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Cytoskeleton reorganization and FAK phosphorylation are involved in lanthanum(Ⅲ)-promoted proliferation and differentiation in rat osteoblasts

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Progress in Natural Science:Materials International 2009年第3期19卷 331-335页

作者： Xi Wang,Jian huang*,Tianlan Zhang*,kui Wang Department of Chemical Biology,Peking University School of Pharmaceutical Sciences,38 Xueyuan Road,Beijing 100083,China Department of Chemical Biology Peking University School of Pharmaceutical Sciences 38 Xueyuan Road Beijing 100083 China

The effect of lanthanum ion(La 3+ )on osteoblast function and cytoskeleton is assessed in *** were isolated from Sprague- Dawley fetal neonatal *** proliferation and gene expression levels of cbfa-1,alkaline phosphatase(ALP),osteocalcin(OC),bone sialo- protein(BSP)and osteopontin(OPN)were examined by cell counting and *** F-actin was stained with rhodamine-con- jugated phalloidin and was visualized by a confocal *** the results,10à 8-10 à4M La 3+-induced osteoblast proliferation on day 2. Data from the RT-PCR assay revealed that 10à 6M La 3+up-regulated the expression levels of ALP,BSP,and cbfa-1 on day 4,while it enhanced the expressions of OC and OPN on day *** F-actin cytoskeleton was strengthened and reorganized under the exposure of La3 +.In addition, the phosphorylation of focal adhesion kinase(FAK)was significantly promoted in 24 h evaluated by Western blot *** findings indi- cate that La3 +promotes osteoblast activity through the phosphorylation of FAK and reorganization of the cytoskeleton.

关键词： La3 + Osteoblasts Proliferation Differentiation Cytoskeleton FAK phosphorylation

X射线工业CT成像过程复杂伪影抑制方法综述

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自动化学报 2023年第4期49卷 687-704页

作者：杨富强杨瑶李志翔黄魁东西北工业大学航空发动机高性能制造工业和信息化部重点实验室西安710072 西北工业大学航空发动机先进制造技术教育部工程研究中心西安710072

X射线工业计算机断层(Computerized tomography,CT)技术是一种先进的非接触式无损三维检测技术,能在无损伤情况下以灰度图像的形式对物体内部结构进行全面、详细地分析,在航空航天、工业生产、安检等领域发挥着重要的作用.针对工业CT伪... 详细信息

X射线工业计算机断层(Computerized tomography,CT)技术是一种先进的非接触式无损三维检测技术,能在无损伤情况下以灰度图像的形式对物体内部结构进行全面、详细地分析,在航空航天、工业生产、安检等领域发挥着重要的作用.针对工业CT伪影严重降低图像质量问题,对工业CT成像过程复杂伪影形成机理进行分析,对不同类型伪影抑制方法进行归纳总结.阐述了基于射线衰减、探测器及高密度差异、采样数据及重建等不同过程伪影成因及伪影消除相关算法的最新技术进展,并对近年来人工智能深度学习背景下新兴的基于深度学习及神经网络的工业CT无损检测研究与发展方向进行了总结和展望.

关键词：工业CT 伪影抑制深度学习智能检测

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Comprehensive analysis of the protein phosphatase 2A regulatory subunit B56ε in pan-cancer and its role and mechanism in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 475-492页

作者： Hong-Mei Wu Yuan-Yuan huang Yu-Qiu Xu Wei-Lai Xiang Chang Yang Ru-Yuan Liu Di Li Xue-Feng Guo Zheng-Bao Zhang Chun-Hua Bei Sheng-kui Tan Xiao-Nian Zhu Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health Guilin Medical UniversityGuilin 541199Guangxi Zhuang Autonomous RegionChina

BACKGROUND B56εis a regulatory subunit of the serine/threonine protein phosphatase 2A,which is abnormally expressed in tumors and regulates various tumor cell *** present,the application of B56εin pan-cancer lacks a comprehensive analysis,and its role and mechanism in hepatocellular carcinoma(HCC)are still *** Cancer Genome Atlas,Genotype-Tissue Expression,Gene Expression Profiling Interactive Analysis,and Tumor Immune Estimation Resource databases were used to analyze B56εexpression,prognostic mutations,somatic copy number alterations,and tumor immune characteristics in 33 *** relationships between B56εexpression levels and drug sensitivity,immuno-therapy,immune checkpoints,and human leukocyte antigen(HLA)-related genes were further *** Set Enrichment Analysis(GSEA)was performed to reveal the role of B56εin *** Cell Counting Kit-8,plate cloning,wound healing,and transwell assays were conducted to assess the effects of B56εinterference on the malignant behavior of HCC *** In most tumors,B56εexpression was upregulated,and high B56εexpression was a risk factor for adrenocortical cancer,HCC,pancreatic adenocarcinoma,and pheochromocytoma and paraganglioma(all P<0.05).B56εexpression levels were correlated with a variety of immune cells,such as T helper 17 cells,B cells,and *** was a positive correlation between B56εexpression levels with immune checkpoint genes and HLA-related genes(all P<0.05).The expression of B56εwas negatively correlated with the sensitivity of most chemotherapy drugs,but a small number showed a positive correlation(all P<0.05).GSEA analysis showed that B56εexpression was related to the cancer pathway,p53 downstream pathway,and interleukin-mediated signaling in *** of B56εexpression in HCC cells inhibited the proliferation,migration,and invasion capacity of tumor *** Tip:The expression of protein phosphatase 2A(PP2A)subunit B56εis up-regulated in most tumors,and its high

关键词： B56ε Prognosis Tumor microenvironment Immune infiltration Immunotherapy Hepatocellular carcinoma

Silurian integrative stratigraphy, biotas and palaeogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

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Science China Earth Sciences 2024年

作者： Zhongyang CHEN Qing CHEN Guangxu WANG Xiang FANG Peng TANG Guanzhou YAN Wenwei YUAN Bing huang Xiaole ZHANG kui YAN Yuandong ZHANG Yi WANG University of Chinese Academy of Sciences State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences

The Silurian palaeontology and stratigraphy of the Qinghai-Tibetan Plateau have been studied for more than100 years. With the launch of the Second Tibetan Plateau Scientific Expedition and Research, it is necessary to update the summaries of the Silurian stratigraphy and fossil assemblages of the Qinghai-Tibetan Plateau and their correlation with its surrounding areas. In this study, we have selected 33 sections from the Qinghai-Tibetan Plateau and its surroundings areas,summarised the available data in terms of stratigraphic regionalisation, lithostratigraphy, chronostratigraphy, and biostratigraphy,and divided the study area into four stratigraphic provinces:the Xizang-Western Yunnan-Western Sichuan Province, the KunlunQilian Province, the South China Province, and the Tarim Province. In general, the Silurian strata in the Qinghai-Tibetan Plateau is more complete than those in other areas of China. Palaeobiogeographical studies of the vertebrate faunas, sporomorph assemblages, and brachiopod faunas of the study area indicate a closer geographical relationship between the South China,Tarim, and Indochina palaeoplates, than previously considered. Compared with the surrounding areas where Silurian strata have been extensively studied, the study of Silurian strata in the main part of the Qinghai-Tibetan Plateau is still in the preliminary stage. In the future, it is necessary to conduct research on the age, distribution, and resource potential of basal Silurian black shales to provide new directions for shale gas exploration and development in China. The shallow marine strata of the middle to upper Silurian require further subdivision. Considering that the Silurian System in the Qinghai-Tibetan Plateau is more complete,it has the potential to supplement and improve the study of the carbon isotope stratigraphy of the Silurian in China.

关键词：

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韩国基督新教鸟瞰

世界宗教研究 2008年第2期 127-136页

作者：黄奎中国社会科学院世界宗教研究所

本文对韩国基督新教在日本殖民统治时期奋起抗争、军人独裁统治时期迅猛发展和民主宪政时期衰颓不振的历史脉络作出粗线条勾勒,概述韩国基督新教的民族主义、民主性和现代性诉求在国际国内政治-经济-文化沧桑情境中的曲折表现,尝试揭示... 详细信息

本文对韩国基督新教在日本殖民统治时期奋起抗争、军人独裁统治时期迅猛发展和民主宪政时期衰颓不振的历史脉络作出粗线条勾勒,概述韩国基督新教的民族主义、民主性和现代性诉求在国际国内政治-经济-文化沧桑情境中的曲折表现,尝试揭示韩国基督新教作为普世性基督宗教与局域性韩国宗教传统相结合的产物在全球化时代的文化交融特质及其固有困境。

关键词：韩国基督新教民族主义祈福信仰文化交融全球化

重庆市乡村旅游资源空间特征及其与乡村振兴关系研究

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中国农业资源与区划 2020年第4期41卷 216-224页

作者：黄葵重庆第二师范学院重庆400067

[目的]探究重庆市乡村旅游资源的结构类型和空间特征,分析乡村旅游资源数量与乡村振兴之间的关系,对重庆市乡村旅游产业发展和促进乡村振兴具有指导意义。[方法]文章利用GIS技术定量分析重庆市乡村旅游资源的空间分布特征,通过空间分布... 详细信息

[目的]探究重庆市乡村旅游资源的结构类型和空间特征,分析乡村旅游资源数量与乡村振兴之间的关系,对重庆市乡村旅游产业发展和促进乡村振兴具有指导意义。[方法]文章利用GIS技术定量分析重庆市乡村旅游资源的空间分布特征,通过空间分布模型探究乡村旅游资源空间分布的聚集程度,利用地理联系率探析人口规模和经济发展水平与乡村旅游资源分布的配合度。采用回归模型从整体上对重庆市乡村旅游资源数量与乡村振兴的关系进行分析,利用Pearson相关系数对不同经济发展区域关系进行研究,试图得到乡村旅游资源数量与乡村振兴的辩证关系。[结果]重庆市乡村旅游资源具有4种类型,农事体验类所占的比重最大,达到43.46%,乡村文化类所占比重最低为2.30%。乡村旅游空间布局特征结果表明重庆市4种乡村旅游类型在空间上的分布存在较大的区域差异,都呈现集中分布,4种类型的景点与人口和经济的配合度较高。回归分析结果表明,乡村旅游资源数量与休闲农业和乡村旅游接待人次、农村卫生厕所普及率、村综合性文化服务中心覆盖率、县级以上文明村和乡镇占比和农村居民人均纯收入之间存在均衡关系。Pearson相关性分析结果表明除休闲农业和乡村旅游接待人次外,乡村旅游资源数量仅与农村居民人均纯收入之间存在低度相关性,不同经济区相关系数差异较大。[结论]综合以上研究结果,乡村旅游资源的空间分布特征既受当地经济发展的影响,同时又促进当地经济的发展,表明重庆市乡村旅游资源对乡村振兴具有一定的促进作用。建议在今后的发展中应拓展乡村旅游类型,提高乡村文化类景点的数量和比重,促进重庆市乡村旅游产业的均衡发展,实现不同经济区乡村经济的协调发展。

关键词：乡村旅游分布特征乡村振兴回归模型重庆市

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关注抗战文学研究中被忽视的现象——抗战时期西南大后方文学·文化活动研讨会综述

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中国现代文学研究丛刊 2006年第1期 307-313页

作者：黄葵贵州师范大学文学院 550001

抗战胜利60周年之际，在贵州师范大学秀丽的照壁山麓，2005年10月28日至30日，贵州师大文学·教育与文化传播研究中心与文学院联合举办了“抗战时期西南大后方文学活动与思想文化建设”学术研讨会。来自中国社会科学院、中国现代文学馆... 详细信息

抗战胜利60周年之际，在贵州师范大学秀丽的照壁山麓，2005年10月28日至30日，贵州师大文学·教育与文化传播研究中心与文学院联合举办了“抗战时期西南大后方文学活动与思想文化建设”学术研讨会。来自中国社会科学院、中国现代文学馆、北京大学、南京大学、上海外语学院、武汉大学、厦门大学、福建师大、广西师大等十多所高校和研究机构的40余名专家学者出席了会议，不少学者展示了他们最新的研究成果，令人耳目一新；一批全国著名学者的莅临和发言，更提升了会议的学术水准；举办单位推出的一系列贵州本地文学文化现象研究成果，则显示了贵州师大文学院一批中青年学者的治学努力。而这次研讨会最突出的—个特点是，在对抗战时期的作家作品、文学社团、文体类型、地域文化等方面的研究中，特别关注到以前研究中较薄弱和被忽视的现象。

关键词：抗战时期文学研究大后方研讨会综述文化活动西南贵州师范大学中国社会科学院中国现代文学馆思想文化建设

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Hyaluronic Acid in the Treatment of Knee Osteoarthritis: Review

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Yangtze Medicine 2018年第2期2卷 62-72页

作者： Satish Prasad Koiri Yi Yang huang kui School of Medicine Yangtze University Jingzhou China Department of Orthopaedic First Affiliated Hospital of Yangtze University Jingzhou China

Knee osteoarthritis (OA) is a progressive disease in which the cartilage (cushioning between joints) wears away. As the cartilage wears away, it becomes frayed and rough, and the protective space between the bones decreases. This causes rubbing of bones, resulting in pain, swelling, stiffness, decreased ability to move and formation of bone spurs. Osteoarthritis develops slowly and the pain it causes worsens over time. Although there is no cure, there are many treatment options available to help manage pain and keep people staying active. Intra-articular (IA) hyaluronic acid (HA) injection is one of the treatment options. Hyaluronic acid is a polysaccharide, an anionic, non-sulfated glycosaminoglycan and is a naturally occurring substance found in the synovial fluid surrounding joints. It acts as a lubricant to enable bones to move smoothly over each other and as a shock absorber for joint loads. People with knee osteoarthritis have lower concentration and altered volume of hyaluronic acid than normal in their joints. Due to lower concentration and volume, exogenous hyaluronic acid may be injected into the knee joint. Treatment with exogenous hyaluronic acid contributes to restore the elastic and viscous properties of the synovial fluid, pain reduction and functional improvement. It is indicated for patients who have failed to respond adequately to conservative non-pharmacological therapy and simple analgesic.

关键词： Osteoarthritis Intra-Articular Hyaluronic Acid Viscosupplementation

Comprehensive analysis of gene mutations and mismatch repair in Chinese colorectal cancer patients

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2673-2682页

作者： huang Chen Rui-Ying Jiang Zhan Hua Xiao-Wei Wang Xiao-Li Shi Ye Wang Qian-Qian Feng Jie Luo Wu Ning Yan-Fen Shi Da-kui Zhang Bei Wang Jian-Zheng Jie Ding-Rong Zhong Department of Pathology China-Japan Friendship HospitalBeijing 100029China Department of Gastrointestinal Surgery China-Japan Friendship HospitalBeijing 100029China Department of Scientific Research GeneisBeijing 100012China

BACKGROUND RAS,BRAF,and mismatch repair(MMR)/microsatellite instability(MSI)are crucial biomarkers recommended by clinical practice guidelines for colorectal cancer(CRC).However,their characteristics and influencing factors in Chinese patients have not been thoroughly *** To analyze the clinicopathological features of KRAS,NRAS,BRAF,and PIK3CA mutations and the DNA MMR status in *** We enrolled 2271 Chinese CRC patients at the China-Japan Friendship *** proteins were tested using immunohistochemical analysis,and the KRAS/NRAS/BRAF/PIK3CA mutations were determined using quantitative polymerase chain *** status was determined using an MSI detection *** analyses were conducted using SPSS software and logistic *** The KRAS,NRAS,BRAF,and PIK3CA mutations were detected in 44.6%,3.4%,3.7%,and 3.9% of CRC patients,*** mutations were more likely to occur in patients with moderate-to-high *** mutations were more likely to occur in patients with right-sided CRC,poorly differentiated,or no perineural *** MMR(dMMR)was detected in 7.9% of all patients and 16.8% of those with mucinous ***,NRAS,BRAF,and PIK3CA mutations were detected in 29.6%,1.1%,8.1%,and 22.3% of patients with dMMR,*** dMMR was more likely to occur in patients with a family history of CRC,aged<50 years,right-sided CRC,poorly differentiated histology,no perineural invasion,and with carcinoma in situ,stage I,or stage II *** This study analyzed the molecular profiles of KRAS,NRAS,BRAF,PIK3CA,and MMR/MSI in CRC,identifying key influencing factors,with implications for clinical management of CRC.

关键词： Colorectal cancer Deficient mismatch repair Microsatellite instability Gene mutation Comprehensive analysis