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Epidemiological characteristics of pulmonary tuberculosis in patients with pneumoconiosis based on its social determinants and risk factors in China:a cross-sectional study from 27 provinces

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Chinese Medical Journal 2022年第24期135卷 2984-2997页

作者： Huanqiang Wang huaping dai Jiayu He Xiangpei Lyu Xinran Zhang Tao Li Department of Occupational Respiratory Disease National Institute for Occupational Health and Poison ControlChinese Center for Disease Control and PreventionBeijing 100050China National Center for Respiratory Medicine National Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100029China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China Department of Clinical Research and Data Management Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China

Background:Patients with pneumoconiosis have an elevated risk of contracting pulmonary tuberculosis(PTB)and need particular attention.However,extensive population-based studies on the prevalence of PTB in patients with pneumoconiosis have not been reported in China since 1992.This study aimed to investigate the epidemiological characteristics of PTB in patients with pneumoconiosis based on its social determinants and risk factors in China.Methods:Based on the Commission on Social Determinants of Health(CSDH)framework,data were obtained from a questionnaire survey of patients with pneumoconiosis from China’s 27 provinces(autonomous regions,municipalities)from December 2017 to June 2021.By chi-square and multivariate logistic regression analyses,the epidemiological characteristics of PTB in the patients were identified based on its prevalence and odds ratio(OR)and associated social determinants and risk factors.The population attributable fractions(PAFs)of significant risk factors were also calculated.Results:The prevalence of PTB in patients with pneumoconiosis(n=10,137)was 7.5%(95%confidence interval[CI]:7.0-8.0%).Multivariate logistic regression analysis showed that risk factors included in-hospital exposure to patients with PTB(OR=3.30,95%CI:2.77-3.93),clinically diagnosed cases(OR=3.25,95%CI:2.42-4.34),and northeastern regions(OR=2.41,95%CI:1.76-3.31).In addition,lack of work-related injury insurance(WRII),being born in a rural area,being unemployed,living in western regions,household exposure to patients with PTB,smoking,being underweight,complications of pulmonary bullae or pneumothorax,hospitalization history,and former drinkers among the rural patients were also statistically significant risk factors.Being born in a rural area,lack of WRII and in-hospital exposure to patients with PTB had higher PAFs,which were 13.2%(95%CI:7.9-18.5%),12.5%(95%CI:8.3-16.7%),and 11.6%(95%CI:8.8-14.3%),respectively.Conclusion:The prevalence of PTB in pneumoconiosis remains high in China;it is basically in line with the CSDH m

关键词： Pulmonary tuberculosis Pneumoconiosis Social determinants Risk factors

Single-cell RNA sequencing profiling of the effects of aging on alveolar stem cells

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Science China(Life Sciences) 2019年第8期62卷 1028-1037页

作者： Tingting Lv Kewu Jiang Jiawen Wang Nan Tang huaping dai Chen Wang Department of Pulmonary and Critical Care Medicine Center of Respiratory Medicine China-Japan Friendship Hospital National ClinicalResearch Center for Respiratory Diseases Institute of Respiratory Medicine Chinese Academy of Medical Sciences Beijing100029China Graduate School of Peking Union Medical College Chinese Academy of Medical Science and Peking Union Medical CollegeBeijing100005China National Institute of Biological Sciences Beijing102206China

The aging of alveolar stem cells has been linked to many chronic lung diseases, including pulmonary fibrosis. However, the effects of aging on alveolar stem cells during homeostasis and post-injury alveolar repair have not been well characterized. Here we conducted a single-cell RNA sequencing(scRNA-seq) analysis of alveolar stem cells of 3-month-old and 12-month-old mice to characterize the aging effect on alveolar stem cells. Our results have shown that the transcriptomes of alveolar stem cells of 3-month-old and 12-month-old mice are not significantly different under the steady condition. However, after a bleomycin-induced lung injury, the alveolar stem cells of 12-month-old mice show enhanced inflammatory responses and decreased lipid metabolism. Our study suggests a close relationship among aging, lipid metabolism, inflammatory responses and chronic lung diseases.

关键词： single-cell RNA sequencing (scRNA-seq) aging pulmonary alveolar stem cells inflammation response lipid metabolism

Clinical characteristics of hypersensitivity pneumonitis:non-fibrotic and fibrotic subtypes

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Chinese Medical Journal 2023年第23期136卷 2839-2846页

作者： Xueying Chen Xiaoyan Yang Yanhong Ren Bingbing Xie Sheng Xie Ling Zhao Shiyao Wang Jing Geng Dingyuan Jiang Sa Luo Jiarui He Shi Shu Yinan Hu Lili Zhu Zhen Li Xinran Zhang Min Liu huaping dai Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalNational Center for Respiratory MedicineNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100029China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalCapital Medical UniversityBeijing 100029China Department of Radiology China-Japan Friendship HospitalBeijing 100029China Department of Pathology China-Japan Friendship HospitalBeijing 100029China Institute of Clinical Medical Sciences Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China

Background:The presence of fibrosis is a criterion for subtype classification in the newly updated hypersensitivity pneumonitis(HP)guidelines.The present study aimed to summarize differences in clinical characteristics and prognosis of non-fibrotic hypersensitivity pneumonitis(NFHP)and fibrotic hypersensitivity pneumonitis(FHP)and explore factors associated with the presence of fibrosis.Methods:In this prospective cohort study,patients diagnosed with HP through a multidisciplinary discussion were enrolled.Collected data included demographic and clinical characteristics,laboratory findings,and radiologic and histopathological features.Logistic regression analyses were performed to explore factors related to the presence of fibrosis.Results:A total of 202 patients with HP were enrolled,including 87(43.1%)NFHP patients and 115(56.9%)FHP patients.Patients with FHP were older and more frequently presented with dyspnea,crackles,and digital clubbing than patients with NFHP.Serum levels of carcinoembryonic antigen,carbohydrate antigen 125,carbohydrate antigen 153,gastrin-releasing peptide precursor,squamous cell carcinoma antigen,and antigen cytokeratin 21-1,and count of bronchoalveolar lavage(BAL)eosinophils were higher in the FHP group than in the NFHP group.BAL lymphocytosis was present in both groups,but less pronounced in the FHP group.Multivariable regression analyses revealed that older age,<20%of lymphocyte in BAL,and≥1.75%of eosinophil in BAL were risk factors for the development of FHP.Twelve patients developed adverse outcomes,with a median survival time of 12.5 months,all of whom had FHP.Conclusions:Older age,<20%of lymphocyte in BAL,and≥1.75%of eosinophil in BAL were risk factors associated with the development of FHP.Prognosis of patients with NFHP was better than that of patients with FHP.These results may provide insights into the mechanisms of fibrosis in HP.

关键词： Interstitial lung disease Hypersensitivity pneumonitis Clinical characteristics Fibrosis Prognosis

A trial of pirfenidone in hospitalized adult patients with severe coronavirus disease 2019

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Chinese Medical Journal 2022年第3期135卷 368-370页

作者： Fengqin Zhang Yanqiu Wei Li He Huilan Zhang Qiongjie Hu Huihui Yue Jianhan He huaping Da Department of Respiratory and Critical Care Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 10029China Peking University Health Science Center Beijing 100029China Department of Respiratory and Critical Care Medicine Jingzhou Central HospitalJingzhouHubei 434200China Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesBeijing 100029China

To the Editor:Coronavirus disease 2019(COVID-19),which broke out in 2019,has become a global pandemic.Similar to severe acute respiratory syndrome coronavirus(SARS-CoV)in 2003,SARS-CoV-2 could cause acute lung injury and cytokine storms characterized by the increased interleukin(IL)-8,IL-6,and tumor necrosis factorα(TNF-α).[1]Perspective studies in those survivors from the severe acute respiratory syndrome(SARS)epidemic in 2003 revealed that those SARS patients manifested varying degrees of pulmonary interstitial fibrosis.[2]Similarly,patients with severe COVID-19 are also featured by the diffuse alveolar damage along with alveolar interstitial fibrosis.[3]

关键词： patients acute respiratory

Extracorporeal blood therapy in sepsis and acute respiratory distress syndrome： the ＂purifying dream＂

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Chinese Medical Journal 2014年第24期127卷 4263-4270页

作者： Xu Xuefeng dai huaping Jia Chun'e Wang Chen National Clinical Research Centre for Respiratory Medicine Beijing Hospital Beijing 100730 China Department of Respiratory and Critical Care Medicine B eijing Chao- Yang Hospital Capital Medical University Beijing 100020 China Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders Beijing Institute of Respiratory Medicine Capital Medical University Beijing 100020 China

Objective To discuss the rationale, hypothesis, modality of extracorporeal blood purification （EBP） techniques for the critically ill animal models or patients, and to summarize the experimental and clinical studies with inconsistent data which explored the EBP＇s efficacy in the areas of critical care medicine. Data sources Articles referred in this review were collected from the database of PubMed published in English up to June 2014. Study selection We had done a literature search by using the term ＂（sepsis OR acute lung injury OR acute respiratory distress syndrome） AND （extracorporeal blood purification OR hemofiltretion OR hemoperfusion OR plasma exchange OR plasmapheresis OR adsorpiton）＂. Related original or review articles were included and carefully analyzed. Results Acute cellular and humoral immune disturbances occur in both sepsis and acute respiratory distress syndrome （ARDS）. Treatments aimed at targeting one single pro-/anti-inflammatory mediator have largely failed with no proven clinical benefits. Such failure shifts the therapeutic rationale to the nonspecific, broad-spectrum methods for modulating the over-activated inflammatory and anti-inflammatory response. Therefore, EBP techniques have become the potential weapons with high promise for removing the circulating pro-/anti-inflammatory mediators and promoting immune reconstitution. Over the years, multiple extracorporeal techniques for the critically ill animal models or patients have been developed, including hemoflltration （HF）, high-volume hemofiltration （HVHF）, high-cutoff hemofiltration （HCO-HF）, hemo-perfusion or -adsorption （HP/HA）, coupled plasma filtration adsorption （CPFA）, and plasma exchange （PE）. These previous studies showed that EBP therapy was feasible and safe for the critically ill animal models or patients. However, data on their efficacy （especially on the clinical benefits, such as mortality） were inconsistent. Conclusions It is not now to conclude that EBP intervention can purify septic or ARDS patients with high clinical

关键词： acute lung injury acute respiratory distress syndrome extracorporeal blood purification sepsis

A novel case of Hyper IgE syndrome combined with natural killer cell deficiency

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Chinese Medical Journal 2014年第5期127卷 982-983页

作者： Zhang Xiaolei Liu Yangang Liu Yan dai huaping Department of Pulmonary and Critical Care Beijing Institute of Respiratory Medicine Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China

The Hyper IgE syndrome （HIES） is a rare,complex primary immunodeficiency.Here we report a case of HIES combined with natural killer cell deficiency,which has not been previously documented in the literature.Written ... 详细信息

关键词： hyper IgE Syndrome natural killer cell deficiency infection

Cigarette smoking contributes to idiopathic pulmonary fibrosis associated with emphysema

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Chinese Medical Journal 2014年第3期127卷 469-474页

作者： Ye Qiao Huang Kewu Ding Yi Lou Baohui Hou Ziliang dai huaping Wang Chen Department of Respiratory and Critical Care Medicine Beijing Chao Yang Hospital Capital Medical University Beijing 100020 China Department of Radiology Beijing Chao Yang Hospital Capital Medical University Beijing 100020 China Institute of Respiratory Medicine Beijing Hospital Ministry of Heath Beijing 100730 China

Background Combined emphysema and pulmonary fibrosis,including idiopathic pulmonary fibrosis （IPF）,is a distinct disorder described with upper-lobe emphysema and lower-lobe fibrosis on chest computed tomography.Smoking appears to be the predominant risk factor for this disorder.We aimed to compare clinical features,smoking history,physiological and radiological findings between IPF with and without emphysema.Methods A sample of 125 IPF patients over a period of 48 months were evaluated.High resolution CT scans were reviewed blinded to clinical data.The IPF patients with or without emphysema were classified accordingly.Results The prevalence of emphysema in this IPF sample was 70/125.IPF with emphysema was significantly associated with smoking status （OR 63; 95％ CI 4.4 to 915; P=0.002） and smoking pack year （OR 1.1; 95％ CI 1.05 to 1.13; P=-0.000）.The patients with IPF and emphysema had a higher decrease in carbon monoxide diffusing capacity adjusted for alveolar volume （（58±19）％ pred vs.（66：±：21）％ pred; P=-0.021） and a higher prevalence of pulmonary hypertension （24/70 vs.7/55; P=0.006）.The two groups of patients had similar forced and residual volumes.No significant differences were found in cell differentials of bronchoalveolar lavage or the scores of fibrosis on chest CT.Survival of the patients with emphysema was significantly less than that of patients with IPF alone.Conclusions Cigarette smoking induces IPF combined with emphysema.Emphysema further impairs physiological function and increases the prevalence of pulmonary hypertension that leads to poor prognosis.The inclusion of the patients with combined pulmonary fibrosis and emphysema in IPF clinical trials may lead to under evaluation of the effect of treatment in patients.

关键词： idiopathic pulmonary fibrosis emphysema smoking

Fibroblast-localized lncRNA CFIRL promotes cardiac fibrosis and dysfunction in dilated cardiomyopathy

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Science China(Life Sciences) 2024年第6期67卷 1155-1169页

作者： Shuai Yuan Xudong Zhang Jiabing Zhan Rong Xie Jiahui Fan Beibei dai Yanru Zhao Zhongwei Yin Qian Liu Dao Wen Wang huaping Li Chen Chen Division of Cardiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders Wuhan 430030China Department of Forensic Medicine Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

CFIRL is a long noncoding RNA(lnc RNA),we previously identified as the most significantly upregulated lnc RNA in the failing hearts of patients with dilated cardiomyopathy(DCM).In this study,we determined the function of CFIRL and its role in DCM.Real-time polymerase chain reaction and in situ hybridization assays revealed that CFIRL was primarily localized in the nucleus of cardiac fibroblasts and robustly increased in failing hearts.Global knockdown or fibroblast-specific knockout of CFIRL attenuated transverse aortic constriction(TAC)-induced cardiac dysfunction and fibrosis in vivo.Overexpression of CFIRL in vitro promoted fibroblast proliferation and aggravated angiotensin II-induced differentiation to myofibroblasts.CFIRL knockdown attenuated these effects.Mechanistically,RNA pull-down assay and gene expression profiling revealed that CFIRL recruited ENO1,a newly identified noncanonical transcriptional factor,to activate IL-6transcription.IL-6 exerted a paracrine effect on cardiomyocytes to promote cardiac hypertrophy,which can be prevented by CFIRL knockdown.These findings uncover the critical role of CFIRL,a fibroblast-associated lnc RNA,in heart failure by facilitating crosstalk between fibroblasts and cardiomyocytes.CFIRL knockdown might be a potent strategy to prevent cardiac remodeling in heart failure,particularly in DCM.

关键词： lncRNA fibroblast fibrosis dilated cardiomyopathy heart failure

Clinical features and outcomes of 210 patients with idiopathic pulmonary fibrosis

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Chinese Medical Journal 2014年第10期127卷 1868-1873页

作者： Cai Miaotian Zhu Min Ban Chengjun Su Jin Ye Qiao Liu Yan Zhao Wen Wang Chen dai huaping Department of Respiratory and Critical Care Medicine Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China Beijing Key Laboratory of Respiratory and Pulmonary Circulation Beijing Institute of Respiratory Medicine Beijing 100020 China Beijing Youan Hospital Capital Medical University Beijing 100069China Beijing Hospital National Clinical Research Center for RespiratoryMedicine Beijing 100730 China

Background Idiopathic pulmonary fibrosis （IPF） is a lethal chronic interstitial lung disease （ILD） of unknown cause and having a variable and unpredictable course.This study aimed to summarize the clinical features and follow-up outcomes and to identify potential factors useful for the assessment of prognosis in IPF.Methods Two hundred and ten patients hospitalized and diagnosed as IPF in our unit from January 1999 to June 2007 were enrolled into this study.The baseline demographic,clinical,radiologic and physiologic characteristics were summarized.Clinical follow-up data until February 2010 were collected,and the median survival time and 1-,2-,and 5-year survival rates,as well as the influences of the summarized baseline variables on the prognosis were analyzed.Results The age at diagnosis as IPF was （64±10） years,the duration before diagnosis of 106 patients （50％） was shorter than 2 years,and 73％ were males.One hundred and forty-five patients （69％） had a history of smoking with a median pack-year of 18.Eighty-nine patients （42％） had emphysema and 62 patients （29％） pulmonary arterial hypertension （PAH）.One hundred and twenty-four patients were followed up,of which 99 patients died from various causes including respiratory failure related to IPF （93％）.The follow-up period was （21±23） months.The median survival time was 38months.The 1-,2-,and 5-year survival rates were 61％,52％,and 39％,respectively.Multivariate analysis showed clubbing,PAH,duration from initial onset to diagnosis,and forced expiratory volume in 1 second （FEV1）/forced vital capacity （FVC） were independent prognostic indicators of IPF.Conclusion IPF patients who have clubbing,PAH,a higher FEVJFVC,and a short duration from initial onset to diagnosis have a poorer outcome.

关键词： idiopathic pulmonary fibrosis clinical feature follow-up outcome