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Periodically hydrologic alterations decouple the relationships between physicochemical variables and chlorophyll-a in a dam-induced urban lake

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Journal of Environmental Sciences 2021年第1期33卷 187-195页

作者： Tianyang Li Yuqi Zhang Binghui He Bing Yang Qi huang College of Resources and Enuironment Southwest UniversityChongqing 400715China Chongqing Eco-Environmental Monitoring Center Chongqing 401147China Guiyang Engineering Corporation Limited Power ChinaGuiyang 550081China

Periodically hydrologic alterations driven by seasonal change and water storage capacity management strongly modify physicochemical properties and chlorophyll-a(Chl-a)and their interactions in dam-induced ***,the extent and magnitude of these changes still remain *** study aimed to determine the effects of periodically hydrologic alterations on physicochemical variables and Chl-a in the dam-induced urban Hanfeng Lake,upstream of Three Gorges *** in Chl-a and 13 physicochemical variables were recorded monthly in the lake from January 2013 to December ***-a was neither seasonal nor inter-annual differences while a few physical variables such as flow velocity(V)exhibited significantly seasonal variabilities,and chemical variables like total nitrogen(TN),nitrate-nitrogen(NO3-N),total phosphorus(TP),dissolved silica(DSi)were markedly inter-annual *** TN:TP(40:1)and lower NO3-N:DSi(0.8:1)relative to balanced stoichiometric ratios suggested changes in composition of phytoplankton communities and potentially increased proportion of diatom in Hanfeng ***-a was predicable by combination of dissolved oxygen(DO),TN and DSi in dry season,and by V alone in wet *** the whole study period,Chl-a was solely negatively correlated with TN:TP,indicating decline in N concentration and increase in P could therefore increase *** results highlight pronounced decoupling of linkages between Chl-a and physicochemical variables affected by periodically hydrologic alterations in dam-induced aquatic systems.

关键词： Chlorophyll-a Nutrients Dissolved silica Dam Hydrologic alterations

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The transcriptome analysis of cleft lip/palate-related PTCH1 variants in GMSM-K cells show carcinogenic potential

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BIOCELL 2023年第1期47卷 205-214页

作者： MINGZHAO LI QIAN ZHANG WENBIN huang SHIYING ZHANG NAN JIANG XIAOSHUAI huang FENG CHEN Department of Orthodontics Peking University School and Hospital of StomatologyBeijingChina Central Laboratory Peking University School and Hospital of StomatologyBeijingChina Biomedical Engineering Department Peking UniversityBeijingChina

Cancer progression involves the sonic hedgehog(SHH)pathway,in which the receptor PTCH1 actives the downstream *** of PTCH1 can lead to nevoid basal cell carcinoma Syndrome(NBCCs)including neoplastic disease and congenital *** evaluate the relationship between PTCH1 and cancer,we applied the CRISPR/Cas9 system to knock out PTCH1 in oral nontumorous epithelial cells(GMSM-K).Then we screened six PTCH1 variants associated with cleft lip/palate(CL/P),one of the congenital disorders in NBCCs,and generated PTCH1 variant and wild-type recombinant PTCH1^(−/−)GMSM-K cell *** sequencing was conducted in these cell *** results revealed that differentially expressed genes(DEGs)in PTCH1^(−/−)GMSM-K were enriched in extracellular compartments,contributing epithelial diseases by pathway enrichment ***-PCR confirmed that KRT34,KRT81,KRT86,PDGFB,and WNT10B genes,associated with extracellular compartments were highly expressed in PTCH1^(−/−).The Kyoto Encyclopedia of Genes and Genomes analysis also suggested that DEGs are closely related to focal adhesion,transcriptional misregulation,and proteoglycans in breast and gastric *** analysis of samples revealed that the CL/P-associated PTCH1 variants A443G and V908G are potentially *** findings provide new insights into the carcinogenic potential of PTCH1 dysfunction.

关键词： CRISPR/Cas9 PTCH1 variant Carcinogenic potential Transcriptome sequencing

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Sulfur Distribution during Hydrothermal Liquefaction of Lignite, Wheat Straw and Plastic Waste in Sub-Critical Water

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China Petroleum Processing & Petrochemical Technology 2015年第1期17卷 24-30页

作者： Wang Baofeng huang Yaru Zhang Jinjun School of Chemistry & Material Science Shanxi Normal University

The distribution and transformation of sulfur in products during hydrothermal liquefaction of lignite, wheat straw and plastic waste in sub-critical water were investigated in an autoclave. The influence of blending ratio, temperature, initial nitrogen pressure, residence time and additives on sulfur distribution was studied systematically. The results showed that most of sulfur existed as organic sulfur and transferred into the residue, and only a small part of sulfur transferred into oil and gas during hydrothermal liquefaction of lignite, wheat straw and plastic waste in sub-critical water. The results also showed that lower temperature(less than 300 ℃) was favorable for obtaining oil with low sulfur content. It can be also seen from the results that the best condition to obtain the oil with low sulfur content should be implemented at a lignite/wheat straw/plastic waste blending ratio of 5:4:1, an initial nitrogen pressure of 3 MPa and a residence time of 30 minutes. Furthermore, the results indicated that adding tourmaline during hydrothermal liquefaction of lignite, wheat straw and plastic waste was beneficial to production of oil with low sulfur content.

关键词： lignite, wheat straw, plastic waste, hydrothermal liquefaction, sulfur

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Intelligent virtualization of crane lifting using laser scanning technology

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Virtual Reality & Intelligent Hardware 2020年第2期2卷 87-103页

作者： Lihui huang Souravik DUTTA Yiyu CAI School of Mechanical and Aerospace Engineering Nanyang Technological University50 Nanyang Avenue 639798Singapore Interdisciplinary Graduate School(IGS) Nanyang Technological University21 Nanyang Link 637371Singapore Energy Research Institute@NTU(ERI@N) Nanyang Technological UniversityLevel XF-550 Nanyang Drive 637553Singapore

Background This paper presents an intelligent path planner for lifting tasks by tower cranes in highly complex environments,such as old industrial plants that were built many decades ago and sites used as tentative storage ***,these environments do not have workable digital models and 3 D representations are *** The current investigation introduces the use of cutting edge laser scanning technology to convert real environments into virtualized versions of the construction sites or plants in the form of point *** challenge is in dealing with the large point cloud datasets from the multiple scans needed to produce a complete virtualized *** tower crane is also virtualized for the purpose of path planning.A parallelized genetic algorithm is employed to achieve intelligent path planning for the lifting task performed by tower cranes in complicated environments taking advantage of graphics processing unit technology,which has high computing performance yet low *** Optimal lifting paths are generate d in several seconds.

关键词： Laser scanning Point cloud Intelligent modeling Virtualization of complex environments Virtual tower crane Automatic lifting path planning Rasterization

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Clinical proteomics identifies potential biomarkers in Helicobacter pylori for gastrointestinal diseases

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World Journal of Gastroenterology 2014年第6期20卷 1529-1536页

作者： Chun-Hao huang Shyh-Horng Chiou Quantitative Proteomics Center and Graduate Institute of Medicine Kaohsiung Medical University Institute of Biological Chemistry Academia Sinica

The development of gastrointestinal diseases has been found to be associated with Helicobacter pylori (H. pylori) infection and various biochemical stresses in stomach and intestine. These stresses, such as oxidative, osmotic and acid stresses, may bring about bi-directional effects on both hosts and H. pylori, leading to changes of protein expression in their proteomes. Therefore, proteins differentially expressed in H. pylori under various stresses not only reflect gastrointestinal environment but also provide useful biomarkers for disease diagnosis and prognosis. In this regard, proteomic technology is an ideal tool to identify potential biomarkers as it can systematically monitor proteins and protein variation on a large scale of cell’s translational landscape, permitting in-depth analyses of host and pathogen interactions. By performing two-dimensional polyacrylamide gel electrophoresis (2-DE) followed by liquid chromatography-nanoESI-mass spectrometry (nanoLC-MS/MS), we have successfully pinpointed alkylhydroperoxide reductase (AhpC), neutrophil-activating protein and non-heme iron-binding ferritin as three prospective biomarkers showing up-regulation in H. pylori under oxidative, osmotic and acid stresses, respectively. Further biochemical characterization reveals that various environmental stresses can induce protein structure change and functional conversion in the identified biomarkers. Especially salient is the antioxidant enzyme AhpC, an abundant antioxidant protein present in H. pylori. It switches from a peroxide reductase of low-molecular-weight (LMW) oligomers to a molecular chaperone of high-molecular-weight (HMW) complexes under oxidative stress. Different seropositivy responses against LMW or HMW AhpC in H. pylori-infected patients faithfully match the disease progression from disease-free healthy persons to patients with gastric ulcer and cancer. These results has established AhpC of H. pylori as a promising diagnostic marker for gastroin

关键词： Proteomics Biomarker Helicobacter pylori Gastritis Gastric ulcer Gastric cancer Alkylhydroperoxide reductase Neutrophil-activating protein Non-heme iron-binding ferritin

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Vehicle Active Damping Control with Considering Time Delay

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Journal of Beijing Institute of Technology 2017年第4期26卷 449-457页

作者： Danna Jiang Ying huang Donghao Hao Laboratory for Integrated Power System Technology Beijing Institute of TechnologyBeijing 100081China

A model predictive control（ MPC） based active damping controller for automotive driveline oscillations with time-delay consideration is proposed. A simplified driveline model considering time delay is modeled and converted to a linear parameter varying state space equation. Based on the model and model predictive control theory,an active damping controller is designed for drivability and comfortability improvement. In order to verify the designed controller,a driveline with engine is modeled to simulate the tip-in/out driving operation. An MPC active damping controller without considering time delay is simulated together with the proposed controller. The simulation results show that,by adopting the new MPC active damping controller,the vibration of the vehicle is reduced and the drivability and comfortability are improved.

关键词： model predictive control (MPC) drive train oscillations active damping control time delay tip-in/out

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Finite Element Analysis of Maxwell’s Equations in Dispersive Lossy Bi-Isotropic Media

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Advances in Applied Mathematics and Mechanics 2013年第4期5卷 494-509页

作者： Yunqing huang Jichun Li Yanping Lin Hunan Key Laboratory for Computation and Simulation in Science and Engineering Xiangtan UniversityHunan 411105China Department of Mathematical Sciences University of Nevada Las VegasLas VegasNevada 89154-4020USA Department of AppliedMathematics Hong Kong Polytechnic UniversityHung HomHong Kongand Department of Mathematical and Statistics ScienceUniversity of AlbertaEdmonton ABAlberta T6G 2G1Canada

In this paper,the time-dependent Maxwell’s equations used to modeling wave propagation in dispersive lossy bi-isotropic media are *** and uniqueness of the modeling equations are *** fully discrete finite element sch... 详细信息

关键词： Maxwell’s equations bi-isotropic media finite element method

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Existence and asymptotic behavior of invasion wave solutions in temporally discrete diffusion systems with delays

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International Journal of Biomathematics 2018年第2期11卷 1-25页

作者： Hui Xue Jianhua huang Zhixian Yu College of Science National University of Defense Technology Changsha Hunan 410073 P. R. China College of Science University of Shanghai for Science and Technology Shanghai 200093 P. R. China

This paper is concerned with the existence and asymptotic behavior of invasion wave solutions for a time-discrete delayed diffusion competitive system with non-quasimonotone conditions. The existence of invasion wave solution is investigated by applying upper lower solutions method and Schauder＇s fixed point theorem. Further, with the help of Ikeharas＇ theorem, we establish the exponential decay asymptotic behavior of traveling wave solutions at the minus/plus infinity.

关键词： Invasion wave solutions non-quasi-monotonicity diffusive competition sys-tems asymptotic behavior.

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High Dynamic Bounding and Jumping Motion of Quadruped Robot Based on Stable Optimization Control

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Journal of Bionic Engineering 2024年第1期21卷 101-111页

作者： Sai Gu Fei Meng Botao Liu Junyao Gao Qiang huang School of Mechatronical Engineering Beijing Institute of Technology100081 BeijingChina Key Laboratory of Biomimetic Robots and Systems Ministry of EducationBeijing 100081China

Aiming at the environment such as ravines and obstacles that may be encountered in the actual movement,this paper proposes a method for optimizing the bounding and jumping motion based on the ground touching force trajectory and the air motion trajectory of the quadruped *** method of optimizing the ground reaction force according to the speed of the demand and the height of the jump,and adjusting the stance and swing time according to the relationship of dynamics and momentum *** the same time,under the constraints of dynamics and energy consumption of the robot system,considering the jumping distance and height,a method for optimizing the air trajectory of bounding and jumping is *** switching and landing stability control are also ***,the experimental results show that the quadruped robot has strong bounding and jumping ability,and has achieved stable bounding movement and forward jump movement of 0.8 m.

关键词： Quadruped robot High dynamic motion control-Periodic limit cycle Trajectory optimization

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Bifurcation analysis of a fractional-order SIQR model with double time delays

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International Journal of Biomathematics 2020年第7期13卷 231-261页

作者： Shouzong Liu Ling Yu Mingzhan huang College of Mathematics and Statistics Xinyang Normal University Xinyang 464000 P.R.China

In this paper,a fractional-order delayed SIQR model with nonlinear incidence rate is *** time delays are incorporated in the model to describe the incubation period and the time caused by the healing *** analyzing the associated characteristic equations,the stability of the endemic equilibrium and the existence of Hopf bifurcation are obtained in three different ***,the critical values of time delays at which a Hopf bifurcation occurs are obtained,and the influence of the fractional order on the dynamics behavior of the system is also ***,it has been shown that when the endemic equilibrium is locally stable,the convergence rate of the system becomes slower with the increase of the fractional ***,our studies also imply that the decline of the fractional order may convert a oscillatory system into a stable ***,we find in all these three cases,the bifurcation values are very sensitive to the change of the fractional order,and they decrease with the increase of the order,which means the Hopf bifurcation gradually occurs in advance.

关键词： Fractional order delay stability Hopf bifurcation

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