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Efficiency and safety of Tripterygium Wilfordii Hook F for IgA nephropathy: an update systematic review and meta-analysis

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Pharmacology Discovery 2024年第2期4卷 24-31页

作者： zi-Yi He hui-chuan Tian Yan Zhao Rui-Yu Mou Hong-Wei Yuan Department of Cardiology The Second Affiliated Hospital of Tianjin University of Chinese MedicineTianjin 300150China Department of Oncology The First Affiliated Hospital of Tianjin University of Chinese MedicineTianjin 300110China Department of Oncology National Clinical Research Center of Chinese Acupuncture and MoxibustionTianjin 301617China Department of Chinese Medicine Macao University of Science and TechnologyMacao 999078China

Background:Immunoglobulin A Nephropathy(IgAN)currently stands as the most prevalent primary chronic glomerular disease *** latest guidelines recommend the application of renin-angiotensin system inhibitors(RASi)in conjunction with corticosteroids for the treatment of IgAN patients exhibiting persistent proteinuria of≥1 g/***,numerous randomized controlled trials(RCTs)have revealed a heightened risk of adverse events associated with corticosteroid ***-glycoside of Tripterygium wilfordii Hook.f.(GTW),a traditional Chinese medicine(TCM),has been employed in the treatment of Chronic Kidney Disease(CKD)for an extensive *** years have witnessed an increasing number of RCTs providing evidence supporting the effectiveness of GTW therapy in *** this,there remains a paucity of systematic reviews on the application of GTW therapy for ***,this study undertakes a systematic review to assess the clinical efficacy and safety of GTW therapy,aiming to elucidate the role of GTW therapy in the treatment of ***:To collect relative information of randomized controlled trials(RCTs)of GTW in the treatment of IgAN,we searched for theses and dissertations publicized before April 10,2023,in PubMed,Embase,the Cochrane Library,China National Knowledge Infrastructure(CNKI),Wanfang Data knowledge service platform(Wanfang Data),Chinese Scientific Journal Database(VIP),and Clinical *** language limitation is English and ***,two reviewers performed literature screening,data extraction,and quality evaluation,and the meta-analysis was carried out with RevMan 5.4 and StataSE 15.0 ***:21 RCTs involving 1,405 Chinese patients were *** to ACEI/ARB alone or in combination,GTW with RASi or alone reduced 24 h-Upro,ALB,Scr,GFR,BUN,CD4+,VEGF,ET-1,and improved clinical ***,no associations were found for TC,Ccr,and adverse events due to limited ***:This study hi

关键词： Tripterygium IgA nephropathy systematic review meta-analysis

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Analysis of status and influencing factors of mental health in patients with systemic lupus erythematosus

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World Journal of Psychiatry 2024年第6期14卷 829-837页

作者： Xuan Zhang Zhe Wang Gui-Ling Lin Fang-Zhi Wei Yan-Ping Zhuang Wen-Lu Xu Qi Zhang hui-Tao Wu zi-Man He Xi-Yu Yin Ying Liu Long Mi Ai-Min Gong School of Traditional Chinese Medicine Hainan Medical UniversityHaikou 571101Hainan ProvinceChina Department of Rheumatology and Immunology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikou 570311Hainan ProvinceChina Department of Radiology The First Affiliated Hospital of Hainan Medical UniversityHainan Medical UniversityHaikou 570100Hainan ProvinceChina

BACKGROUND Systemic lupus erythematosus(SLE)is a heterogeneous autoimmune disorder with varied clinical courses and prognoses,not only did the patients suffer from physical impairment,but also various physical and psychiatric *** evidence have suggested that mental disorders in SLE patients,can lead to various adverse *** To explored the features and influencing factors of mental health in patients with SLE and clarifying the correlations between mental health and personality characteristics and perceived social *** results would provide a basis for psychological intervention in patients with *** The clinical data of 168 patients with SLE admitted at the First Affiliated Hospital of Hainan Medical University between June 2020 and June 2022 were *** assessment and correlation analysis were conducted using the Symptom Checklist-90(SCL-90)and Perceived Social Support Scale,and the collected data were compared with the national norms in *** relevant factors influencing mental health were identified by statistical analysis.A general information questionnaire,the Revised Life Orientation Test,and Short-Form 36-Item Health Survey were employed to assess optimism level and quality of life(QoL),*** Patients with SLE obtained higher scores for the somatization,depression,anxiety,and phobic anxiety subscales than national norms(P<0.05).A correlation was identified between total social support and total SCL-90 score or each subscale(P<0.05).The factors significantly affecting patients’mental health were hormone dosage and disease activity index(DAI)(P<0.05).The average optimism score of patients with SLE was 14.36±4.42,and 30 cases were in the middle and lower levels.A positive correlation was found between optimism level and QoL *** Patients with SLE develop psychological disorders at varying degrees,which are significantly influenced by hormone dosage and ***’menta

关键词： Systemic lupus erythematosus Mental health Quality of life Influencing factors

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240 nm AlGaN-based deep ultraviolet micro-LEDs:size effect versus edge effect

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Journal of Semiconductors 2024年第1期45卷 55-62页

作者： Shunpeng Lu Jiangxiao Bai Hongbo Li Ke Jiang Jianwei Ben Shanli Zhang zi-hui Zhang Xiaojuan Sun Dabing Li State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Electronic Materials and Devices of Tianjin School of Electronics and Information EngineeringHebei University of TechnologyTianjin 300401China

240 nm AlGaN-based micro-LEDs with different sizes are designed and ***,the external quantum efficiency(EQE)and light extraction efficiency(LEE)are systematically investigated by comparing size and edge ***,it is revealed that the peak optical output power increases by 81.83%with the size shrinking from 50.0 to 25.0μ***,the LEE increases by 26.21%and the LEE enhancement mainly comes from the sidewall light *** notably,transversemagnetic(TM)mode light intensifies faster as the size shrinks due to the tilted mesa side-wall and Al reflector ***,when it turns to 12.5μm sized micro-LEDs,the output power is lower than 25.0μm sized *** underlying mechanism is that even though protected by SiO2 passivation,the edge effect which leads to current leakage and Shockley-Read-Hall(SRH)recombination deteriorates rapidly with the size further ***,the ratio of the p-contact area to mesa area is much lower,which deteriorates the p-type current spreading at the mesa *** findings show a role of thumb for the design of high efficiency micro-LEDs with wavelength below 250 nm,which will pave the way for wide applications of deep ultraviolet(DUV)micro-LEDs.

关键词： AlGaN deep ultraviolet micro-LEDs light extraction efficiency size effect edge effect

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Gas microchannel plate-pixel detector for X-ray polarimetry

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Nuclear Science and Techniques 2024年第5期35卷 60-73页

作者： Huan-Bo Feng Hong-Bang Liu Dong Wang zi-Li Li Shu-Lin Liu Qian Liu Hang-Zhou Li Bin-Long Wang Yan-Jun Xie Zong-Wang Fan hui Wang Ran Chen Di-Fan Yi Rui-Ting Ma Fei Xie Bo Peng Xiang-Ming Sun Jin Li En-Wei Liang Present Address:Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China PLAC Key Laboratory of Quark and Lepton Physics(MOE)Central China Normal UniversityWuhan 430079China School of Science Huzhou UniversityHuzhou 313000China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China School of Physical Science University of Chinese Academy of SciencesBeijing 100049China The 13th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050057China

POLAR-2 is a gamma-ray burst(GRB)polarimeter that is designed to study the polarization in GRB radiation emissions,aiming to improve our knowledge of related ***-2 is expected to utilize an on-board polarimeter that is sensitive to soft X-rays(2-10 keV),called low-energy polarization *** have developed a new soft X-ray polari-zation detector prototype based on gas microchannel plates(GMCPs)and pixel chips(Topmetal).The GMCPs have bulk resistance,which prevents charging-up effects and ensures gain stability during *** detector is composed of low outgassing materials and is gas-sealed using a laser welding technique,ensuring long-term stability.A modulation factor of 41.28%±0.64% is obtained for a 4.5 keV polarized X-ray beam.A residual modulation of 1.96%±0.58% at 5.9 keV is observed for the entire sensitive area.

关键词： X-ray polarimetry Gas microchannel plate-pixel detector Gamma-ray bursts

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Preparation of kakkatin derivatives and their anti-tumor activity

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World Journal of Clinical Oncology 2024年第8期15卷 1078-1091页

作者： Yu-Ying Jiang hui-Hua Dong Wen-Ting Zhou Jia-zi Luo Xian Wei Yan-Qiang Huang Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Collaborative Innovation Center for Guangxi Ethnic Medicine The School of Chemistry and Pharmaceutical SciencesYoujiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Research Center for the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina

BACKGROUND Modern pharmacological studies have confirmed that plant-derived compounds from Puerariae flos(PF)has significant biological activities against liver damage,tumors and *** is an isoflavone polyphenolic compound isolated from PF ***,the effect of kakkatin and its derivatives on anti-tumor has not been well *** To design and synthesize a kakkatin derivative[6-(hept-6-yn-1-yloxy)-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one(HK)]to explore its anti-tumor biological *** Hept-6-yn-1-yl ethanesulfonate was introduced to replace hydrogen at the hydroxyl position of kakkatin phenol,and the derivative of kakkatin was prepared;the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide was used to detect cell viability,a clone formation assay was adopted to detect cell proliferation,apoptosis,necrosis,and cell cycles were analyzed by Annexin V/propidium iodide staining and flow *** migration and invasion ability were evaluated by cell scratch assay and transwell *** potential mechanism of HK on hepatocellular carcinoma(HCC)SMMC-7721 cells was explored through network pharmacology and molecular docking,and finally real-time PCR assays was used to verify the potential targets and evaluate the biological activity of *** Compared with kakkatin,the modified HK did not significantly increase the inhibitory activity of gastric cancer MGC803 cells,but the inhibitory activity of HCC SMMC-7721 cells was increased by about 30 times,with an IC50 value of 2.5μM,and the tumor inhibition effect was better than cisplatin,which could significantly inhibit the cloning,invasion and metastasis of HCC SMMC-7721 cells,and induce apoptosis and G2/M cycle *** mechanism of action is mainly related to the upregulation of PDE3B and NFKB1 target proteins in the cAMP *** HK have a significant inhibitory effect on HCC SMMC-7721 cells,and the targets of their action may be PDE3B and NFKB1 prote

关键词： Kakkatin Derivative Hepatocellular carcinoma Anti-tumor Biological activity

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东北地区经济联系的空间格局演变及影响因素分析

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城市问题 2024年第4期 42-51页

作者：廉晓梅姜姿卉吉林大学东北亚研究中心吉林大学东北亚学院

加强东北地区经济联系有助于提升东北区域一体化水平,形成推动东北全面振兴的整体合力。基于修正后的引力模型和社会网络分析法对东北地区经济联系空间格局的演变特征进行分析,结果表明,东北地区经济联系网络整体密度呈先升后降的趋势,... 详细信息

加强东北地区经济联系有助于提升东北区域一体化水平,形成推动东北全面振兴的整体合力。基于修正后的引力模型和社会网络分析法对东北地区经济联系空间格局的演变特征进行分析,结果表明,东北地区经济联系网络整体密度呈先升后降的趋势,经济联系网络受省级行政区划的制约较为明显,同一省份内的城市经济联系更为密切。经济联系强度较强的地区主要集中在以沈阳市、大连市为中心的辽中南城市群,长春市、沈阳市、哈尔滨市三个省会城市的中心地位突出,黑河市、伊春市等资源枯竭型城市的经济联系强度偏弱,整体形成“南高北低”的分布格局,且网络重心具有向辽中南城市群移动的态势。促进制造业转型升级、提升市场需求、增强基础设施建设、加大对外开放力度有助于加强东北地区经济联系。

关键词：东北振兴经济联系空间格局网络分析

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GRB 210610B:The Internal and External Plateau as Evidence for the Delayed Outflow of Magnetar

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Research in Astronomy and Astrophysics 2024年第7期24卷 170-180页

作者： Yi-Ning Wei Xiang-Gao Wang Da-Bin Lin Wei-Kang Zheng Liang-Jun Chen Sheng-Yu Yan Shuang-Xi Yi Qi Wang zi-Min Zhou hui-Ya Liu En-Wei Liang Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China GXU-NAOC Center for Astrophysics and Space Sciences Nanning 530004China Department of Astronomy University of CaliforniaBerkeleyCA 94720-3411USA Department of Physics and Tsinghua Center for Astrophysics(THCA) Tsinghua UniversityBeijing 100084China School of Physics and Physical Engineering Qufu Normal UniversityQufu 273165China

After launching a jet,outflows of magnetar were used to account for the achromatic plateau of afterglow and the early X-ray flux plateau known as“internal plateau”.The lack of detecting magnetic dipole emission together with the energy injection feature in a single observation poses confusion until the long gamma-ray burst(GRB)210610B is *** 210610B is presented with an optical bump following an early X-ray plateau during the afterglow *** plateau followed by a steep decline flux overlays in the steadily decaying X-ray flux with indexα_(X,1)~2.06,indicating an internal origin and that can be fitted by the spin-down luminosity law with the initial plateau luminosity log_(10)L_(X)~48.29 erg s~(-1)and the characteristic spin-down timescale T~2818 s.A subsequent bump begins at~4000 s in the R band with a rising indexα_(R,1)~-0.30 and peaks at~14125 s,after which a decay indexα_(R,2)~0.87 and finally transiting to a steep decay withα_(R,3)~1.77 achieve the closure relation of the external shock for the normal decay phase as well as the magnetar spin-down energy injection phase,provided that the average value of the photon indexΓ_γ=1.80 derived from the spectral energy distributions(SEDs)between the X-ray and optical *** closure relation also works for the late X-ray *** to the traditional picture of GRB,the outflow powers the early X-ray plateau by dissipating energy internally and collides with the leading decelerating blast burst as time goes on,which could interpret the exotic feature of GRB *** carry out a Markov Chain Monte Carlo simulation and obtain a set of best parameters:■.The artificial light curve can fit the afterglow data *** that,we estimated the average Lorentz factor and the X-ray radiation efficiency of the later ejecta are 35%and 0.13%,respectively.

关键词： (stars)gamma-ray burst individual(GRB 210610B)-(stars)gamma-ray burst general-stars jets

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Effectiveness and safety of early lens extraction during par plana vitrectomy for proliferative diabetes retinopathy with mild cataract:a randomized clinical trial

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 528-536页

作者： Wei-Bo Feng Lei Zheng Ying-Qi Li Yong-Hao Li Guo-Ming Zhang Xian Wang Bing-Qian Liu Ling Jin Yi-Nuo Huang Yang-Fan Yang zi-Dong Chen Da-hui Ma Qing-Shan Chen Chao-Jun Qin Bing-Min Feng Zhu-Min Yang Xing Huang Cheng-Jie Yang Sheng-hui Liu Ming-Xing Wu State Key Laboratory of Ophthalmology Guangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesZhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510275Guangdong ProvinceChina Shenzhen Eye Hospital Affiliated to Jinan University Shenzhen 518040Guangdong ProvinceChina The Affiliated Hospital of Guizhou Medical University Guiyang 550004Guizhou ProvinceChina Guangzhou Aier Eye Hospital Guangzhou 510000Guangdong ProvinceChina

●AIM:To evaluate the effectiveness and safety of early lens extraction during pars plana vitrectomy(PPV)for proliferative diabetic retinopathy(PDR)compared to those of PPV with subsequent cataract surgery.●METHODS:This multicenter randomized controlled trial was conducted in three Chinese hospitals on patients with PDR,aged>45y,with mild *** participants were randomly assigned to the combined(PPV combined with simultaneously cataract surgery,i.e.,phacovitrectomy)or subsequent(PPV with subsequent cataract surgery 6mo later)group and followed up for *** primary outcome was the change in best-corrected visual acuity(BCVA)from baseline to 6mo,and the secondary outcomes included complication rates and medical expenses.●RESULTS:In total,129 patients with PDR were recruited and equally randomized(66 and 63 in the combined and subsequent groups respectively).The change in BCVA in the combined group[mean,36.90 letters;95%confidence interval(CI),30.35–43.45]was significantly better(adjusted difference,16.43;95%CI,8.77–24.08;P<0.001)than in the subsequent group(mean,22.40 letters;95%CI,15.55–29.24)6mo after the PPV,with no significant difference between the two groups at *** overall surgical risk of two sequential surgeries was significantly higher than that of the combined surgery for neovascular glaucoma(17.65%vs 3.77%,P=0.005).No significant differences were found in the photocoagulation spots,surgical time,and economic expenses between two *** the subsequent group,the duration of work incapacity(22.54±9.11d)was significantly longer(P<0.001)than that of the combined group(12.44±6.48d).●CONCLUSION:PDR patients aged over 45y with mild cataract can also benefit from early lens extraction during PPV with gratifying effectiveness,safety and convenience,compared to sequential surgeries.

关键词： lens extraction pars plana vitrectomy proliferative diabetic retinopathy cataract simultaneously operations

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Employing a random forest model to forecast the likelihood of coronary artery lesions in Kawasaki disease: a study centered on four biomarkers

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Medical Data Mining 2024年第3期7卷 1-7页

作者： Chu-Xiong Gong Yue-Wen Li Ya-Min Li zi-Yu Wang hui-Qing Gao Xiao-Mei Liu Department of Infectious Diseases Children’s Hospital Affiliated of Kunming Medical UniversityKunming Children’s HospitalKunming 650228China Department of Rehabilitation and Palliative Medicine The Third Affiliated Hospital of Kunming Medical UniversityKunming 650000China

Background:Kawasaki disease is an acute immune vasculitis,which is more common in children under 5 years *** disease mainly affects the cardiovascular system,especially the coronary *** coronary artery damage occurs,it can significantly impact the patient’s ***,in some countries and regions,Kawasaki disease has become a common acquired heart ***:First,univariate analysis was conducted on each predictive ***,Least Absolute Shrinkage and Selection Operator and random forest algorithms were used to screen all predictive factors,and the prediction model was evaluated using receiver operating characteristic curve,calibration curve,and Decision Curve ***:This study,based on data from 228 Kawasaki disease patients,utilized a random forest model to identify four predictive factors:white blood cell count,creatine kinase isoenzyme MB,albumin,and neutrophil *** factors were used to construct a prediction model,which achieved an area under the curve of ***:We developed a forest plot based on white blood cell count,creatine kinase isoenzyme MB,albumin,and neutrophil count to effectively predict the occurrence of coronary artery lesions in Kawasaki disease.

关键词： Kawasaki disease coronary artery lesions nomogram machine learning

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金刚石/碳纳米管异质界面热导及声子热输运特性

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物理学报 2024年第13期73卷 346-355页

作者：刘子怡褚福强魏俊俊冯妍卉北京科技大学能源与环境工程学院北京100083 北京科技大学新材料技术研究院北京100083

碳纳米管作为新一代热界面材料,在天然材料中具有最高的热导率,有望解决金刚石半导体超高热流密度的散热问题.因此,本文提出将金刚石和碳纳米管结合,可大幅度提高器件性能及稳定性,减小封装尺寸,实现器件小型化设计.采用非平衡分子动力... 详细信息

碳纳米管作为新一代热界面材料,在天然材料中具有最高的热导率,有望解决金刚石半导体超高热流密度的散热问题.因此,本文提出将金刚石和碳纳米管结合,可大幅度提高器件性能及稳定性,减小封装尺寸,实现器件小型化设计.采用非平衡分子动力学方法从微观层面探究了金刚石/碳纳米管异质结构界面热特性及影响因素.研究发现碳纳米管层数增加使声子态密度峰值增大并向低频波段移动,低频声子增多更有利于界面传热,同时声子重叠能提高,声子耦合振动增强提升了界面传热效率;同时,一定范围内体系温度的升高及碳纳米管长径比的增大可以提高近界面处金刚石和碳纳米管的态密度截止频率,提升低频波段的峰值,进一步增强两侧声子的耦合振动,提高了界面热导.最后,采用正交试验模拟获得了金刚石/碳纳米管界面热导的最优值,结果远优于目前一般半导体/金属的界面热导.该工作为优化金刚石/碳纳米管异质界面的热输运提供了思路,并将有利于器件热管理和芯片材料设计.

关键词：碳纳米管金刚石界面热导分子动力学

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