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High dimensional proteomic mapping of bone marrow immune characteristics in immune thrombocytopenia

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Science china(Life Sciences) 2024年第8期67卷 1635-1647页

作者： Feng-Qi Liu Qing-yuan Qu Ying Lei Qi Chen Yu-Xiu Chen Meng-Lin Li Xue-Yan Sun Ye-Jun Wu Qiu-Sha huang {2.-Xia Fu yuan Kong Yue-Ying Li Qian-Fei Wang Xiao-Jun huang Xiao-Hui Zhang Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Collaborative Innovation Centre of Hematology Peking UniversityBeijing 100044China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of chinese academy of Sciences Beijing 100049China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100074China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China

To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia(ITP),this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight(CyTOF).Thirtysix patients with ITP and nine healthy volunteers were enrolled in the *** soluble immunomodulatory molecules,more sCD2. and sGalectin-9 were detected in ITP *** the cell surface,co-stimulatory molecules like ICOS and HVEM were observed to be upregulated in mainly central memory and effector T *** contrast,co-inhibitory molecules such as CTLA-4 were significantly reduced in Th1 and Th17 cell *** a platelet count of 30×10^(9)L^(−1)as the cutoff value,ITP patients with high and low platelet counts showed different T cell immune ***-presenting cells such as monocytes and B cells may regulate the activation of T cells through CTLA-4/CD86 and HVEM/BTLA interactions,respectively,and participate in the pathogenesis of *** conclusion,the proteomic and soluble molecular profiles brought insight into the interaction and modulation of immune cells in the bone marrow of *** may offer novel targets to develop personalized immunotherapies.

关键词： immune thrombocytopenia autoimmune diseases co-stimulatory co-inhibitory immune checkpoint CTLA4 Cytometry by Time of Flight bone marrow

An optimal flow rate allocation model of the oilfield treated oil pipeline network

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Petroleum 2024年第1期10卷 93-100页

作者： hai Li Tianyou Fan Kun Wang Xueyuan Long Yu He Meng Wang Wen Cheng Qian {2. Huirong {2. Weichao Yu Petrochina Southwest Oil&Gasfield Company Chengdu 610056China china Petroleum Planning&Engineering institute Beijing 100083China School of Petroleum Engineering Chongqing University of Science and TechnologyChongqing 401331China Pipechina Oil&Gas Control Center Dongtucheng RoadChaoyang DistrictBeijing 100028China

Oilfield treated oil pipeline network is the link connecting the upstream oilfields and the downstream *** to the differences in operating costs and transportation fee between different pipelines and the fluctuation in the demand and sales prices of the treated oil,there is an optimal flow allocation plan for the pipeline network to make the oilfield company obtain the highest social and economic *** this study,a mixed integer nonlinear programming(MINLP)model is developed to determine the optimal flow rate allocation plan of the large-scale and complex treated oil pipeline network,and both the social and economic benefits are considered *** optimization objective is the multi-objective which includes the largest user satisfaction and the highest economic *** model constraints include the oilfield production capacity,refinery demand,pipeline transmission capacity,flow,pressure,and temperature of the node and station,and the pipeline hydraulic and thermal *** 3.7 is utilized for the programming of the off-line calculation procedure and the MINLP model,and GUROBI 9.0.2.is served as the MINLP ***,the model is applied to a real treated oil pipeline network located in china,and three optimization scenarios are *** social benefit,the values of the user satisfaction of each refinery and the total network are 1 before and after optimization for scenarios 1,2.and *** economic benefit,the annual revenue can be increased by 0.2.7,0.2.3,and 0.548 billion yuan after the optimization in scenario 1,2.and 3,respectively.

关键词： Treated oil pipeline network Flow rate allocation Optimal User satisfaction Economic benefit

Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain

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Science china(Life Sciences) 2024年第1期67卷 67-82页

作者： Chun-Kui Zhang Pan Wang yuan-yuan Ji Jian-Shuai Zhao Jun-Xiang Gu Xian-Xia Yan Hong-Wei Fan Ming-Ming Zhang Yu Qiao Xiao-Die Liu Bao-Juan Li Ming-Hui Wang {2.-Long Dong Hao-Hong Li Peng-Cheng huang Yun-Qing Li Wu-Gang Hou Jin-Lian Li Tao Chen Department of Anatomy and K.K.Leung Brain Research Centre Fourth Military Medical UniversityXi’an 710032China beijing institute of Basic Medical Sciences Beijing 100850China Key Laboratory of Ministry of Public Health for Forensic Science Xi’an Jiaotong UniversityXi’an 710061China Department of Anesthesiology Xijing HospitalFourth Military Medical UniversityXi’an 710032China Department of Neurosurgery the Second Affiliated Hospital of Xian Jiaotong UniversityXi’an 710004China School of Biomedical Engineering Fourth Military Medical UniversityXi’an 710032China Affiliated Mental Health Centre and Hangzhou Seventh People’s Hospital Zhejiang University School of MedicineHangzhou 310013China The MOE Frontier Research Center of Brain&Brain-machine Integration Zhejiang University School of Brain Science and Brain MedicineHangzhou 310058China Department of Neurology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Anatomy School of MedicineNorthwest UniversityXi’an 710069China

Chronic pain often develops severe mood changes such as ***,how chronic pain leads to depression remains elusive and the mechanisms determining individuals’responses to depression are largely *** we found that depression-like behaviors could only be observed in 67.9%of mice with chronic neuropathic pain,leaving 32.1%of mice with depression *** determined that the spike discharges of the ventral tegmental area(VTA)-projecting lateral habenula(LHb)glutamatergic(Glu)neurons were sequentially increased in sham,resilient and susceptible mice,which consequently inhibited VTA dopaminergic(DA)neurons through a LHbGlu-VTAGABA-VTADA ***,the LHbGlu-VTADA excitatory inputs were dampened via GABAB receptors in a pre-synaptic *** of LHb-VTA pathway largely affected the development of depressive symptoms caused by chronic *** study thus identifies a pivotal role of the LHb-VTA pathway in coupling chronic pain with depression and highlights the activity-dependent contribution of LHbGlu-to-VTADA inhibition in depressive behavioral regulation.

关键词： chronic pain depression lateral habenula ventral tegmental area dopamine susceptibility

A multicenter prospective study on the management of hepatoblastoma in children:a report from the chinese Children's Cancer Group

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World Journal of Pediatrics 2024年第6期20卷 590-601页

作者： Meng-Jie Tang Xiao-Li Ma Xiang-Ling He Wei-Hua Pan Xiao-Hong Zhang Sha-Yi Jiang Ju Gao Fu Li Wei Yao Song Gu Wei-Ling Zhang Qiang Zhao Shi-Hao huang Yong-Jun Fang Wei Liu Hui-Zhong Niu Chun-Mei Wang Li-rong Sun Hui Gao Yun-Peng Dai Shun-Gen huang Zhi-Yong Zhong Xi-Ge Wang Zhong-rong Li Liang-Chun Yang Ye-Ming Wu Huan-Min Wang Xin Sun Xiao-Jun yuan Department of Pediatric Hematology/Oncology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineNo.1665Kongjiang RoadYangpu DistrictShanghai 200092China Medical Oncology Department Pediatric Oncology CenterBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Hematology/Oncology Children's Medical CenterHunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 41005China Department of Pediatric Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Hematology/Oncology Guangzhou Women and Children's Medical CenterNational Children's Medical Center for South Central RegionGuangzhou 510623China Department of Hematology Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200062China Department of Pediatrics West China Second University HospitalSichuan UniversityChengdu 610041China Department of Hematology/Oncology Qilu Children's Hospital of Shandong UniversityJinan 250022China Department of Pediatric Surgery Children's Hospital of Fudan UniversityShanghai 201102China Department of General Surgery Shanghai Children's Medical Center(National Children's Medical Center-Shanghai)Shanghai Jiao Tong University School of MedicineShanghai 200127China Department of Pediatrics Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Pediatric Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060China Department of Hematology/Oncology Children's Hospital of Nanjing Medical UniversityNanjing 210008China Department of Hematology/Oncology Henan Children's HospitalZhengzhou 450018China Department of Pediatric General Surgery Hebei Children's Hospital of Hebei Medical UniversityShijiazhuang City 050031China Children's Hospital the First Affliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Paediatric

Background This study aimed to identify survival risk factors in chinese children with hepatoblastoma(HB)and assess the effectiveness of the new treatment protocol proposed by the chinese Children's Cancer Group(CCCG)in *** A multicenter,prospective study that included 399 patients with HB from January 2.15 to June 2.2. was *** demographics,treatment protocols,and other related information were *** regression models and Kaplan-Meier curve methods were *** The 4-year event-free survival(EFS)and overall survival(OS)were 76.9 and 93.5%,*** 4-year EFS rates for the very-low-risk,low-risk,intermediate-risk,and high-risk groups were 100%,91.6%,81.7%,and 51.0%,*** 4-year 0S was 100%,97.3%,94.4%,and 86.8%,*** regression analysis found that age,tumor rupture(R+),and extrahepatic tumor extension(E+)were independent prognostic factors.A total of 2.9 patients had complete remission,and 19 *** with declining alpha-fetoprotein(AFP)>75%after the first two cycles of neoadjuvant chemotherapy had a better EFS and OS than those≤75%.Conclusions The survival outcome of HB children has dramatically improved since the implementation of CCCG-HB-2.16 ***≥8 years,R+,and E+were independent risk factors for *** with a declining AFP>75%after the first two cycles of neoadjuvant chemotherapy had better EFS and OS.

关键词： Alpha-fetoprotein Hepatoblastoma Multicenter Prospective study Survival

Development of a MWDC prototype of the CSR external-target experiment

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NUCLEAR SCIENCE AND TECHNIQUES 2024年第10期35卷 1-14页

作者： He, Zhou-Bo Qin, Zhi Ma, Peng Yang, He-Run Wei, Xiang-Lun Lu, Chen-Gui Wen, Xiang-Jie Zhang, Xiu-Ling Chen, Tao Li, Zhi-Jie Yang, yuan-Sheng Zhan, Mei-Qiang Liu, Can-Wen Li, Meng Qiu, Tian-Li Gong, Yi-Wei huang, Xin-Jie Yin, Xiao-Hao He, Zhi-Xuan Zhang, Jun-Wei Zou, {2.-Chuan Fu, Sheng-Wei Guo, Dong Yan, Jun-Wei Cao, Zhe Deng, Zhi Kong, Jie Xiao, Zhi-Gang Hu, rong-Jiang Duan, Li-Min chinese Acad Sci Inst Modern Phys Lanzhou 730000 Peoples R China Univ chinese Acad Sci Sch Nucl Sci & Technol Beijing 100049 Peoples R China Tsinghua Univ Dept Phys Beijing 100084 Peoples R China Univ Sci & Technol china Hefei 230026 Peoples R China Sichuan Univ Inst Nucl Sci & Technol Key Lab Radiat Phys & Technol Minist Educ Chengdu 610064 Peoples R China Lanzhou Univ Sch Nucl Sci & Technol Lanzhou 730000 Peoples R China North china Univ Water Resources & Elect Power Zhengzhou 450000 Peoples R China

The cooling storage ring (CSR) external-target experiment (CEE) is a spectrometer used in construction to study the properties of nuclear matter in high-baryon density regions at the Heavy-Ion Research Facility in Lanzhou (HIRFL). This study presents the design, simulation, manufacturing, and testing of a half-size prototype of a multi-wire drift chamber (MWDC) for the CEE. First, the performance of the MWDC connected to homemade electronics was simulated. The results demonstrated that an energy resolution of 18.5% % for 5.9-keV X-rays and a position resolution of 194 mu m for protons can be achieved by the current design. Because the size of the largest MWDC reached 176 cm x 314 cm, a set of 98 cm x 98 cm prototypes was built using the new techniques. The positioning accuracy of the anode wires in this prototype is better than 2. mu m. After optimization, using commercially available electronics, the prototype can achieved an energy resolution of 19.7% % for a Fe-55 X-ray source. The CEE-MWDC detector and electronics were simultaneously tested. An energy resolution of 2.% % was achieved for the Fe-55 source; the track residuals were approximately 330 mu m for the cosmic rays. The results demonstrate that the current design and techniques meet the requirements of the CEE-MWDC array.

关键词： CEE MWDC Garfield plus plus Fe-55 source Position resolution DRIFT CHAMBER HIRFL-CSR

Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study

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World Journal of Hepatology 2024年第5期16卷 809-821页

作者： yuan-Yao Zhang Sen Luo hai Li Shu-Ning Sun Xian-Bo Wang Xin Zheng Yan {2. Bei-Ling Li Yan-Hang Gao Zhi-Ping Qian Feng Liu Xiao-Bo Lu Jun-Ping Liu Hao-Tang Ren Yu-Bao Zheng Hua-Dong Yan Guo-Hong Deng Liang Qiao Yan Zhang Wen-Yi Gu Xiao-Mei Xiang Yi Zhou Yi-Xin Hou Qun Zhang Yan Xiong Cong-Cong Zou Jun Chen Ze-Bing {2. Xiu-Hua Jiang Ting-Ting Qi yuan-yuan Chen Na Gao Chun-Yan Liu Wei yuan Xue Mei Jing Li Tao Li rong-Jiong Zheng Xin-Yi Zhou Jun Zhao Zhong-Ji Meng Department of Infectious Disease Institute of Biomedical ResearchRegulatory Mechanism and Targeted Therapy for Liver Cancer Shiyan Key LaboratoryHubei provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver CancerTaihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Gastroenterology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200120China Department of Infectious Diseases Southwest HospitalThe Third Military Medical University(Army Medical University)Chongqing 400000China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100020China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430020Hubei ProvinceChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 110051Hunan ProvinceChina Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 200093China Tianjin institute of Hepatology Nankai University Second People's HospitalTianjin 300192China Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Department of Infectious Diseases and Hepatology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Infectious Diseases The Thir

BACKGROUND Acute-on-chronic liver disease(AoCLD)accounts for the majority of patients hospitalized in the Department of Hepatology or Infectious *** To explore the characterization of AoCLD to provide theoretical guidance for the accurate diagnosis and prognosis of *** Patients with AoCLD from the chinese Acute-on-Chronic Liver Failure(ACLF)study cohort were included in this *** clinical characteristics and outcomes,and the 90-d survival rate associated with each clinical type of AoCLD were analyzed,using the Kaplan-Meier method and the log-rank *** A total of 3375 patients with AoCLD were enrolled,including 1679(49.7%)patients with liver cirrhosis acute decompensation(LC-AD),850(2..2.)patients with ACLF,577(17.1%)patients with chronic hepatitis acute exacer-bation(CHAE),and 2.9(8.0%)patients with liver cirrhosis active phase(LC-A).The most common cause of chronic liver disease(CLD)was HBV infection(71.4%).The most common precipitants of AoCLD was bacterial infection(2..8%).The 90-d mortality rates of each clinical subtype of AoCLD were 43.4%(2.2.535)for type-C ACLF,36.0%(36/100)for type-B ACLF,2..0%(58/2.5)for type-A ACLF,9.0%(151/1679)for LC-AD,3.0%(8/2.9)for LC-A,and 1.2.(7/577)for *** HBV infection is the main cause of CLD,and bacterial infection is the main precipitant of *** most common clinical type of AoCLD is *** diagnosis and timely intervention are needed to reduce the mortality of patients with LC-AD or ACLF.

关键词： Acute-on-chronic liver disease Acute-on-chronic liver failure Liver cirrhosis Clinical features Prognosis

外源性Shh因子补充对骨质疏松症模型小鼠骨吸收和骨形成能力的影响

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中华骨质疏松和骨矿盐疾病杂志 2024年第4期17卷 344-351页

作者：黄华崔静曾进海王荣彭瀚元张涛王璐曹跃朋北京积水潭医院贵州医院骨内科三病区贵阳550014 北京积水潭医院贵州医院骨科十一病区贵阳550014 北京积水潭医院贵州医院骨科十病区贵阳550014 北京积水潭医院贵州医院骨科九病区贵阳550014 贵州中医药大学第二附属医院风湿免疫科贵阳550003

目的探讨外源性音猬(Sonic Hedgehog,Shh)因子补充对骨质疏松症模型小鼠骨吸收和骨形成能力的影响。方法取健康雌性小鼠48只,随机分为空白对照组、模型组、Shh组,建模和干预后最终分别入组16、8、7只。模型组、Shh组小鼠采取手术切除双... 详细信息

目的探讨外源性音猬(Sonic Hedgehog,Shh)因子补充对骨质疏松症模型小鼠骨吸收和骨形成能力的影响。方法取健康雌性小鼠48只,随机分为空白对照组、模型组、Shh组,建模和干预后最终分别入组16、8、7只。模型组、Shh组小鼠采取手术切除双侧卵巢构建骨质疏松症模型,Shh组小鼠尾静脉注射2.L Shh液,空白组及模型组尾静脉注射等体积生理盐水,三组均持续干预7 d。观察小鼠组织病理学,比较骨密度值、Shh基因水平、雌二醇(estradiol,E2.、碱性磷酸酶(alkaline phosphatase,ALP)、骨吸收指标[Ⅰ型胶原交联C-末端肽(C-telopeptide of typeⅠcollagen,CTX-Ⅰ)、抗酒石酸酸性磷酸酶5b(tartrate-resistant acid phosphatase 5b,TPACP5b)、骨钙素N端中分子片段(N-terminal mid-fragment of osteocalcin,N-MID)水平]、骨形成能力[骨保护素(osteoprotegerin,OPG)、骨钙素(bone gla protein,BGP)、骨特异性碱性磷酸酶(bone specific alkaline phosphatase,BALP)]及破骨细胞分化因子[核因子κB受体活化因子配体(receptor activator of nuclear factor-kappaB ligand,RANKL)]、自噬相关蛋白1(autophagy related protein 1,Beclin-1)、微管相关蛋白1轻链3-Ⅱ(microtubule associated-protein 1 light chain 3-Ⅱ,LC3-Ⅱ)蛋白相对表达量。结果模型组见大量脂肪细胞增生,部分胞核消失或破碎或空骨陷窝;空白对照组髓腔脂肪细胞结构完整、大小及形态均匀;Shh组脂肪细胞形态基本正常、结构完整。空白对照组、Shh组、模型组Shh因子、骨密度值、E2.N-MID、BV/TV、***、Tb.N依次明显降低,ALP、CTX-Ⅰ、TPACP5b、***依次明显增高,组间两两比较差异有统计学意义(P1、LC3-Ⅱ蛋白相对表达量较空白对照组、Shh组明显高,Shh组也明显高于空白对照组,差异均有统计学意义(P1、LC3-Ⅱ蛋白表达,促进骨质疏松症小鼠骨形态的恢复。

关键词： Shh因子骨质疏松症小鼠骨吸收骨形成

Effect of water fluctuation on agricultural production in the huang-Huai-hai Plain,{2.

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Journal of Geographical Sciences 1999年第3期9卷 313-316页

作者： WU Kai, TANG Deng-yin, XIE Xian-qun(institute of Geography, chinese {2. of Sciences, beijing 100101, china)

The biggest load of water resources for agricultural economy in the huang-Huai Plainwill only arcount for 67.1 % of the forecasted irrigated area in 2.10. The irrigated area and thequantity of water diverting from the huanghe River was 2.2.million hm2.and 10.8 billion m3respectively in the lowe reaches of the river in the 1990s. The annual amount of yield increase forgrain is 6.3 billion kg calculated by converting and the annual benefit of yield-increase is 4.4 billionRMB {2. in the irrigated area of the region. The daily economic losses of industry and agricultureby absence of flow in the area in the 1990s is 44. 1 million RMB {2.. The annual water quantity willbe increased by 9.9 billion m3 after diverting water from the huanghe River and 12.6 billion m3 afterdiverting water from the Changjiang River respectively in the plain in 2.10.

关键词： the huang-Huai-hai Plain Water fluctuation, agricultural production

Research on the development methodology for clinical practice guidelines for organic integration of traditional chinese medicine and Western medicine

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Military Medical Research 2024年第3期11卷 313-322页

作者： Ying-Hui Jin Yan-Ping Wang Ying-Lan Xie Gui-Hua Tian Xiao-Yu Zhang Nan-Nan Shi Ke-Hu Yang Xin Sun Yao-Long Chen Da-rong Wu Xin-Feng Guo Long Ge Chen Zhao Cheng Lu Yin Jiang Jing Guo Si-Yu Yan Yong-Bo Wang Qiao huang Xiang-Ying Ren Ying-Yue Rao Yun-Yun Wang Meng-Qian {2. Xian-Tao Zeng Hong-Cai Shang Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China china Center for Evidence Based Traditional chinese Medicine Beijing 100029China Hubei Provincial Hospital of Traditional chinese Medicine Wuhan 430074China Key Laboratory of chinese Internal Medicine of Ministry of Education and beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhou 730000China china Center for Evidence-Based Medicine West China Hospital of Sichuan UniversityChengdu 610041China State Key Laboratory of Dampness Syndrome of chinese Medicine the Second Affliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China Evidence-based Medicine Team Guangdong Provincial Hospital of Traditional Chinese MedicineGuangzhou 510120China Nanjing University of chinese Medicine Nanjing 210023China Jiangsu Province Hospital of chinese Medicine Nanjing 210029China

Integrated traditional chinese medicine(TCM)and Western medicine(WM)is a new medical science grounded in the knowledge bases of both TCM and WM,which then forms a unique modern medical system in *** TCM and WM has a long history in china,and has made important achievements in the process of clinical diagnosis and ***,the methodological defects in currently published clinical practice guidelines(CPGs)limit its *** organic integration of TCM and WM is a deeper integration of TCM and *** realize the progression of"integration"to"organic integration",a targeted and standardized guideline development methodology is ***,the purpose of this study is to establish a standardized development procedure for clinical practice guidelines for the organic integration of TCM and WM to promote the systematic integration of TCM and WM research results into clinical practice guidelines in order to achieve optimal results as the whole is greater than the sum of the parts.

关键词： Methodology Traditional chinese medicine Western medicine Organic integration Clinical practice guidelines(CPGs)