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High efficiency second harmonic generation of nanojoule-level femtosecond pulses in the visible based on BiBO

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High Power Laser Science and Engineering 2019年第1期7卷 82-89页

作者： Mario Galletti hugo pires Victor Hariton Celso Paiva Joao Swen Künzel Marco Galimberti Goncalo Figueira GoLP/Instituto de Plasmas e Fusao Nuclear Instituto Superior Técnico Universidade de Lisboa Central Laser Facility Science and Technology Facilities Council Rutherford Appleton Laboratory Harwell Science and Innovation Campus

We demonstrate high efficiency second harmonic generation(SHG) of near infrared femtosecond pulses using a BiB3 O6 crystal in a single-pass tight focusing geometry setup. A frequency doubling efficiency of 63% is achieved, which is,to the best of our knowledge, the highest value ever reported in the femtosecond regime for such low energy(nJ-level)pumping pulses. Theoretical analyses of the pumping scheme focusing waist and the SHG efficiency are performed, by numerically solving the three wave mixing coupled equations in the plane-wave scenario and by running simulations with a commercial full 3 D code. Simulations show a good agreement with the experimental data regarding both the efficiency and the pulse spectral profile. The simulated SHG pulse temporal profile presents the characteristic features of the group velocity mismatch broadening in a ‘thick' crystal.

关键词： nonlinear process second harmonic generation pumping scheme parametric amplification/oscillators high power laser

Thermal lens analysis in a diode-pumped 10 Hz 100 mJ Yb:YAG amplifier

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High Power Laser Science and Engineering 2020年第2期8卷 24-31页

作者： Victor Hariton Celso Paiva Joao hugo pires Mario Galletti Goncalo Figueira GoLP/Instituto de Plasmas e Fusao Nuclear Instituto Superior TécnicoUniversidade de LisboaAv.Rovisco Pais1049-001 LisbonPortugal Central Laser Facility Science and Technology Facilities CouncilRutherford Appleton LaboratoryHarwell Science and Innovation CampusDidcot OX110QXUK

We address the power scaling issue in end-pumped laser rod amplifiers by studying,experimentally and numerically,the magnitude of thermal lensing in a high-energy diode-pumped Yb:YAG *** spatio-temporal temperature profile of the gain medium and the focal length of the induced thermal lens are determined *** influence of the repetition rate and pumping power on the temperature distribution is *** measurements covered repetition rates between 1 and 10 Hz and up to 4 kW pumping power.

关键词： diode-pumped lasers high-energy laser amplifiers thermal effects in lasers ytterbium-doped laser media

Ultrashort pulse capability at the L2I high intensity laser facility

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High Power Laser Science and Engineering 2017年第1期5卷 7-11页

作者： Gonqalo Figueira Joana Alves Joao M.Dias Marta Fajardo Nuno Gomes Victor Hariton Tayyab Imran Celso P.Joao Jayanath Koliyadu Swen Kunzel Nelson C.Lopes hugo pires Filipe Ruao Gareth Williams GoLP/Instituto de Plasmas e Fusao Nuclear lnstituto Superior TecnieoUniversidade de LisboaLisbonPortugal Faculdade de Ciências e Tecnologia Universidade Nova de LisboaCaparicaPortugal Department of Physics&Astronomy College of ScienceKing Saud UniversityRiyadhSaudi Arabia

The Laboratory for Intense Lasers(L2I) is a research centre in optics and lasers dedicated to experimental research in high intensity laser science and technology and laser plasma interaction. Currently the laboratory is undergoing an upgrade with the goal of increasing the versatility of the laser systems available to the users, as well as increasing the pulse repetition rate. In this paper we review the current status of the laser research and development programme of this facility, namely the upgraded capability and the recent progress towards the installation of an ultrashort, diode-pumped OPCPA laser system.

关键词： diode-pumped solid-state laser and applications femtosecond laser and applications frequency conversion laser amplifiers nonlinear optics

A Systematic Review of Computer Vision Techniques for Quality Control in End-of-Line Visual Inspection of Antenna Parts

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Computers, Materials & Continua 2024年第8期80卷 2387-2421页

作者： Zia Ullah Lin Qi E.J.Solteiro pires Arsénio Reis Ricardo Rodrigues Nunes School of Electrical and Information Engineering Zhengzhou UniversityZhengzhou450001China School of Science and Technology Universidade de Trás-os-Montes e Alto DouroVila Real5000-801Portugal

The rapid evolution of wireless communication technologies has underscored the critical role of antennas in ensuring seamless *** defects,ranging from manufacturing imperfections to environmental wear,pose significant challenges to the reliability and performance of communication *** review paper navigates the landscape of antenna defect detection,emphasizing the need for a nuanced understanding of various defect types and the associated challenges in visual *** review paper serves as a valuable resource for researchers,engineers,and practitioners engaged in the design and maintenance of communication *** insights presented here pave the way for enhanced reliability in antenna systems through targeted defect detection *** this study,a comprehensive literature analysis on computer vision algorithms that are employed in end-of-line visual inspection of antenna parts is *** PRISMA principles will be followed throughout the review,and its goals are to provide a summary of recent research,identify relevant computer vision techniques,and evaluate how effective these techniques are in discovering defects during *** contains articles from scholarly journals as well as papers presented at conferences up until June *** research utilized search phrases that were relevant,and papers were chosen based on whether or not they met certain inclusion and exclusion *** this study,several different computer vision approaches,such as feature extraction and defect classification,are broken down and ***,their applicability and performance are *** review highlights the significance of utilizing a wide variety of datasets and measurement *** findings of this study add to the existing body of knowledge and point researchers in the direction of promising new areas of investigation,such as real-time inspection systems and multispectral *** review,on its whole,of

关键词： Computer vision end-of-line visual inspection of antenna parts machine learning algorithms image processing techniques deep learning models

The occurrence,inheritance,and segregation of complex genomic structural variation in synthetic Brassica napus

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The Crop Journal 2024年第2期12卷 515-528页

作者： Dandan Hu Jin Lu Wenwen Li Yinghui Yang Junxiong Xu Han Qin Hao Wang Yan Niu Huaiqi Zhang Qingqing Liu Xiangxiang He Annaliese S.Mason JChris pires Zhiyong Xiong Jun Zou National Key Laboratory of Crop Genetic Improvement College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070HubeiChina College of Agronomy Henan Agricultural UniversityZhengzhou 450002HenanChina Key Laboratory of Herbage and Endemic Crop Biotechnology Inner Mongolia UniversityHohhot 010070Inner MongoliaChina Plant Breeding Department University of BonnBonn 53115Germany Department of Soil and Crop Sciences Colorado State UniversityFort CollinsCO 80523USA

"Synthetic"allopolyploids recreated by interspecific hybridization play an important role in providing novel genomic variation for crop *** synthetic allopolyploids often undergo rapid genomic structural variation(SV).However,how such SV arises,is inherited and fixed,and how it affects important traits,has rarely been comprehensively and quantitively studied in advanced generation synthetic lines.A better understanding of these processes will aid breeders in knowing how to best utilize synthetic allopolyploids in breeding ***,we analyzed three genetic mapping populations(735 DH lines)derived from crosses between advanced synthetic and conventional Brassica napus(rapeseed)lines,using whole-genome sequencing to determine genome *** observed high tolerance of large structural variants,particularly toward the telomeres,and preferential selection for balanced homoeologous exchanges(duplication/deletion events between the A and C genomes resulting in retention of gene/chromosome dosage between homoeologous chromosome pairs),including stable events involving whole chromosomes("pseudoeuploidy").Given the experimental design(all three populations shared a common parent),we were able to observe that parental SV was regularly inherited,showed genetic hitchhiking effects on segregation,and was one of the major factors inducing adjacent novel and larger ***,novel SV occurred at low frequencies with no significant impacts on observed fertility and yield-related traits in the advanced generation synthetic ***,incorporating genome-wide SV in linkage mapping explained significantly more genetic variance for *** results provide a framework for detecting and understanding the occurrence and inheritance of genomic SV in breeding programs,and support the use of synthetic parents as an important source of novel trait variation.

关键词： Allopolyploid Large Genome structural variation Linkage mapping Synthetic polyploids Inheritance and segregation

山药多糖对地塞米松诱导IR-3T3-L1脂肪细胞的降血糖作用及机制研究

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中国比较医学杂志 2024年第4期34卷 73-83页

作者：刘昕玥王凤忠郑涵文 Alberto Carlos pires Dias 范蓓王琼中国农业科学院农产品加工研究所/农业农村部农产品加工质量安全风险评估实验室/农业农村部农产品质量安全收贮运管控重点实验室北京100193 西南医科大学附属中医医院中葡中医药国际合作中心四川泸州646000 葡萄牙米尼奥大学生物系中葡药食植物资源研究中心葡萄牙布拉加4710-057

目的探究山药多糖(Chinese yam polysaccharide,CYPS)在地塞米松(dexamethasone,DEX)诱导的3T3-L1胰岛素抵抗(IR-3T3-L1)细胞模型中的降血糖作用。方法将IR-3T3-L1脂肪细胞随机分为对照组(Con)、DEX组(DEX)、Met组(Met,阳性药组)、CYPS组(0.05、0.15、0.45 mg/mL),通过DEX(1μmol/L)诱导建立IR-3T3-L1细胞模型,进行给药后细胞对葡萄糖的消耗量和细胞中血脂(总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C))与丙二醛(malondialdehyde,MDA)和谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)、己糖激酶(hexokinase,HK)、丙酮酸激酶(pyruvate kinase,PK)含量的检测,并采用qRT-PCR对AMPK-PI3K/Akt信号通路中相关基因表达进行检测。结果DEX组与Con组相比,1μmol/L DEX处理48 h显著降低了IR-3T3-L1细胞的葡萄糖消耗量(P<0.01),且在60 h内维持稳定。0.05、0.15、0.45 mg/mL CYPS处理IR-3T3-L1细胞显著增加了细胞中葡萄糖的消耗(P<0.01)、HK、PK、GSH-Px酶活性(P<0.01)、HDL-C含量(P<0.01);降低了MDA酶活性(P<0.01)、T-CHO、TG、LDL-C含量(P<0.01)。同时,CYPS可以显著回调PI3K、Akt、GLUT-4、AMPK、IRS-2、PPARa、Adiponectin的mRNA水平(P<0.05),降低IRS-1、GSK-3β、ACC、FAS的mRNA表达水平(P<0.01)。结论CYPS能够改善DEX诱导的IR-3T3-L1细胞对葡萄糖的消耗,调节脂代谢紊乱,缓解氧化应激,其作用机制可能通过调控IR-3T3-L1脂肪细胞的AMPK-PI3K/Akt信号通路来实现糖脂代谢紊乱和胰岛素抵抗调节来实现。

关键词：山药多糖胰岛素抵抗地塞米松 3T3-L1细胞二甲双胍 AMPK-PI3K/Akt信号通路

The Use of Insulin Negatively Impacts the Mortality of Severe COVID-19 in Patients with Type 2 Diabetes—A Systematic Review

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Journal of Diabetes Mellitus 2024年第3期14卷 166-176页

作者： Caio F. Biolcatti Marcela R. Simoes Thais P. Prado Milena Monfort-pires Licio A. Velloso Obesity and Comorbidities Research Center Campinas Brazil Turku PET Centre University of Turku Turku Finland National Institute of Science and Technology on Neuroimmunomodulation Campinas Brazil

Obesity and type 2 diabetes are among the most important risk factors for severe coronavirus disease-19. Some studies have suggested that the use of insulin as a therapeutic agent to treat hyperglycemia and the metabolic abnormalities associated with type 2 diabetes during the acute phase of severe coronavirus disease-19 could have a negative impact on the disease’s progression;however, there is no consensus on this issue. Here, we performed a systematic review in an attempt to answer this important question. We included 29 articles published from December 2019 to August 2023, which reported the outcomes of 3,070,657 patients with severe coronavirus disease-19 that had the diagnosis of diabetes and were treated with either insulin or other glucose-reducing agents. The results show that using insulin as a pharmacological intervention to treat type 2 diabetes in patients with severe coronavirus disease-19 increases the likelihood of mortality by 193%.

关键词： SARS-CoV2 Obesity Inflammation Metabolism Glucose

黄花菜醇提物对斑马鱼抑郁样行为的改善作用研究

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中国比较医学杂志 2024年第4期34卷 20-27页

作者：郑涵文王梓航刘昕玥于佳玮 Alberto Carlos pires Dias 王凤忠王琼西南医科大学附属中医医院中葡中医药国际合作中心四川泸州646000 中国农业科学院农产品加工研究所北京100193 中国农业大学食品科学与营养工程学院北京100083 葡萄牙米尼奥大学生物系中葡药食植物资源研究中心葡萄牙布拉加4710-057

目的探究黄花菜醇提物(Hemerocallis citrina Baroni,HCE)在利血平(reserpine)诱导的斑马鱼幼鱼(Danio rerio)模型中对抑郁行为的改善作用。方法将斑马鱼幼鱼分为对照(Con)组、利血平组、氟西汀组、黄花菜低剂量组(1.5 mg/L)、黄花菜... 详细信息

目的探究黄花菜醇提物(Hemerocallis citrina Baroni,HCE)在利血平(reserpine)诱导的斑马鱼幼鱼(Danio rerio)模型中对抑郁行为的改善作用。方法将斑马鱼幼鱼分为对照(Con)组、利血平组、氟西汀组、黄花菜低剂量组(1.5 mg/L)、黄花菜中剂量组(3 mg/L)、黄花菜高剂量组(4.5 mg/L)。采用斑马鱼声音刺激和光刺激进行抑郁样行为学分析。利用RT-qPCR研究黄花菜醇提物对抑郁症有关的星状胶质细胞标志物及其衍生物基因(GFAP、C3、C4B、EMP-1和S100α-10)以及神经营养因子(BDNF)及其自身受体转录基因(P75、TrkB)的调节功能。结果与对照组相比,模型组在440 Hz声音刺激与8000 Lux光照刺激下运动距离缩短、运动时间减少(P<0.05,P<0.001,P<0.0001),呈现运动的不敏感性。而经过黄花菜醇提物给药后的斑马鱼幼鱼对于光与声音的刺激敏感度相较于模型组有明显升高(P<0.05,P<0.0001)。与对照组相比,利血平组斑马鱼脑中的星形胶质细胞标志物基因表达上调(P<0.0001),而各给药组相较于利血平组,星形胶质细胞标志物表达显著下调(P<0.0001),神经营养因子及其受体基因表达与对照组相比,模型组斑马鱼脑中的BDNF、P75、TrkB下调(P<0.0001),而黄花菜醇提物给药组相较于模型组BDNF、P75、TrkB表达显著上调(P<0.01,P<0.0001)。表明黄花菜醇提物抑制了星形胶质细胞激活诱发的炎症表现,同时促进了神经营养因子及其受体基因的生成,对抑郁起到了改善作用。结论黄花菜醇提物可以改善利血平诱导的斑马鱼幼鱼的抑郁样行为变化,斑马鱼脑中星形胶质细胞标志物的表达量减少,同时促进神经营养因子及其受体基因的生成,起到抗抑郁作用。

关键词：黄花菜抑郁症利血平斑马鱼

基于网络药理学和实验验证探究酸枣仁复方治疗抑郁症的作用机制

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中国实验动物学报 2024年第7期32卷 901-912页

作者：郑涵文刘昕玥赵海燕王佳音罗福龙范蓓 Alberto Carlos pires Dias 王凤忠王琼中国农业科学院农产品加工研究所北京100193 西南医科大学附属中医医院中葡中医药国际合作中心四川泸州646000 西南医科大学附属中医医院脾胃病科四川泸州646000 首都医科大学宣武医院急诊科北京100053 葡萄牙米尼奥大学生物系中葡药食植物资源研究中心葡萄牙布拉加4710-057

目的通过网络药理学技术预测酸枣仁复方(Ziziphi spinosae semen formula, ZSSF)对于抑郁症的关键作用靶点,并通过利血平诱导的抑郁斑马鱼模型验证酸枣仁复方治疗抑郁症的作用机制。方法通过TCMSP数据库检索酸枣仁复方的药物作用靶点... 详细信息

目的通过网络药理学技术预测酸枣仁复方(Ziziphi spinosae semen formula, ZSSF)对于抑郁症的关键作用靶点,并通过利血平诱导的抑郁斑马鱼模型验证酸枣仁复方治疗抑郁症的作用机制。方法通过TCMSP数据库检索酸枣仁复方的药物作用靶点,利用UniProt数据库对靶点名称进行校正。采用GeneCards、OMIM、NCBI数据库检索抑郁症相关靶点,并对3个数据库的靶点结果进行汇总去比重。利用STRING数据库预测了交集靶点的蛋白质-蛋白质相互作用(protein-protein interaction, PPI)信息,利用Metascape数据库构建进行富集研究,并利用微生信对KEGG和GO的富集结果实现了可视化。通过利血平诱导的斑马鱼抑郁模型进行行为学实验和RT-qPCR实验,验证酸枣仁复方对抑郁症的治疗作用。结果筛选出抑郁症与酸枣仁复方的交集靶点188个,蛋白质-蛋白质相互作用结果显示,酸枣仁复方抗抑郁主要作用于肿瘤坏死因子-α(TNF-α)、血清白细胞介素2(IL-2)、血清白细胞介素6(IL-6)、血清白细胞介素1β(IL-1β)、血清白细胞介素10(IL-10)等靶点,KEGG通路富集分析表明,酸枣仁复方通过TNF信号通路、PI3K-Akt信号通路、cGMP-PKG信号通路等多种信号通路发挥其治疗抑郁症的作用。动物实验结果显示,与利血平组相比,酸枣仁复方高、中、低剂量组斑马鱼在声光刺激下的运动距离显著延长(P<0.05),运动速度显著增快(P<0.01)。RT-qPCR结果显示,与利血平组相比,酸枣仁复方高、中、低剂量给药组斑马鱼脑组织中TNF-α、IL-2、IL-6、IL-1β、IL-10 mRNA表达水平上调(P<0.001)。结论酸枣仁复方通过多成分、多靶点发挥抗抑郁作用,且其抗抑郁作用可能与抑制炎症因子的表达有关。

关键词：网络药理学酸枣仁复方抑郁症炎症因子