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A comparative in vitro study on the effect of SGLT2 inhibitors on chemosensitivity to doxorubicin in MCF-7 breast cancer cells

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Oncology Research 2024年第5期32卷 817-830页

作者： SHAHID KARIM ALANOUD NAHER ALGHANMI MAHA JAMAL huda alkreathy ALAM JAMAL HIND A.ALKHATABI MOHAMMED BAZUHAIR AFTAB AHMAD Department of Clinical Pharmacology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Biochemistry Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia Department of Biochemistry College of ScienceUniversity of JeddahJeddah21959Saudi Arabia Health Information Technology Department The Applied CollegeKing Abdulaziz UniversityJeddahSaudi Arabia Pharmacovigilance and Medication Safety Unit Center of Research Excellence for Drug Research and Pharmaceutical IndustriesKing Abdulaziz UniversityJeddahSaudi Arabia

Cancer frequently develops resistance to the majority of chemotherapy *** study aimed to examine the synergistic cytotoxic and antitumor effects of SGLT2 inhibitors,specifically Canagliflozin(CAN),Dapagliflozin(DAP),Empagliflozin(EMP),and Doxorubicin(DOX),using in vitro *** precise combination of CAN+DOX has been found to greatly enhance the cytotoxic effects of doxorubicin(DOX)in MCF-7 ***,it was shown that cancer cells exhibit an increased demand for glucose and ATP in order to support their ***,when these medications were combined with DOX,there was a considerable inhibition of glucose consumption,as well as reductions in intracellular ATP and lactate ***,this effect was found to be dependent on the dosages of the *** addition to effectively inhibiting the cell cycle,the combination of CAN+DOX induces substantial modifications in both cell cycle and apoptotic gene *** work represents the initial report on the beneficial impact of SGLT2 inhibitor medications,namely CAN,DAP,and EMP,on the responsiveness to the anticancer properties of *** underlying molecular mechanisms potentially involve the suppression of the function of SGLT2.

关键词： SGLT2 Cancer Cytotoxicity ATP Cell cycle

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A novel polyherbal formulation containing thymoquinone attenuates carbon tetrachloride-induced hepatorenal injury in a rat model

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Asian Pacific Journal of Tropical Biomedicine 2020年第4期10卷 147-155页

作者： Aftab Ahmad Mohammed F.Abuzinadah huda M.alkreathy Hussam I.Kutbi Noor Ahmad Shaik Varish Ahmad Shakir Saleem Asif Husain Health Information Technology Department Faculty of Applied StudiesKing Abdulaziz UniversityJeddah-21589Kingdom of Saudi Arabia Department of Medical Laboratory Technology Faculty of Applied Medical SciencesKing Abdulaziz UniversityP.O.Box 80402 Jeddah-21589JeddahKingdom of Saudi Arabia Department of Pharmacology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Pharmacy Practice Faculty of PharmacyKing Abdulaziz UniversityJeddahSaudi Arabia Department of Genetic Medicine Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Public Health College of Health SciencesSaudi Electronic UniversityRiyadhKingdom of Saudi Arabia Department of Pharmaceutical Chemistry School of Pharmaceutical Education and ResearchJamia Hamdard(Hamdard University)New Delhi110062India

Objective:To evaluate a novel polyherbal formulation(BSVT)containing the standardized extracts from the leaves of Boerhavia diffusa,Solidago virgaurea,Vitex negundo,and thymoquinone in CCl4 induced hepatorenal toxicity in ***:A total of 36 rats were divided into six groups including normal control,CCl4(2 mL/kg,i.p.),CCl4(2 mL/kg,i.p.)+Cystone?(750 mg/kg p.o.),CCl4(2 mL/kg,i.p.)+BSVT(25 mg/kg,p.o.),CCl4(2 mL/kg,i.p.)+BSVT(50 mg/kg,p.o.),and CCl4(2 mL/kg,i.p.)+BSVT(100 mg/kg,p.o.).All treatments were given for four *** levels of aspartate transaminase,alanine transaminase,alkaline phosphatase,cholesterol,total protein,serum urea,blood urea nitrogen and creatinine were *** dismutase,malondialdehyde,and glutathione peroxidase were evaluated in tissue *** histopathological study of liver and kidney tissues was also ***:Aspartate transaminase,alanine transaminase,alkaline phosphatase,cholesterol,serum urea,blood urea nitrogen and creatinine were significantly elevated(P<0.001)while total protein was considerably reduced in the CCl4 group as compared to the normal control(P<0.001),which indicated hepatorenal *** addition,superoxide dismutase and glutathione peroxidase activities were significantly decreased(P<0.001)while malondialdehyde levels were increased markedly(P<0.001).Treatment with BSVT formulation recovered these parameters towards a normal level in a dose-dependent ***:BSVT formulation ameliorates the hepatorenal toxicity in a dose-dependent ***,clinical studies are required to confirm its efficacy.

关键词： Boerhavia diffusa Solidago virgaurea Vitex negundo Thymoquinone Cystone^(█) Carbon tetrachloride Hepatorenal

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Accuracy and precision of dried urine spot method for the detection of Schistosoma mansoni circulating cathodic antigens in resource-limited settings

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Infectious Diseases of Poverty 2024年第1期13卷 103-104页

作者： Abdallah Zacharia Clemence Kinabo Twilumba Makene huda Omary George Ogweno Faraja Lyamuya Billy Ngasala Muhimbili University of Health and Allied Sciences Dar es Salaam Tanzania National Institute for Medical Research Mwanza Tanzania Neglected Tropical Diseases Control Program Ministry of Health Dodoma Tanzania

Background The World Health Organization recommends the use of Schisto point-of-care circulating cathodic anti-gens(Schisto POC-CCA)for screening of Schistosoma mansoni as it offers better sensitivity than ***,there are limitation facing the use of this method including timely availability of the test *** aim of this study was to determine the reliability of dried urine spot(DUS)method for collection of urine and detection of *** using Schisto POC-CCA cassettes in a resource-limited *** A cross-sectional study was conducted between October and November 2022 among 250 primary school children in Sengerema District,northwestern *** CCA was detected in filter paper-based DUSs,liquid urine using DUS Schisto POC-CCA(index),and direct urine Schisto POC-CCA(comparator)methods *** eggs in stool were detected using duplicate Kato-Katz(KK)*** measures of accuracy were com-puted and compared between the index and comparator *** strength of agreement between inter-raters precisions was tested using Cohen's kappa(k).Results This study revealed *** prevalence rates of 28.8%,54.0%and 50.8%by duplicate KK,direct urine Schisto POC-CCA and DUS Schisto POC-CCA methods *** mean intensity of infection among infected participants Was 86.3 eggs per gram of stool(EPG)ranging from 12.0 EPG to 824.0 *** sensitivity of DUS Schisto POC-CCA and direct urine Schisto POC-CCA Was 94.44%(95%CI:89.15-99.74%)and 97.22%(95%CI:93.43-100.00%)*** DUS Schisto POC-CCA method had slightly higher specificity(66.85%)than direct urine Schisto POC-CCA method(63.48%).The accuracy of the DUS Schisto POC-CCA Was found to be slightly high(74.80%,95%CI:68.94-79.06%)compared to that of direct urine Schisto POC-CCA(73.20%,95%CI:67.25-78.59%).There was good agreement between two laboratory technologists who performed the DUS Schisto POC-CCA method on similar samples(k=0.80,95%CI:0.59-0.95).Con

关键词： Accuracy Point-of-care circulating cathodic antigen Dried urine spot Schistosoma mansoni Sensiti Specificity

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Graphene oxide-coated microbottle resonators for relative humidity sensing

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Optoelectronics Letters 2024年第7期20卷 400-405页

作者： huda Adnan Zain Malathy Batumalay Md Ashadi Md Johari Hazli Rafis Abdul Rahim Sulaiman Wadi Harun Department of Electrical Engineering Faculty of Engineering University of Malaya Faculty of Data Science and Information Technology INTI International University Faculty of Electrical and Electronic Engineering Technology Universiti Teknikal Malaysia Melaka Faculty of Electronic and Computer Engineering Universiti Teknikal Malaysia Melaka

Graphene oxide(GO) is a 2D coating material used to improve fiber optics sensors' response to relative humidity. Microbottle resonators(MBRs) have garnered more attention as sensing media structures. An MBR with a 190 μm diameter was coated with GO. Then, tapered fiber light coupling was used to investigate the relative humidity sensing performance in the range of 35—70%RH at 25 °C. The MBR showed a higher Q factor before and after GO coating. The sensitivity of 0.115 d B/%RH was recorded with the 190 μm GO-coated MBR sample compared to a sensitivity of 0.022 d B/%RH for the uncoated MBR sample. These results show that the MBR can be used in fiber optic sensing applications for environmental sensing.

关键词： A

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The impact of foot reflexology on fatigue and sleep quality in school-aged children undergoing hemodialysis

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Journal of Integrative Nursing 2024年第2期6卷 76-82页

作者： Amal Hashem MOHAMED Mostafa SHABAN huda Hamdy MOHAMMED Randa Mohamed ABOBAKER Salman Hamdan ALSAQRI Rania Abd-Elnaby Mohammed ALLAM Faculty of Nursing Minia UniversityMinyaEgypt College of Nursing Jouf UniversitySakakaSaudi Arabia Faculty of Nursing Cairo UniversityGizaEgypt Northern College of Nursing ARARSaudi Arabia College of Nursing University of HailHailSaudi Arabia

Objective:This study aimed to evaluate the effects of foot reflexology on fatigue and sleep quality in school-aged children receiving ***:A quasi-experimental pretest-posttest design was *** children of ages 6-12 undergoing in-center hemodialysis were *** Pittsburgh Sleep Quality Index(PSQI)and Inventory of Fatigue Symptom(IFS)scales were administered at *** then received 30 min of foot reflexology massage before hemodialysis sessions 3 days per week for 12 *** administration of the sleep and fatigue scales occurred after the intervention ***:Reflexology massage led to significant improvements in sleep quality components,including duration(0%-30%normal sleepers),efficiency(0%-50%>85%),latency(50%-0%>60 min),disturbances,and daytime *** mean PSQI score decreased from 18.2 to 9.7(P<0.05).Fatigue severity substantially decreased,with the mean IFS score improving from 105.7 to 64.1(P<0.05).Conclusion:Foot reflexology is an effective nursing intervention for reducing fatigue and improving sleep quality in children on hemodialysis,warranting integration into routine care.

关键词： Fatigue hemodialysis massage pediatric reflexology sleep

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Perception of dental appearance and aesthetic analysis among patients,laypersons and dentists

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World Journal of Clinical Cases 2024年第23期12卷 5354-5365页

作者： Alhanoof Aldegheishem Hadeel Mohammed Alfayadh Munirah AlDossary Shahad Asaad Elzahraa Eldwakhly Nour AL huda AL Refaei Dana Alsenan Mai Soliman Department of Clinical Dental Sciences College of DentistryPrincess Nourah Bint Abdulrahman UniversityRiyadh 11671Saudi Arabia Department of Oral Medicine and Pathology Ministry of HealthRiyadh 11176Saudi Arabia Department of Prosthodontics Ministry of HealthRiyadh 11176Saudi Arabia Department of Pediatric Ministry of HealthRiyadh 11176Saudi Arabia

BACKGROUND Current concepts of beauty are increasingly subjective,influenced by the viewpoints of *** aim of the study was to evaluate divergences in the perception of dental appearance and smile esthetics among patients,laypersons and dental *** study goals were to evaluate the influence of age,sex,education and dental specialty on the participants’judgment and to identify the values of different esthetic *** sample included 50 patients who responded to a dental appearance questionnaire(DAQ).Two frontal photographs were taken,one during a smile and one with retracted *** and dentists were asked to evaluate both photographs using a Linear Scale from(0-10),where 0 represent(absolutely unaesthetic)and 10 represent(absolutely aesthetic).One-way analysis of variance(ANOVA)and t-test analysis were measured for each *** patients in the sample expressed satisfaction with most aspects of their smiles and dental *** laypersons(including 488 participants),47 pictures“with lips”out of 50 had higher mean aesthetic scores compared to pictures“without lips”.Among the dentist sample,90 dentists’perception towards the esthetic smile and dental appearance for photos“with lips”and“without lips”were the same for 23 out of 50 *** of smile aesthetics differed between patients,laypersons and *** factors can contribute to shape the perception of smile *** To compare the perception of dental aesthetic among patients,laypersons,and professional dentists,to evaluate the impact of age,sex,educational background,and income on the judgments made by laypersons,to assess the variations in experience,specialty,age,and sex on professional dentists’judgment,and to evaluate the role of lips,skin shade and tooth shade in different participants’*** Patients sample included 50 patients who responded to *** frontal photographs were taken:one during a smile and one with retracted lip

关键词： Aesthetic perception Laypersons Dental appearance Dentists Smile analysis Dental aesthetic

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Assessment of BRRI Whole Feed Combine Harvester (Model BRRI WCH2021) for Mechanized Rice Harvesting in Bangladesh

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Agricultural Sciences 2024年第2期15卷 274-291页

作者： Arafat Ullah Khan Akm Saiful Islam Md. Kamruzzaman Pintu Subrata Paul Md. Durrul huda Md. Anwar Hossen Md. Monirul Islam Md. Moudud Ahmmed Farm Machinery and Postharvest Technology Division Bangladesh Rice Research Institute Gazipur Bangladesh Workshop Machinery & Maintenance Division Bangladesh Rice Research Institute Gazipur Bangladesh

Agricultural mechanization plays a pivotal role in the transition from subsistence to commercial agriculture, with a particular focus on labour-intensive activities like harvesting. This study assesses the operational characteristics of the BRRI Whole Feed Combine Harvester (Model BRRI WCH2021) at the field level. Developed under the SFMRA project, the harvester’s technical performance and loss assessment were conducted during the Boro 2022 and Aman 2022 seasons in farmer fields in Bangladesh’s Rangpur region. The field efficiency of the harvester was determined to be 62.5% and 57.9% in the Boro and Aman seasons, respectively. Fuel consumption rates were recorded at 2.77 l/ha and 2.31 l/ha for the Boro and Aman seasons. The total harvesting losses, encompassing cutter bar, shatter, cylinder, and separation loss, averaged 0.56% and 0.48% in the Boro and Aman seasons, respectively. Mechanized harvesting with the BRRI Whole Feed Combine Harvester significantly reduced paddy losses by 5.81% compared to manual methods. The field evaluation results indicate the combine harvester’s satisfactory performance, highlighting its potential to alleviate labour demands during peak harvesting. The development of the BRRI WCH offers a sustainable solution for rice harvesting mechanization among progressive farmers. It paves the way for the broader adoption of advanced agricultural technology in Bangladesh.

关键词： BRRI Whole Feed Combine Harvester Field Efficiency Fuel Consumption Harvesting Loss

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Tidal triggering of seismicity in the region of Palu, Central Sulawesi, Indonesia

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Geodesy and Geodynamics 2023年第4期14卷 377-384页

作者： Ibnu Nurul huda Sebastien Lambert Jean Souchay Research Center for Computing National Research and Innovation AgencyBogorIndonesia Department of Astronomy and Bosscha Observatory FMIPAInstitut Teknologi BandungBandungIndonesia SYRTE Observatoire de ParisUniversité PSLCNRSSorbonne UniversitéLNEParisFrance

This paper investigates the correlation between tidal stress and earthquakes for periods ranging from hours to months in the limited zone of the Palu region(Central Sulawesi,Indonesia).Through Schuster and binomial tests,we examined the relation between the seismicity(time density of seismic events)and tidal potential arising from the Moon and Sun,using all tidal components simultaneously and focusing on the estimation of specific *** results show significant correlations between the seismicity and tidal potential for S2(0.5 d)and O1(1.075 d)tidal components in the case of solely isolated earthquake events,particularly for shallow ***,there is a strong relationship between aftershocks and tidal components larger than the Mf period(13.661 d).Finally,the analysis of the temporal variation of the earthquake-tide relation reveals an optimal correlation for about six years before the 2018 great Palu *** correlation becomes insignificant afterwards.

关键词： Tidal triggering Earth tides Palu region Statistical test

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A Global Training Model for Beat Classification Using Basic Electrocardiogram Morphological Features

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Computers, Materials & Continua 2022年第3期70卷 4503-4521页

作者： Shubha Sumesh John Yearwood Shamsul huda Shafiq Ahmad School of Information Technology Deakin UniversityBurwoodVIC3128Australia Industrial Engineering Department College of EngineeringKing Saud UniversityP.O.Box 800Riyadh11421Saudi Arabia

Clinical Study and automatic diagnosis of electrocardiogram(ECG)data always remain a challenge in diagnosing cardiovascular *** analysis of ECG data relies on various factors like morphological features,classification techniques,methods or models used to diagnose and its performance *** crucial factor in themethodology is howto train the model for each *** approaches use standard training model which faces challenges when training data has variation due to individual patient characteristics resulting in a lower detection *** paper proposes an adaptive approach to identify performance improvement in building a training model that analyze global trainingmethodology against an individual training methodology and identifying a gap between *** provide our investigation and comparative study on these methods and model with standard classification techniques with basic morphological features and Heart RateVariability(HRV)thatmay aid real time *** approach helps in analyzing and evaluating the performance of different techniques and can suggests adoption of a best model identification with efficient technique and efficient attribute set for real-time systems.

关键词： ECG morphological feature HRV global adaptive training multilayer perceptron(MLP) support vector machine(SVM) random forest(RF)

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Prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam

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Asian Pacific Journal of Tropical Medicine 2023年第1期16卷 9-15页

作者： Liling Chaw Nurul huda Jeludin Kyaw Thu PAPRSB Institute of Health Sciences Universiti Brunei DarussalamGadongBrunei Darussalam Disease Control Division Department of Environmental Health ServicesMinistry of HealthBandar Seri BegawanBrunei Darussalam

Objective:To determine the prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam and to explore its underlying ***:A retrospective cohort study was conducted where data on socio-demographics,clinical characteristics and treatment outcomes of all tuberculosis patients registered at the National tuberculosis Coordinating Centre between 2013 and 2017 were *** tuberculosis mortality and the proportion of tuberculosis-related deaths were *** regression analysis was used to determine the risk factors of tuberculosis mortality when compared to those who are cured and/or completed tuberculosis ***:Of 1107 tuberculosis cases,99 died,giving an overall tuberculosis mortality rate of 8.9%(95%CI 7.4%-10.8%).Significant risk factors associated with tuberculosis mortality were age≥40 years(adjusted OR for 40-59 years was 3.89;95%CI 1.13-1.69;adjusted OR for≥60 years was 22.3;95%CI 7.27-91.9,using 20-39 years as reference),female sex(adjusted OR 1.74;95%CI 1.09-2.79),having renal disease(adjusted OR 25.7;95%CI 2.82-191.50)and having any cancers(adjusted OR 3.61;95%CI 1.26-10.00).The majority(75.8%)of the recorded deaths were not related to ***:Tuberculosis patients who were older than 40 years,female,and having renal disease and any cancer will need close monitoring in their management program to prevent tuberculosis *** should also focus on other non-tuberculosis aspects of the patient’s medical history.

关键词： Mycobacterium infections Tuberculosis Mortality Brunei

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