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从五体痹和五脏痹分层论治系统性红斑狼疮

中国中医基础医学杂志 2024年第6期30卷 935-938页

作者：黄慧萍陈薇薇朱博玉刘智超上海中医药大学附属市中医医院上海200071

系统性红斑狼疮病因复杂,临床表现多样,中医药治疗具有一定优势。本文从五体痹、五脏痹病因、症状角度出发,分层论治SLE各种系统表现。皮肤红斑(皮痹)当以养阴清热为先,血管炎表现(脉痹)重在活血化瘀,筋挛节痛(筋痹)治以祛邪柔肝;肌肉... 详细信息

系统性红斑狼疮病因复杂,临床表现多样,中医药治疗具有一定优势。本文从五体痹、五脏痹病因、症状角度出发,分层论治SLE各种系统表现。皮肤红斑(皮痹)当以养阴清热为先,血管炎表现(脉痹)重在活血化瘀,筋挛节痛(筋痹)治以祛邪柔肝;肌肉麻木、痿软不利(肌痹)应健脾固本;关节表现(骨痹)重视平补肝肾;肝脏受累(肝痹)需辨虚实,实则疏肝,虚则养肝;心脏受累(心痹)养心同时不忘疏肝;消化系统受累(脾痹)全程注意固护后天之本;肺脏受累(肺痹)应根据不同阶段及临床表现,分别施以祛风散寒、清热化痰、宣肺止咳、养阴润肺之法;肾脏受累(肾痹)注意分期辨治,早期清肾益肾,后期补肾填精兼祛痰瘀。

关键词：五体痹五脏痹分层论治系统性红斑狼疮

SENEX-mediated CDK4/6 inhibition promotes senescence and confers apoptosis resistance in B-cell non-Hodgkin lymphoma

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BIOCELL 2024年第3期48卷 453-462页

作者： JIYU WANG LIUYING YI KEKE huang YANGYANG WANG huiping WANG ZHIMIN ZHAI Department of Hematology The Second Affiliated Hospital of Anhui Medical UniversityHefei230601China Department of Hematology The Fourth Affiliated HospitalZhejiang University School of MedicineYiwu322000China

Background:The primary cause of treatment failure in patients with refractory or relapsed B-cell non-Hodgkin lymphoma(r/r B-NHL)is resistance to current therapies,and therapy-induced senescence(TIS)stands out as a crucial mechanism contributing to tumor drug ***,we analyzed SENEX/Rho GTPase Activating Protein 18(ARHGAP18)expression and prognostic signiﬁcance in doxorubicin-induced B-NHL-TIS model and r/r B-NHL patients,investigating its target in B-NHL cell senescence and the effect of combining speciﬁc inhibitors on apoptosis resistance in B-NHL-TIS ***:Raji cells were transfected with the human SENEX shRNA recombinant lentiviral vector(Sh-SENEX)and the empty vector negative(NC)to construct a stable transfection cell line with knockdown of *** of SENEX-silencing on B-NHL-TIS formation,cell function and cell cycle-related pathways was *** doxorubicin(DOX)-inducible senescent B-NHL cells combined with the speciﬁc cyclin dependent kinase 4/6(CDK4/6)inhibitor Palbociclib to observe that blocking CDK4/6 effects on TIS *** expression of 21 B-NHL patients and 8 healthy controls were analyzed by qRT-PCR,and the correlation between its expression and clinical indicators were ***:The downregulation of SENEX expression promotes G1-S phase transition and apoptosis while inhibiting cell proliferation,collectively suppressing the formation of TIS in *** of CDK4/6 promotes the DOX-induced G1 phase arrest to enhance TIS formation in B-NHL cells which can reverse the regulatory effect of silencing SENEX on B-NHL cell cycle regulation and *** expression levels of SENEX were notably elevated in B-NHL patients compared to healthy controls,and Elevated expression levels of SENEX were associated with poor prognosis of B-NHL ***:SENEX enhances apoptosis resistance in B-NHL by inhibiting CDK4/6,thereby preventing G1-S phase transition and promoting TIS formation.

关键词： SENEX B-cell non-Hodgkin lymphoma CDK4/6 G1-S phase transition Therapy-induced senescence Apoptosis resistance

不同磁刺激盆底模式对围绝经期盆底肌筋膜疼痛综合征的治疗效果研究

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重庆医学 2024年第5期53卷 712-716页

作者：汪玲玲黄惠萍陈鸣华李嫜洁马芮许晶无锡市妇幼保健院康复医学科江苏无锡214000

目的研究不同磁刺激盆底模式治疗围绝经期盆底肌筋膜疼痛综合征(MPSS)的临床效果。方法选取2022年5月至2023年5月该院临床诊断为MPSS的围绝经期女性60例作为研究对象,采用随机数字表法分为A、B、C组,每组20例。3组患者均给予盆底肌筋... 详细信息

目的研究不同磁刺激盆底模式治疗围绝经期盆底肌筋膜疼痛综合征(MPSS)的临床效果。方法选取2022年5月至2023年5月该院临床诊断为MPSS的围绝经期女性60例作为研究对象,采用随机数字表法分为A、B、C组,每组20例。3组患者均给予盆底肌筋膜手法松解治疗;A组给予盆底磁刺激治疗(10 Hz和50 Hz交替);B组给予骶神经根磁刺激治疗(50 Hz);C组同时给予盆底磁刺激联合骶神经根磁刺激治疗。3组每周治疗2次,连续治疗8周。分别于治疗前后采用视觉模拟量表(VAS)评估盆底肌筋膜压痛程度,Glazer盆底表面肌电评估盆底肌肉功能。结果与治疗前比较,3组治疗后主观疼痛VAS评分、盆底肌筋膜压痛VAS评分均有降低,差异均有统计学意义(P<0.05);治疗后与A、B组比较,C组主观疼痛VAS评分、盆底肌筋膜压痛VAS评分明显降低,差异有统计学意义(P<0.05)。与治疗前比较,3组治疗后前静息电位、后静息电位的平均波幅及变异系数(CV)均降低,差异有统计学意义(P<0.05);与治疗前比较,仅C组快速收缩最大波幅,10 s持续收缩、60 s持久收缩的平均波幅及CV均有改善,差异有统计学意义(P<0.05);与A、B组比较,C组治疗后前静息电位、后静息电位的平均波幅及变异系数(CV)均降低,快速收缩最大波幅和10 s持续收缩、60 s持久收缩的平均波幅及CV均有改善,差异均有统计学意义(P<0.05)。结论盆底磁刺激和骶神经根磁刺激治疗围绝经期MPSS均可有效缓解疼痛,改善盆底肌力,两者联合应用的效果最好。

关键词：盆底磁刺激骶神经根磁刺激围绝经期女性盆底肌筋膜疼痛综合征

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Making the Complicated Simple:A Minimizing Carrier Strategy on Innovative Nanopesticides

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Nano-Micro Letters 2024年第10期16卷 31-46页

作者： Wenjie Shangguan Qiliang huang huiping Chen Yingying Zheng Pengyue Zhao Chong Cao Manli Yu Yongsong Cao Lidong Cao State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193People's Republic of China College of Plant Protection China Agricultural UniversityBeijing 100193People's Republic of China State Key Laboratory of Element-Organic Chemistry Department of Chemical BiologyCollege of ChemistryNankai UniversityTianjin 300071People's Republic of China

The flourishing progress in nanotechnology offers boundless opportunities for agriculture,particularly in the realm of nanopesticides research and ***,concerns have been raised regarding the human and environmental safety issues stemming from the unrestrained use of non-therapeutic nanomaterials in *** is also important to consider whether the current development strategy of nanopesticides based on nanocarriers can strike a balance between investment and return,and if the complex material composition genuinely improves the efficiency,safety,and circularity of ***,we introduced the concept of nanopesticides with minimizing carriers(NMC)prepared through prodrug design and molecular self-assembly emerging as practical tools to address the current limitations,and compared it with nanopesticides employing non-therapeutic nanomaterials as carriers(NNC).We further summarized the current development strategy of NMC and examined potential challenges in its preparation,performance,and ***,we asserted that the development of NMC systems can serve as the innovative driving force catalyzing a green and efficient revolution in nanopesticides,offering a way out of the current predicament.

关键词： Nanopesticides Green agrochemicals Self-assembly Nanomaterial safety Sustainable development strategies

Quantitative lithium substitution of carboxyl hydrogens in polyacrylic acid binder enables robust SiO electrodes with durable lithium storage stability

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Journal of Energy Chemistry 2024年第10期97卷 352-360,I0007页

作者： Weihua Wang Wenyi Li Siyi Jing huiping Yang Huiqun Wang Ling huang Yuxiang Mao Xikun Pang Yudai huang Li Zhang State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemical and Biochemical EngineeringCollege of Chemistry and Chemical EngineeringCollaborative Innovation Centre of Chemistry for Energy Materials(iChEM)Xiamen UniversityXiamen 361005FujianChina State Key Laboratory of Chemistry and Utilization of Carbon-Based Energy Resources College of ChemistryXinjiang UniversityUrumqi 830017XinjiangChina

The design of advanced binders plays a critical role in stabilizing the cycling performance of large-volume-effect silicon monoxide(SiO)*** the classic polyacrylic acid(PAA)binder,the self-association of-COOH groups in PAA leads to the formation of intramolecular and intermolecular hydrogen bonds,greatly weakening the bonding force of the binder to SiO ***,strengthening the binder-material interaction from the perspective of binder molecular regulation poses a significant ***,a modified PAA-Li_(x)(0.25≤x≤1)binder with prominent mechanical properties and adhesion strength is specifically synthesized for SiO anodes by quantitatively substituting the carboxylic hydrogen with *** appropriate lithium substitution(x=0.25)not only effectively increases the number of hydrogen bonds between the PAA binder and SiO surface owing to charge repulsion effect between ions,but also guarantees moderate entanglement between PAA-Li_x molecular chains through the ion-dipole *** such,the PAA-Li_(0.25)/SiO electrode exhibits exceptional mechanical properties and the lowest volume change,as well as the optimum cycling(1237.3 mA h g^(-1)after 100cycles at 0.1 C)and rate performance(1000.6 mA h g^(-1)at 1 C),significantly outperforming the electrode using pristine PAA *** work paves the way for quantitative regulation of binders at the molecular level.

关键词： Polyacrylic acid binder SiO anode Quantitative lithium substitution Charge repulsion effect Adhesion strength

基于博弈论与模糊区间理论的森林康养基地评价方法

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高师理科学刊 2024年第1期44卷 22-29页

作者：陈洪敏黄慧萍陈楚楚李永超崔文静张子超三明学院信息工程学院福建三明361005 三明学院三明学院-中兴通讯ICT学院福建三明361005

为了提高森林康养基地等级划分的精度,对相同等级下不同地区之间的优劣做出比较,提出了一种基于博弈论与模糊区间理论的森林康养基地评价方法,建立了区间型森林康养基地评价指标体系.利用博弈论将模糊熵与变异系数权重进行组合,借助模... 详细信息

为了提高森林康养基地等级划分的精度,对相同等级下不同地区之间的优劣做出比较,提出了一种基于博弈论与模糊区间理论的森林康养基地评价方法,建立了区间型森林康养基地评价指标体系.利用博弈论将模糊熵与变异系数权重进行组合,借助模糊区间理论构建评价模型,并采用格贴近度公式得到待评价地区隶属的等级,引入TOPSIS模型对所选取的待评价地区进行优劣排序.结果表明,该评价方法具有良好的适用性与有效性.

关键词：森林康养基地博弈论组合赋权法模糊区间综合评价格贴近度等级评价

Pd single atoms cooperate with S vacancies in ZnIn_(2)S_(4) nanosheets for photocatalytic pure-water splitting

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Science China Chemistry 2024年第3期67卷 855-861页

作者： Lin Sun huiping Peng Fei Xue Shangheng Liu Zhiwei Hu Hongbo Geng Xiaozhi Liu Dong Su Yong Xu Xiaoqing huang State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Guangzhou Key Laboratory of Low-Dimensional Materials and Energy Storage Devices Collaborative Innovation Center of Advanced Energy MaterialsSchool of Materials and EnergyGuangdong University of TechnologyGuangzhou 510006China Max Planck Institute for Chemical Physics of Solids Nothnitzer Strasse 40Dresden 01187Germany School of Materials Engineering Changshu Institute of TechnologyChangshu 215500China Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of SciencesBeijing 100190China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China

Photocatalytic water splitting has emerged as a new frontier for converting solar energy to green H_(2) and value-added ***,great challenges still remain for developing efficient photocatalysts for pure water splitting without sacrificial *** this work,we demonstrate that doping hexagonal ZnIn_(2)S_(4)(ZIS) with Pd single atoms(Pd_(0.03)/ZIS) can serve as a highly efficient photocatalyst for pure water splitting to simultaneously produce H_(2) and H_(2)O_(2) without any sacrificial *** from aberration-corrected high-angle annular dark field scanning transmission electron microscopy,X-ray fine spectroscopy,insitu electron paramagnetic resonance and diffuse Fourier transform infrared spectroscopy reveal that doping ZIS with Pd single atoms facilitates the formation of S vacancies(S_(v)),where the photogenerated electrons can transfer to Pd single atoms,as a result of enhanced separation of electron-hole pairs and improved photocatalytic ***,Pd_(0.03)/ZIS displays a stoichiometric ratio of H_(2) and H_(2)O_(2) with the productivity of 1,037.9 and 1,021.4μmol g^(-1)h^(-1),respectively,which has largely outperformed pure ZIS and other reported catalysts for pure water *** work provides an efficient photocatalyst for water splitting to produce H_(2) and H_(2)O_(2),which may attract rapid interest in materials science,chemistry,and heterogeneous catalysis.

关键词： ZnIn_(2)S_(4) Pd single atom S vacancy pure water splitting H_(2)O_(2)

Red list assessments of Chinese higher plants

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International Journal of Digital Earth 2023年第1期16卷 2762-2775页

作者： Liping Li Haining Qin Eimear Nic Lughadha Yaomin Zheng Huawei Wan Jack Plummer Melanie-Jayne R.Howes Huiyuan Liu Yangming Jiang Tuo Wang Huihui Zhao Zhanfeng Shen huiping huang Chinese Academy of Sciences Aerospace Information Research InstituteBeijingPeople’s Republic of China Chinese Academy of Sciences Institute of BotanyBeijingPeople’s Republic of China Royal Botanic Gardens KewRichmondUK School of International Economics and Management Beijing Technology and Business UniversityBeijingPeople’s Republic of China. Satellite Environmental Application Center Ministry of Ecology and EnvironmentBeijingPeople’s Republic of China. University of Chinese Academy of Sciences BeijingPeople’s Republic of China

Based on the two most recent assessments of Chinese higher plants in 2013 and 2020,of 34,450 and 39,330 species,respectively,we analysed the threatened status of Chinese higher *** 2020,around 4,088(10.39%)of the assessed species in China are threatened,2,875(7.31%)Near Threatened,27,593(70.16%)not currently threatened and categorised as Least Concern and 4,752(12.08%)categorised as Data *** in 2013,3,767(10.93%)of the assessed higher plants in China are threatened,2,723(7.90%)Near Threatened,24,296(70.53%)Least Concern and 3,612(10.48%)Data *** of the Red List Index in the two years show different patterns when using different weighting methods with the equal steps weighting method showing a slight decrease(0.91675-0.91495)and the extinction risk weighting method showing a slight increase(0.98792-0.98797).We inferred that China's threatened plant species were likely/relatively effectively ***,attention should also be given to the non-threatened species in the future as an additional strategy for their conservation,to maintain their non-threatened status.

关键词： Chinese higher plants conservation IUCN red list assessment red list index(RLI) sustainable development goals(SDGs)

1949～2007年全国干旱灾害特征、成因及减灾对策

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干旱区资源与环境 2010年第11期24卷 94-98页

作者：黄会平华北水利水电学院资源与环境学院郑州450011

根据近60年来干旱灾情统计资料,分析了我国干旱灾害的时空分布特征及其变化趋势。统计结果表明:近60年来,我国干旱灾害的受灾面积、成灾面积、经济损失有逐步增加的趋势,灾害发生的频率也在不断加快。空间分布上,陕西、甘肃,宁夏、内蒙... 详细信息

根据近60年来干旱灾情统计资料,分析了我国干旱灾害的时空分布特征及其变化趋势。统计结果表明:近60年来,我国干旱灾害的受灾面积、成灾面积、经济损失有逐步增加的趋势,灾害发生的频率也在不断加快。空间分布上,陕西、甘肃,宁夏、内蒙、山西、青海、黑龙江、吉林、辽宁、重庆、山东、河北、北京、天津等是成灾严重的省区;北方的黄河流域、松辽河流域、海滦河流域、淮河流域受灾严重,南方的长江流域、珠江流域、太湖流域等受灾相对较低,但总体上都有不断加重的趋势。通过分析中国干旱灾害的成因,提出若干抗灾、减灾措施。

关键词：干旱统计特征旱灾成因减灾对策