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Decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

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Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： hui li Laurent Seugnet Department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina Centre de Recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid

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Super-high bed sintering for iron ores:variation and optimization of bed resistance

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Journal of Iron and Steel Research International 2025年第1期32卷 40-51页

作者： liang-ping Xu lin Xiong hui-bo liu Xi-duan Yang Ai-xiang Mao Pei-dun Chen Guang-hui li School of Minerals Processing and Bioengineering Central South UniversityChangsha410083HunanChina Central Research Institute Baosteel Group Co.Ltd.Shanghai201900China Manufacturing Management Department Guangdong Zhongnan Iron and Steel Co.Ltd.Shaoguan512123GuangdongChina Technology and Development Center Shandong Taishan Iron and Steel Group Co.Ltd.Jinan271100ShandongChina

As the bed depth increases,sintering yield increases,but the productivity *** reveal the reasons for the decrease in productivity and explore targeted solutions,the bed resistance of mixtures,wet zone,and combustion zone was analyzed in the *** results showed that the decreased porosity of mixture resulted in the increased bed resistance by 160.56%when the bed depth increased from 600 to 1000 *** improving porosity of 1%by adding loosening bars with optimized size and distribution,the bed resistance decreased,and the productivity increased by 5%.The increase in bed depth increased the thickness of the wet zone from 120 to 680 mm and the resistance from 1.56 to 8.83 *** using a three-stage intensive mixer and pre-adding water for granulation,the moisture of mixture was reduced by 0.6%,and the sintering productivity increased by 4%.Besides,the high bed resistance is mainly caused by the increase in the thickness of the combustion zone from 31.9 to 132.7 mm,and the bed resistance increased from 0.70 to 5.62 *** bed resistance of the combustion zone at 900 mm was increased by 90.51%compared to 700 *** optimization of the distribution of coke breeze,the thickness of combustion zone at the lower layer decreased from 132.7 to 106.84 mm and permeability improved significantly.

关键词： Super-high bed sintering Bed resistance Permeability Productivity Wet zone Combustion zone

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Modular assembly of Co4-thiacalix[4]arene units and Keggin-type SiW12O40 for visible-light photothermal conversion

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Tungsten 2025年第1期7卷 112-119页

作者： Jia-hui li Qing Zhao Dong-Ao Mao Kun Zhou Bao-Kuan Chen Yan-Feng Bi School of Petrochemical Engineering Liaoning Petrochemical University

The construction of metal-organic coordination clusters（MCCs） using modular secondary building units is an important method for preparing functional *** this study,two new MCCs modularly assembled from Keggin-type {SiW12O40}H4TC4A=p-tert-Butylthiacalix[4]arene(SiW12) units and thiacalixarene-supported Co4-thiacalix[4]arene(Co4-TC4A polynuclear second-building units（PSBUs,H4TC4A=p-tert-Butylthiacalix[4]arene） are *** two MCCs,abbreviated as Co4-SiW12and Co8-SiW12,were structurally characterized by single-crystal X-ray *** Co4-SiW12is a supramolecular structure involving cation-anion interactions between Co4-TC4A PSBUs and ***8-SiW12features "barbell-like" shapes with two Co4-TC4A coordinatively linked to a Keggin-type SiW12unit on opposite via W-O_t-Co *** coordination of Co4-TC4A to SiW12in Co8-SiW12resulted in significantly improved photothermal conversion performances compared with Co4-SiW12and pure SiW12or ***-gap determination and photophysical analysis combined with density functional theory calculations indicated the binding mode between Co4-TC4A PSBUs and SiW12,which considerably influences the way of electron transport and the conversion ability of visible light to heat.

关键词： Modular construction Photothermal conversion Polyoxometalate Thiacalixarene

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The Stereocomplex Crystallites Improve the Stability of Biodegradable Poly(L-lactic acid)/Poly(D-lactic acid) Melt-Blown Nonwovens

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CHINESE JOURNAL OF POLYMER SCIENCE 2025年第2期43卷 368-379页

作者： Yu, Jin-Shuo Huan, Yue-Wei Pan, Hong-Wei liu, Zhi-Gang Zhao, Yan Tan, Zhi-Yong Bian, Jun-Jia Yang, hui-li Zhang, hui-liang Chinese Acad Sci Changchun Inst Appl Chem Key Lab Polymer Ecomat Changchun 130022 Peoples R China Changchun Univ Technol Coll Mat & Engn Engn Res Ctr Synthet Resin & Special Fiber Sch Chem EngnMinist Educ Changchun 130012 Peoples R China Shandong Fufeng Fermentat Co Ltd Linyi 276600 Shandong Peoples R China Jilin COFCO Biochem Co Ltd Natl Engn Res Ctr Corn Deep Proc Changchun 130033 Peoples R China

Poly(lactic acid) (PLA) is a biodegradable and eco-friendly polymer that is increasingly being incorporated into various applications in contemporary society. However, the limited stability of PLA-based products remains a significant challenge for their broader use in various applications. In this study, poly(L-lactic acid)(PLLA)/poly(D-lactic acid) (PDLA) melt-blown nonwovens were prepared by melt spinning. The structure, thermal properties, thermal stability, biodegradability and crystalline morphology of the melt-blown nonwovens were investigated. DSC and WAXD confirmed the formation of stereocomplex (SC) crystallites in the PLLA matrix. The storage modulus (G '), loss modulus (G ''), and complex viscosity (divided by eta*divided by) of the PLLA/PDLA blend increased with an increase in SC crystallite content. The thermal degradation temperatures of PLLA/PDLA melt-blown nonwovens increased with the incorporation of SC crystallites, and the maximum rate of decomposition increased to 385.5 degrees C, thus enhancing the thermal stability. Compared with neat PLLA melt-blown nonwovens, the hydrophobicity of PLLA/PDLA melt-blown nonwovens was improved, and WCA increased to 139.7 degrees. The SC crystallites were more resistant to degradation by proteinase K compared to neat PLLA. However, the degradation rate of PLLA/PDLA melt-blown nonwovens remained at a high level. This work provides an effective strategy to obtain high-performance PLLA melt-blown nonwovens.

关键词： PLLA PDLA Melt-blown nonwovens Stereocomplex crystallites Thermal stability Enzymatic degradation

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Multivariate synergy for heightening ionic HOF robustness and proton conductivity

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Science China Chemistry 2025年

作者： Xiang-Tian Bai li-hui Cao Xu-Yong Chen Jia-Yu Wang Zi-Ye Zhou Shaanxi Key Laboratory of Chemical Additives for Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and Technology

Multicomponent crystalline materials construct more complex and diversified structures with different combinations and modes,which expands the material structure space and application *** this work,we have successfully synthesized two twocomponent ionic hydrogen-bonded organic frameworks （iHOF-32 and iHOF-33） and a three-component iHOF （iHOF-34）.Guanidine hydrochloride which is rich in N and H and has a short chain length strengthens the hydrogen bonding network of iHOF,thereby aiding in the efficient migration of *** rigid architecture of 1,1'-diamino-4,4'-bipyridine diiodide furnishes additional scaffolding for the iHOFs and enhances its robustness under harsh ***-34 accomplishes the combination of the ultra-high proton conductivity of iHOF-32 and the robustness of iHOF-33 by the synergistic interaction among the three components of *** addition,iHOF-34 was fabricated as a composite membrane with a peak proton conductivity of 1.55×10-1S cm-1,which is 3.8 times higher than that of recast Nafion,and has extensive potential in fuel *** self-assembly strategy of multicomponent HOFs opens up new avenues for constructing diverse structures while promising new opportunities for applications in the fields of proton conduction and energy storage.

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论立德树人的成长性原则

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中山大学学报(社会科学版) 2025年第1期65卷 7-9页

作者：李辉中山大学马克思主义学院广州510275

习近平总书记致中山大学建校100周年的贺信中强调,希望中山大学传承红色基因,坚持为党育人、为国育才。立德树人是教育的根本任务和中心环节。立德树人要坚持以学生成长成才为中心,尊重人的成长性。成长是从小到大、从不成熟到成熟的过... 详细信息

习近平总书记致中山大学建校100周年的贺信中强调,希望中山大学传承红色基因,坚持为党育人、为国育才。立德树人是教育的根本任务和中心环节。立德树人要坚持以学生成长成才为中心,尊重人的成长性。成长是从小到大、从不成熟到成熟的过程。重视成长性原则,要把成长与人的本质力量的提升过程统一起来,把握成长的时与势。

关键词：立德树人提升过程人的本质力量中山大学学生成长成才红色基因成长性中心环节

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Dyssynchronous heart failure models in canines:New insights into electrocardiographic,echocardiographic and histological features

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Animal Models and Experimental Medicine 2025年第1期8卷 142-153页

作者： Han Jin Shengwen Yang Hao Huang Sijing Cheng Pengkang He Sixian Weng Min Gu Hongxia Niu Wei Hua Yiran Hu hui li Cardiology Department Peking University First HospitalBeijingChina Department of Heart Center Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Cardiac Arrhythmia Center Fuwai HospitalState Key Laboratory of Cardiovascular DiseaseNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology and Macrovascular Disease Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Ultrasound State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background:We investigated the similarities and differences between two experimental approaches using tachy-pacing technology to induce desynchronized heart failure in ***:A total of eight dogs were included in the experiment,four were tachypaced in right ventricle apex (RVAP) and 4 were paced in right atrium after the ablation of left bundle branch to achieve left bundle branch block (RAP+LBBB).Three weeks of follow-up were conducted to observe the changes in cardiac function and myocardial staining was performed at the end of the ***:Both experimental approaches successfully established heart failure with reduced ejection fraction models,with similar trends in declining cardiac *** RAP+LBBB group exhibited a prolonged overall ventricular activation time, delayed left ventricular activation,and lesser impact on the right *** RVAP approach led to a reduction in overall right ventricular compliance and right ve ntricular *** RAP+LBBB group exhibited significant reductions in left heart compliance (LVGLS,%:RAP+LBBB-12.60±0.12 to-5.93±1.25;RVAP-13.28±0.62to-8.05±0.63, p=0.023;LASct,%:RAP+LBBB-15.75±6.85 to-1.50±1.00;RVAP-15.75±2.87 to-10.05±6.16,p=0.035).Histological examination revealed more pronounced fibrosis in the left ventricular wall and left atrium in the RAP+LBBBgroup while the RVAP group showed more prominent fibrosis in the right ventricular ***:Both approaches establish HFrEF models with comparable *** RVAP group shows impaired right ventricular function,while the RAP+LBBB group exhibits more severe decreased compliance and fibrosis in left ventricle.

关键词： dyssynchrony heart failure tachy-pacing technology

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Rising of natural therapies:Potential and challenges of traditional Chinese medicine in the management of gastrointestinal diseases

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World Journal of Gastroenterology 2025年第9期31卷 1-8页

作者： Xiao-Tong Tian Jiang-Ping Zhan Chang Qiao Jian-li Ge De-hui li Graduate School Hebei University of Chinese MedicineShijiazhuang 050091Hebei ProvinceChina Internal Medicine Chengde Kangyang HospitalChengde 067000Hebei ProvinceChina Department of Peripheral Vascular The First Affiliated Hospital of Hebei University of Chinese Medicine(Hebei Province Hospital of Chinese Medicine)Shijiazhuang 050000Hebei ProvinceChina Department of Oncology II The First Affiliated Hospital of Hebei University of Chinese Medicine(Hebei Province Hospital of Chinese Medicine)Key Laboratory of Integrated Chinese and Western Medicine for Gastroenterology ResearchHebei Industrial Technology Institute for Traditional Chinese Medicine PreparationShijiazhuang 050000Hebei ProvinceChina

In the contemporary medical landscape,the burgeoning interest in natural therapies,particularly for managing gastrointestinal disorders,has brought traditional Chinese medicine(TCM)to the *** article explains the core principles and clinical applications of TCM in treating these conditions,furthering the discourse through an examination of integrated TCM strategies,as demonstrated in the study by Zhou et *** TCM has shown promising clinical outcomes,it encounters significant hurdles in standardization,mechanistic research,and clinical *** investigations should aim to solidify the scientific underpinnings of TCM and expand its use in gastrointestinal disease management,striving for a seamless fusion of traditional and contemporary medical practices.

关键词： Natural therapy Traditional Chinese medicine Gastrointestinal diseases Clinical efficacy Disease management

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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-hui Jiang hui-li Kang Yi Jiang Hua-Wei Zhang Xiao-Mei Song Yu-Ze li Wen-li Huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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列车运行监控装置制动距离计算的优化研究

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铁道标准设计 2025年第1期69卷 185-190页

作者：徐效宁李辉中国铁道科学研究院集团有限公司通信信号研究所北京100081

列车运行监控装置(LKJ)是用于防止列车冒进信号、运行超速事故和辅助司机提高操纵能力的重要行车设备。其中,制动距离计算是LKJ模式控制的基础,直接关系到行车安全和运输效率。对比LKJ不同版本技术规范对于制动距离计算的条文规定,梳理... 详细信息

列车运行监控装置(LKJ)是用于防止列车冒进信号、运行超速事故和辅助司机提高操纵能力的重要行车设备。其中,制动距离计算是LKJ模式控制的基础,直接关系到行车安全和运输效率。对比LKJ不同版本技术规范对于制动距离计算的条文规定,梳理制动距离计算公式及参数的取值依据,分析现行规范下货物列车制动距离过长的原因。通过研究《铁路技术管理规程》《列车牵引计算规程》等相关标准规范及条文说明,对换算摩擦系数、列车换算制动率和制动计算系数等参数进行分析,提出LKJ制动距离计算的优化方案。最后,从制动距离和限速曲线两方面对方案进行仿真计算验证。研究结果表明,该方案有效缩短了LKJ的制动距离,优化了限速曲线,能够提高普速铁路的运输效率。

关键词：列车运行监控装置制动距离换算摩擦系数列车换算制动率制动计算系数

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