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Artificial intelligence in colonoscopy

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World Journal of Gastroenterology 2021年第29期27卷 4802-4817页

作者： Joel Joseph Ella Marie lepage Catherine Phillips Cheney Rishi Pawa Department of Internal Medicine Wake Forest Baptist Medical CenterWinston SalemNC 27157United States Department of Internal Medicine Wake Forest School of MedicineWinston SalemNC 27157United States Department of Internal Medicine Section of Gastroenterology and HepatologyWake Forest Baptist Medical CenterWinston-SalemNC 27157United States

Colorectal cancer remains a leading cause of morbidity and mortality in the United *** in artificial intelligence(AI),specifically computer aided detection and computer-aided diagnosis offer promising methods of increasing adenoma detection rates with the goal of removing more pre-cancerous ***,these methods also may allow for smaller non-cancerous lesions to be diagnosed in vivo and left in place,decreasing the risks that come with unnecessary *** review will provide an overview of current advances in the use of AI in colonoscopy to aid in polyp detection and characterization as well as areas of developing research.

关键词： Colonoscopy Artificial intelligence Computer-aided detection Detection Characterization Computer-aided diagnosis

Deformation induced decoupling between U-Pb and trace elements in titanite revealed through petrochronology and study of localized deformation

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Geoscience Frontiers 2023年第2期14卷 217-240页

作者： Charles Kavanagh-lepage Félix Gervais Kyle Larson Riccardo Graziani Abdelali Moukhsil Département des génies civils géologiques et des minesPolytechnique MontréalMontréal H3T 1J4QuébecCanada Earth and Environmental Sciences IKBSASUniversity of British Columbia Okanagan3247 University WayKelownaBC V1V 1V7Canada Natural Resources Canada Government of Canada601 Booth St.OttawaON K1A 0E8Canada Direction de l’acquisition des connaissances géoscientifiques Ministère de l’Énergie et des Ressources naturelles du Québec57004e Avenue Ouest QuébecQC G1H 6R1QuébecCanada

In this contribution,we analyzed a pair of mafic samples collected from a recently identified shear zone and its proximal footwall from the Manicouagan Imbricate Zone(MIZ)of the central Grenville Province,Québec,*** petrochronology,metamorphic phase equilibria modelling,trace element thermometry,and electron backscattered diffraction data were used to define a Pressure-Temperature-timeDeformation path for the two *** interconnected dislocation network within titanite grains,as outlined with Kerneled Average Misorientation maps,are spatially correlated with variation in the U-Pb system but not with that observed for trace element These results suggest that the U-Pb system was decoupled from trace and rare earth elements and that deformation,rather than interface-coupled dissolution-precipitation reactions or re-crystallisation,was the main driver for this *** addition to highlighting a potential pitfall of titanite petrochronology,our P-T-t-D path reveals that ductile shear zones were active later than previously suggested within the MIZ.

关键词： Titanite petrochronology U-Pb Geochronology Phase equilibria modelling Trace elements Deformation Decoupling

Trends in incidence and management of cancer of the ampulla of vater

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World Journal of Gastroenterology 2014年第29期20卷 10144-10150页

作者： Florian Rostain Samia Hamza Antoine Drouillard Jean Faivre Anne-Marie Bouvier C?me lepage Registre Bourguignon des Cancers Digestifs INSERM U866CHU de DijonFaculté de Médecine21079 Dijon CedexFrance

AIM: To provide trends in incidence, management and survival of cancer of the ampulla of vater in a well-defined French population.

关键词： Cancer of the ampulla of vater Incidence Survival Treatment Epidemiology

Mucosal healing progression after acute colitis in mice

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World Journal of Gastroenterology 2019年第27期25卷 3572-3589页

作者： Sandra vidal-Lletjós Mireille Andriamihaja Anne Blais Marta Grauso Patricia lepage Anne-Marie Davila Claire Gaudichon Marion Leclerc Francois Blachier Annaig Lan UMR PNCA AgroParisTechINRAUniversite Paris-SaclayParis 75005France UMR MICALIS INRAUniversite Paris-SaclayJouy-en-Josas 78350France

BACKGROUND Mucosal healing has become a therapeutic goal to achieve stable remission in patients with inflammatory bowel diseases. To achieve this objective, overlapping actions of complex cellular processes, such as migration, proliferation, and differentiation, are required. These events are longitudinally and tightly controlled by numerous factors including a wide range of distinct regulatory proteins. However, the sequence of events associated with colon mucosal repair after colitis and the evolution of the luminal content characteristics during this process have been little *** To document the evolution of colon mucosal characteristics during mucosal healing using a mouse model with chemically-induced *** C57 BL/6 male mice were given 3.5% dextran sodium sulfate(DSS) in drinking water for 5 d. They were euthanized 2(day 7), 5(day 10), 8(day 13), and 23(day28) d after DSS removal. The colonic luminal environment and epithelial repair processes during the inflammatory flare and colitis resolution were analyzed with reference to a non-DSS treated control group, euthanized at day 0. Epithelial repair events were assessed histo-morphologically in combination with functional permeability tests, expression of key inflammatory and repairing factors, and evaluation of colon mucosa-adherent microbiota composition by 16 S rRNA *** The maximal intensity of colitis was concomitant with maximal alterations of intestinal barrier function and histological damage associated with goblet cell depletion in colon mucosa. It was recorded 2 d after termination of the DSStreatment, followed by a progressive return to values similar to those of control mice. Although signs of colitis were severe(inflammatory cell infiltrate, crypt disarray, increased permeability) and associated with colonic luminal alterations(hyperosmolarity, dysbiosis, decrease in short-chain fatty acid content), epithelial healing processes were launched early during the inflammat

关键词： Colon luminal environment Dextran sodium sulfate-induced colitis Dysbiosis Epithelial repair Acute colitis

very late transcatheter heart valve thrombosis

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World Journal of Cardiology 2017年第2期9卷 196-199页

作者： Etienne L Couture Serge lepage Jean-Bernard Masson Benoit Daneault Division of Cardiology Centre Hospitalier Universitaire de Sherbrooke Division of Cardiology Centre Hospitalier Universitaire de Montréal

We describe a case of very late transcatheter heart valve(THv) thrombosis of a first-generation SAPIEN prosthesis(Edwards Lifesciences, Irvine, CA) implanted in a 64-yearold woman with severe symptomatic aortic stenosis. More than 54 mo after implantation, she presented with severe symptomatic prosthesis dysfunction(stenosis) which was successfully treated with oral anticoagulation. To our knowledge, this is the tardiest case of THv thrombosis ever reported. This case should increase clinical awareness for THv thrombosis even beyond the first two-year period following implantation.

关键词： valve thrombosis Transcathether heart valve Transcatheter aortic valve replacement

Widely tunable 2.3μm III-v-on-silicon vernier lasers for broadband spectroscopic sensing

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Photonics Research 2018年第9期6卷 858-866页

作者： RUIJUN WANG STEPHAN SPRENGEL ANTON vASILIEv GERHARD BOEHM JORIS vAN CAMPENHOUT GuY lepage PETER vERHEYEN ROEL BAETS MARKUS-CHRISTIAN AMANN GUNTHER ROELKENS Photonics Research Group Ghent University-IMECTechnologiepark-Zwijnaarde 15B-9052 GhentBelgium Center for Nano-and Biophotonics(NB-Photonics) Ghent UniversityB-9052 GhentBelgium Walter Schottky Institut Technische Universitat MunchenAm Coulombwall 485748 GarchingGermany IMEC Kapeldreef 75Leuven B-3001Belgium

Heterogeneously integrating III-v materials on silicon photonic integrated circuits has emerged as a promising approach to make advanced laser sources for optical communication and sensing applications. Tunable semiconductor lasers operating in the 2–2.5 μm range are of great interest for industrial and medical applications since many gases(e.g., CO_2, CO, CH_4) and biomolecules(such as blood glucose) have strong absorption features in this wavelength region. The development of integrated tunable laser sources in this wavelength range enables low-cost and miniature spectroscopic sensors. Here we report heterogeneously integrated widely tunable III-v-on-silicon vernier lasers using two silicon microring resonators as the wavelength tuning components. The laser has a wavelength tuning range of more than 40 nm near 2.35 μm. By combining two lasers with different distributed Bragg reflectors, a tuning range of more than 70 nm is achieved. Over the whole tuning range, the side-mode suppression ratio is higher than 35 dB. As a proof-of-principle, this III-v-on-silicon vernier laser is used to measure the absorption lines of CO. The measurement results match very well with the high-resolution transmission molecular absorption(HITRAN) database and indicate that this laser is suitable for broadband spectroscopy.

关键词：硅光子集成电路通讯技术发展现状