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Application of Nanogold Probe Coupled with Silver Enhancement in Rapid cTnI Colorimetric Immunoassay

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Chinese Chemical Letters 2005年第12期16卷 1625-1628页

作者： Nong Yue HE hui shi guo Di YANG Chun Rong GU Zhi Ping BIAN Wen hui WAN Ji Nan ZHANG State Key Laboratory of Bioelectronics Southeast University Nanjing 210096 Institute of Cardiovascular Disease First Affiliated Hospital of Nanjing Medical University Nanjing 210029

A rapid, inexpensive, reliable, and flexible quantitative immunoassay for cardiac troponin I （cTnI） based on the concepts of one-step dual monoclonal antibody “sandwich” principle. The low density protein array, the nanogold probe, and the silver enhancement on the gold particle were provided. The whole detection procedure of the assay could be fulfilled within 40 min with the pretreated colloidal gold-labeled detection antibody and supporting substrate. The assay showed good specific response to cTnI with very low cross-reactivity ratio to the skeletal isoforms of troponin I （sTnI）, cardiac troponin T （cTnT）, and myoglobin. 588 serum samples were assayed simultaneously by enzyme-linked immuno sorbent assay （ELISA） and this colloidal gold method to test the validity of the method and the data were analyzed using the statistical package SPSS version 11.0 （SPSS Inc.）. There was no significant difference between these two assays （P=0.66〉0.05）. The agreement between this method （〉 or 〈0.3 ng/mL） and ELISA was 86%.

关键词： Cardiac troponin I protein array nanogold particles silver enhancement rapidquantitative immunoassay

Abrupt onset of type 1 diabetes mellitus during recombinant interferon-alpha 2b therapy in a patient with chronic hepatitis B

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World Journal of Gastroenterology 2008年第29期14卷 4713-4715页

作者： Yuan-Yuan Lv Bing-Yin shi hui guo Department of Endocrinology First Affiliated Hospital Medical School of Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China

We describe a case of a 33-year-old female patient with chronic hepatitis B who developed type 1 diabetes mellitus (DM) after a 13-mo period of treatment with recombinant human interferon-alpha (IFN-α) 2b. The patient presented with polydipsia, polyuria, hypergly-cemia, diabetic ketoacidosis, combined with C-peptide secretion defi ciency and positive islet cell autoantibody (ICAb). IFN-α 2b treatment was terminated and in-stead insulin treatment was initiated. Five months after cessation of the recombinant human IFN-α 2b therapy, the patient remained insulin-dependent. Her serum HBV DNA became negative and serum transaminase returned to the normal level after a 10-mo period of IFN therapy. Type 1 DM induced by IFN-α is relatively rare in patients with chronic hepatitis B. We should pay more attention to patients on IFN-α therapy to avoid destruction of pancreatic beta cells. This is the first case report from China.

关键词： Interferon-alpha Islet cell autoantibody Type 1 diabetes mellitus Autoimmune disease Chronichepatitis B

Design of multifunctional interfaces on ceramic solid electrolytes for high-performance lithium-air batteries

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Green Energy & Environment 2025年第1期10卷 183-192页

作者： Yunxin shi Ziyang guo Changhong Wang Mingze Gao Xiaoting Lin hui Duan Yonggang Wang Xueliang Sun College of Energy Material and Chemistry College of Chemistry and Chemical EngineeringInner Mongolia UniversityHohhot010021China Department of Mechanical and Materials Engineering Western UniversityLondonONN6A 5B9Canada Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New EnergyiChEM(Collaborative Innovation Center of Chemistry for Energy Materials)Fudan UniversityShanghai200433China Eastern Institute for Advanced Study Eastern Institute of TechnologyNingboZhejiang315100China

High-energy-density lithium(Li)–air cells have been considered a promising energy-storage system,but the liquid electrolyte-related safety and side-reaction problems seriously hinder their *** address these above issues,solid-state Li–air batteries have been widely ***,many commonly-used solid electrolytes generally face huge interface impedance inLi–air cells and also showpoor stability towards ambient air/Li ***,we fabricate a differentiating surface-regulated ceramic-based composite electrolyte(DSCCE)by constructing disparately LiI-containing polymethyl methacrylate(PMMA)coating and Poly(vinylidene fluoride-co-hexafluoropropylene)(PVDF-HFP)layer on both sides of Li_(1.5)Al_(0.5)Ge_(1.5)(PO_(4))_(3)(LAGP).The cathode-friendly LiI/PMMA layer displays excellent stability towards superoxide intermediates and also greatly reduces the decomposition voltage of discharge products in Li–air ***,the anode-friendly PVDF-HFP coating shows low-resistance properties towards ***,Li dendrite/passivation derived from liquid electrolyte-induced side reactions and air/I-attacking can be obviously suppressed by the uniformand compact composite *** a result,the DSCCE-based Li–air batteries possess high capacity/low voltage polarization(11,836mAh g^(-1)/1.45Vunder 500mAg^(-1)),good rate performance(capacity ratio under 1000mAg^(-1)/250mAg^(-1) is 68.2%)and longterm stable cell operation(~300 cycles at 750 mA g^(-1) with 750 mAh g^(-1))in ambient air.

关键词： Li-air batteries Li_(1.5)Al_(0.5)Ge_(1.5)(PO_(4))_(3) Polymers Composite electrolyte Ambient air

Study on the off situ reconstruction of the core neutron field based on dual-task hybrid network architecture

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Nuclear Science and Techniques 2025年第1期36卷 175-191页

作者： Pei Cao hui Ding Cheng-Long Cao Zi-hui Yang guo-Min Sun School of Artificial Intelligence and Big Data Hefei UniversityHefei 230001China College of Electronic Engineering National University of Defense TechnologyHefei 230001China Institute of Nuclear Energy Safety Technology HFIPSChinese Academy of SciencesHefei 230027China

The off situ accurate reconstruction of the core neutron field is an important step in realizing real-time reactor *** existing off situ reconstruction method of the neutron field is only applicable to cases wherein a single region changes at a specified location of the ***,when the neutron field changes are complex,the accurate identification of the individual changed regions becomes challenging,which seriously affects the accuracy and stability of the neutron field ***,this study proposed a dual-task hybrid network architecture(DTHNet)for off situ reconstruction of the core neutron field,which trained the outermost assembly reconstruction task and the core reconstruction task jointly such that the former could assist the latter in the reconstruction of the core neutron field under core complex ***,to exploit the characteristics of the ex-core detection signals,this study designed a global-local feature upsampling module that efficiently distributed the ex-core detection signals to each reconstruction unit to improve the accuracy and stability of *** experiments were performed on the simulation datasets of the CLEAR-I reactor to verify the accuracy and stability of the proposed *** results showed that when the location uncertainty of a single region did not exceed nine and the number of multiple changed regions did not exceed ***,the reconstructed ARD was within 2%,RD_(max)was maintained within 17.5%,and the number of RD≥10%was maintained within ***,when the noise interference of the ex-core detection signals was within±2%,although the average number of RD≥10%increased to 16,the average ARD was still within in 2%,and the average RD_(max)was within 22%.Collectively,these results show that,theoretically,the DTHNet can accurately and stably reconstruct most of the neutron field under certain complex core changes.

关键词： Real-time reactor monitoring Core neutron field reconstruction Dual-task hybrid network architecture Global-local feature upsampling module

Unraveling the significance of cobalt on transformation kinetics,crystallography and impact toughness in high-strength steels

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 380-390页

作者： Yishuang Yu Jingxiao Zhao Xuelin Wang hui guo Zhenjia Xie Chengjia Shang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

This work reveals the significant effects of cobalt(Co)on the microstructure and impact toughness of as-quenched highstrength steels by experimental characterizations and thermo-kinetic *** results show that the Co-bearing steel exhibits finer blocks and a lower ductile-brittle transition temperature than the steel without ***,the Co-bearing steel reveals higher transformation rates at the intermediate stage with bainite volume fraction ranging from around 0.1 to *** improved impact toughness of the Co-bearing steel results from the higher dense block boundaries dominated by the V1/V2 variant ***,the addition of Co induces a larger transformation driving force and a lower bainite start temperature(BS),thereby contributing to the refinement of blocks and the increase of the V1/V2 variant *** findings would be instructive for the composition,microstructure design,and property optimization of high-strength steels.

关键词： high-strength steel cobalt transformation kinetics crystallography impact toughness

Oxalate modification enabled advanced phosphate removal of nZVI:In Situ formed surface ternary complex and altered multi-stage adsorption process

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Journal of Environmental Sciences 2025年第3期149卷 79-87页

作者： shiyu Cao Jiangshan Li Yanbiao shi Furong guo Tingjuan Gao Lizhi Zhang Key Laboratory of Pesticide&Chemical Biology of Ministry of Education Institute of Environmental&Applied ChemistryCollege of ChemistryCentral China Normal UniversityWuhan 430079China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China

Nano zero-valent iron(nZVI)is a promising phosphate adsorbent for advanced phosphate ***,the rapid passivation of nZVI and the low activity of adsorption sites seriously limit its phosphate removal performance,accounting for its inapplicability to meet the emission criteria of 0.1 mg P/L *** this study,we report that the oxalate modification can inhibit the passivation of nZVI and alter the multi-stage phosphate adsorption mechanism by changing the adsorption *** expected,the stronger antipassivation ability of oxalate modified nZVI(OX-nZVI)strongly favored its phosphate ***,the oxalate modification endowed the surface Fe(III)sites with the lowest chemisorption energy and the fastest phosphate adsorption ability than the other adsorption sites,by in situ forming a Fe(III)-phosphate-oxalate ternary complex,therefore enabling an advanced phosphate removal *** an initial phosphate concentration of 1.00 mg P/L,pH of 6.0 and a dosage of 0.3 g/L of adsorbents,OX-nZVI exhibited faster phosphate removal rate(0.11 g/mg/min)and lower residual phosphate level(0.02 mg P/L)than nZVI(0.055 g/mg/min and 0.19 mg P/L).This study sheds light on the importance of site manipulation in the development of high-performance adsorbents,and offers a facile surface modification strategy to prepare superior iron-basedmaterials for advanced phosphate removal.

关键词： Oxalate modification Advanced phosphate removal Nano zero-valent iron(nZVI) Surface ternary complex Multi-stage adsorption

Meteorological effects on sources and future projection of nitrogen deposition to lakes in China

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Journal of Environmental Sciences 2025年第5期151卷 100-112页

作者： Cheng shi Hao guo Xue Qiao Jingsi Gao Ying Chen Hongliang Zhang Department of Biological and Ecological Engineering Oregon State UniversityCorvallisOR 97331USA State Key Laboratory of Organic Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China Institute of New Energy and Low-carbon Technology Sichuan UniversityChengdu 610065China Engineering Technology Development Center of Urban Water Recycling Shenzhen PolytechnicShenzhen 518055China Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention Department of Environmental Science and EngineeringFudan UniversityShanghai 200438China IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health Fudan UniversityShanghai 200438China

Lake ecosystems are extremely sensitive to nitrogen growth,which leads to water quality degradation and ecosystem health *** depositions,as one of the main sources of nitrogen in water,are expected to change under future climate change ***,it remains not clear how nitrogen deposition to lakes respond to future meteorological *** this study,a source-oriented version of Community Multiscale Air Quality(CMAQ)Model was used to estimate nitrogen deposition to 263 lakes in 2013 and under three RCP scenarios(4.5,6.0 and 8.5)in *** total deposition of 58.2 Gg nitrogen was predicted for all lakes,with 23.3 Gg N by wet deposition and 34.9 Gg N by dry *** and ammonium in aerosol phase are the major forms of wet deposition,while NH3 and HNO_(3)in gas phase are the major forms of dry *** emissions contribute to 57%of wet deposition and 44%of dry *** future meteorological conditions,wet deposition is predicted to increase by 5.5%to 16.4%,while dry deposition would decrease by 0.3%to 13.0%.Changes in wind speed,temperature,relative humidity(RH),and precipitation rates are correlated with dry and wet deposition *** predicted changes in deposition to lakes driven by meteorological changes can lead to significant changes in aquatic chemistry and ecosystem *** from future emission scenarios,different climate scenarios should be considered in future ecosystem health evaluation in response to nitrogen deposition.

关键词： Deposition Nitrogen Lakes CMAQ Meteorological variations

Transcatheter closure of coronary artery fistula in children

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Chinese Medical Journal 2010年第7期123卷 822-826页

作者： XU Liang XU Zhong-ying JIANG shi-liang ZHENG Hong ZHAO shi-hua LING Jian ZHANG Ge-jun WU Wen-hui LI shi-guo HU Hai-bo Department of Radiology Peking Union Medical College Chinese Academy of Medical Sciences Cardiovascular Institute & Fu Wai Hospital Beijing 100037 China

Background Transcatheter closure of coronary artery fistula （CAF） has emerged as a successful alternative to surgery. We described our experiences in 10 children patients who were accepted for transcatheter closure of CAF. Methods Ten children were 3-10 years old （seven males） with CAF who underwent percutaneous transcatheter closure between October 1995 and April 2008. Sites of origin of these fistulas were： right coronary artery in seven, left anterior descending coronary artery in two, and left circumflex coronary artery in one patient. Drainage sites of these fistulas were： right atrium in seven, right ventricle in two and left ventricle in one patient. All of these fistulas were congenital and had only one orificium *** A Cook coil was used in four patients and an Amplatzer patent ductus arteriosus （PDA） occluder was used in six patients. Checking the angiogram after the procedure revealed complete occlusion in nine patients （90%） and minimal residual flow in one （10%） patient. Technical success was achieved in all patients. Follow-up studies at short term showed complete abolition of shunt in all patients with no evidence of recanalization leading to recurrence of shunt. Conclusions Transcatheter therapy using either Cook coil or Amplatzer PDA occluder is suggested to be a safe and effective method of occlusion. The midterm outcome of the intervention for CAF is satisfactory.

关键词： coronary artery fistula transcatheter occlusion Cook coil Amplatzer patent ductus arteriosus occluder

Artificial intelligence advances drug delivery system and its clinical transition

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Science Bulletin 2025年第3期70卷 305-308页

作者： hui Wang Xiao-Yan You guo-Ping Zhao Master Lab for Innovative Application of Nature Products National Center of Technology Innovation for Synthetic BiologyTianjin Institute of Industrial BiotechnologyChinese Academy of Sciences(CAS)Tianjin 300308China Henan Engineering Research Center of Food Microbiology College of Food and BioengineeringHenan University of Science and TechnologyLuoyang 471023China Haihe Laboratory of Synthetic Biology Tianjin 300308China CAS-Key Laboratory of Synthetic Biology CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Since November 2022,ChatGPT,an artificial intelligence(AI)chatbot,has rapidly captured global attention for its detailed responses and articulated answers across a broad spectrum of knowledge domains[1],[2].All industries will reorient around it,prompting a reevaluation of how this technology could further promote scientifical research and its clinical applications.

关键词： system transition spectrum