活共同富... 详细信息

精神生活共同富裕是党的十八大以来,新一届党和国家领导人提出的全新命题。从其出场逻辑来讲,是实现人的自由全面发展的内在要求,是中国共产党长期奋斗的历史目标,是应对社会主要矛盾变化的现实需要。从其内涵来看,是以物质生活共同富裕为前提、以满足人民群众精神文化需要为现实要求、以共建共享为基本路径、以实现人的自由全面发展为最终价值旨归。客观而言,它是党在新的时空逻辑中对共同富裕理论的创新性发展,这一理念的提出极大丰富了党对马克思主义关于人的发展理论的科学认知,凸显了中国式现代化的独特价值,有利于铸牢中华民族共同体意识,向全球彰显了人类文明新形态的重要价值。

关键词：精神生活共同富裕中国式现代化中华民族共同体意识人类文明新形态

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考虑设备转换成本的MRI检查预约调度优化

系统管理学报 2024年第1期33卷 59-75页

作者：林晖王杉上海交通大学安泰经济与管理学院上海200030 中山大学管理学院广州510275

核磁共振成像(MRI)检查是现代医学影像诊断的重要手段之一。MRI设备在扫描不同部位时会产生转换成本,为同时提高设备利用率和患者满意度,建立了马尔可夫决策过程模型,以最小化医院的长期成本。该模型是首个对MRI设备转换成本和患者日间... 详细信息

核磁共振成像(MRI)检查是现代医学影像诊断的重要手段之一。MRI设备在扫描不同部位时会产生转换成本,为同时提高设备利用率和患者满意度,建立了马尔可夫决策过程模型,以最小化医院的长期成本。该模型是首个对MRI设备转换成本和患者日间等候成本进行权衡的优化模型。通过策略迭代算法可得到该模型的最优调度。为降低计算复杂度,设计了基于单日规则、开放获取规则和短视规则的多项式时间算法。除此之外,通过忽略容量约束,提出了分解算法,在MRI设备检查能力紧张或充足时,其表现与最优解接近。通过对比上海某大型综合医院的实际排程,验证了上述算法能够在检查能力、患者拒绝比例、患者平均等待天数、日平均检查类型数等指标上取得显著改善。

关键词：医疗卫生预约调度马尔可夫决策过程组合优化近似算法

复合框架、综合判断与融合表达——新文科视域下中国应用新闻学教育的转型

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新闻大学 2024年第5期 32-44,117,118页

作者：林晖杜薇上海财经大学人文学院上海200433

无论中外,从记者职业诞生到专业新闻教育发轫,融通理论和业务的应用新闻学教育和研究都奠定了新闻人才培养的基础和方向。20世纪初,中国本土新闻学理论和实务初兴。此后百年间,人才培养也从起初的杂家应用型、复合型、专门型过渡到大融... 详细信息

无论中外,从记者职业诞生到专业新闻教育发轫,融通理论和业务的应用新闻学教育和研究都奠定了新闻人才培养的基础和方向。20世纪初,中国本土新闻学理论和实务初兴。此后百年间,人才培养也从起初的杂家应用型、复合型、专门型过渡到大融合时代的“专家型”。当前尚未完全适应网络技术转型的应用新闻教育在人工智能的强烈冲击下又一次到了转折期。“新闻专业危机”背后映射的是信任危机与职业认同危机,是对新闻传播专业的质疑与叩问。“融+通”的新文科,贯通人文学科内部、跨越文理工的界限,以复合框架、综合判断、融合表达为目标,将为百年来中国应用新闻教育带来剧烈、深刻的变革。

关键词：应用新闻学教育人才培养新文科融合

TRPM2 Mediates Hepatic Ischemia–Reperfusion Injury via Ca^(2+) -Induced Mitochondrial Lipid Peroxidation through Increasing ALOX12 Expression

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Research 2024年第1期2023卷 351-368页

作者： Cheng Zhong Jing Yang Yiyin Zhang Xiaoxiao Fan Yang Fan Ning Hua Duguang Li Shengxi Jin Yirun Li Peng Chen Yongle Chen Xiaobo Cai Yi Zhang linhua Jiang Wei Yang Peilin Yu hui lin Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouP.R.China Department of Biophysics and Department of Neurology of the Fourth Affiliated Hospital Zhejiang University School of MedicineHangzhou 310000P.R.China Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province Xinxiang Medical University453003 XinxiangHenanP.R.China School of Biomedical Sciences Faculty of Biological SciencesUniversity of LeedsLS29JT LeedsUK Department of Toxicology and Department of Medical Oncology of Second Affiliated Hospital Zhejiang University School of MedicineHangzhouP.R.China Zhejiang Engineering Research Center of Cognitive Healthcare Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310020P.R.China College of Biomedical Engineering and Instrument Science Zhejiang UniversityHangzhou 310058P.R.China

Hepatic ischemia–reperfusion(IR)injury is a serious clinical problem that complicates liver resection and *** recent advances in understanding of the pathophysiology of hepatic IR injury,effective interventions and therapeutics are still ***,we examined the role of transient receptor potential melastatin 2(TRPM2),a Ca^(2+)-permeable,non-selective cation channel,in mediating hepatic IR *** data showed that TRPM2 deficiency attenuated IR-induced liver dysfunction,inflammation,and cell death in ***,RNA sequencing analysis indicated that TRPM2-induced IR injury occurs via ferroptosis-related ***,as a ferroptosis inducer,(1S,3R)-RSL3 treatment induced mitochondrial dysfunction in hepatocytes and a TRPM2 inhibitor suppressed ***,TRPM2-mediated calcium influx caused mitochondrial calcium accumulation via the mitochondrial Ca^(2+)-selective uniporter and increased the expression level of arachidonate 12-lipoxygenase(ALOX12),which results in mitochondrial lipid peroxidation during hepatic IR ***,hepatic IR injury-induced ferroptosis was obviously relieved by a TRPM2 inhibitor or calcium depletion,both in vitro and in ***,these findings demonstrate a crucial role for TRPM2-mediated ferroptosis in hepatic IR injury via increased Ca^(2+)-induced ALOX12 expression,indicating that pharmacological inhibition of TRPM2 may provide an effective therapeutic strategy for hepatic IR injury-related diseases,such as during liver resection and transplantation.

关键词： TRPM2 Lipid Hepatic