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物理学报 2008年第9期57卷 5911-5917页

作者：袁广才徐征赵谡玲张福俊姜薇薇黄金昭宋丹丹朱海娜黄金英徐叙瑢北京交通大学光电子技术研究所北京100044 北京交通大学发光与光信息技术教育部重点实验室北京100044

通过扫描电镜和X射线衍射对SiO2.底上生长并五苯和酞菁铜薄膜的表面形貌进行表征,并得到在SiO2.底上生长的并五苯薄膜是以岛状结构生长,其大小约为100 nm,且薄膜有较好的结晶取向,呈多晶态存在.酞菁铜薄膜则没有表现出明显的生长机理... 详细信息

通过扫描电镜和X射线衍射对SiO2.底上生长并五苯和酞菁铜薄膜的表面形貌进行表征,并得到在SiO2.底上生长的并五苯薄膜是以岛状结构生长,其大小约为100 nm,且薄膜有较好的结晶取向,呈多晶态存在.酞菁铜薄膜则没有表现出明显的生长机理,其呈非晶态存在.还对通过掩膜的方法制作得以酞菁铜和并五苯为有源层的顶栅极有机薄膜晶体管的特性进行了研究.有源层的厚度为40 nm,绝缘层SiO2.厚度为2.0 nm,器件的沟道宽长比(W/L)为2..通过Keithley 2.10I-V测量仪对OTFTs器件的电学性质进行表征,其器件的开关电流比(on/off)分别为105和104,阈值电压VTH分别为-2. V和-15 V,器件的场效应载流子迁移率μEF分别为0.0694 cm2.V.s和1.2.1cm2.V.s.

关键词：有机薄膜晶体管并五苯薄膜酞菁铜薄膜场效应迁移率(μ_(EF))

Electric gating of the multichannel conduction in LaAlO_(3)/SrTiO_(3) superlattices

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chinese Physics B 2021年第1期30卷 477-482页

作者： Shao-Jin Qi Xuan Sun Xi Yan Hui Zhang Hong-Rui Zhang Jin-E Zhang hai-Lin huang Fu-{2. Han Jing-Hua Song Bao-Gen Shen yuan-Sha Chen beijing National Laboratory for Condensed Matter Physics and institute of Physics Chinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China

The electric gating on the transport properties of two-dimensional electron gas(2.EG) at the interface of LaAlO_(3)/SrTiO_(3)(LAO/STO) heterostructure has attracted great research interest due to its potential application in fieldeffect devices. Most of previous works of gate effect were focused on the LAO/STO heterostructure containing only one conductive interface. Here, we systematically investigated the gate effect on high-quality LAO/STO superlattices(SLs)fabricated on the TiO_(2.-terminated(001) STO substrates. In addition to the good metallicity of all SLs, we found that there are two types of charge carriers, the majority carriers and the minority carriers, coexisting in the SLs. The sheet resistance of the SLs with a fixed thickness of the LAO layer increases monotonically as the thickness of the STO layer increases. This is derived from the dependence of the minority carrier density on the thickness of STO. Unlike the LAO/STO heterostructure in which minority and majority carriers are simultaneously modulated by the gate effect, the minority carriers in the SLs can be tuned more significantly by the electric gating while the density of majority carriers is almost invariable. Thus, we consider that the minority carriers may mainly exist in the first interface near the STO substrate that is more sensitive to the back-gate voltage, and the majority carriers exist in the post-deposited STO layers. The SL structure provides the space separation for the multichannel conduction in the 2.DEG, which opens an avenue for the design of field-effect devices based on LAO/STO heterostructure.

关键词： superlattices gate effect minority carriers majority carriers

A 3.06-Mb interstitial deletion on 12.11.2.-12.1 caused brachydactyly type E combined with pectus carinatum

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chinese Medical Journal 2019年第14期132卷 1681-1688页

作者： Jia huang Hong-Yan Liu rong-rong Wang hai Xiao Dong Wu Tao Li Ying-hai Jiang Xue Zhang The Research Center for Medical Genomics Key Laboratory of Medical Cell BiologyChinese Ministry of EducationCollege of Basic Medical ScienceChina Medical UniversityShenyangLiaoning 110122China institute of Medical Genetics Henan Provincial People's HospitalPeople's Hospital of Zhengzhou UniversitySchool of Clinical MedicineHenan UniversityZhengzhouHenan 450003China McKusick-Zhang Center for Genetic Medicine State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China

Background:Brachydactyly,a developmental disorder,refers to shortening of hands/feet due to small or missing metacarpals/ metatarsals and/or *** brachydactyly type E (BDE),characterized by shortened metacarpals and/or metatarsals,consists in a small proportion of patients with Homeobox D13 (HOXD13) or parathyroid-hormone-like hormone (PTHLH) *** is often accompanied by other anomalies that are parts of many congenital *** this study,we investigated a chinese family presented with BDE combined with pectus carinatum and short ***:A four-generation chinese family was recruited in June *** informed consent was obtained,venous blood was collected,and genomic DNA was extracted by standard ***-exome sequencing was performed to screen pathogenic mutation,array comparative genomic hybridization (Array-CGH) analysis was used to analyze copy number variations,and quantitative real-time polymerase c{2.n reaction (PCR),stride over breakpoint PCR (gap-PCR),and Sanger sequencing were performed to confirm the candidate ***:A 3.06-Mb deletion (chr12.2.473650-2.536747) was identified and segregated with the phenotype in this *** deletion region encompasses 2. annotated genes,one of which is PTHLH which has been reported to be causative to the *** is an important regulator of endochondral bone *** affected individuals showed bilateral,severe,and generalized brachydactyly with short stature,pectus carinatum,and prematurely fusion of *** feature of pectus carinatum has not been described in the PTHLH-related BDE patients ***:The haploinsufficiency of PTHLH might be responsible for the disease in this *** study has expanded the knowledge on the phenotypic presentation of PTHLH variation.

关键词： Brachydactyly type E Parathyroid-hormone-like hormone Pectus carinatum Short stature Copy number variation

Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang Yong-Hao Chen Jing-Yu Tang Rui-Rui Fan Qiang Li Gong Li Dong Liu Zheng-Yao Jin Xing-Zhu Cui Tian-Xiang Chen Yi-Wei Yang rong Liu Han Yi Yang Li Zhen Yang Qi An Hao-Fan Bai Jiang-Bo Bai Jie Bao Ping Cao Qi-Ping Chen Zhen Chen Zeng-Qi Cui An-Chuan Fan Chang-Qing Feng Fan-Zhen Feng Ke-Qing Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu Han-Xiong huang Wei-Hua Jia Hao-yu Jiang Wei Jiang Zhi-jie Jiang Ling Kang Bo Li Chao Li Jia-Wen Li Xiao Li Jie Liu Shu-Bin Liu Guang-{2. Luan Chang-Jun Ning Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Xin Tan Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Yong-Ji Yu Guo-Hui Zhang Lin-Hao Zhang Mo-Han Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Yue Zhang Zhi-Yong Zhang Mao-{2. Zhao Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Sino-French institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest institute of Nuclear Technology Xi’an 710024China University of chinese academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the china Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

Hydrolysis of Dipeptide Heptyl Esters with Newlase F

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chinese Chemical Letters 2001年第8期12卷 693-696页

作者： Zhong Zhou CHEN Yan Mei LI Xiu Fen KOU Xue LI Fu rong huang {2. Yan WANG Ming Ming MA Yu Fen ZHAO Key Laboratory for Bioorganic Phosphorus Chemistry of Education Ministry Department of ChemistrySchool of Life Science and EngineeringTsinghua UniversityBeijing 100084 The institute of Microbiology Chinese Academy of SciencesBeijing 100080

Newlase F is a rude enzyme which contains triacylglycerol lipase and acid protease. Hydrolysis of dipeptide heptyl esters with Newlase F was studied in phosphate buffer-organic solvent by HPLC. When the Newlase F's level reached 5 mg/mL under mild condition (PH 7.0, 30 degreesC), the lipase had the highest activity. The reaction was also affected greatly by organic solvents and their concentrations. It is found that protease in Newlase F does not hydrolyze amide bond under this condition (pH 7.0, r.t.).

关键词： Newlase F dipeptide heptyl esters HPLC

Microphysical characteristics of precipitating cumulus cloud based on airborne Ka-band cloud radar and droplet measurements

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Atmospheric and Oceanic Science Letters 2022年第2期15卷 65-70页

作者： Lei Wei Mengyu huang rong Zhang Yuhuan Lü Tuanjie Hou Hengchi Lei Delong Zhao Wei Zhou {2. Fu beijing Weather Modification Center BeijingChina Key Laboratory for Cloud Physics of china Meteorological Administration BeijingChina Wuqing Meteorological Observatory of Tianjin TianjinChina institute of Atmospheric Physics Chinese Academy of SciencesBeijingChina Zhejiang Meteorological Observatory HangzhouChina beijing Key Laboratory of Cloud Precipitation and Atmospheric Water ResourcesBeijingChina beijing Meteorological Bureau BeijingChina

Based on cloud-probe data and airborne Ka-band cloud radar data collected in Baoding on 5 August 2.18,the microphysical structural characteristics of cumulus(Cu)cloud at the precipitation stage were *** cloud droplets in the Cu cloud were found to be significantly larger than those in stratiform(STF)*** the Cu cloud,most cloud particles were between 7 and 10μm in diameter,while in the STF cloud the majority of cloud particles grew no larger than 2.*** sensitivity of cloud properties to aerosols varied with *** cloud droplet effective radius showed a negative relationship with the aerosol number concentration(Na)in the cloud planetary boundary layer(PBL)and upper layer above the ***,the cloud droplet concentration(Nc)varied little with decreased Na in the high liquid water content region above 1500 *** Na values of between 300 and 1853 cm-3 were found in the PBL,and the maximum Na was sampled near the surface in August in the Hebei region,which was lower than that in autumn and *** radar reflectivity corresponded to large FCDP(fast cloud droplet probe)particle concentrations and small aerosol particle concentrations,and vice versa for low radar *** updrafts in the Cu cloud increased the peak radius and Nc,and broadened cloud droplet spectrum;lower air temperature was favorable for particle condensational growth and produced larger droplets.

关键词： Airplane observation Microphysical processes Ka-band cloud radar Cumulus

Vitamin C Inhibits Benzo[a]pyrene-Induced Cell Cycle Changes Partly via Cyclin D1/E2. Pathway in Human Embryo Lung Fibroblasts

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Biomedical and Environmental Sciences 2006年第3期19卷 239-244页

作者： AI GAO BING-CI LIU XIANG-LIN SHI CHUAN-SHU huang XIAO-WEI JIA BAO-rong YOU MENG YE FU-{2. SHEN HONG-JU DU National institute of Occupation Health and Poison Control Chinese Center for Disease Control and Prevention Beijing 100050 China National institute for Occupational Safety and Health 1095 Willowdale RoadMorgantown WV26506 USA Nelson institute of Environmental Medicine New York University School of Medicine 57 Old Forge Road Tuxedo NY 10987

Objective To study the molecular mechanism of the inhibitory effects of vitamin C on benzo[a]pyrene （B[a]P）-induced changes of cell cycle in human embryo lung fibroblast （HELF） cells. Methods The stable transfectants, HELF transfected with antisense cyclin D1 and antisense CDK4, were established. Cells were cultured and pretreated with vitamin C before stimulation with B[a]P for 2. h. The expression levels of cyclin DI, CDK4, E2.I, and E2.4 were determined by Western blot. Flow cytometric analysis was employed to detect the distributions of cell cycle. Results B[a]P significantly elevated the expression levels of cyclin D 1, E2.1, and E2.4 in HELF cells. Vitamin C decreased the expression levels of cyclin D 1, E2.1, and E2.4 in B [a]P-stimulated HELF cells. Dose-dependent relationships were not found between the different concentrations of vitamin C （10, 100, 500, 1000, and 5000 lamol/L） and the expression levels of cyclin D 1, E2.1, and E2.4 in HELF cells. The expression levels of cyclin D1, E2.I, and E2.4 in B[a]P-treated transfectants were lower than those in B[a]P-treated HELF cells. The expression levels of cyclin DI and E2.4 treated with vitamin C and antisense cyclin D1 were decreased compared with those treated with antisense cyclin DI alone. The effects of vitamin C combined with antisense CDK4 on the expression levels of cyclin DI and E2.I/E2.4 were similar to those of antisense CDK4 alone. B[a]P progressed HELF cells from GI to S phase. Both vitamin C and antisense cyclin DI suppressed the changes of cell cycle progressed by B[a]P. However, antisense CDK4 did not attenuate the above changes. Vitamin C combined with antisense CDK4 markedly suppressed B[a]P-induced changes of cell cycle as compared with antisense CDK4. But the inhibitory effects of vitamin C combined with antisense cyclin DI on B[a]P-induced changes of cell cycle were similar to those of vitamin C alone or antisense cyclin DI alone. Conclusions B[a]P progressed HELF cells from G1 to S phase

关键词： B[a]P Ascorbic acid Cyclin D1 E2. Cell cycle Antisense

Multifunctional Gold Nanoparticles@Imidazolium-Based Cationic Covalent Triazine Frameworks for Efficient Tandem Reactions

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CCS Chemistry 2021年第9期3卷 2368-2380页

作者： Chang He Qiu-Jin Wu Min-Jie Mao Yu-huang Zou Bai-Tong Liu yuan-Biao huang rong Cao State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002 University of chinese academy of Sciences Beijing 100049 Fujian College University of Chinese Academy of SciencesFuzhou 350002

Tandem catalytic reactions have attracted extensive interest because of their ability to reduce reaction steps,energy consumption,and ***,the construction of highly efficient tandem catalytic systems is still a significant challenge due to the problematic integration of multiple active sites in one reaction system and the incompatibility of different reaction *** metal nanoparticles(MNPs)supported on porous framework materials have shown excellent catalytic performances in various reactions,their cooperative catalysis for tandem reactions is rarely reported.

关键词： tandem reaction imidazolium covalent triazine framework Lewis acid and base gold

Ethylene promotes seed iron storage during Arabidopsis seed maturation via ERF95 transcription factor

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Journal of Integrative Plant Biology 2020年第8期62卷 1193-1212页

作者： Ying Sun Jia Qi Li Jing Ying Yan Jun Jie yuan Gui Xin Li Yun rong Wu Ji Ming Xu rong Feng huang Nicholas P.Harberd Zhong Jie Ding Shao Jian Zheng State Key Laboratory of Plant Physiology and Biochemistry College of Life SciencesZhejiang UniversityHangzhou 310058China Agricultural Experimental Station Zhejiang UniversityHangzhou 310058China College of Agronomy and Biotechnology Zhejiang UniversityHangzhou 310058China Biotechnology Research institute Chinese Academy of Agricultural SciencesBeijing 100081China Department of Plant Science University of OxfordOxford OX13RBUnited Kingdom

Because Iron(Fe)is an essential element,Fe storage in plant seeds is necessary for seedling establishment following ***,the mechanisms controlling seed Fe storage during seed development remain largely *** we reveal that an ERF95 transcription factor regulates Arabidopsis seed Fe *** show that expression of ERF95 increases during seed maturation,and that lack of ERF95 reduces seed Fe accumulation,consequently increasing sensitivity to Fe deficiency during seedling ***,overexpression of ERF95 has the opposite *** show that lack of ERF95 decreases abundance of FER1 messenger RNA in developing seed,which encodes Fe-sequestering ***,a fer1-1 loss-of-function mutation confers reduced seed Fe accumulation,and suppresses ERF95-promoted seed Fe *** addition,ERF95 binds to specific FER1 promoter GCC-boxes and transactivates FER1 *** show that ERF95 expression in maturing seed is dependent on EIN3,the master transcriptional regulator of ethylene *** lack of EIN3 reduces seed Fe content,overexpression of ERF95 rescues Fe accumulation in the seed of ein3 loss-of-function ***,we show that ethylene production increases during seed *** conclude that ethylene promotes seed Fe accumulation during seed maturation via an EIN3-ERF95-FER1-dependent signaling pathway.

关键词： expression. ERF Arabidopsis