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Particuology 2024年第6期89卷 99-108页

作者： Weihao Liu huanhuan he Qingtao Liu Xin Wan Jianglan Shui School of Materials Science and Engineering Beihang UniversityBeijing100191China School of Space and Environment Beihang UniversityBeijing102206China Tianmushan Laboratory Hangzhou310023China

The excellent oxygen reduction reaction(ORR)activity of Fe–N–C catalysts in acidic media makes them potential for low-cost proton exchange membrane fuel *** recent years,it has been shown that heteroatoms(B,O,S,P,Cl,F,etc.)can be used as electron-withdrawing groups to modulate the planar structure and electron distribution of the Fe–Nx active sites to achieve simultaneous improvement of catalytic activity and ***,the optimal location of the heteroatoms remains ***,taking chalcogen heteroatoms(S and Se)as an example,we control the doping positions and investigate their effect on the ORR performance of the Fe–N–C *** first coordination shell of the iron single atom is identified as the optimal doping *** optimized catalysts Fe–N_(3)Se_(1)/NC and Fe–N_(3)Se_(1)/NC demonstrate improved activity and stability in both half cells and fuel *** work provides insights into the enhancement mechanism of heteroatom doping in single-atom catalysts.

关键词： Oxygen reduction reaction Fe-N-C catalysts hetero-atom doping Doping position Enhancement mechanism

汉语哲学核心概念“无我”的词汇变迁与思想演进

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语言战略研究 2024年第2期9卷 28-40页

作者：何欢欢浙江大学哲学学院浙江杭州310058

“无我”本是佛教哲学中的核心概念。从梵语的否定表达来看,佛教对“我”的否定,即“无我”,分为两种情况:(1)否定“我”的存在而无任何肯定,“无我”义为不存在(轮回解脱的)本体或主体;(2)通过排除“常、一、主、宰”等特殊属性而肯定... 详细信息

“无我”本是佛教哲学中的核心概念。从梵语的否定表达来看,佛教对“我”的否定,即“无我”,分为两种情况:(1)否定“我”的存在而无任何肯定,“无我”义为不存在(轮回解脱的)本体或主体;(2)通过排除“常、一、主、宰”等特殊属性而肯定相对立的“识”,“无我”就意味着肯定“唯识”。但汉译佛典对此不作区分甚至无法予以区分,因此,作为翻译名相的“无我”以及另一译词“非我”都妨碍了对作为外来义理之“无我”的正确理解。佛教入华之初多用老庄术语翻译佛典,曾以“非身”对译“无我”这一目标概念,“非身”源于老子的“无身”;而后“非身”完全被“无我”所替代,“无我”的本土思想资源应为庄子的“吾丧我”。随着佛教思想渗入中国文化,“无我”又由佛入儒,在词义和用法上发生了重要转变。儒家的“无我”源于孔子“毋我”,但宋明理学家受到佛教义理的浸润,对“我”的理解从私利转化为私利主体,把佛教中以本体论意义为主的“无我”,诠释成儒学体系中表达道德境界为主的名相。“无我”从“汉译”到“汉化”“中国化”的词汇变迁与思想演进,展示了外来语词传播、发展、融入并最终成为汉语哲学本身的一种典型模式。

关键词：无我非身吾丧我毋我无私

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氯乙烯气柜安全稳定运行分析

聚氯乙烯 2024年第1期52卷 42-44页

作者：何欢欢陕西金泰氯碱神木化工有限公司陕西榆林719000

为了确保氯乙烯气柜安全稳定运行,对氯乙烯气柜结构、工艺流程以及其正常运行时各项工艺指标的偏差进行了分析。根据偏差产生的原因和造成的后果,制定了氯乙烯气柜平稳运行的保护措施,可以进一步防范氯乙烯气柜泄漏的风险,从而保证了氯... 详细信息

为了确保氯乙烯气柜安全稳定运行,对氯乙烯气柜结构、工艺流程以及其正常运行时各项工艺指标的偏差进行了分析。根据偏差产生的原因和造成的后果,制定了氯乙烯气柜平稳运行的保护措施,可以进一步防范氯乙烯气柜泄漏的风险,从而保证了氯乙烯气柜的安全稳定长周期运行。

关键词：氯乙烯气柜工艺参数偏差

过表达sFRP3对小鼠原代心肌成纤维细胞活化增殖的影响

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安徽医科大学学报 2024年第5期59卷 809-814页

作者：江舜祥涂彬宋凯何缓缓陶辉曹炜安徽医科大学第二附属医院胸外科合肥230601 安徽医科大学第二附属医院麻醉与围手术期医学科合肥230601

目的探讨Wnt信号通路调控剂分泌型卷曲相关蛋白3(sFRP3)在小鼠心肌成纤维细胞(CFs)活化增殖中的作用。方法购入1~3 d的小鼠乳鼠,行手术对心脏取材,消化后分离CFs进行培养。细胞贴壁生长后使用转化生长因子(TGF-β1)刺激构建CFs活化增殖... 详细信息

目的探讨Wnt信号通路调控剂分泌型卷曲相关蛋白3(sFRP3)在小鼠心肌成纤维细胞(CFs)活化增殖中的作用。方法购入1~3 d的小鼠乳鼠,行手术对心脏取材,消化后分离CFs进行培养。细胞贴壁生长后使用转化生长因子(TGF-β1)刺激构建CFs活化增殖模型;确认模型构建成功后分别向实验组和对照组细胞转染sFRP3过表达质粒和空载质粒24~48 h。通过Western blot、qRT-PCR的方法在分子层面对sFRP3、Periostin(POSTN)、Ⅰ型胶原(CollagenⅠ)和增殖细胞核抗原(PCNA)的表达进行检测;使用MTT法、CCK-8法和EdU染色法检测细胞增殖能力的改变。结果在TGF-β1刺激构建的CFs活化增殖模型中,相较于对照组,模型组sFRP3蛋白及mRNA表达下降,活化增殖相关蛋白PCNA、POSTN和CollagenⅠ表达上调。另外,在质粒转染sFRP3过表达组的CFs中,PCNA、POSTN和CollagenⅠ蛋白及mRNA表达相较于空载组下降。MTT、CCK-8与EdU实验表明,质粒转染sFRP3过表达组的CFs增殖活性较空载组明显下降。结论过表达sFRP3明显抑制CFs活化增殖,提示sFRP3可能是参与调控CFs活化增殖的关键基因。

关键词： sFRP3 心肌成纤维细胞心肌纤维化活化增殖

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导轨拉拔式红花采收装置设计与试验

中国农机化学报 2024年第1期45卷 42-48页

作者：何欢欢杨双平封伟新疆应用职业技术学院机电工程学院新疆奎屯833200 新疆农业大学机电工程学院乌鲁木齐市830000 河北省农业机械鉴定总站石家庄市050031

针对目前红花丝人工采收强度大、效率低及机械化采收程度低等问题,设计一种导轨拉拔式红花采收装置。以新疆裕民无刺红花为研究对象,模拟人手抓取拉拔动作,通过夹取导轨与拉拔导轨相配合,正向行程内夹花板在导轨内先收紧后上升,实现对... 详细信息

针对目前红花丝人工采收强度大、效率低及机械化采收程度低等问题,设计一种导轨拉拔式红花采收装置。以新疆裕民无刺红花为研究对象,模拟人手抓取拉拔动作,通过夹取导轨与拉拔导轨相配合,正向行程内夹花板在导轨内先收紧后上升,实现对花丝的夹取和拉拔动作,通过负压收集拉拔下来的花丝,完成采收。对夹紧导轨、拉拔导轨、辅助导轨和挡花口等关键部件进行设计,计算并分析各导轨从动件的运动位移、运动速度和加速度。并在SolidWorks软件中对模型进行运动仿真分析,验证爬升架和夹花板的运动轨迹和运动规律。以装置采净率和花丝破损率为试验指标,以开花后1~5天的新疆裕民无刺红花(含水率≤44.5%)为试验对象,以采收频率为试验因素,进行单因素5水平试验,验证装置可行性并寻求最优采收频率。结果表明:当采收频率为20次/min时,导轨拉拔式红花采收装置采净率为97.64%,破损率为3.32%。研究结果可为红花机械化采收机具的研究提供参考依据。

关键词：红花采收装置夹取机构运动仿真

An anti-collision algorithm for robotic search-and-rescue tasks in unknown dynamic environments

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Frontiers of Information Technology & Electronic Engineering 2024年第4期25卷 569-584页

作者： Yang CheN Dianxi SHI huanhuan YANG Tongyue LI Zhen WANG School of Computer Science Peking UniversityBeijing 100871China Tianjin Artificial Intelligence Innovation Center Tianjin 300457China Intelligent Game and Decision Lab Beijing 100071China College of Computer National University of Defense TechnologyChangsha 410073China

This paper deals with the search-and-rescue tasks of a mobile robot with multiple interesting targets in an unknown dynamic *** problem is challenging because the mobile robot needs to search for multiple targets while avoiding obstacles *** ensure that the mobile robot avoids obstacles properly,we propose a mixed-strategy Nash equilibrium based Dyna-Q(MNDQ)***,a multi-objective layered structure is introduced to simplify the representation of multiple objectives and reduce computational *** structure divides the overall task into subtasks,including searching for targets and avoiding ***,a risk-monitoring mechanism is proposed based on the relative positions of dynamic *** mechanism helps the robot avoid potential collisions and unnecessary ***,to improve sampling efficiency,MNDQ is presented,which combines Dyna-Q and mixed-strategy Nash *** using mixed-strategy Nash equilibrium,the agent makes decisions in the form of probabilities,maximizing the expected rewards and improving the overall performance of the Dyna-Q ***,a series of simulations are conducted to verify the effectiveness of the proposed *** results show that MNDQ performs well and exhibits robustness,providing a competitive solution for future autonomous robot navigation tasks.

关键词： Search and rescue Reinforcement learning Game theory Collision avoidance Decision-making

Automatic diagnosis of diabetic retinopathy using vision transformer based on wide-field optical coherence tomography angiography

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Journal of Innovative Optical health Sciences 2024年第2期17卷 35-44页

作者： Zenan Zhou huanhuan Yu Jiaqing Zhao Xiangning Wang Qiang Wu Cuixia Dai Shanghai Institute of Technology Shanghai P.R.China Shanghai Sixth People'sHospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai P.R.China

Diabetic retinopathy(DR)is one of the major causes of visual impairment in adults with *** coherence tomography angiography(OCTA)is nowadays widely used as the golden criterion for diagnosing ***,wide-field OCTA(WF-OCTA)provided more abundant information including that of the peripheral retinal degenerative changes and it can contribute in accurately diagnosing *** need for an automatic DR diagnostic system based on WF-OCTA pictures attracts more and more attention due to the large diabetic population and the prevalence of retinopathy *** this study,automatic diagnosis of DR using vision transformer was performed using WF-OCTA images(12 mm×12 mm single-scan)centered on the fovea as the ***-OCTA images were automatically classified into four classes:No DR,mild nonproliferative diabetic retinopathy(NPDR),moderate to severe NPDR,and proliferative diabetic retinopathy(PDR).The proposed method for detecting DR on the test set achieves accuracy of 99.55%,sensitivity of 99.49%,and specificity of 99.57%.The accuracy of the method for DR staging reaches up to 99.20%,which has been proven to be higher than that attained by classical convolutional neural network *** show that the automatic diagnosis of DR based on vision transformer and WF-OCTA pictures is more effective for detecting and staging DR.

关键词： Wide field optical coherence tomography angiography diabetic retinopathy vision transformer image classification

TRPV4 Regulates Soman-Induced Status Epilepticus and Secondary Brain Injury via NMDA Receptor and NLRP3 Inflammasome

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Neuroscience Bulletin 2021年第7期37卷 905-920页

作者： Shuai Wang huanhuan he Jianhai Long Xin Sui Jun Yang Guodong Lin Qian Wang Yongan Wang Yuan Luo State Key Laboratory of Toxicology and Medical Countermeasures Institute of Pharmacology and ToxicologyAcademy of Military Medical SciencesBeijing 100850China

Nerve agents are used in civil wars and terrorist attacks,posing a threat to public *** exposure to nerve agents such as soman(GD)causes serious brain damage,leading to death due to intense seizures induced by acetylcholinesterase inhibition and neuronal injury resulting from increased excitatory amino-acid levels and ***,data on the anticonvulsant and neuroprotective efficacies of currently-used countermeasures are ***,we evaluated the potential effects of transient receptor vanilloid 4(TRPV4)in the treatment of soman-induced status epilepticus(SE)and secondary brain *** demonstrated that TRPV4 expression was markedly up-regulated in rat hippocampus after soman-induced *** of the TRPV4 antagonist GSK2193874 prior to soman exposure significantly decreased the mortality rate in rats and reduced SE ***4-knockout mice also showed lower incidence of seizures and higher survival rates than wild-type mice following soman *** in vivo and in vitro experiments demonstrated that blocking TRPV4 prevented NMDA receptor-mediated glutamate *** protein levels of the NLRP3 inflammasome complex and its downstream cytokines IL-1βand IL-18 increased in soman-exposed rat ***,TRPV4 inhibition or deletion markedly reversed the activation of the NLRP3 inflammasome *** conclusion,our study suggests that the blockade of TRPV4 protects against soman exposure and reduces brain injury following SE by decreasing NMDA receptor-mediated excitotoxicity and NLRP3-mediated *** our knowledge,this is the first study regarding the“dual-switch”function of TRPV4 in the treatment of soman intoxication.

关键词： Nerve agents Soman TRPV4 NMDA receptor NLRP3 inflammasome

Targeting RAF dimers in RAS mutant tumors:From biology to clinic

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Acta Pharmaceutica Sinica B 2024年第5期14卷 1895-1923页

作者： huanhuan Yin Qiulin Tang Hongwei Xia Feng Bi Division of Abdominal Cancer Department of Medical OncologyCancer Center and Laboratory of Molecular Targeted Therapy in OncologyWest China HospitalSichuan UniversityChengdu 610041China

RAS mutations occur in approximately 30%of tumors worldwide and have a poor prognosis due to limited *** targeting of KRAS G12C has achieved significant success in recent years,but there is still a lack of efficient therapeutic approaches for tumors with non-G12C KRAS mutations.A highly promising approach is to target the MAPK pathway downstream of RAS,with a particular focus on RAF ***-generation RAF inhibitors have been authorized to treat BRAF mutant tumors for over a ***,their use in RAS-mutated tumors is not recommended due to the paradoxical ERK activation mainly caused by RAF *** address the issue of RAF dimerization,type II RAF inhibitors have emerged as leading *** clinical studies have shown the initial effectiveness of these agents against RAS mutant ***,type II RAF inhibitors in combination with MEK or ERK inhibitors have demonstrated impressive efficacy in RAS mutant *** review aims to clarify the importance of RAF dimerization in cellular signaling and resistance to treatment in tumors with RAS mutations,as well as recent progress in therapeutic approaches to address the problem of RAF dimerization in RAS mutant tumors.

关键词： RAS mutations RAF dimerization RAF inhibitors Cancer therapy Drug resistance

On-chip spiking neural networks based on add-drop ring microresonators and electrically reconfigurable phase-change material photonic switches

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Photonics Research 2024年第4期12卷 755-766页

作者： QIANG ZHANG NING JIANG YIQUN ZHANG ANRAN LI huanhuan XIONG GANG HU YONGSheNG CAO KUN QIU School of Information and Communication Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

We propose and numerically demonstrate a photonic computing primitive designed for integrated spiking neural networks (SNNs) based on add-drop ring microresonators (ADRMRs) and electrically reconfigurable phasechange material (PCM) photonic switches. In this neuromorphic system, the passive silicon-based ADRMR,equipped with a power-tunable auxiliary light, effectively demonstrates nonlinearity-induced dual neural dynamics encompassing spiking response and synaptic plasticity that can generate single-wavelength optical neural spikes with synaptic weight. By cascading these ADRMRs with different resonant wavelengths, weighted multiple-wavelength spikes can be feasibly output from the ADRMR-based hardware arrays when external wavelengthaddressable optical pulses are injected;subsequently, the cumulative power of these weighted output spikes is utilized to ascertain the activation status of the reconfigurable PCM photonic switches. Moreover, the reconfigurable mechanism driving the interconversion of the PCMs between the resonant-bonded crystalline states and the covalent-bonded amorphous states is achieved through precise thermal modulation. Drawing from the thermal properties, an innovative thermodynamic leaky integrate-and-firing (TLIF) neuron system is proposed. With the TLIF neuron system as the fundamental unit, a fully connected SNN is constructed to complete a classic deep learning task:the recognition of handwritten digit patterns. The simulation results reveal that the exemplary SNN can effectively recognize 10 numbers directly in the optical domain by employing the surrogate gradient algorithm. The theoretical verification of our architecture paves a whole new path for integrated photonic SNNs, with the potential to advance the field of neuromorphic photonic systems and enable more efficient spiking information processing.

关键词： neural networks precise