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S-1 plus temozolomide as second-line treatment for neuroendocrine carcinoma of the breast:A case report

World Journal of Clinical Cases 2021年第24期9卷 7146-7153页

作者： Xin Wang Yan-Fen Shi Jiang-Hui Duan Chao Wang huang-ying tan Beijing University of Chinese Medicine Department of Integrative OncologyChina-Japan Friendship HospitalBeijing 100029China Department of Pathology China-Japan Friendship HospitalBeijing 100029China Department of Radiology China-Japan Friendship HospitalBeijing 100029China Department of Integrative Oncology China-Japan Friendship HospitalBeijing 100029China

BACKGROUND Neuroendocrine carcinoma of the breast(NECB)is a rare type of malignant *** to the rarity of NECB,the relevant literature mostly comprises case *** data on treatment options for NECB are very *** SUMMARY A 62-year-old woman presented to our hospital in October 2016 for intermittent vomiting and diarrhea and masses in the liver found on abdominal computed tomography(CT)*** was diagnosed in July 2012 with neuroendocrine carcinoma of the right breast in local *** patient initially presented with a painful lesion of the right *** then undergone surgical resection and adjuvant chemotherapy with pirarubicin and paclitaxel for four cycles as well as endocrine *** was regularly followed every 3 mo after *** abdominal CT imaging at our hospital revealed multiple suspicious masses in the liver with the largest lesion measuring 8.4 cm×6.3 *** CT revealed masses in the anterior chest wall and *** needle biopsy of the lesion revealed liver metastases of NECB.A bone scan showed right second anterior rib *** endoscopy and colonoscopy did not provide any evidence of another possible primary *** stopped receiving endocrine therapy and then received etoposide and cisplatin(EP)chemotherapy as a firstline treatment regimen for six cycles at our hospital after liver,bone,and lung *** October 2017,the chemotherapy regimen was changed to S-1(40mg twice daily,days 1-14)combined with temozolomide(200 mg once daily,days 10-14)(STEM)every 21 d as a second-line treatment regimen due to disease ***-free survival(PFS)and adverse effects after treatment were analyzed,and the efficacy of the STEM regimen was assessed using RECIST version *** patient achieved a partial response after using the STEM regimen,with a PFS of 23 *** effects included only grade 1 digestive tract reactions with no need for a reduction in *** This ca

关键词： Neuroendocrine carcinoma Breast S-1 Temozolomide Case report

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Advances in medical treatment for pancreatic neuroendocrine neoplasms

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World Journal of Gastroenterology 2022年第20期28卷 2163-2175页

作者： Yuan-Liang Li Zi-Xuan Cheng Fu-Huan Yu Chao Tian huang-ying tan Department of Integrative Oncology China-Japan Friendship HospitalBeijing 100029China Graduate School Beijing University of Chinese MedicineBeijing 100029China

Pancreatic neuroendocrine neoplasms(PanNENs)are rare neoplasms with strong heterogeneity that have experienced an increasing incidence rate in recent *** patients with locally advanced or distant metastatic PanNENs,systemic treatment options vary due to the different differentiations,grades and *** available options for systemic therapy include somatostatin analogs,molecularly targeted agents,cytotoxic chemotherapeutic agents,immune checkpoint inhibitors,and peptide receptor radionuclide *** addition,the development of novel molecularly targeted agents is currently in *** sequence of selection between different chemotherapy regimens has been of great interest,and resistance to chemotherapeutic agents is the major limitation in their clinical *** agents and high-level clinical evidence continue to emerge in the field of antiangiogenic *** receptor radionuclide therapy is increasingly employed for the treatment of advanced neuroendocrine tumors,and greater therapeutic efficacy may be achieved by emerging radiolabeled *** immune checkpoint inhibitor monotherapies for PanNENs appear to have limited antitumor activity,dual immune checkpoint inhibitor therapies or combinations of antiangiogenic therapies and immune checkpoint inhibitors have been applied in the clinic to improve clinical *** the use of a variety of agents with different mechanisms of action provides new possibilities for clinical *** the future,the study of systemic therapies will continue to focus on the screening of the optimal benefit population and the selection of the best treatment sequence strategy with the aim of truly achieving individualized precise treatment of PanNENs.

关键词： Pancreatic neuroendocrine neoplasms Advanced neuroendocrine tumors Medical treatment Peptide receptor radionuclide therapy Advances

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Hsa-miR-202-3p,up-regulated in type 1 gastric neuroendocrine neoplasms,may target DUSP1

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World Journal of Gastroenterology 2018年第5期24卷 573-582页

作者： Dou Dou Yan-Fen Shi Qing Liu Jie Luo Ji-Xi Liu Meng Liu ying-ying Liu Yuan-Liang Li Xu-Dong Qiu huang-ying tan Department of Integrative Oncology China-Japan Friendship Hospital Beijing University of Chinese Medicine Beijing 100029China Department of Integrative Oncology China-Japan Friendship HospitalBeijing 100029China Department of Pathology China-Japan Friendship HospitalBeijing 100029China Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China Department of Integrative Oncology Luoyang Central Hospital Affiliated to Zhengzhou UniversityLuoyang 471009Henan ProvinceChina

AIM To detect abnormal micro RNA(miRNA) expression in type 1 gastric neuroendocrine neoplasms(g-NENs) and find potential target *** Tumour tissues from patients with type 1 g-NENs were used as experimental samples, and gastric mucosal tissues from the same patients obtained during gastroscopy review after several months were used as control samples. miRNA expression was examined with Agilent human miRNA chips and validated via RTPCR. Three types of target gene prediction software(TargetScan, PITA, and microRNAorg) were used to predict potential target genes of the differentially expressed miRNAs, and a dual-luciferase reporter assay system was used for verification. RESULTS Six miRNAs were significantly upregulated or downregulated in the tumours compared to the control samples. Among them, miR-202-3 p was extraordinarily upregulated. RT-PCR of seven sample sets confirmed that miR-202-3 p was upregulated in tumour tissues. In total, 215 target genes were predicted to be associated with miR-202-3 p. Among them, dual-specificity phosphatase 1(DUSP1) was reported to be closely related to tumour occurrence and development. The dual-luciferase reporter assay showed that miR-202-3 p directly regulated DUSP1 in 293 T cells. CONCLUSION miR-202-3 p is upregulated in type 1 g-NEN lesions and might play important roles in the pathogenesis of type 1 g-NENs by targeting DUSP1.

关键词： microRNA type 1 g-NEN neuroendocrine neoplasm recurrence

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A Novel Extremum Seeking Control to Enhance Convergence and Robustness in the Presence of Nonlinear Dynamic Sensors

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Journal of Systems Science & Complexity 2024年第1期37卷 3-21页

作者： LIU Hengchang tan ying OETOMO Denny School of Electrical Mechanical and Infrastructure EngineeringThe University of MelbourneParkville VIC 3010Australia

This paper focuses on optimizing an unknown cost function through extremum seeking(ES)control in the presence of a slow nonlinear dynamic sensor responsible for measuring the *** contrast to traditional perturbation-based ES control,which often suffers from sluggish convergence,the proposed method eliminates the time-scale separation between sensor dynamics and ES control by using the relative degree of the nonlinear sensor *** improve the convergence rate,the authors incorporate high-frequency dither signals and a *** enhance the robustness with the existence of rapid disturbances,an off-the-shelf linear high-gain differentiator is *** first result demonstrates that,for any desired convergence rate,with properly tuned parameters for the proposed ES algorithm,the input of the cost function can converge to an arbitrarily small neighborhood of the optimal solution,starting from any initial condition within any given compact ***,the second result shows the robustness of the proposed ES control in the presence of sufficiently fast,zero-mean periodic *** results substantiate these theoretical findings.

关键词： Averaging extremum seeking optimization singular perturbation time-scale separation

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Synchronization of Drive-Response Networks With Delays on Time Scales

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 1063-1065页

作者： Yanxia tan Zhenkun huang the School of Science Jimei UniversityXiamen 361021China

Dear Editor,This letter deals with the synchronization in drive-response networks with discrete and distributed delays on time *** on the theory of calculus on time scales,Lyapunov functional method and inequality technique,we obtain new sufficient conditions to ensure synchronization criteria which are dependent on boundedness of grainness but independent of the types of *** simulations are given to illustrate the effectiveness of our new results.

关键词： inequality letter boundedness

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Influence of laser parameters on the microstructures and surface properties in laser surface modification of biomedical magnesium alloys

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Journal of Magnesium and Alloys 2024年第1期12卷 72-97页

作者： Chee ying tan Cuie Wen Hua Qian Ang School of Engineering RMIT UniversityMelbourneVictoria 3001Australia

Biodegradable implants from magnesium(Mg)alloys have emerged in the biomedical field especially in the orthopedic and cardiovascular stent applications owing to their low density,high specific strength,excellent machinability,good biocompatibility,and *** primary shortcoming of Mg-based implants is their low corrosion resistance in the physiological environment,which results in premature mechanical integrity loss before adequate healing and the production of excessive hydrogen gas,which is harmful to the body tissues and negatively affects the biocompatibility of the *** surface modification has recently received attention because it can improve the surface properties such as surface chemistry,roughness,topography,corrosion resistance,wear resistance,hydrophilicity,and thus cell response to the surface of the *** composition and microstructures including textures and phases of laser-treated surfaces depend largely on the laser processing parameters(input laser power,laser scan velocity,frequency,pulse duration,pressure,gas circulation,working time,spot size,beam focal position,and laser track overlap)and the thermophysical properties of the substrate(solubility,melting point,and boiling point).This review investigates the impacts of various laser surface modification techniques including laser surface melting,laser surface alloying,laser cladding,laser surface texturing,and laser shock peening,and highlights their significance in improving the surface properties of biodegradable Mg alloys for implant ***,we explore how different laser process parameters affect its composition,microstructure,and surface properties in each laser surface modification technique.

关键词： Biocompatibility Biodegradability Corrosion Implant applications Laser surface modification Magnesium alloys

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Clinicopathological characteristics and prognosis of 77 cases with type 3 gastric neuroendocrine tumours

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World Journal of Gastrointestinal Oncology 2020年第12期12卷 1416-1427页

作者： Yuan-Liang Li Xu-Dong Qiu Jie Chen Yu Zhang Jie Li Jian-Ming Xu Chao Wang Zhi-Rong Qi Jie Luo huang-ying tan Beijing University of Chinese Medicine Beijing 100029China Department of Integrative Oncology China-Japan Friendship HospitalBeijing 100029China Department of Gastroenterology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510000Guangdong ProvinceChina Department of Gastrointestinal Oncology Peking University Cancer Hospital and Beijing Cancer HospitalBeijing 100037China Department of Gastrointestinal Oncology The Fifth Medical CenterChinese PLA General HospitalBeijing 100071China Department of Pathology China-Japan Friendship HospitalBeijing 100029China

BACKGROUND For the rarity of type 3 gastric neuroendocrine tumours(g-NETs),their clinicopathological characteristics and prognosis are not well *** To describe the clinicopathological features and outcome of type 3 g-NETs in the Chinese *** Based on the 2019 WHO pathological classification,the clinicopathological characteristics and prognosis of patients with type 3 g-NETs in China were retrospectively *** A total of 77 patients(55.8%of females)with type 3 g-NETs were analysed,with a median age of 48 years(range:28-79 years).The tumours were mainly located in the gastric fundus/body(83.1%)and were mostly solitary(83.1%),with a median size of 1.5 cm(0.8-3.5 cm).Of these,there were 37 G1 tumours(48.1%),31 G2(40.3%),and 9 G3(11.7%).Ten(13.0%)and 24(31.2%)patients had lymph node and distant metastasis,*** addition,type 3 g-NETs were *** with G1 NETs,G2 NETs had a higher lymph node metastasis rate,and G3 NETs had a higher distant metastasis rate.G1 and G2 NETs with stage I/II disease(33/68)received endoscopic treatment,and no tumour recurrence or tumour-related death was observed within a median follow-up time of 36 *** and distant metastasis were identified to be independent risk factors for prognosis in multivariable *** Type 3 g-NETs are obviously heterogeneous,and the updated WHO 2019 pathological classification may be used to effectively evaluate their biological behaviors and ***,endoscopic treatment should be considered for small(<2 cm),low grade,superficial tumours.

关键词： Type 3 gastric neuroendocrine tumours Clinicopathological characteristics Endoscopic treatment Prognosis Chinese population

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Meromorphic Functions Sharing Two Values

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Wuhan University Journal of Natural Sciences 2024年第1期29卷 7-12页

作者： ZHAO ying huang Zhigang School of Mathematical Sciences Suzhou University of Science and TechnologySuzhou 215009JiangsuChina

Let f and g be two nonconstant meromorphic functions,and n be a positive *** f^(n)(z)and g^(n)(z)share 1 CM(counting multiplicities),f(z)and g(z)share∞IM(ignoring multiplicities),and N(r,1f)+N(r,1g)=S(r,f)+S(r,g),then either f(z)≡tg(z)or f(z)g(z)≡t,where t^(n)=*** an application,shared values problems of a meromorphic function related to its shifts and difference operators are also investigated.

关键词： meromorphic function shared values difference operator shift

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Dynamic Stability and Fuzzy Reliability Analysis of Toppling Perilous Rock Under Seismic Excitation

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Journal of Earth Science 2024年第1期35卷 248-262页

作者： Linfeng Wang Jixu Zhang Wanchun Xia Xiaoming huang Guojin tan Key Laboratory of Geological Hazards Mitigation for Mountainous Highway and Waterway Chongqing Jiaotong UniversityChongqing 400074China School of Transportation Southeast UniversityNanjing 211189China College of Transportation Jilin UniversityChangchun 130012China

To predict the occurrence of the collapse disaster in toppling perilous rock under the action of bidirectional earthquakes,the dynamic stability and fuzzy reliability calculation method of toppling perilous rock under the action of bidirectional earthquakes is ***,the mass viscoelasticity model is used to simulate two main control surfaces of toppling perilous rock,the seismic dynamic response model and motion equation of toppling perilous rock are established based on the D'Alembert principle,and the Newmark-β method is used to solve the dynamic motion ***,the instability event of toppling perilous rock is considered a fuzzy event,the membership function expression of the stability coefficient of toppling perilous rock is determined based on the fuzzy failure criterion,the calculation equations of the toppling perilous rock dynamic stability coefficient and fuzzy reliability are established,and the fuzzy reliability evaluation method based on the probability distribution of reliability is ***,the influence of different superposition modes of seismic excitation on the fuzzy reliability of toppling perilous rock is *** calculation results of toppling perilous rock in the engineering case show that the fuzzy reliability calculated after considering the fuzzy failure criterion is reduced by 10.73% to 25.66% compared with the classical *** the bidirectional seismic excitation,the fuzzy reliability of toppling perilous rock is reduced by 5.46% to 14.89%.Compared with using the acceleration peak time encounter mode to superpose the seismic excitation,the fuzzy reliability of toppling perilous rock is reduced by 3.4% when the maximum action effect time encounter mode is adopted.

关键词： toppling perilous rock bidirectional earthquake fuzzy failure criterion dynamic stability fuzzy reliability Newmark-βmethod probability distribution function

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Bioinspired sensing-memory-computing integrated vision systems: biomimetic mechanisms, design principles, and applications

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Science China(Information Sciences) 2024年第5期67卷 5-27页

作者： Yujie huang Yinlong tan Yan KANG Yabo CHEN Yuhua tanG Tian JIANG Institute for Quantum Information and State Key Laboratory of High Performance Computing College of Computer National University of Defense Technology College of Advanced Interdisciplinary Studies National University of Defense Technology Institute for Quantum Science and Technology College of ScienceNational University of Defense Technology

With the explosion of sensory data in the Internet of Things(Io T) era, conventional machine vision systems are becoming increasingly difficult to meet the requirements of high efficiency, low energy consumption, and low latency due to their inherent shortcomings of separate sensing, memory, and computing units. Inspired by the retina and neuromorphic computing, the sensing-memory-computing integrated vision system(SMCVS) that features low power consumption, low latency, and high parallelism has been considered a promising technology to surpass the von Neumann architecture and realize strong artificial ***, novel materials like two-dimensional semiconductors and quantum dots with novel optoelectronic performance provide hardware carriers for implementing integrated sensing-memory-computing architectures,attracting considerable attention. This paper reviews the recent research progress in bioinspired vision systems in terms of biomimetic mechanisms, design principles, computational architectures, and ***, the biomimetic mechanisms are illustrated to guide the design of high-performance artificial visual perception systems. Then the research progress of optoelectronic-synapse-based bioinspired vision systems in the device principles and applications including image filtering, color recognition, visual adaptation, and motion detection are summarized. Finally, the challenges and future developing directions of the SMCVS are provided regarding bionic application, architecture design, and device fabrication.

关键词： sensing-memory-computing architecture neuromorphic computing retinomorphic device image recognition visual system

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