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Chinese Chemical Letters 2024年第09期 288-291页

作者： Yanqi Wu Yuhong guan Peilin huang Hui Chen Liping Bai Zhihong Jiang State Key Laboratory of Quality Research in Chinese Medicine Macau University of Science and Technology Shenzhen LemnisCare Medical Technology Co. Ltd. Hunan Key Laboratory of Biomedical Nanomaterials and Devices Hunan University of Technology

Norovirus is an infectious disease that can cause non-bacterial gastroenteritis, which has a low infectious dose, rapid onset, and strong transmission ability; therefore, rapid and sensitive detection is essential to reduce the transmission of gastroenteritis. In the study, a norovirus GII loop-mediated isothermal amplification assay was developed and prepared into freeze-drying microspheres, and a closed-cassette-based,integrated, reagent-ambient storage, on-site instant detection platform for norovirus GII was constructed using a commercial, fully automated nucleic acid analyzer with integrated magnetic bearing based nuclear acid extraction and nucleic acid detection, with a sensitivity of 10 copies/μL, with no cross-reactivity with other 5 viruses. For 28 simulated samples, the integrated assay platform was consistent with the experimental results of reverse transcription-quantitative polymerase chain reaction(RT-qPCR) assays after conventional laboratory nucleic acid extraction. The entire process can be finished in about 1 h, which is ideal for immediate rapid detection.

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TBK1:a new target for overcoming cancer immunotherapy resistance

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Science China(Life Sciences) 2024年第1期67卷 217-218页

作者： Jizhong guan Long Zhang Fangfang Zhou Institutes of Biology and Medical Science Soochow UniversitySuzhou 215123China MOE Laboratory of Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network Life Sciences InstituteZhejiang UniversityHangzhou 310058China

In a recent study published in Nature,Sun et al.(2023)discovered that targeting TANK-binding kinase 1(TBK1)can successfully overcome resistance to immune checkpoint blockade(ICB)treatment and the study revealed its potential *** authors provided evidence that the disruption of TBK1 signal enhances the blockade of programmed cell death protein-1(PD-1)and promotes anti-tumor immunity in the tumor microenvironment(TME).Tumor cells rely on Janus kinase(JAK)and signal transducer as well as activator of transcription(STAT)signals to elicit an immune response by perceiving tumor necrosis factorα(TNF-α)and interferon-γ(IFN-γ),resulting in receptor-interacting protein kinase(RIPK)-caspase-mediated cell death in tumor cells(Figure 1).

关键词： TBK1 immunity

A new deformable cable for rock support in high stress tunnel: Steel pipe shrinkable energy-absorbing cable

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International Journal of Mining Science and Technology 2024年第08期 1083-1093页

作者： Xuezhen Wu Mingzhu Zhao Qing Ye Yujing Jiang tao Deng Hanfang Zheng Gang Wang Zhenchang guan College of Civil Engineering Fuzhou University School of Engineering Nagasaki University Key Laboratory of Underground Engineering Fujian University of Technology

High stress in surrounding rock will lead to serious problems, e.g., rock burst in hard rock and large deformation in soft rock. The applied support system under high in-situ stress conditions should be able to carry high load and also accommodate large deformation without experiencing severe damage. In this paper, a specially designed energy-absorbing component for rock bolt and cable that can solve the above problems was proposed. The energy-absorbing component can provide support resistance by plastic deformation of the metal including constraint annulus and compression pipe. For practical engineering,two forms were proposed. One was installed in the surrounding rock by reaming, and the other was installed directly outside the surrounding rock. During the dilation of the surrounding rock, the relative displacement of constraint annulus and compression pipe occurs, resulting in deformation *** resistance is transmitted to the rock bolt or cable, providing support resistance. The lab test and numerical simulation showed that the energy-absorbing component can perfectly achieve the large deformation effect, the deformation amount is as high as 694 mm, and the bearing capacity is stable at367 k N. The field application tests were carried out in the mining roadway of Xinjulong coal mine, and the results showed that the new type of cable can ensure itself not to break under the condition of large deformation of the surrounding rock. The energy-absorbing component has the superiorities of performing large constant resistance and controllable deformation to effectively control the unpredictable disasters such as large deformation in soft rock and rock burst in hard rock encountered in deep strata.

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Could natural phytochemicals be used to reduce nitrogen excretion and excreta‑derived N_(2)O emissions from ruminants?

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Journal of Animal Science and Biotechnology 2024年第2期15卷 490-508页

作者： Yuchao Zhao Ming Liu Linshu Jiang Leluo guan Beijing Key Laboratory of Dairy Cow Nutrition College of Animal Science and TechnologyBeijing University of AgricultureBeijing 102206China College of Animal Science and Technology China Agricultural UniversityBeijing 100193China Department of Agricultural Food and Nutritional ScienceUniversity of AlbertaEdmontonAB T6G 2R3Canada

Ruminants play a critical role in our food system by converting plant biomass that humans cannot or choose not to consume into edible high-quality ***,ruminant excreta is a significant source of nitrous oxide(N_(2)O),a potent greenhouse gas with a long-term global warming potential 298 times that of carbon *** phytochemicals or forages containing phytochemicals have shown the potential to improve the efficiency of nitrogen(N)utilization and decrease N_(2)O emissions from the excreta of *** inclusion of tannins can shift more of the excreted N to the feces,alter the urinary N composition and consequently reduce N_(2)O emissions from *** oils or saponins could inhibit rumen ammonia production and decrease urinary N *** grazed pastures,large amounts of glucosinolates or aucubin can be introduced into pasture soils when animals consume plants rich in these compounds and then excrete them or their metabolites in the urine or *** inhibitory compounds are excreted in the urine,they would be directly applied to the urine patch to reduce nitrification and subsequent N_(2)O *** phytochemicals’role in sustainable ruminant production is undeniable,but much uncertainty ***,transient effects,and adverse effects limit the effectiveness of these phytochemicals for reducing N *** this review,we will identify some current phytochemicals found in feed that have the potential to manipulate ruminant N excretion or mitigate N_(2)O production and deliberate the challenges and opportunities associated with using phytochemicals or forages rich in phytochemicals as dietary strategies for reducing N excretion and excreta-derived N_(2)O emissions.

关键词： Nitrogen metabolism Nitrous oxide Plant bioactive compounds Ruminant Urine patches

Design of Protograph LDPC-Coded MIMO-VLC Systems with Generalized Spatial Modulation

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China Communications 2024年第3期21卷 118-136页

作者： Dai Lin Fang Yi guan Yongliang Mohsen Guizani School of Information Engineering Guangdong University of TechnologyGuangzhou 51006China The State Key Laboratory of Integrated Services Networks Xidian UniversityXi’an 710126China School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore Department of Machine Learning Mohamed Bin Zayed University of Artificial Intelligence(MBZUAI)Abu DhabiUnited Arab Emirates

This paper investigates the bit-interleaved coded generalized spatial modulation(BICGSM) with iterative decoding(BICGSM-ID) for multiple-input multiple-output(MIMO) visible light communications(VLC). In the BICGSM-ID scheme, the information bits conveyed by the signal-domain(SiD) symbols and the spatial-domain(SpD) light emitting diode(LED)-index patterns are coded by a protograph low-density parity-check(P-LDPC) code. Specifically, we propose a signal-domain symbol expanding and re-allocating(SSER) method for constructing a type of novel generalized spatial modulation(GSM) constellations, referred to as SSERGSM constellations, so as to boost the performance of the BICGSM-ID MIMO-VLC ***, by applying a modified PEXIT(MPEXIT) algorithm, we further design a family of rate-compatible P-LDPC codes, referred to as enhanced accumulate-repeat-accumulate(EARA) codes,which possess both excellent decoding thresholds and linear-minimum-distance-growth property. Both analysis and simulation results illustrate that the proposed SSERGSM constellations and P-LDPC codes can remarkably improve the convergence and decoding performance of MIMO-VLC systems. Therefore, the proposed P-LDPC-coded SSERGSM-mapped BICGSMID configuration is envisioned as a promising transmission solution to satisfy the high-throughput requirement of MIMO-VLC applications.

关键词： bit-interleaved coded modulation generalized spatial modulation multiple-input multipleoutput protograph LDPC codes visible light communication

A near-complete cucumber reference genome assembly and Cucumber-DB,a multi-omics database

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Molecular Plant 2024年第8期17卷 1178-1182页

作者： Jiantao guan Han Miao Zhonghua Zhang Shaoyun Dong Qi Zhoul Xiaoping Liu Diane M.Beckles Xingfang Gul Sanwen huang Shengping Zhang State Key Laboratory of Vegetable Biobreeding Institute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijing 100081China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenChina Engineering Laboratory of Genetic Improvement of Horticultural Crops of Shandong Province College of HorticultureQingdao Agricultural UniversityQingdao266109China Department of Plant Sciences University of CaliforniaDavisOne Shield AvenueDavisCA95616USA

Dear Editor,Cucumber(Cucumis sativus)is a key vegetable crop and an essential model for genetics and genomics research in Cucurbitaceae,especially in studies on plant sex determination and vascular *** the first sequenced genome among vegetable crops,the cucumber reference genome has been a crucial genetic resource for comparative genomics and genetic ***,the latest version of the cucumber *** Long reference genome(CLv3.0),generated using PacBio long-reads data,is *** a predicted genome size of 350-367 Mb,CLv3.0 encompasses only 226.2 Mb,leaving 72 gaps and over 120 Mb of unknown *** low assembly completeness(approximately 62%)is primarily due to the high proportion(~30%)of heterochromatic satellite and rDNA sequences in cucumber,substantially higher than that observed in many other species such as Arabidopsis,rice,maize,and watermelon,where it is less than 5%(Han et al.,2008;huang et al.,2009;Li et al.,2019).

关键词： crops incomplete cucumber

Quantitative assessment of the supply,demand and flows of ecosystem services in the Yangtze River Basin,China

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Frontiers of Earth Science 2024年第2期18卷 422-445页

作者： Dongjie guan Xiaofeng FAN Lilei ZHOU Kangwen ZHU School of Smart City Institute Chongqing Jiaotong UniversityChongqing 400074China

Ecosystem service flow is essential for transporting,transforming,and maintaining ecosystem services and connecting supply and *** study attempted to quantitatively assess the supply and demand flows of ecosystem services in the Yangtze River Basin in 2000,2010,and 2020;assess the evolution of the spatial patterns of ecosystem service flow at the provincial,watershed and urban agglomeration scales;and design a zoning standard for ecosystem service *** results showed as follows.1)Between 2000 and 2020,the Yangtze River had a progressive drop in its freshwater supply,water conservation service and carbon sequestration service *** decline rates for these services were measured at 10.90%,11.11%,and 5.17%,*** climate regulation service flow exhibited a pattern of initial fall followed by a subsequent increase,characterized by a decline rate of 35.53%.2)The lowest was the ecosystem service flow in the lower reaches of the Yangtze River and the Yangtze River Delta urban *** supply service flow and water conservation service flow were the highest in the upper reaches of the Yangtze River and the Chengdu-Chongqing urban *** sequestration service flow and climate regulation service flow were the highest in the middle reaches of the Yangtze River Basin and the urban agglomeration in the middle reaches of the Yangtze River.3)From 2000 to 2020,the change ratios of the area proportion of the confluence,flow,and outflow areas in the Yangtze River Basin were 1.06,3.17,and 0.86,*** results of this research could offer decision support for regulating ecosystem services in the Yangtze River Basin,promoting sustainable regional development and achieving rational use of the basin resources.

关键词： Yangtze River Basin ecosystem services supply and demand service flow quantitative assessment spatial matching

1.42-fold enhancement of formate selectivity by linker conversion on the Zn-based metal organic framework catalyst

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Journal of Energy Chemistry 2024年第3期90卷 183-190,I0006页

作者： Yayu guan Yuyu Liu Fanghua Ning Jin Yi Jiujun Zhang Institute for Sustainable Energy College of SciencesShanghai UniversityShanghai 200444China

Electro-reduction of carbon dioxide(ERCO_(2)) is considered an effective method to alleviate the greenhouse effect and produce value-added *** the dominant selectivity of Zn-based catalysts for formate remains a *** this article,the ZnIn-E_(12) catalyst is successfully prepared by solvent assisted ligand exchange(SALE) method to convert organic ligands,achieving a Faradaic efficiency of 72.28% for formate at-1.26 V ***(V_(RHE)),which is 1.42 times higher than the original *** shows that the successful conversion of organic ligands can transform the catalyst from the original large size polyhedron to cross-linked network of particles with a diameter of about 30 *** increased specific surface area can expose more active sites and facilitate the electrocatalytic conversion of CO_(2) to *** work is expected to provide inspiration for the regulation of formate selectivity and catalyst size in Zn-based catalysts.

关键词： Electrocatalyst Carbon dioxide Formate Linker conversion

Atomically Substitutional Engineering of Transition Metal Dichalcogenide Layers for Enhancing Tailored Properties and Superior Applications

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Nano-Micro Letters 2024年第5期16卷 248-284页

作者： Zhaosu Liu Si Yin Tee Guijian guan Ming‑Yong Han Institute of Molecular Plus Tianjin UniversityTianjin 300072People’s Republic of China Institute of Materials Research and Engineering A*STARSingapore 138634Singapore

Transition metal dichalcogenides(TMDs)are a promising class of layered materials in the post-graphene era,with extensive research attention due to their diverse alternative elements and fascinating semiconductor *** MX2 layers with different metal and/or chalcogen elements have similar structural parameters but varied optoelectronic properties,providing opportunities for atomically substitutional engineering via partial alteration of metal or/and chalcogenide atoms to produce ternary or quaternary *** resulting multinary TMD layers still maintain structural integrity and homogeneity while achieving tunable(opto)electronic properties across a full range of composition with arbitrary ratios of introduced metal or chalcogen to original counterparts(0–100%).Atomic substitution in TMD layers offers new adjustable degrees of freedom for tailoring crystal phase,band alignment/structure,carrier density,and surface reactive activity,enabling novel and promising *** review comprehensively elaborates on atomically substitutional engineering in TMD layers,including theoretical foundations,synthetic strategies,tailored properties,and superior *** emerging type of ternary TMDs,Janus TMDs,is presented specifically to highlight their typical compounds,fabrication methods,and potential ***,opportunities and challenges for further development of multinary TMDs are envisioned to expedite the evolution of this pivotal field.

关键词： Transition metal dichalcogenides Atomic substitution Tailored structure Tunable bandgap Enhanced applications

A GMDA clustering algorithm based on evidential reasoning architecture

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Chinese Journal of Aeronautics 2024年第1期37卷 300-311页

作者： Haibin WANG Xin guan Xiao YI Shuangming LI Guidong SUN Naval Aviation University Yantai 264001China Unit 92941 of PLA Huludao 125001China Institute of Systems Engineering Beijing 100082China

The traditional clustering algorithm is difficult to deal with the identification and division of uncertain objects distributed in the overlapping region,and aimed at solving this problem,the Evidential Clustering based on General Mixture Decomposition Algorithm(GMDA-EC)is ***,the belief classification of target cluster is carried out,and the sample category of target distribution overlapping region is ***,on the basis of General Mixture Decomposition Algorithm(GMDA)clustering,the fusion model of evidence credibility and evidence relative entropy is constructed to generate the basic probability assignment of the target and achieve the belief division of the ***,the performance of the algorithm is verified by the synthetic dataset and the measured *** experimental results show that the algorithm can reflect the uncertainty of target clustering results more comprehensively than the traditional probabilistic partition clustering algorithm.

关键词： Evidential clustering Credal partition Evidential reasoning Mixed decomposition Gaussian mixture model