检索结果-南通市图书馆

Association between composite dietary antioxidant index and stroke among individuals with diabetes

World Journal of Diabetes 2024年第8期15卷 1742-1752页

作者： Hong-Qiang Zhang Jie Shi tong Yue Jia-Hao Weng Xu-Lin Wang Hao Wang Xiao-Yu Su Xue-Ying Zheng Si-hui Luo Yu Ding Chao-Fan Wang Department of Cardiology Centre for Leading Medicine and Advanced Technologies of IHMThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Endocrinology Centre for Leading Medicine and Advanced Technologies of IHMThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Graduate School Bengbu Medical CollegeBengbu 233030Anhui ProvinceChina Department of Endocrinology and Metabolism The Third Affiliated Hospital of Sun Yat-sen UniversityGuangdong Provincial Key Laboratory of DiabetologyGuangzhou 510630Guangdong ProvinceChina

BACKGROUND Recent research has underscored the potentially protective role of dietary antioxidants against chronic conditions,such as cardiovascular diseases and *** composite dietary antioxidant index(CDAI),which reflects the overall intake of key dietary antioxidants,has been identified as a crucial metric for exploring this *** previous research has shown a negative correlation between CDAI levels and stroke risk in prediabetic individuals,there remains a substantial gap in understanding this association among individuals with diabetes,who are at an inherently greater risk for cerebrovascular *** To investigate the association between CDAI and stroke risk in individuals with *** Using a cross-sectional study design,this investigation analyzed data from the National Health and Nutrition Examination Survey spanning from 2003 to 2018 that included 6735 participants aged over 20 years with *** CDAI was calculated from 24-h dietary recalls to assess intake of key antioxidants:Vitamins A,C,and E;carotenoids;selenium;and *** logistic regression and restricted cubic spline analysis were used to rigorously examine the relationship between CDAI and stroke *** The participant cohort,with an average age of 59.5 years and a slight male majority,reflected the broader demographic characteristics of individuals with *** analysis revealed a strong inverse relationship between CDAI levels and stroke ***,those in the highest quintile of CDAI demonstrated a 43%lower prevalence of stroke compared to those in the lowest quintile,even after adjustments for various *** finding not only highlights the negative association between CDAI and stroke risk but also underscores the significant potential of antioxidant-rich diets in reducing stroke prevalence among patients with *** Our findings suggested that CDAI was inversely associated with stroke prevalence among pa

关键词： Stroke Diabetes Composite dietary antioxidant index National Health and Nutrition Examination Survey Crosssectional study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of cetuximab plus FOLFOX4 regimen on clinical outcomes in advanced gastric carcinoma patients receiving evidence-based care

引用

World Journal of Clinical Cases 2024年第18期12卷 3360-3367页

作者： hui Ying Ren-Jun Huang Xiao-Min Jing Yan Li Qun-Qiu tong Department of General Surgery Yongkang First People's HospitalYongkang 321300Zhejiang ProvinceChina Department of Oncology Yongkang First People's HospitalYongkang 321300Zhejiang ProvinceChina

BACKGROUND Although chemotherapy is effective for treating advanced gastric carcinoma(aGC),it may lead to an adverse *** a highly effective and low-toxicity chemotherapy regimen is necessary for improving efficacy and outcomes in aGC *** To determine the efficacy and safety of cetuximab(CET)combined with the FOLFOX4 regimen(infusional fluorouracil,folinic acid,and oxaliplatin)as firstline therapy for patients with aGC,who received evidence-based care(EBC).METHODS A total of 117 aGC patients who received EBC from March 2019 to March 2022 were *** these,60 in the research group(RG)received CET+FOLFOX4 as first-line therapy,whereas 57 in the control group(CG)received *** efficacy[clinical response rate(RR)and disease control rate(DCR)],safety(liver and kidney dysfunction,leukopenia,thrombocytopenia,rash,and diarrhea),serum tumor marker expression[STMs;carbohydrate antigen(CA)19-9,CA72-4,and carcinoembryonic antigen(CEA)],inflammatory indicators[interleukin(IL)-2 and IL-10],and quality of life(QOL)of the two groups were *** A markedly higher RR and DCR were observed in the RG compared with the CG,with an equivalent safety profile between the two *** exhibited notably reduced CA19-9,CA72-4,CEA,and IL-2 levels following treatment,which were lower than the pre-treatment levels and those in the ***-treatment IL-10 was statistically increased in RG,higher than the pre-treatment level and the ***,a significantly improved QOL was evident in the *** The CET+FOLFOX4 regimen is highly effective as first-line treatment for aGC patients receiving *** facilitates the suppression of STMs,ameliorates the serum inflammatory microenvironment,and enhances QOL,without increased adverse drug effects.

关键词： Cetuximab FOLFOX4 regimen Evidence-based care Advanced gastric carcinoma Efficacy and safety

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Two different mutational types of familial gastrointestinal stromal tumors:Two case reports

引用

World Journal of Gastrointestinal Oncology 2024年第9期16卷 4028-4036页

作者： Xiao-Ke Wang Lu-Fan Shen Xin Yang He Su Tao Wu Peng-Xian Tao Hong-Ying Lv tong-Han Yao Lin Yi Yuan-hui Gu The First School of Clinical Medical Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina School of Traditional Chinese and Western Medicine Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Department of General Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal(GI)tract,and cases of GISTs tend to be of the disseminated type,with a global incidence of 10 to 15 cases/million each *** rarer familial GISTs,which often represent a population,differ in screening,diagnosis,and *** GISTs include primary familial GISTs with predominantly KIT/PDGFRA mutations and wild-type ***,whether the same genetic family has different phenotypes has not been *** SUMMARY We report two cases of rare GISTs in the same family:A male patient with the V561D mutation in exon 12 of the PDGFRA gene,who has been taking the targeted drug imatinib since undergoing surgery,and a female patient diagnosed with wild-type GIST,who has been taking imatinib for 3 years since undergoing *** favorable prognosis of these patients during the 7-year follow-up period validates the accuracy of our treatment strategy,and we have refined the entire process of diagnosis and treatment of familial GISTs in order to better manage this rare familial *** Different mutation types of familial GISTs in the same family are very rare,thus it is very important to make the correct diagnosis and treatment strategies according to the results of molecular detection for the management of familial GISTs.

关键词： Gastrointestinal stromal tumor Familial gastrointestinal stromal tumor Wild-type gastrointestinal stromal tumors PDGFRA Imatinib Treatment Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Novel photoresponsive dinuclear nickel catalysts for ethylene(co)polymerization

引用

Science China Chemistry 2024年

作者： Chenlong Nan tong Pang Jiaxing Zhao Lijia Fan Chen Zou Xin-Qi Hao Mao-Ping Song Jun-Fang Gong Changle Chen hui Jiang College of Chemistry Pingyuan Laboratory Zhengzhou University CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and Engineering University of Science and Technology of China

Compared with the conventional strategies of electronic and/or steric perturbation, catalytic olefin polymerization modulated by light irradiation or metal-metal cooperativity effect is a fascinating challenge that attracts considerable attention in the academic community. In this context, we design a strategy that could employ both effects to influence the polymerization process. Some dinuclear salicylaldimine and α-imino-ketone nickel complexes bearing a stiff-stilbene bridge were prepared, which could transfer between(E)-isomers and(Z)-isomers under ultraviolet irradiation. This isomerization can tune the electronic, steric and metal-metal cooperativity effects of the nickel catalysts. In this way, the catalytic activity, as well as polymer microstructures including molecular weight and branching density can be modulated in ethylene polymerization and copolymerization *** strategy is generally applicable to other olefin polymerization catalytic systems and other types of transition metal mediated catalysis.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

替雷利珠单抗联合XELOX方案治疗晚期胃癌的临床研究

引用

现代药物与临床 2024年第3期39卷 700-704页

作者：童慧邢鹏泾县医院肿瘤内科安徽宣城242500

目的探讨替雷利珠单抗注射液联合XELOX方案治疗晚期胃癌的临床疗效。方法选取2021年1月—2023年1月泾县医院收治的60例晚期胃癌患者,采用随机数字表法将纳入患者分为对照组和治疗组,每组30例。对照组采用XELOX方案:第1天静脉滴注注射用... 详细信息

目的探讨替雷利珠单抗注射液联合XELOX方案治疗晚期胃癌的临床疗效。方法选取2021年1月—2023年1月泾县医院收治的60例晚期胃癌患者,采用随机数字表法将纳入患者分为对照组和治疗组,每组30例。对照组采用XELOX方案:第1天静脉滴注注射用奥沙利铂130 mg/m^(2),同时口服卡培他滨片1000 mg/m^(2),2次/d,连续治疗14 d,并以3周为1个疗程。治疗组在对照组基础上静脉滴注替雷利珠单抗注射液200 mg/次,3周用药1次,3周为1个疗程。两组患者均连续治疗3个疗程。比较两组近期临床疗效、免疫功能指标和血清肿瘤标志物。结果治疗组的总有效率高于对照组的总有效率(P<0.05)。治疗后,对照组CD3^(+)T细胞、CD4^(+)T细胞和CD4^(+)T/CD8^(+)T比值均显著降低,治疗组CD3^(+)T细胞、CD4^(+)T细胞和CD4^(+)T/CD8^(+)T比值均显著升高(P<0.05);治疗组患者CD3^(+)T细胞、CD4^(+)T细胞和CD4^(+)T/CD8^(+)T比值均明显高于对照组(P<0.05)。治疗后,两组血清糖类抗原199(CA199)、基质金属蛋白酶-2(MMP-2)、血管内皮生长因子(VEGF)水平均显著降低(P<0.05),且治疗组血清CA199、MMP-2、VEGF水平均低于对照组(P<0.05)。结论替雷利珠单抗联合XELOX方案可提高晚期胃癌患者的近期疗效,促进免疫功能恢复,加强抗肿瘤效果。

关键词：替雷利珠单抗注射液 XELOX方案注射用奥沙利铂卡培他滨片晚期胃癌 CD3+T细胞 CD4+T细胞 CD4+T/CD8+T比值糖类抗原199 基质金属蛋白酶-2 血管内皮生长因子

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tunnelling of electrons via the neighboring atom

引用

Light(Science & Applications) 2024年第1期13卷 127-134页

作者： Ming Zhu Jihong tong Xiwang Liu Weifeng Yang Xiaochun Gong Wenyu Jiang Peifen Lu hui Li Xiaohong Song Jian Wu School of Physics and Optoelectronic Engineering Hainan UniversityHaikou 570288China School of Information and Communication Engineering Hainan UniversityHaikou 570288China State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200241China Center for Theoretical Physics Hainan UniversityHaikou 570288China

As compared to the intuitive process that the electron emits straight to the continuum from its parent ion,there is an alternative route that the electron may transfer to and be trapped by a neighboring ionic core before the eventual ***,we demonstrate that electron tunnelling via the neighboring atomic core is a pronounced process in light-induced tunnelling ionization of molecules by absorbing multiple near-infrared *** devised a siteresolved tunnelling experiment using an Ar-Kr+ion as a prototype system to track the electron tunnelling dynamics from the Ar atom towards the neighboring Kr+by monitoring its transverse momentum distribution,which is temporally captured into the resonant excited states of the Ar-Kr+before its eventual *** influence of the Coulomb potential of neighboring ionic cores promises new insights into the understanding and controlling of tunnelling dynamics in complex molecules or environment.

关键词： neighboring straight resonant

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于“技术道德化”理论的生成式人工智能教育应用潜能与风险研究

引用

电化教育研究 2024年第7期45卷 12-18页

作者：童慧杨彦军江西科技师范大学教育学部江西南昌330038 南昌大学教育发展研究院江西南昌330031

随着生成式人工智能的快速发展及其在教育领域的广泛应用,国内外研究者围绕它及其背后的大语言模型教育应用问题展开了热烈的讨论,但大部分研究因缺乏对生成式人工智能技术原理的了解而在问题探讨中存在伊莉莎效应。研究首先在对生成式... 详细信息

随着生成式人工智能的快速发展及其在教育领域的广泛应用,国内外研究者围绕它及其背后的大语言模型教育应用问题展开了热烈的讨论,但大部分研究因缺乏对生成式人工智能技术原理的了解而在问题探讨中存在伊莉莎效应。研究首先在对生成式人工智能技术学原理进行深入剖析的基础上,从维贝克“人—技杂合”视角对生成式人工智能的本质展开技术哲学分析;其次,基于“技术道德化”理论分析了生成式人工智能教育应用的四大潜能和面临的五大风险挑战;最后,提出基于“人—技杂合”的思想从“设计者”和“使用者”两种视角构建“双向奔赴”的全球人工智能治理体系,将成为未来探索的重要方向。

关键词：生成式人工智能技术道德化大模型人—技杂合应用风险

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sea-level change in coastal areas of China:Status in 2021

引用

Advances in Climate Change Research 2024年第3期15卷 515-524页

作者： Wen-Shan LI hui WANG Wen-Xi XIANG Ai-Mei WANG Wei-Qing XU Yu-Xi JIANG Xin-hui WU Meng-Yuan QUAN National Marine Data and Information Service Tianjin 300171China Ocean University of Chin1 Qingdao 266100China University of Michigan‒Shanghai Jiao tong University Joint Institute Shanghai 200030China

The sea level in coastal areas of China reached the second highest in 2021,just after that recorded in *** force and dynamic analyses based on tide gauges,satellite observations,reanalysis data and regional numerical outputs were conducted to understand these abnormally high sea levels and determine their possible *** show that the coastal sea level of China had increased at an annual rate of 3.4±0.3 mm during 1980-2021,with an acceleration of 0.06±0.02 mm per *** superposition of significant oscillations of quasi-2,3-7,quasi-9,quasi-11,quasi-19 and 20-30 years contributed to the anomalously high sea *** negative-phased El Nino/Southern Oscillation was correlated with the anomalously high sea level and the north-south anti-phase pattern of the coastal sea level in ***,phase lags of 1-4 months occurred with the sea-level *** a decadal timescale,the Pacific Decadal Oscillation(PDO)was negatively correlated with the anomalous mean sea level(MSL),and the negative-phased PDO contributed to the anomalous sea-level change in ***,the monthly MSL peaked in April and July,and the contribution of wind stress to the anomalously high sea level was 38.5%in the south of the Taiwan Strait in April and 30%along the coast of China in *** results were consistent with the tide gauge and satellite *** agreement was also observed between the coastal sea-level fingerprint and the air and sea surface temperatures.

关键词： Sealevel La Nina PDO Wind stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Constitutive Behavior of the Interface between UHPC and Steel Plate without Shear Connector:From Experimental to Numerical Study

引用

Computer Modeling in Engineering & Sciences 2024年第8期140卷 1863-1888页

作者： Zihan Wang Boshan Zhang hui Wang Qing Ai Xingchun Huang School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China Department of Bridge Engineering Tongji UniversityShanghai200092China

The application of ultra-high performance concrete(UHPC)as a covering layer for steel bridge decks has gained widespread *** employing a connection without a shear connector between the steel plate and UHPC,namely,the sandblasted interface and the epoxy adhesive with sprinkled basalt aggregate interface,the installation cannot only be simplified but also the stress concentration resulting from the welded shear connectors can be *** study develops constitutive models for these two interfaces without shear connectors,based on the interfacial pull-off and push-out *** validation,three-point bending tests on the steel-UHPC composite plates are *** results indicated that the proposed bilinear traction-separation model for the sandblasted interface and the trapezoidal traction-separation model for the epoxy adhesive with sprinkled basalt aggregate interface can generally calibrate the interfacial ***,the utilization of the experimentally determined pure shear strength underestimates the load-carrying capacity of the composite plates in the case of three-point bending *** recalling the Mohr-Coulomb criterion,this underestimation is attributed to the enhancement of the interface shear strength by the presence of normal stress.

关键词： Cohesive zone model interfacial behavior finite element simulation UHPC steel plate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于多孔介质方法的钠冷快堆冷却剂沸腾现象模拟

引用

强激光与粒子束 2024年第7期36卷 106-114页

作者：惠天宇佟立丽曹学武上海交通大学机械与动力工程学院上海200240

基于两流体六方程模型针对钠的气液两相分别构建守恒方程,采用蒸发冷凝模型表征两相质量交换,分别使用显式和隐式处理方法对蒸发冷凝模型进行计算,同时考虑了Sobolev阻力模型、两相对流换热模型以及相间动量交换等本构关系,开发了适用... 详细信息

基于两流体六方程模型针对钠的气液两相分别构建守恒方程,采用蒸发冷凝模型表征两相质量交换,分别使用显式和隐式处理方法对蒸发冷凝模型进行计算,同时考虑了Sobolev阻力模型、两相对流换热模型以及相间动量交换等本构关系,开发了适用于模拟钠冷快堆冷却剂沸腾的多孔介质分析方法,利用KNS-37失流实验L22工况数据进行了对比验证,并利用L29工况流量数据验证模型的适用性。结果表明,所建立的钠沸腾多孔介质分析方法可以较好地模拟钠冷快堆沸腾现象,预测沸腾发生时间在6.3 s左右,与实验相差0.2 s,温度和流量的总体变化趋势与实验数据吻合较好。

关键词：钠冷快堆钠沸腾多孔介质方法两流体六方程

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：