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Science china(Physics,{1. & Astronomy) 2005年第5期48卷 614-625页

作者： huang zhangfeng 1,{1.,2 & zhou heng 1,2 1. department of mechanics, tianjin university, tianjin 300072, china 2. Liu-Hui Center of Applied Mathematics, Nankai university and tianjin university, tianjin 300072, china department of {1. Tianjin University Tianjin China Liu-Hui Center of Applied Mathematics Nankai University and Tianjin University Tianjin China

Temporal mode direction numerical simulation has been done for the transition of a supersonic boundary layer on a flat plate with Mach number 4.5. Analysis of the result showed that during the breakdown process in laminar-turbulent transition, the mechanism causing the mean flow profile to evolve swiftly from laminar to turbulent was that the modification of mean flow profile by the disturbances,when they became larger,led to a remarkable change of its stability characteristics. Though the most unstable T-S wave was of second mode for laminar flow, the first mode waves played the key role in the breakdown process in laminar-turbulent transition.

关键词： supersonic boundary layer, transition, breakdown.

A numerical investigation of the evolution of 2-D disturbances in hypersonic boundary layers and the effect on the flow structure due to the existence of shocklets

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Science china(Physics,{1. & Astronomy) 2004年第2期47卷 244-255页

作者： cao wei & zhou heng department of mechanics,tianjin university Liu Hui Center of Applied Mathematics,Nankai and tianjin university,tianjin 300072,china Correspondence should be addressed to zhou heng(email:hzhou 1 @ ***) department of {1. Tianjin University China Liu Hui Center of Applied Mathematics Nankai China tianjin {1. Tianjin China

The evolution of 2-D disturbances in hypersonic boundary layer with Mach number 6,8, and 1. was investigated numerically by three different numerical schemes. At the entrance, second mode T-S waves with different amplitudes were introduced, and the relation between the Mach number and the amplitude of the disturbance when shocklets started to appear was investigated. By comparing the disturbance velocity profiles with those provided by linear stability theory, the effects of shocklets on flow structures were also investigated.

关键词： hypersonic boundary layers, T-S wave, shocklet, direct numerical simulation.

Ligand modulation of active center to promote lead-free Cs_(2)AgInCl_(6)photocatalytic CO_(2)reduction

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Journal of Energy Chemistry 2024年第8期95卷 660-669,I0015页

作者： Baofei Sun wei Chen Yanyi {1. Daofu Wu heng Luo Faguang Kuang Hongmei Ran Yichen Liu Liqin Gao Jinchen zhou Bo Gao Qiang {1. Xiaosheng Tang Key Laboratory of Human Brain Bank for Functions and Diseases of department of Education of Gui{1. Province College of Basic MedicalGuizhou Medical UniversityGuiyang 550025GuizhouChina School of Electromechanical and Automotive Engineering Yantai UniversityYantai 264005ShandongChina State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina College of Optoelectronic Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065China Key Laboratory of Optoelectronic Technology&Systems(Ministry of Education) College of Optoelectronic EngineeringChongqing UniversityChongqing 400044China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001HenanChina

Metal halide perovskites(MHP)are potential candidates for the photocatalytic reduction of CO_(2)due to their long photogenerated carrier lifetime and charge diffusion ***,the conventional long-chain ligand impedes the adsorption and activation of CO_(2)molecules in practical ***,a ligand modulation technology is employed to enhance the photocatalytic CO_(2)reduction activity of lead-free Cs_(2)AgInCl_(6)microcrystals(MCs).The Cs_(2)AgInCl_(6)MCs passivated by Oleic acid(OLA)and Octanoic acid(OCA)are used for photocatalytic CO_(2)*** results show that the surface defects and electronic properties of Cs_(2)AgInCl_(6)MCs can be adjusted through ligand *** with the OLA-Cs_(2)AgInCl_(6),the OCA-Cs_(2)AgInCl_(6)catalyst demonstrated a significant improvement in the catalytic yield of CO and CH_(4).The CO and CH_(4)catalytic yields of OCA-Cs_(2)AgInCl_(6)reached 1.1.88 and34.1.μmol g^(-1.h^(-1.which were 2.03 and 1..98 times higher than those of OLA-Cs_(2)AgInCl_(6),and the total electron consumption rate of OCA-Cs_(2)AgInCl_(6)was 61..2μmol g^(-1.h^(-1.which was 3.25 times higher than that of OLA-Cs_(2)AgInCl_(6).Furthermore,in situ diffuse reflectance infrared Fourier transform spectra revealed the enhancement of photocatalytic activity in Cs_(2)AgInCl_(6)MCs induced by ligand *** study illustrates the potential of lead-free Cs_(2)AgInCl_(6)MCs for efficient photocatalytic CO_(2)reduction and provides a ligand modulation strategy for the active promotion of MHP photocatalysts.

关键词： Surface ligand Photocatalysis CO_(2)reduction Lead-free perovskite Reactive mechanism

Targeting autophagy overcomes cancer-intrinsic resistance to CAR-T immunotherapy in B-cell malignancies

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Cancer Communications 2024年第3期44卷 408-432页

作者： Lu Tang Huan Zhang Fen zhou Qiuzhe {1. Mengyi Du Jianghua Wu Chenggong Li Wenjing Luo Jie zhou Xindi Wang Zhaozhao Chen Yinqiang Zhang Zhongpei huang Zhuolin Wu Yuxi Wen Huiwen Jiang Danying Liao Haiming Kou {1. Xiong heng Mei Yu Hu Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China Hubei Clinical Medical Center of Cell Therapy For Neoplastic Disease WuhanHubeiP.R.China Key Laboratory of Biological Targeted Therapy the Ministry of EducationWuhanHubeiP.R.China department of Thoracic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China department of Pediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China Hubei Key Laboratory of Biological Targeted Therapy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China

Background:Chimeric antigen receptor T(CAR-T)therapy has substantially revolutionized the clinical outcomes of patients with hematologic malignan-cies,but the cancer-intrinsic mechanisms underlying resistance to CAR-T cells remain yet to be fully *** study aims to explore the molecular deter-minants of cancer cell sensitivity to CAR-T cell-mediated killing and to provide a better understanding of the underlying mechanisms and potential modulation to improve clinical ***:The human whole-genome CRISPR/Cas9-based knockout screening was conducted to identify key genes that enable cancer cells to evade CD1. CAR-T-cell-mediated *** in vitro cytotoxicity assays and evaluation of tumor tissue and bone marrow specimens were further conducted to confirm the role of the key genes in cancer cell susceptibility to CAR-T *** addition,the specific mechanisms influencing CAR-T cell-mediated cancer clearance were elucidated in mouse and cellular ***:The CRISPR/Cas9-based knockout screening showed that the enrich-ment of autophagy-related genes(ATG3,BECN1.and RB1.C1.provided protec-tion of cancer cells from CD1. CAR-T cell-mediated *** findings were further validated by in vitro cytotoxicity assays in cells with genetic and pharmacological inhibition of ***,higher expression of the three autophagy-related proteins in tumor samples was correlated with poorer respon-siveness and worse survival in patients with relapsed/refractory B-cell lymphoma after CD1. CAR-T *** RNA sequencing analysis of bone marrow samples from B-cell leukemia patients also suggested the clinical relevance of autophagy to the therapeutic response and relapse after CD1. CAR-T cell *** inhibition of autophagy and knockout of RB1.C1.could dramatically sensitize tumor cells to CD1. CAR-T cell-mediated killing in mouse models of both B-cell leukemia and ***,our study revealed that cancer-intrinsic

关键词： CAR-T resistance Autophagy Immune evasion Apoptosis Chemotaxis

分子串模型中空间弛豫模式的弛豫动力学的蒙特卡罗模拟

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物理学报 2011年第12期60卷 400-405页

作者：樊小辉赵兴宇王丽娜张丽丽周恒为张晋鲁黄以能伊犁师范学院物理科学与技术学院新疆凝聚态相变与微结构实验室伊宁835000 南京大学物理学院固体微结构物理国家重点实验室南京210093 新疆教育学院科研处乌鲁木齐830043

基于玻璃化转变的分子串模型的分子串弛豫方程,提出了更为精确的模拟分子串中所有空间弛豫模式(SRM)的蒙特卡罗模拟方案.模拟得出各个SRM的弛豫时间随温度和分子串长度的变化结果与分子串模型中分子串弛豫方程的预言完全一致,即理论预... 详细信息

基于玻璃化转变的分子串模型的分子串弛豫方程,提出了更为精确的模拟分子串中所有空间弛豫模式(SRM)的蒙特卡罗模拟方案.模拟得出各个SRM的弛豫时间随温度和分子串长度的变化结果与分子串模型中分子串弛豫方程的预言完全一致,即理论预期和模拟结果相互印证.应当指出,分子串能否作为液态中集体单元的必要条件是在考虑到分子串之间的不均匀随机相互作用后,分子串的所有SRM的定性特征是不能改变的,这就需要对不同分子串的SRM之间的耦合进行研究.但是迄今为止,仍未发现相关的严格解,仅有近似的自洽弛豫平均场方法.由此可知,所提出的模拟方案为研究不同分子串的SRM之间的耦合(包括上述自洽场的可行性)提供了必要的基础.

关键词：玻璃化转变弛豫动力学蒙特卡罗模拟分子串

Study of the response of 1.B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： Qiang Li Li‑Jiao Wang Xiang‑Biao Qiu Jing‑Wen Li wei Xu Tao Li Ze‑Bin Lin Chang‑Jun Ning Yong‑Hao Chen Rui‑Rui Fan Kang Sun Jing‑Yu Tang Rong Zhang Han‑Tao Jing Bo Mei Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping {1. Qi‑Ping Chen Zhen Chen Zeng‑Qi Cui An‑Chuan Fan Chang‑Qing Feng Fan‑Zhen Feng Ke‑Qing Gao Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑Cheng He Yang Hong Yi‑wei Hu Han‑Xiong huang wei‑Hua Jia Hao‑Yu Jiang wei Jiang Zhi‑Jie Jiang Zheng‑Yao Jin Ling Kang Bo Li Chao Li Gong Li Jia‑Wen Li Xiao Li Yang Li Jie Liu Rong Liu Shu‑Bin Liu Guang‑Yuan Luan Bin‑Bin Qi Jie Ren Zhi‑zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Zhi‑Xin Tan Sheng‑Da Tang Peng‑Cheng Wang Zhao‑Hui Wang Zhong‑wei Wen Xiao‑Guang Wu Xuan Wu Li‑Kun Xie Yi‑wei Yang Han Yi Yong‑Ji Yu Guo‑Hui Zhang Lin‑Hao Zhang Mo‑Han Zhang Qi‑wei Zhang Xian‑Peng Zhang Yu‑Liang Zhang Yue Zhang Zhi‑Yong Zhang Mao‑Yuan Zhao Lu‑Ping zhou Zhi‑Hao zhou Ke‑Jun Zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China university of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.1.B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 1. mol%1.B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the china Spallation Neutron *** neutron detection efficiency was calibrated at 1.eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 1. B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 1.B-doped MCP Neutron response Wide-energy range neutrons

1.B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

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Nuclear Science and Techniques 2024年第8期35卷 58-68页

作者： Qiang Li Li‑Jiao Wang Jing‑Yu Tang Xiang‑Biao Qiu Zhen Chen Mao‑Yuan Zhao Chang‑Jun Ning Kai Pan wei Xu Tao Li Su‑Peng Lu Han Yi Rui‑Rui Fan Chang‑Qing Feng Rong Zhang Xiao‑Yang Sun Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping {1. Qi‑Ping Chen Yong‑Hao Chen Zeng‑Qi Cui An‑Chuan Fan Fan‑Zhen Feng Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑Cheng He Yang Hong Yi‑wei Hu Han‑Xiong huang wei Jiang Zhi‑Jie Jiang Zheng‑Yao Jin Ling Kang Bo Li Gong Li Xiao Li Yang Li Jie Liu Rong Liu Shu‑Bin Liu Yi‑Na Liu Guang‑Yuan Luan Jie Ren Zhi‑zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Kang Sun Zhi‑Xin Tan Sheng‑Da Tang Jin‑Cheng Wang Peng‑Cheng Wang Zhao‑Hui Wang Zhong‑wei Wen Xiao‑Guang Wu Xuan Wu Cong Xia Yong‑Ji Yu Guo‑Hui Zhang Hang‑Chang Zhang Lin‑Hao Zhang Qi‑wei Zhang Xian‑Peng Zhang Yu‑Liang Zhang Yue Zhang Zhi‑Yong Zhang Zhi‑Hao zhou Ke‑Jun Zhu Chong Zou Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision Science and Technology(Nanjing)Research Institute Co.Ltd Nanjing 211106China department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China china Academy of Engineering Physics Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China university of Chinese Academy of Sciences Beijing 100049China china Shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1.80s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the china Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 1.B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1.1.0 eV energy range;the more difficult medium-{1.ght elements such as iron,copper,and aluminum with resonance peaks in the 1.1.0 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 1.B doped MCP detector White neutron source Sample nuclide identification

Identification of Disregulated Differential Signaling Pathway in the Epstein-Barr Virus-Associated Malignancies Nasopharyngeal Carcinoma by cDNA microarray and Gene Set Enrichment Analysis

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Identification of Disregulated Differential Signaling Pathwa...

皮肤恶性黑色素瘤组织miR-205、miR-367表达及其临床意义

2008年中国病理生理学会第十一届肿瘤和第十二届免疫专业委员会学术会议

作者： Wen-Ling Zhang~(a,1. Zhao-Yang Zeng~(a,1. Yan-Hong zhou~(a,1. {1. Xiong~(a,1. Song-Qing Fan~(b,1. Lan Xiao~(a,1. Xiao-Ling Li~a Dong-Hai huang~c Ming-Hua Wu~a Dan Li~a Shou-Rong Shen~d Li cao~a Ke Tang~a Gui-Yuan Li~(a,**) a Cancer Research Institute,Xiang-Ya School of Medicine,Central South university,Changsha,Hunan 41.078,china b department of Pathology,The Second Xiang-Ya Hospital,Central South university,Changsha,Hunan 41.01.,china c The First Xiang-Ya Hospital,Central South university,Changsha,Hunan 41.078,china d The Third Xiang-Ya Hospital,Central South university,Changsha,Hunan 41.01.,china

Nasopharyngeal carcinoma (NPC) is an epithelial cancer and studies have revealed that Epstein-Barr Virus (EBV) is closely associated with *** aim of this study was to characterize the globally pathways affected in the... 详细信息

关键词： signaling pathway nasopharyngeal carcinoma Gene Set Enrichment Analysis cDNA microarray tissue microarray Epstein-Barr Virus

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局解手术学杂志 2024年第1期33卷 84-88页

作者：张丽君严伟恒黄国庆孙充洲电子科技大学医学院附属绵阳医院/绵阳市中心医院烧伤整形外科四川绵阳621000

目的探讨皮肤恶性黑色素瘤(CMM)组织中miR-205、miR-367的表达及与临床病理特征和预后的关系。方法选取201.年5月至201.年1.月我院收治的85例CMM患者术中切除的肿瘤组织作为CMM组,另选取同期于本院治疗的80例皮肤良性色素痣患者的痣组... 详细信息

目的探讨皮肤恶性黑色素瘤(CMM)组织中miR-205、miR-367的表达及与临床病理特征和预后的关系。方法选取201.年5月至201.年1.月我院收治的85例CMM患者术中切除的肿瘤组织作为CMM组,另选取同期于本院治疗的80例皮肤良性色素痣患者的痣组织标本作为对照组。采用qRT-PCR法检测miR-205、miR-367的表达水平。收集CMM患者的临床病理资料,分析miR-205、miR-367表达与临床病理特征的关系。Kaplan-Meier法绘制患者术后3年的生存曲线,采用Log-rank检验分析患者生存率。COX比例风险回归模型分析预后的影响因素。结果CMM组患者miR-205表达水平低于对照组(P205低表达组患者溃疡、临床分期高、肿瘤侵袭、KPS评分低、原发灶厚、Clark分级高、淋巴结转移的比例高于miR-205高表达组(P28.3个月,失访1.。Kaplan-Meier生存曲线显示,miR-205高表达组患者3年生存率高于miR-205低表达组(P205表达升高为其保护因素(P205低表达,miR-367高表达,且均与患者溃疡、临床分期高、肿瘤侵袭、KPS评分低、原发灶厚、Clark分级高、淋巴结转移和预后不良有关,可作为CMM患者预后评估的潜在标志物。

关键词：皮肤恶性黑色素瘤 miR-205 miR-367 临床病理特征预后

Inherent mass transfer engineering of a Co,N co-doped carbon material towards oxygen reduction reaction

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Journal of Energy Chemistry 2021年第7期30卷 391-396页

作者： Yanzhi Wang Bin Wang Haitao Yuan Zuozhong Liang Zhehao huang Yuye {1. wei Zhang Haoquan Zheng Rui cao Key Laboratory of Applied Surface and Colloid Chemistry Ministry of EducationSchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’an 710119ShaanxiChina department of Materials and Environmental Chemistry Stockholm UniversityStockholm SE-10691Sweden KTH Royal Institute of Technology School of Engineering Sciences in ChemistryBiotechnology and HealthDepartment of ChemistryDivision of Applied Physical ChemistryAnalytical ChemistryStockholm SE-10044Sweden

Oxygen reduction reaction (ORR) is an important process for the conversion and utilization of a wide range of renewable energy sources, and is critical for the shape of future energy scenario [1.1.]. However, ORR is a complex four-electron transfer process and is kinetically sluggish. It is urgent to develop high-efficient electrocatalysts to solve this problem [1.–1.]. Up to now, precious metal-based catalysts such as Pt-based electrocatalysts have been widely studied and found to be one of the most efficient electrocatalysts for ORR. However, the high price and the small reserves limit their large-scale commercialization [1.,1.–23]. Therefore, in order to fulfill needs for the practical applications, it is necessary to develop low-cost electrocatalysts, also with high activity and great stability [1.,24–28].

关键词： Co,N co-doped porous carbon Electrocatalysis Oxygen reduction reaction Zn-air battery