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The Expression of miRNAs in Sudanese Patients with Systemic Lupus Erythematosus in Khartoum State

Open Journal of Rheumatology and Autoimmune Diseases 2022年第4期12卷 128-136页

作者： Sarah Mohammed Dafalla Ahmed Elhadi Elsadig Tarig A. M. Hamid huda mohamed haroun Sana Eltahir Abdalla Department of Haematology Medical Laboratory Sciences Program Alyarmouk College Khartoum Sudan Department of Haematology Faculty of Medical Laboratory Sciences Alzaiem Al Azhari University Khartoum Sudan Department of Haematology and Immunohematology Sharq El Nile College Khartoum North Sudan Department of Haematology Faculty of Medical Laboratory Sciences University of Gezira Madani Sudan Department of Pathology Faculty of Medicine Al Neelain University Khartoum Sudan

Background: MicroRNAs (miRs) are noncoding gene regulators that may have a role as diagnostic or prognostic biomarkers in systemic lupus erythematosus (SLE). Aim: To measure the blood levels of miR-146a, miR-126 and miR-30a in Sudanese SLE patients and to investigate their potential role in disease pathogenesis and utility as biomarkers for SLE. Material and Methods: A total of 48 SLE patients and 20 matched healthy individuals were enrolled in this study. SLE disease activity index (SLEDAI) was assessed. The blood levels of miR-146a, miR-126 and miR-30a were determined by Real-time polymerase chain reaction (PCR) in all participants. Γ-INF and IL-2 were analyzed by ELISA, and CD markers were used in flow cytometry. Results: The mean age of the patients was 31.5 ± 8.5 years with disease duration > 5 years. In SLE patients, the mean blood level fold changes of miR-146a (0.33 ± 0.277;P 0.305) compared to controls. Down regulation of miR-146a increase expression of γ-INF (P 0.05) as no differences between the SLE patients and healthy control. Conclusion: Circulating miR-146a and miR-126 could be a potential noninvasive biomarker in SLE. This study provides an overview of the current state of research on the role of miRNAs in the immune pathogenesis and regulation of SLE. Further studies are needed in miRNAs profiling expressions of SLE diseases.

关键词： Systemic Lupus Erythematosus (SLE) MicroRNAs

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Assessment of plant diversity of endemic species of the Saharo-Arabian region in Egypt

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Journal of Arid Land 2024年第7期16卷 1000-1021,I0002-I0044页

作者： Asmaa S ABO HATAB Yassin M AL-SODANY Kamal H SHALTOUT Soliman A haroun mohamed M EL-KHALAFY Botany and Microbiology Department Faculty of ScienceKafrelsheikh UniversityKafrelsheikh 33511Egypt Botany Department Faculty of ScienceTanta UniversityTanta 31527Egypt

Savanna, semi-deserts, and hot deserts characterize the Saharo-Arabian region, which includes Morocco, Mauretania, Algeria, Tunisia, Libya, Egypt, Palestine, Kuwait, Saudi Arabia, Qatar, Bahrain, the United Arab Emirates, Oman, Yemen, southern Jordan, Syria, Iraq, Iran, Afghanistan, Pakistan, and northern India. Its neighboring regions, the Sudano-Zambezian region belonging to the Paleotropical Kingdom and the Mediterranean and Irano-Turanian regions included in the Holarctic Kingdom, share a large portion of their flora with the Saharo-Arabian region. Despite the widespread acknowledgment of the region's global importance for plant diversity, an up to date list of the Saharo-Arabian endemics is still unavailable. The available data are frequently insufficient or out of date at both the whole global and the national scales. Therefore, the present study aims at screening and verifying the Saharo-Arabian endemic plants and determining the phytogeographical distribution of these taxa in the Egyptian flora. Hence, a preliminary list of 429 Saharo-Arabian endemic plants in Egypt was compiled from the available literature. Indeed, by excluding the species that were recorded in any countries or regions outside the Saharo-Arabian region based on different literature, database reviews, and websites, the present study has reduced this number to 126 taxa belonging to 87 genera and 37 families. Regarding the national geographic distribution, South Sinai is the richest region with 83 endemic species compared with other eight phytogeographic regions in Egypt, followed by the Isthmic Desert(the middle of Sinai Peninsula, 53 taxa). Sahara regional subzone(SS1) distributes all the 126 endemic species, Arabian regional subzone(SS2) owns 79 taxa, and Nubo-Sindian subzone(SS3) distributes only 14 endemics. Seven groups were recognized at the fourth level of classification as a result of the application of the two-way indicator species analysis(TWINSPAN) to the Saharo-Arabian endemic sp

关键词： endemism phytogeographical regions Saharo-Arabian floristic region Egyptian flora plant diversity two-way indicator species analysis(TWINSPAN)

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Exploring groundwater quality in semi-arid areas of Algeria:Impacts on potable water supply and agricultural sustainability

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Journal of Arid Land 2024年第2期16卷 147-167页

作者： Noua ALLAOUA Hinda HAFID haroun CHENCHOUNI Laboratory of Natural Resources and Management of Sensitive Environments Larbi Ben M'hidi UniversityOum-El-Bouaghi 04000Algeria Department of Nature and Life Sciences Faculty of Exact Sciences and Nature and Life SciencesLarbi Ben M'hidi UniversityOum-El-Bouaghi 04000Algeria Laboratory of Algerian Forests and Climate Change Higher National School of ForestsKhenchela 40000Algeria

Groundwater quality assessment is important to assure safe and durable water *** semi-arid areas of Algeria,groundwater represents the main water resource for drinking water supply of the rural population as well as for irrigation of agricultural *** samples from wells and springs were collected from the Gargaat Tarf and Annk Djemel sub-watersheds of the Oum El Bouaghi,Algeria,and were analyzed and compared with the World Health Organization(WHO)*** showed that most of the measured physical and chemical parameters exceeded the quality limits according to the WHO *** had a slightly alkaline water pH(7.00-7.79),electrical conductivity>1500μS/cm,chloride>500 mg/L,calcium>250 mg/L,and magnesium>155 mg/*** quality index(WQI)results showed that 68%of the area had excellent water quality,24%of the samples fell into good category,and only 8%were of poor quality and unsuitable for human *** wells in the area showed bacterial *** coliforms(453.9(±180.3)CFU(colony-forming units)/100 mL),fecal coliforms(243.2(±99.2)CFU/100 mL),and fecal streptococci(77.9(±32.0)CFU/100 mL)loads were above the standard limits set by the *** results confirmed that water resources in the study area were strongly influenced by anthropogenic activities and were not recommended for consumption as drinking water.

关键词： bacteriological indicator groundwater watershed physical-chemical parameter water quality index

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Upper Tract Treatment of Urogenital Fistulas at the National Fistula Treatment Center (CNTF)

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Open Journal of Urology 2024年第1期14卷 11-19页

作者： Mahamat Ali Mahamat Vadandi Valentin Aché haroun Saleh Nedjim Abderassoul Abdraman Gadam Kimassoum Rimtebaye Faculty of Health Sciences University of N’Djamena N’Djamena Chad Faculty of Health Sciences University of Adam Barka Abeche Chad University Hospital of National Reference N’Djamena Chad

Introduction: Urogenital fistula is the existence of an abnormal pathway between a urinary organ and a genital organ. It is a public health problem because of its frequency and social aspect. The aim of this study was to analyse the management of urogenital fistulas by the upper route at the National Fistula Treatment Centre in N’Djamena. Material and Methods: This was a 10-year retrospective descriptive and analytical study from May 2011 to April 2021. The records of all patients who had received fistula treatment during this period were identified and analysed. Results: During the study period 2369 patients were managed for cure of urogenital fistula including 84 by the upper route, i.e. 3.5%. The mean age was 28.5 ± 8.13 years. Loss of urine was the most common reason for consultation (71.4%). Primigravida were represented in 50% (n = 42). The average gestational age was 3.2 ± 2.8 with extremes of 0 to 9 pregnancies. Obstetric aetiology was the most common (92.8%). Ureterovaginal fistulas were the most common anatomoclinical type (36.9%). Uretero-vesical reimplantation was the main surgical procedure (41.7%). Late postoperative follow-up was successful in 85.7% of cases. Conclusion: Urogenital fistulas are common in our practice. The only way to combat this scourge is through prevention through information, education and communication.

关键词： Urogenital Fistula Upper Tract CNTF N’Djamena Chad

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Application of the N + 2 Transversal Network Method to the Study of a Coupled Resonator Filter

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Open Journal of Applied Sciences 2024年第6期14卷 1412-1424页

作者： Charmolavy Goslavy Lionel Nkouka Moukengue Conrad Onésime Oboulhas Tsahat haroun Abba Labane Barol Mafouna Kiminou Achille Makouka Electrical and Electronic Engineering Laboratory ENSP Marien Ngouabi University Brazzaville Congo Electrical Engineering Research Laboratory Polytechnic University of Mongo Mongo Tchad

This paper presents a new approach to synthesize admittance function polynomials and coupling matrices for coupled resonator filters. The N + 2 transversal network method is applied to study a coupled resonator filter. This method allowed us to determine the polynomials of the reflection and transmission coefficients. A study is made for a 4 poles filter with 2 transmission zeros between the N + 2 transversal network method and the one found in the literature. A MATLAB code was designed for the numerical simulation of these coefficients for the 6, 8, and 10 pole filter with 4 transmission zeros.

关键词： Resonator Filter Coupling Matrix Transmission Zero Transversal Network Method

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Dunbar Syndrome and Hypoxic Hepatitis: An Unusual Presentation

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Open Journal of Gastroenterology 2024年第6期14卷 226-232页

作者： Hajar Cherkaoui Ismail Chaouech Yousra El Abidi haroun Robleh Asmae Lamine Maria Lahlali Nada Lahmidani Amine Mekkaoui Mounia Elyousfi Dafr Allah Benajah Adil Ibrahimi Mohammed El Abkari Nizar Bouardi Mohammed Maaroufi Hakima Abid Department of Gastroenterology University Hospital Hassan II Fez Morocco Faculty of Medicine and Pharmacy Fez Morocco Department of Radiology University Hospital Hassan II Fez Morocco

Hypoxic hepatitis, also known as ischemic hepatitis, is characterized by acute hepatocellular injury due to inadequate oxygen delivery to the liver. Celiac trunk stenosis can lead to hepatic ischemia and subsequent liver damage. We present the case of an 81-year-old patient with a history of hypertension, ischemic heart disease, hypothyroidism, and biliary lithiasis, who developed hypoxic hepatitis secondary to Dunbar syndrome and a stenosis of the superior mesenteric artery. The patient improved symptoms and liver function tests with conservative management, including intravenous fluids and supportive care. Long-term management involved continued antiplatelet therapy and statins, with consideration of further interventions for celiac trunk stenosis. This case underscores the importance of recognizing Dunbar syndrome as well as superior mesentery trunk stenosis as a potential cause of hypoxic hepatitis. It highlights the need for multidisciplinary management in such cases.

关键词： Dunbar Syndrome Hypoxic Hepatitis Stenosis of Mesentery Artery

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Do aeolian deposits and sand encroachment intensity shape patterns of vegetation diversity and plant functional traits in desert pavements?

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Journal of Arid Land 2023年第6期15卷 667-694页

作者： M'hammed BOUALLALA Souad NEFFAR Lyès BRADAI haroun CHENCHOUNI Laboratory of Saharan Natural Resources Faculty of Sciences and TechnologyUniversity of Ahmed DraiaAdrar 01000Algeria Department of Nature and Life Sciences Faculty of Exact Sciences and Nature and Life SciencesUniversity of TebessaTebessa 12002Algeria Laboratory Water and Environment University of TebessaTebessa 12002Algeria Laboratory of Saharan Bioresources Preservation and Valorization Faculty of Nature and Life SciencesUniversity of Kasdi MerbahOuargla 30000Algeria Department of Forest Management Higher National School of ForestsKhenchela 40000Algeria Laboratory of Natural Resources and Management of Sensitive Environments University of Oum-El-BouaghiOum-El-Bouaghi 04000Algeria

The effects of sand encroachment on composition,diversity,and functional patterns of vegetation in drylands are rarely studied,and yet addressing these aspects is important to deepen our understanding of the biodiversity *** study aimed to investigate the effect of sand encroachment on plant functional biodiversity of desert pavements(gravel deserts)in the Sahara Desert of *** were sampled and analyzed in three desert pavements with different levels of sand encroachment(LSE)and quantity of aeolian deposits(low,LLSE;medium,MLSE;and high,HLSE).Within the sample-plot area(100 m^(2)),density of every plant species was identified and total vegetation cover was *** taxonomic and functional diversity were analyzed and compared between *** showed that 19 plant species in desert pavements were classified into 18 genera and 13 *** and Poaceae were the most important *** species Anabasis articulata(Forssk)*** LLSE desert pavements with 11 species,whereas Thymelaea microphylla Coss.&Durieu ex *** Calobota saharae(C&D)Boatwr.&van Wyk were dominant species of desert pavements with MLSE(14 species)and HLSE(10 species),*** highest values of species richness and biodiversity were recorded in desert pavements with MLSE,while low values of these ecological parameters were obtained in desert pavements with *** pavements with LLSE were characterized with the highest values of species *** communities were dominated by chamaephytes,anemochorous,arido-active,and competitive stress-tolerant *** increase in LSE along the gradient from LLSE to HLSE induced significant changes in plant community variables including decreases in plant density,plant rarity,lifeform composition,morphological type,and aridity *** pavements with HLSE favor the degradation of vegetation and trigger biodiversity erosion.

关键词： desert pavements hot and arid rangeland plant diversity land degradation sand encroachment plant functional trait Sahara Desert

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Dietary effects of A zolla pinnata combined with exogenous digestive enzyme(Digestin^(TM)) on growth and nutrients utilization of freshwater prawn, Macrobrachium rosenbergii(de Man 1879)

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Journal of Oceanology and Limnology 2018年第4期36卷 1434-1441页

作者： GODA Ashraf SAAD Amal HANAFY mohamed SHARAWY Zaki EL-haroun Ehab Aquaculture Division National Institute of Oceanography and Fisheries (NIOF) Institute of Oceanology Chinese Academy of Sciences Division of Aquaculture College of Agriculture Food Science and Sustainable Systems Kentucky State University

The present study was conducted to evaluate the effect of either individual or combined wheat bran(WB) replacement with Azolla pinnata supplemented with Digestin^(TM) in the diet of freshwater prawn, Macrobrachium rosenbergii Postlarvae(PL) on growth performance, nutrient utilization, chemical body composition and survival(%). Experimental diets were a wheat bran-soybean based diet with no Azolla and Digestin^(TM)(control, T_1), and diets containing 17% Azolla supplemented with Digestin^(TM) 0%(T_2), 1%(T_3), 2%(T_4) and 3%(T 5). Each experimental diet was allocated into three tanks(6 m^3/tank) fed for 12 wks. Each tank was subdivided into three equal pens by nets(2 m^3) and stoked with 84 PL/m^2. The experimental diets were readily consumed by prawns PLs where both high growth and good feed efficiency were achieved for all diets. The results showed that the diets containing A. pinnata supplemented with Digestin? at the level up to 3% have the higher growth and better nutrient utilization than the control diet. No differences were observed for moisture and protein content among the experimental diets. However, the highest protein content was observed on prawns fed on diets T_1 and T 5 respectively, while the lowest value was recorded for T_4 diet. The results also show that prawn PLs fed the diets contain A. pinnata and supplemented with Digestin^(TM) recorded the highest values of body lipid content compared to the control diet. Feed efficiency and economic conversion rate(ECR) values show that economic performance and the cost-effectiveness of the A. pinnata supplemented with up to 3% Digestin^(TM) recorded the highest net return, and therefore it is recommended for prawn, M. rosenbergii PL's. These results are clearly indicating that A. pinnata have a good potential for use in prawn diets at reasonable levels than other conventional diets.

关键词：淡水虾营养学营养价值饲养方法

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Electroconductive Composites Containing Nanocellulose,Nanopolypyrrole,and Silver Nanoparticles

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Journal of Renewable Materials 2019年第2期7卷 193-203页

作者： Samir Kamel Ahmed A.haroun Amany M.EI-Nahrawy mohamed A.Diab Cellulose and Paper Department National Research Centre33 El Bohouth st.Dokki GizaP.O.12622Egypt Industrial Research Division National Research Centre33 El Bohouth st.Dokki GizaP.O.12622Egypt Solid State physics Department Physics Research DivisionNational Research Centre33 El Bohouth st.Dokki GizaP.O.12622Egypt

In this work,conducting composites of nanocellulose(NC)/polypyrrole nanoparticles(NPPy)and silver nanoparticles(AgNPs),i.e.,NC/NPPyAg,were synthesized for the first time,to the best of our knowledge,via in situ emulsion polymerization of pyrrole in the presence of surfactant *** AgNPs acted as an oxidizing agent to simultaneously incorporate nanoparticles into the prepared *** structures and morphologies of the prepared composites were studied using Fourier transform infrared(FTIR)spectroscopy,X-ray diffraction(XRD),UV-Vis Spectra,thermogravimetric analysis(TGA),and scanning and transmission electron microscopy(SEM and TEM)***,the prepared composites were characterized by their conductivities,and the dielectric constants(e΄),dielectric losses(e˝),and AC conductivities were studied for the prepared composites with an increasing NPPy content as a function of the frequency.

关键词： Nanocellulose nanopolypyrrole emulsion polymerization silver nanoparticles conductive nanocomposites

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Are diurnal time-budgets and activity patterns density-dependent in the Shelduck (Tadorna tadorna) wintering in Algeria? An analysis across multiple temporal scales

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Avian Research 2019年第2期10卷 171-185页

作者： Djamel Bensizerara haroun Chenchouni Department of Biology Faculty of Nature and Life SciencesUniversity of Abbes Laghrour40000 KhenchelaAlgeria Department of Natural and Life Sciences Faculty of Exact Sciences and Natural and Life SciencesUniversity of Tebessa12002 TebessaAlgeria Laboratory of Natural Resources and Management of Sensitive Environments 'RNAMS’ University of Oum-El-Bouaghi04000 Oum-El-BouaghiAlgeria

Background: The Shelduck (Tadorna tadorna) is a characteristic waterbird species of inland wetlands in northeastern Algeria. Its wintering behavior in relation to changes of local abundances and foraging group density is poorly known. Objectives: This study aims at monitoring patterns of diurnal activities and the variation of behavioral time-budgets in relation to numbers of wintering Shelducks. We investigate temporal variations of diurnal activities across multipletime scales and consider their interrelationships. Methods: Assessments of local population abundance were weekly surveyed during two wintering seasons (2010– 2012), whereas diurnal activities (feeding, sleeping, swimming, preening, loafing, flying, courtship, and antagonism) were studied three times a month during seven hours (08:00–16:00) using the Scan method. Time budget variations of each behavioral activity were tested using nested ANOVAs following multiple time scales. Generalized linear mixedeffects models (GLMM) tested whether variations in diurnal activities were density-dependent. Results: During the wintering season, Shelduck’s numbers followed a bell-shaped trend, which indicated that the species was typically a wintering migrant in Sabkha Djendli. The first individuals arrived onsite in October–November then numbers reached a peak in January (up to 2400 individuals in 2012) with steady density during December–February, afterward individuals left the site progressively until late April when the site is deserted. During both wintering seasons, diurnal activities were dominated by feeding (60%), followed by sleeping (12%) then swimming and preening with 9% and 8%, respectively. The rest of the activities (loafing, flying, courtship and antagonistic behaviors) had low proportions of time budget. ANOVAs showed that activity time budgets varied significantly following multiple time scales (year, season, month, day, semi-hour). Time budgets of diurnal activities during each wintering season were

关键词： Anatidae Multi-temporal scales North African wetlands Time budget Waterbird census

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