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A high-performance multi-wavelength optical switch based on multiple Fano resonances in an all-dielectric metastructure

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Optoelectronics Letters 2024年第4期20卷 193-199页

作者： CAO Shuangshuang FAN Xinye FANG Wenjing CHEN huawei BAI Chenglin tong Cunzhu School of Physics Science and Information Engineering Liaocheng UniversityLiaocheng 252000China Shandong Provincial Key Laboratory of Optical Communication Science and Technology Liaocheng 252000China Liaocheng Key Laboratory of Industrial-Internet Research and Application Liaocheng 252000China Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China

The multi-wavelength optical switch based on an all-dielectric metastructure consisting of four asymmetric semi-circular rings was designed and analyzed in this *** Fano resonance modes,which can be explained by bound states in the continuum(BIC)theory,are excited in our structure with a maximum Q-factor of about 2450 and a modulation depth close to 100%.By changing the polarization direction of the incident light,the transmission amplitude of Fano resonances can get effectively *** on this tuning property,the metastructure can achieve a multi-wavelength optical switch in the near-infrared region(900—980 nm)and the maximum extinction ratio can reach 38.3 d *** addition,the results indicate that the Fano resonances are sensitive to the changes in the refractive *** sensitivity(S)and the figure of merit(FOM)are 197 nm/RIU and 492 *** proposed metastructure has promising potential in applications such as optical switches,sensors,modulators and lasers.

关键词： dielectric structure resonance

预制装配式型钢混凝土梁抗剪承载力的智能模型研究

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建筑钢结构进展 2024年第3期26卷 12-20页

作者：刘坚招渝刘长江马宏伟邢增林周观根肖海鹏彭林苗任达陈原童华炜戚玉亮杨勤鹏张专涛广州大学土木工程学院广州510006 广州大学广东省复杂钢结构工程技术研究中心广州510006 华南理工大学土木与交通学院广州510641 广东省建筑设计研究院有限公司广州510010 浙江东南网架股份有限公司杭州311209 广州建筑产业研究院有限公司广州510653 杭萧钢构(广东)有限公司广东珠海519055

通过建立计算预制装配式型钢混凝土(PSRC)梁抗剪承载力的智能模型,在一定程度上提高了计算精度与适用性。基于BP人工神经网络算法,通过对影响PSRC梁抗剪承载力的相关参数进行梳理,选取14个主要影响参数作为输入层,以试算法确定隐含层节... 详细信息

通过建立计算预制装配式型钢混凝土(PSRC)梁抗剪承载力的智能模型,在一定程度上提高了计算精度与适用性。基于BP人工神经网络算法,通过对影响PSRC梁抗剪承载力的相关参数进行梳理,选取14个主要影响参数作为输入层,以试算法确定隐含层节点数为5,初步构建了3层结构人工神经网络系统;以收集的76组试验数据作为学习样本,对构建的神经网络系统进行训练,建立了对PSRC梁及SRC梁抗剪承载力计算的N14-5-1智能模型。使用智能模型对6个PSRC梁构件及6个SRC梁构件进行抗剪承载力计算,并通过与规范公式计算结果、试验结果的对比分析,证明了智能模型具有良好的计算精度及较好的泛化能力,具有一定的工程参考意义。运用Garson算法对输入参数进行敏感性分析,结果表明箍筋间距、型钢屈服强度、箍筋屈服强度、型钢腹板含钢率对抗剪承载力影响较大。随着研究试验的开展,在收集更多具有代表性的试验数据以扩充学习样本后,可对智能模型进一步优化。

关键词：预制装配式型钢混凝土梁 BP人工神经网络抗剪承载力智能模型

Programmable deaminase-free base editors for G-to-Y conversion by engineered glycosylase

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National Science Review 2023年第8期10卷 78-87页

作者： huawei tong Nana Liu Yinghui Wei Yingsi Zhou Yun Li Danni Wu Ming Jin Shuna Cui Hengbin Li Guoling Li Jingxing Zhou Yuan Yuan Hainan Zhang Linyu Shi Xuan Yao Hui Yang HuidaGene Therapeutics Co. Ltd. Department of Neurology and Institute of Neurology of First Affiliated Hospital Institute of Neuroscience and Fujian Key Laboratory of Molecular Neurology Fujian Medical University Institute of Neuroscience Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences Shanghai Center for Brain Science and Brain-Inspired Intelligence

Current DNA base editors contain nuclease and DNA deaminase that enables deamination of cytosine(C)or adenine(A), but no method for guanine(G) or thymine(T) editing is available at present. Here we developed a deaminase-free glycosylase-based guanine base editor(gGBE) with G editing ability, by fusing Cas9 nickase with engineered N-methylpurine DNA glycosylase protein(MPG). By several rounds of MPG mutagenesis via unbiased and rational screening using an intron-split EGFP reporter, we demonstrated that gGBE with engineered MPG could increase G editing efficiency by more than 1500 ***, this gGBE exhibited high base editing efficiency(up to 81.2%) and high G-to-T or G-to-C(i.e. G-to-Y) conversion ratio(up to 0.95) in both cultured human cells and mouse embryos. Thus, we have provided a proof-of-concept of a new base editing approach by endowing the engineered DNA glycosylase the capability to selectively excise a new type of substrate.

关键词： glycosylase base excision repair base editor depurination deaminase-free transversion

Neurexin regulates night-time sleep through modulating neural excitability

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Neurexin regulates night-time sleep through modulating neura...

2015年中国中西医结合学会时间生物医学专业委员会学术研讨暨换届会议

作者： huawei tong Qian Li Junhai Han Institute of Life Sciences the Key Laboratory of Developmental Genes and Human DiseaseSoutheast University

Sleep is a universal,essential and evolutionarily conserved behavior among animal species,which is regulated by various neural circuits and closely related to synaptic *** are cell adhesion molecules that function in various neural circuits through mediating synapse formation and synaptic ***,the neuronal circuits and the potential role of Neurexins in sleep regulation are not ***,we show that lack of the Drosophila homolog of α-Neurexin significantly reduce night-time sleep and depletion of Neurexin from different kenyon cell populations either increase or decrease night-time *** further identified the role of different KC populations in night-time sleep *** calcium image analysis,we reveal that nrx mutant KCs exhibits an elevated neural excitability,which results in a decreased night-time ***,we demonstrate that Neurexin associates with Na/K-ATPase and promotes its plasma membrane location,which is essential to govern the neural *** study indicate that different KCs populations play variant roles in night-time sleep regulation and Neurexin regulates night-time sleep through modulating the excitability of KCs,which offers the insights into the neural circuit mechanism of sleep regulation and the molecular function of Neurexin.

关键词： Sleep Neural circuit Mushroom body Kenyon cell Neurexin Na+/K+-ATPase neural excitability

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以专业评估促进地方院校土建类专业建设

高等工程教育研究 2008年第2期56卷 133-136页

作者：童华炜张朝升广州大学土木工程学院副院长

以专业评估为导向促进专业建设,是地方高校土建类专业快速提高专业建设水平的有效途径,也是执业注册工程师培养的基本要求。正确认识专业评估,把握专业评估与专业建设的关系,是以评促建的关键。本文结合地方院校土建类专业建设的经验,... 详细信息

以专业评估为导向促进专业建设,是地方高校土建类专业快速提高专业建设水平的有效途径,也是执业注册工程师培养的基本要求。正确认识专业评估,把握专业评估与专业建设的关系,是以评促建的关键。本文结合地方院校土建类专业建设的经验,就地方院校如何以专业评估促进专业建设作一探讨。

关键词：专业评估专业建设地方院校土建类专业

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考虑深基坑坑角效应的支护结构变形计算

地下空间与工程学报 2011年第3期7卷 479-484页

作者：王晓伟童华炜广州建设工程质量安全检测中心有限公司广州510440 广州大学土木工程学院广州510006

深基坑工程是一个复杂的三维空间问题。本文以悬臂地下连续墙支护体系为研究对象,借助FLAC3D三维有限差分软件对支护结构变形坑角效应及其主要影响因素进行了研究,给出了支护结构变形阴角坑角效应影响系数和坑角效应影响范围,提出了考... 详细信息

深基坑工程是一个复杂的三维空间问题。本文以悬臂地下连续墙支护体系为研究对象,借助FLAC3D三维有限差分软件对支护结构变形坑角效应及其主要影响因素进行了研究,给出了支护结构变形阴角坑角效应影响系数和坑角效应影响范围,提出了考虑深基坑坑角效应的支护结构变形计算方法,即将坑角效应影响系数与依据平面问题计算得到的悬臂连续墙支护结构变形相乘得到支护结构变形空间分布的方法,并通过工程实例验证了此计算方法及所得系数的合理性。

关键词：深基坑支护体系坑角效应支护结构变形三维有限差分

FBXL4 serves as a clock output molecule to regulate sleep through promoting GABAA receptor degradation

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FBXL4 serves as a clock output molecule to regulate sleep th...

含水量对珠三角软土时效变形特性影响试验分析与模型研究

中国神经科学学会第十二届全国学术会议

作者： Qian LI Yi LI Xiao WANG Junxia QI huawei tong Zikai ZHOU Zi Chao ZHANG Junhai HAN Institute of Life Sciences the Key Laboratory of Developmental Genes and Human Disease Southeast University

Sleep is tightly governed by the circadian clock that contains a negative transcriptional feedback loop and synchronizes the physiology and behavior of most animals to daily environmental oscillations. In both vertebrates and invertebrates, the status of sleep and wake is controlled by the electrical activity of pacemaker neurons, which is circadian-regulated and suppressed by inhibitory GABAergic inputs. However, how the circadian clock rhythmically regulates the activity of pacemaker neuron is unclear. Here, we show that the level of Drosophila GABA receptor Resistant to Dieldrin(RDL) undergoes a daily cycle in wake-promoting large ventral lateral neurons(l-LNvs) and identify the E3 ligase Fbxl4 as a clock output molecule promoting RDL poly-ubiquitination and degradation. Depletion of Fbxl4 results in RDL accumulation, shortened sleep onset, and increased sleep time both in the day and the night. Moreover, we reveal that the expression of Fbxl4 in l-LNvs is Clock dependent but fbxl4 mutants exhibit normal locomotor rhythms. Thus, our study uncovers the critical molecular linkage between circadian clock and the electrical activity of pacemaker neurons and demonstrates that clock-dependent Fbxl4 expression downregulates GABAA receptor to increase the activity of pacemaker neurons and promote wakefulness.

关键词： Sleep circadian clock GABAA receptor E3 ligase Fbxl4 degradation

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西安建筑科技大学学报（自然科学版） 2019年第2期51卷 168-176页

作者：童华炜方晓填刘柱辉袁杰广州大学土木工程学院广东广州510006 中交(广州)铁道设计研究院有限公司广东广州510290

软土时效变形特性对于建筑物的稳定性有着重要影响.通过室内直剪蠕变试验,在相同试验条件下完成了5组不同含水量及不同应力水平试样时效变形特性的测试,获得了试样含水量与时效变形特性的关系,研究含水量对珠三角软土时效变形特性的影响... 详细信息

软土时效变形特性对于建筑物的稳定性有着重要影响.通过室内直剪蠕变试验,在相同试验条件下完成了5组不同含水量及不同应力水平试样时效变形特性的测试,获得了试样含水量与时效变形特性的关系,研究含水量对珠三角软土时效变形特性的影响.试验结果表明,该地区软土变形时效特性明显,含水量是影响软土时效变形特性的重要因素之一.采用五元件Kelvin模型和西原正夫模型对试验曲线进行拟合分析,两个模型在不同含水量、不同应力水平组合下的拟合与试验结果都具有良好的一致性,且两个模型拟合效果具有互补性.引入邓肯-张模型非线性E-v模型,使西原正夫模型在低含水量低荷载时的拟合效果显著提高.

关键词：珠江三角洲软土时效变形直剪蠕变含水量模型分析

广州PZB1401项目扣件式双排脚手架竖向承载力非线性分析与应用

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施工技术 2013年第17期42卷 21-25页

作者：李学劲童华炜米翔广州大学土木工程学院广东广州510006 深圳中海建筑有限公司广东深圳518057

利用MIDAS/Gen建立直角扣件半刚性连接的双排脚手架整体计算模型,采用虚拟水平力的方法模拟初始缺陷,计算非线性屈曲承载能力,指出缺陷杆件屈服破坏的判断标准,已有的试验结果验证计算方法合理;与现行规范相比较,计算结果可靠;模型建立... 详细信息

利用MIDAS/Gen建立直角扣件半刚性连接的双排脚手架整体计算模型,采用虚拟水平力的方法模拟初始缺陷,计算非线性屈曲承载能力,指出缺陷杆件屈服破坏的判断标准,已有的试验结果验证计算方法合理;与现行规范相比较,计算结果可靠;模型建立及缺陷模拟方法可应用于复杂工况的脚手架竖向承载力计算。

关键词：脚手架扣件式脚手架竖向承载力非线性分析有限元分析