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RGS22 maintains the physiological function of ependymal cells to prevent hydrocephalus

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Science China(life Sciences) 2025年第2期68卷 441-453页

作者： xue Pang lin Gu Qiu-ying Han Jia-Qing xing ming Zhao Shao-Yi huang jun-Xi Yi Jie Pan Hao hong Wen xue xue-Qing Zhou Zhi-Hui Su xin-Ran zhang li-ming Sun Shao-Zhen Jiang Dan luo ling Chen Zheng-Jie Wang Yu Yu Tian Xia xue-Min zhang Ai-ling li Tao Zhou hong Cai Tao li Nanhu Laboratory National Center of Biomedical AnalysisBeijing 100039China School of Basic Medical Sciences Fudan UniversityShanghai 200032China Department of Basic Medical Sciences School of MedicineTsinghua UniversityBeijing 100084China

Ependymal cells line the wall of cerebral ventricles and ensure the unidirectional cerebrospinal fluid(CSF)flow by beating their motile cilia *** ependymal denudation or ciliary dysfunction causes ***,we report that the deficiency of regulator of Gprotein signaling 22(RGS22)results in severe congenital hydrocephalus in both mice and ***,RGS22 is specifically expressed in ependymal cells within the *** conditional knock-out mice,we further demonstrate that the deletion of Rgs22 exclusively in nervous system is sufficient to induce ***,we show that Rgs22 deficiency leads to the ependymal denudation and impaired *** phenomenon can be attributed to the excessive activation of lysophosphatidic acid receptor(LPAR)signaling under Rgs22^(-/-)condition,as the LPAR blockade effectively alleviates hydrocephalus in Rgs22^(-/-)***,our findings unveil a previously unrecognized role of RGS22 in the central nervous system,and present RGS22 as a potential diagnostic and therapeutic target for hydrocephalus.

关键词： RGS22 hydrocephalus ependymal cells

Ultra-high quality factor and ultra-high accelerating gradient achievements in a 1.3 GHz continuous wave cryomodule

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Nuclear Science and Techniques 2025年第2期36卷 18-26页

作者： Jin-Fang Chen Yue Zong xiao-Yun Pu Sheng-Wang Xiang Shuai xing Zheng li xu-ming liu Yan-Fei Zhai xiao-Wei Wu yong-Zhou He ling-ling Gong Ji-Dong zhang Shan-Shan Cao Wen-Ding Fang Bin-Tuan zhang Kai xu Yi-Bo Yu Guang-hua Chen li-jun lu Ya-Wei huang Shen-Jie Zhao hong-Tao Hou Zhen-Yu Ma Ye-liang Zhao Xiang Zheng Jiu-Ce Sun Sen Sun Zhi-Qiang Jiang Yu-Bin Zhao Meng zhang ying-Bing Yan Yi-yong liu Qiang Gu Bo liu li-xin Yin Dong Wang Hai-xiao Deng Zhen-Tang Zhao Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China zhangjiang Laboratory 201210 ShanghaiChina ShanghaiTech University Shanghai 201210China

We report the world-leading performance of a 1.3 GHz cryomodule equipped with eight 9-cell superconducting radio-frequency cavities that underwent a medium-temperature furnace baking *** continuous wave horizontal testing,these cavities achieved unprecedented average intrinsic quality factors of 4.0×10^(10)at 20 MV/m and 3.2×10^(10)at 29 MV/m,with no instances of field *** cryomodule demonstrates near-complete preservation of ultra-high quality factors and ultra-high accelerating gradients from vertical to horizontal testing,marking a significant milestone in continuous-wave superconducting radio-frequency accelerator *** letter presents the cryomodule development experience,includ-ing cavity preparation,cryomodule assembly,degaussing,fast cooldown,and performance testing.

关键词： SRF cryomodule Mid-T baking High quality factor High accelerating gradient

PandaX-xT——A deep underground multi-ten-tonne liquid xenon observatory

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 105-120页

作者： Abdusalam Abdukerim Zihao Bo Wei Chen xun Chen Chen Cheng Zhaokan Cheng Xiangyi Cui yingjie Fan Deqing Fang lisheng Geng Karl Giboni linhui Gu xunan Guo xuyuan Guo Zhichao Guo Chencheng Han Ke Han Changda He Jinrong He Di huang junting huang Zhou huang Ruquan Hou Yu Hou Xiangdong Ji yonglin Ju Chenxiang li Jiafu li mingchuan li Shuaijie li Tao li Qing lin Jianglai liu Congcong lu xiaoying lu lingyin luo Yunyang luo Wenbo Ma Yugang Ma Yajun Mao Yue Meng xuyang Ning Binyu Pang Ningchun Qi Zhicheng Qian Xiangxiang Ren Nasir Shaheed xiaofeng Shang Xiyuan Shao Guofang Shen lin Si Wenliang Sun Yi Tao Anqing Wang Meng Wang Qiuhong Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang xu Wang Zhou Wang Yuehuan Wei Mengmeng Wu Weihao Wu Yuan Wu Mengjiao xiao Xiang xiao Binbin Yan Xiyu Yan yong Yang Chunxu Yu ying Yuan Zhe Yuan Youhui Yun xinning Zeng Minzhen zhang Peng zhang Shibo zhang Shu zhang Tao zhang Wei zhang Yang zhang yingxin zhang Yuanyuan zhang li Zhao Jifang Zhou Ning Zhou xiaopeng Zhou yong Zhou Yubo Zhou Zhizhen Zhou New Cornerstone Science Laboratory Tsung-Dao Lee InstituteShanghai Jiao Tong UniversityShanghai 200240China School of Physics and Astronomy Shanghai Jiao Tong UniversityKey Laboratory for Particle Astrophysics and Cosmology(MoE)Shanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China Shanghai Jiao Tong University Sichuan Research Institute Chengdu 610213China School of Physics Sun Yat-sen UniversityGuangzhou 510275China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Department of Physics Yantai UniversityYantai 264005China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Physics Beihang UniversityBeijing 102206China Peng huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 102206China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinesen Academy of SciencesHuizhou 516000China Yalong River Hydropower Development Company Ltd.Chengdu 610051China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Physics University of MarylandCollege ParkMaryland 20742USA State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China Key Laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityQingdao 266237China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China School of Physics Nankai UniversityTianjin 300071China SJTU Paris Elite I

We propose a major upgrade to the existing PandaX-4T experiment at the China Jinping Underground *** new experiment,PandaX-xT,will be a multi-ten-tonne liquid xenon,ultra-low background,and general-purpose *** full-scaled PandaX-xT contains a 43-t liquid xenon active *** an experiment will significantly advance our fundamental understanding of particle physics and *** sensitivity of dark matter direct detection will be improved by nearly two orders of magnitude compared to the current best limits,approaching the so-called“neutrino floor”for a dark matter mass above 10 GeV/c^(2),providing a key test to the Weakly Interacting Massive Particle *** searching for the neutrinoless double beta decay of^(136)Xe isotope in the detector,the effective Majorana neutrino mass can be measured to a 10-41 meV/c^(2) sensitivity,providing a key test to the Dirac/Majorana nature of *** neutrinos and other ultra-rare interactions can also be measured and searched for with an unprecedented background level,opening up new windows of *** on the findings,PandaX-xT will seek the next stage upgrade utilizing isotopic separation of natural xenon.

关键词： dark matter neutrino less double beta decay astrophysical neutrinos liquid xenon

Einstein Probe discovery of EP240408a:A peculiar X-ray transient with an intermediate timescale

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Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 218-236页

作者： Wenda zhang Weimin Yuan Zhixing ling yong Chen Nanda Rea Arne Rau Zhiming Cai huaqing Cheng Francesco Coti Zelati lixin Dai Jingwei Hu Shumei Jia Chichuan Jin Dongyue li Paul O’Brien Rongfeng Shen xinwen Shu Shengli Sun xiaojin Sun xiaofeng Wang Lei Yang Bing zhang Chen zhang Shuang-Nan zhang yonghe zhang Jie An David Buckley Alexis Coleiro Bertrand Cordier liming Dou Rob Eyles-Ferris Zhou Fan hua feng Shaoyu Fu Johan P.U.Fynbo Lluis Galbany Saurabh W.Jha Shuaiqing Jiang Albert Kong Erik Kuulkers Weihua Lei Wenxiong li Bifang liu mingjun liu xing liu Yuan liu Zhu liu Chandreyee Maitra Alessio Marino Itumeleng Monageng Kirpal Nandra Jeremy Sanders Roberto Soria lian Tao junfeng Wang Song Wang Tinggui Wang Zhongxiang Wang Qingwen Wu xuefeng Wu Dong xu Yanjun xu Suijian xue yongquan xue Zijian zhang Zipei Zhu Hu Zou Congying Bao Fansheng Chen Houlei Chen Tianxiang Chen Wei Chen Yehai Chen Yifan Chen Chenzhou Cui Weiwei Cui Yanfeng Dai Dongwei Fan Ju Guan Dawei Han Dongjie Hou Haibo Hu Maohai huang Jia Huo Zhenqing Jia Bowen Jiang Ge Jin Chengkui li junfei li Longhui li Maoshun li Wei li Zhengda li Tianying lian Congzhan liu Heyang liu huaqiu liu Fangjun lu Laidan luo Jia Ma xuan Mao Haiwu Pan xin Pan liming Song Hui Sun Yunyin Tan Qingjun Tang Yihan Tao Hao Wang Juan Wang Lei Wang Wenxin Wang Yilong Wang Yusa Wang Qinyu Wu Haitao xu Jingjing xu xinpeng xu Yunfei xu Zhao xu Changbin xue Yulong xue Ailiang Yan Haonan Yang Xiongtao Yang Yanji Yang Juan zhang Mo zhang Wenjie zhang Zhen zhang Zhen zhang Ziliang zhang Donghua Zhao Haisheng Zhao xiaofan Zhao Zijian Zhao hongyan Zhou Yilin Zhou Yuxuan Zhu Zhencai Zhu National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Institute of Space Sciences(ICE) CSICBarcelona E-08193Spain Institut d’Estudis Espacials de Catalunya(IEEC) Barcelona E-08034Spain Max Planck Institute for Extraterrestrial Physics Garching 85748Germany Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201210China Department of Physics University of Hong KongHong Kong 999077China School of Physics and Astronomy University of LeicesterLeicester LE17RHUK School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China Department of Physics Anhui Normal UniversityWuhu 241002China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai 200083China Physics Department Tsinghua UniversityBeijing 100084China Nevada Center for Astrophysics University of Nevada Las VegasLas Vegas NV 89154USA Department of Physics and Astronomy University of Nevada Las VegasLas Vegas NV 89154USA South African Astronomical Observatory Cape Town 7935South Africa Department of Astronomy University of Cape TownRondebosch 7701South Africa Department of Physics University of the Free StateBloemfontein 9300South Africa Universit´e Paris Cit´e CNRSAstroparticule et CosmologieParis F-75013France Universit´e Paris Cit´e CEA Paris-SaclayIRFU/DAp-AIMGif-sur-Yvette 91191France Department of Astronomy Guangzhou UniversityGuangzhou 510006China Cosmic Dawn Center(DAWN) Copenhagen 2200Denmark Niels Bohr Institute University of CopenhagenCopenhagen 2200Denmark Department of Physics and Astronomy Rutgersthe State University of New JerseyPiscataway NJ 08854-8019USA Institute for Cosmic Ray Research The University of TokyoKashiwa City 277-8582Japan ESA/ESTEC Noordwijk 2201 AZThe Netherlands Department of Astronom

We report the discovery of a peculiar X-ray transient,EP240408a,by Einstein Probe(EP)and follow-up studies made with EP,Swift,NICER,GROND,ATCA and other ground-based multiwavelength *** new transient was first detected with Wide-field X-ray Telescope(WXT)on board EP on April 8th,2024,manifested in an intense yet brief X-ray flare lasting for 12 *** flare reached a peak flux of 3:9×10^(−9) erg cm^(−2) s^(−1) in 0.5-4 keV,∼300 times brighter than the underlying X-ray emission detected throughout the *** and more precise follow-up observations by EP/FXT,Swift and NICER confirmed the finding of this new *** X-ray spectrum is non-thermal in 0.5-10 keV,with a power-law photon index varying within *** X-ray light curve shows a plateau lasting for∼4 d,followed by a steep decay till becoming undetectable∼10 d after the initial *** on its temporal property and constraints from previous EP observations,an unusual timescale in the range of 7-23 d is found for EP240408a,which is intermediate between the commonly found fast and long-term *** counterparts have been found in optical and near-infrared,with the earliest observation at 17 h after the initial X-ray detection,suggestive of intrinsically weak emission in these *** demonstrate that the remarkable properties of EP240408a are inconsistent with any of the transient types known so far,by comparison with,in particular,jetted tidal disruption events,gamma-ray bursts,X-ray binaries and fast blue optical *** nature of EP240408a thus remains an *** suggest that EP240408a may represent a new type of transients with intermediate timescales of the order of∼10 *** detection and follow-ups of more of such objects are essential for revealing their origin.

关键词： X-ray transients Einstein Probe

制药污水处理厂污泥中抗生素的污染特征及风险评估:生产负荷的影响

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中国环境科学 2025年第2期45卷 736-747页

作者：彭薪屹李玉花杨晓汝旋陈瑞红秦永丽黄馨慧许丹宁舒小华张倩桂林电子科技大学生命与环境科学学院广西桂林541004 桂林理工大学环境科学与工程学院广西桂林541006

制药污水处理厂污泥是抗生素的主要储存库.研究考察了高、低生产负荷影响下不同污水处理工艺段污泥中抗生素的残留特征,并利用风险熵值(RQ)法评估了物化和生化污泥潜在的生态风险.结果表明,高、低生产负荷下污泥中检测出的11种抗生素种... 详细信息

制药污水处理厂污泥是抗生素的主要储存库.研究考察了高、低生产负荷影响下不同污水处理工艺段污泥中抗生素的残留特征,并利用风险熵值(RQ)法评估了物化和生化污泥潜在的生态风险.结果表明,高、低生产负荷下污泥中检测出的11种抗生素种类相似,总检出浓度分别为401.72μg/g和55.02μg/g,不同抗生素浓度差异显著.生产负荷对废水处理工艺有一定的冲击力.主成分分析(PCA)结果显示高生产负荷下,不同工艺段的抗生素和水质参数之间的差异比低生产负荷下的差异更显著.冗余分析(RDA)结果显示不同的废水水质参数对抗生素的去除存在较大影响.制药过程中产生的抗生素在物化和生化脱水污泥中残留量依旧较高.低生产负荷物化和高生产负荷生化脱水污泥中抗生素残留量仍分别高达9.39μg/g和12.91μg/g.污泥改良土中红霉素、罗红霉素和磺胺氯哒嗪对接收环境的水生生物构成高风险(RQ>10).其中,磺胺二甲氧嘧啶的环境风险最高(RQ>295.04).制药厂大环内酯类和磺胺类抗生素是主要的风险因子,建议标记为优先控制污染物.混合抗生素的生态风险远高于单一抗生素.因此,不管是物化污泥还是生化污泥,都需要谨慎考虑污泥的最终出路.

关键词：制药厂污泥生产负荷工艺抗生素生态风险

基于麦-玉种植系统农田土壤碳库与作物产量的周年秸秆还田量评价

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环境科学 2025年第2期46卷 1016-1024页

作者：吴群文宋佩鸿黄健华钱欣高英波张慧刘开昌王良李宗新青岛农业大学农学院青岛266109 山东省农业科学院养分资源高效利用全国重点实验室济南250100

作物秸秆的处理和循环利用已成为农业科研领域的热点.优化小麦-玉米周年秸秆管理,可实现种植系统碳效率提高,并促进小麦-玉米周年可持续生产.基于持续8a的秸秆还田长期定位试验,设立了麦-玉双季还田(WS-MS)和麦-玉单季还田(WSMN)这两个... 详细信息

作物秸秆的处理和循环利用已成为农业科研领域的热点.优化小麦-玉米周年秸秆管理,可实现种植系统碳效率提高,并促进小麦-玉米周年可持续生产.基于持续8a的秸秆还田长期定位试验,设立了麦-玉双季还田(WS-MS)和麦-玉单季还田(WSMN)这两个处理,对比分析了WS-MS处理和WS-MN处理下秸秆还田量对土壤有机碳(TOC)含量、易氧化有机碳(EOOC)含量、土壤碳储量、碳库管理指数(CPMI)、碳利用效率和作物产量的影响.结果表明,WS-MS处理和WS-MN处理的TOC含量分别增加了8.1%和5.5%,WS-MS处理和WS-MN处理的EOOC含量分别增加了50.4%和45.5%;0~20 cm土层,WS-MS处理和WS-MN处理有机碳储量分别提升了20.5%和18.3%;但是WS-MS处理较WS-MN处理的提升皆不显著.WS-MS处理的碳库指数(CPI)、碳库活度(CPA)、碳库活度指数(CPAI)和CPMI较WS-MN处理分别高出3.7%、20.5%、2.2%和7.9%.对于产量而言,WS-MN处理的麦-玉周年产量较WS-MS处理高出0.2%,年均生产效率和生态效率分别较WS-MS处理显著高出136.1%和64.2%.WS-MN处理降低农田碳投入,导致其碳效益显著高于WS-MS处理.因此,统筹考量秸秆还田方式、秸秆碳利用效率以及作物产量,在不显著影响小麦-玉米周年籽粒产量及其土壤碳库的前提下,仅小麦秸秆单季还田更适于黄淮海地区小麦-玉米一年两熟集约化种植的周年秸秆资源高效利用的管理方式.

关键词：秸秆还田产量有机碳(TOC) 易氧化有机碳(EOOC) 碳利用效率碳库管理指数

Overview of the physics design of the EHL-2 spherical torus

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Plasma Science and Technology 2025年第02期 9-28页

作者：梁云峰谢华生石跃江顾翔姜欣辰董力立王雪韵杨丹可刘文军孙恬恬王嵎民李直蔡剑青宋显明谭沐芝杨光赵寒月董家齐彭元凯宋绍栋陈正元李颖颖刘兵罗迪杨圆明刘敏胜 Jianqing CAI Zhengyuan CHEN Jiaqi DONG lili DONG Kaiming feng xingxin GE Xiang GU Dong GUO Lei HAN Hairong huang Kunwei huang Xianli huang xinchen JIANG Dongxu li hongyue li Pengmin li Songjian li yingying li Zhi li Yunfeng liANG Bing liU Minsheng liU Shuo liU Wenjun liU yong liU Xiuchun luN Di luO Wenwu luO Yueng-Kay Martin PENG Ji QI Yuejiang SHI Shaodong SONG Xianming SONG Tiantian SUN Muzhi TAN Renyi TAO Hanqing WANG xueyun WANG Yu WANG Yumin WANG xiao xiao huasheng XIE Qifeng XIE Danke YANG Enwu YANG Guang YANG xu YANG Yuanming YANG Baoshan YUAN hong ZANG Wenwei zhang Hanyue ZHAO xin ZHAO Yihang ZHAO Peihai ZHOU hongfeng ZHU xiaojun ZHU Debu BANERJEE Zhongyong CHEN Shuyu DAI Di HU Jiankun hua Yanqing huang Zhuo huang Kai li li li Chengyue liU Tong liU Yiliang liU Zhifang liN Haojie MA Zhiwei MA Erhui WANG feng WANG Fuqiong WANG Zhengxiong WANG Shuai xu Qingwei YANG Jie zhang Pingwei ZHENG Wei ZHENG Hebei Key Laboratory of Compact Fusion Forschungszentrum Jülich GmbH Institute of Fusion Energy and Nuclear Waste Management-Plasmaphysik ENN Science and Technology Development Co. Ltd. Southwestern Institute of Physics DISAT Polytechnic University of Turin huazhong University of Science and Technology Key Laboratory of Materials Modification by Laser Ion and Electron Beams (Ministry of Education) School of Physics Dalian University of Technology Beihang University Hengyang Normal University College of Computer Science South-Central Minzu University Centre for Theoretical and Computational Physics College of Physics Qingdao University College of physics Donghua University School of Physics Hefei University of Technology School of Electrical Engineering& Automation Jiangsu Normal University School of liberal Arts and Sciences North China Institute of Aerospace Engineering Zhejiang University Department of Plasma Physics and Fusion Engineering University of Science and Technology of China University of South China

ENN is planning the next generation experimental device EHL-2 with the goal to verify the thermal reaction rates of p-11B fusion,establish spherical torus/tokamak experimental scaling laws at 10's keV ion temperature,and provide a design basis for subsequent experiments to test and realize the p-11B fusion burning *** on 0-dimensional（0-D） system design and 1.5-dimensional transport modelling analyses,the main target parameters of EHL-2 have been basically determined,including the plasma major radius,R0,of 1.05 m,the aspect ratio,A,of 1.85,the maximum central toroidal magnetic field strength,B0,of 3 T,and the plasma toroidal current,Ip,of 3 *** main heating system will be the neutral beam injection at a total power of 17 *** addition,6 MW of electron cyclotron resonance heating will serve as the main means of local current drive and MHD instabilities *** physics design of EHL-2 is focused on addressing three main operating scenarios,i.e.,（1） high ion temperature scenario,（2） high-performance steady-state scenario and（3） high triple product *** scenario will integrate solutions to different important issues,including equilibrium configuration,heating and current drive,confinement and transport,MHD instability,p-11B fusion reaction,plasma-wall interactions,*** that,there are several unique and significant challenges to address,including● establish a plasma with extremely high core ion temperature(Ti,0> 30 keV),and ensure a large ion-to-electron temperature ratio(Ti,0/Te,0> 2),and a boron concentration of 10%-15% at the plasma core;● realize the start-up by non-inductive current drive and the rise of MA-level plasma toroidal *** is because the volt-seconds that the central solenoid of the ST can provide are very limited;● achieve divertor heat and particle fluxes control including complete detachment under high P/R（> 20 MW/m） at relatively low electron *** overview will introduce the advanced progress in the ph

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Single base substitution in Os CDC48 is responsible for premature senescence and death phenotype in rice

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Journal of Integrative Plant Biology 2016年第1期58卷 12-28页

作者： Qi-Na huang yong-feng Shi xiao-Bo zhang li-xin Song Bao-hua feng Hui-Mei Wang Xia xu xiao-hong li Dan Guo Jian-li Wu State Key Laboratory of Rice Biology China National Rice Research Institute Hangzhou 310006 China School of life Sciences Hebei Normal University Shijiazhuang 050024 China

A premature senescence and death 128 （psd128） mutant was isolated from an ethyl methane sulfonate-induced rice IR64 mutant bank. The premature senescence phenotype appeared at the six-leaf stage and the plant died at the early heading stage, psd128 exhibited impaired chloroplast develop- ment with significantly reduced photosynthetic ability, chlorophyll and carotenoid contents, root vigor, soluble protein content and increased malonaldehyde content. Furthermore, the expression of senescence-related genes was significantly altered in psd128. The mutant trait was controlled by a single recessive nuclear gene. Using map- based strategy, the mutation Oryza sativa cell division cycle 48 （OsCDC48） was isolated and predicted to encode a putative AAA-type ATPase with 809 amino-acid residuals. A single base substitution at position C2347T in psd128 resulted in a premature stop codon. Functional complementation could rescue the mutant phenotype. In addition, RNA interference resulted in the premature senescence and death phenotype. OsCDC48 was expressed constitutively in the root, stem, leaf and panicle. Subcellular analysis indicated that OsCDC48：YFP fusion proteins were located both in the cytoplasm and nucleus. OsCDC48 was highly conserved with more than 90% identity in the protein levels among plant species. Our results indicated that the impaired function of OsCDC48 was responsible for the premature senescence and death phenotype.

关键词： Oryza sativa premature senescence and death AAA-ATPase OsCDC48

The application of EPICS in TMSR radiation protection and access control system

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Nuclear Science and Techniques 2016年第2期27卷 58-63页

作者： li-feng Han yong-Zhong Chen jun Cai Hai-Xia xu Wen-Bo huang Ning zhang li-xin Han Peng-Fei hong Shanghai Institute of Applied Physics Chinese Academy of Science

To treat technical problems of data acquisition,alarm management, and historical data archiving of radiation protection control system in Thorium Molten Salt Reactor, a network prototype system was designed based on experimental physics and industrial control *** level of many locations in Jiading campus of Shanghai Institute of Applied Physics is being continuously monitored, and boundaries of accelerator facilities and radiochemical areas are defined by the access control system. In this paper, we introduce the control system design,including human–machine interfaces, alarm system, historical data archiving system, and the software for access control. The software development followed the standard of Capability Maturity Model Integration(CMMIò) Level3, and the software had passed a third-party test, which indicated that the functionality and the reliability could fulfill the requirements of the radiation protection system.

关键词：访问控制系统辐射防护应用能力成熟度模型史诗工业控制系统放射防护历史数据