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经典名方中仙茅的本草考证

中国实验方剂学杂志 2024年第14期30卷 199-208页

作者：罗进芳黄瑶瑶周涛喻杨曹国琼赵丹肖承鸿詹志来贵州中医药大学贵阳550025 中国中医科学院中药资源中心北京100700

通过查阅历代本草、医籍、方书及近现代文献资料,笔者对仙茅药材的名称、基原、产地、品质评价、采收加工、炮制、性味归经与功效主治、毒性、禁忌等方面进行了系统梳理与本草考证,以期为含有仙茅药材经典名方的开发利用提供依据。考证... 详细信息

通过查阅历代本草、医籍、方书及近现代文献资料,笔者对仙茅药材的名称、基原、产地、品质评价、采收加工、炮制、性味归经与功效主治、毒性、禁忌等方面进行了系统梳理与本草考证,以期为含有仙茅药材经典名方的开发利用提供依据。考证结果表明,仙茅始载于《雷公炮炙论》,历代均以仙茅为正名,命名多源于其功效与形态特征;历代主流来源为仙茅Curculigo orchioides和大叶仙茅***的根茎,近代以来则以仙茅***为主要商品来源;古代著录的产地多为西域及我国西南地区,近代以来则推崇四川、贵州等地所产,奉为道地;近代以来总结其品质以根条粗壮、质坚、表面黑褐色者为佳;历代记载的采收加工方法主要为农历二、八、九月采后晒干,现代多于秋、冬二季采收;古代炮制方法众多,主要以米泔水制居多,现代炮制方法则以酒炙为主;性味归经与功能主治古今基本一致;其服用禁忌为忌铁,禁牛乳、牛肉;历代对仙茅毒性的认识虽有部分差异,但大部分本草明确仙茅具有一定毒性。基于考证结论,建议经典名方中采用石蒜科仙茅***的根茎为其来源,按经典名方中药物炮制要求选取相应的炮制方法,未明确炮制要求的则建议选取生品入药。

关键词：经典名方仙茅本草考证学名基原产地炮制

Taxonomy and Phylogeny of a New Marine Planktonic Ciliate, Strombidium pseudorapulum sp. n. (Protozoa, Ciliophora, Oligotrichia)

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Journal of Ocean University of China 2020年第4期19卷 954-960页

作者： LI Fenfen huang yaoyao YU Ying LIU Weiwei LIN Xiaofeng Laboratory of Protozoology Guangzhou Key Laboratory of Subtropical Biodiversity and BiomonitoringCollege of Life ScienceSouth China Normal UniversityGuangzhou 510631China Key Laboratory of Tropical Marine Bio-Resources and Ecology South China Sea Institute of OceanologyChinese Academy of ScienceGuangzhou510301China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou Guangzhou511458China Innovation Academy of South China Sea Ecology and Environmental Engineering Chinese Academy of SciencesGuangzhou 510301China Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystem College of the Environment and EcologyXiamen UniversityXiamen 361005China

As one of the main groups of marine planktonic protozoa,oligotrich ciliates have shown a high ***,a new aloricate oligotrich ciliate,Strombidium pseudorapulum *** isolated from coastal waters of southeast *** living morphology and infraciliature of this species were studied using live cell observation and protargol *** pseudorapulum *** from its congeners by having a radish-like body with a bumped anterior end and an elongated tail-like posterior end,possessing a red‘eyespot’in apical protrusion of cell,adoral zone of membranelles composed of 12–16 collar and 9–12 buccal membranelles,one spindle-shaped macronucleus,girdle kinety in anterior 2/5 of cell with 45–60 densely spaced dikinetids,and ventral kinety occupying about the posterior 1/3 of the cell with 16–19 *** pseudorapulum *** together with those species having‘eyespot’in apical protrusion in the phylogenetic tree based on the small subunit rRNA gene *** is a sister species of *** with 31 unmatched nucleotides between their SSU rRNA gene sequences.

关键词： aloricate oligotrichs morphology new species SSU rRNA gene sequence

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3~6岁儿童患龋的危险因素模型构建

健康研究 2024年第1期44卷 95-99页

作者：黄瑶瑶潘月微吴一梦温州医科大学附属口腔医院儿童口腔科浙江温州325000

目的分析3~6岁儿童患龋的危险因素并构建模型,为降低儿童患龋率提供依据。方法回顾性收集400例3~6岁接受龋齿检查儿童的临床资料,根据龋齿的发病情况分为患龋组(281例)和健康组(119例),分析3~6岁儿童患龋的危险因素。结果患龋组年龄5~6... 详细信息

目的分析3~6岁儿童患龋的危险因素并构建模型,为降低儿童患龋率提供依据。方法回顾性收集400例3~6岁接受龋齿检查儿童的临床资料,根据龋齿的发病情况分为患龋组(281例)和健康组(119例),分析3~6岁儿童患龋的危险因素。结果患龋组年龄5~6岁、有龋齿家族遗传史、家属对口腔相关健康知识认知水平较低、家庭经济收入<5000元/月、刷牙开始年龄≥2岁、刷牙方法错误、儿童看牙频率<1次/6个月、刷牙频率<2次/d、嗜好甜食儿童的比例高于健康组,差异均有统计学意义(均P<0.05);其中,年龄5~6岁、家属对口腔相关健康知识认知水平较低、家庭经济收入<5000元/月、刷牙开始年龄≥2岁、儿童看牙频率<1次/6个月、刷牙频率<2次/d、嗜好甜食为3~6岁儿童患龋的独立危险因素(均P<0.05)。结论家庭应关注嗜好甜食的5~6岁儿童的刷牙频率,提高家属对口腔相关健康知识的认知水平,以降低3~6岁儿童的龋齿发病风险。

关键词：龋齿 3~6岁儿童危险因素干预策略

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辣椒类胡萝卜素生物合成的分子遗传学研究进展

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广东农业科学 2024年第2期51卷 71-80页

作者：邓明华莫云容吕俊恒赵凯黄尧瑶王岩岩张宏云南农业大学园林园艺学院/云南省蔬菜生物学重点实验室云南昆明650201

辣椒(Capsicumspp.)属于茄科辣椒属,作为一种蔬菜和香料作物在世界各地得到广泛栽培。除作为烹饪食材和香料应用外,辣椒在制药和化妆品领域也有广泛的用途。类胡萝卜素是一类天然色素的总称,参与植物许多重要的代谢过程,如光合作用、光... 详细信息

辣椒(Capsicumspp.)属于茄科辣椒属,作为一种蔬菜和香料作物在世界各地得到广泛栽培。除作为烹饪食材和香料应用外,辣椒在制药和化妆品领域也有广泛的用途。类胡萝卜素是一类天然色素的总称,参与植物许多重要的代谢过程,如光合作用、光保护、光形态建成和生长发育等。类胡萝卜素具有多种生物活性,是辣椒果实主要的营养物质之一,培育类胡萝卜素含量更高的辣椒品种需要全面深入了解其生物合成及其调控的分子机制。分子生物学和生物技术的发展促进了类胡萝卜素生物合成基因的鉴定,为培育类胡萝卜素含量更高的辣椒新品种提供了机会。该文描述了类胡萝卜素的生理作用、类胡萝卜素与辣椒果实颜色、类胡萝卜素生物合成途径、辣椒类胡萝卜素生物合成途径的结构基因及调控因子、辣椒果实颜色的分子遗传学及与辣椒果实颜色有关的QTL位点等方面的研究进展。牻牛儿基牻牛儿基焦磷酸合成酶(GGPS)、八氢番茄红素合成酶(PSY)、八氢番茄红素脱氢酶(PDS)、ζ-胡萝卜素去饱和酶(ZDS)、番茄红素环化酶(LCY)、辣椒红素-辣椒玉红素合成酶(CCS)等是辣椒类胡萝卜素生物合成通路的端口酶和限速酶,其表达丰度和活性高低直接调控辣椒体内类胡萝卜素的含量。MYB306、DIVARICATA1、BBX20等转录因子参与辣椒类胡萝卜素生物合成的调控。类胡萝卜素生物合成和调控基因的多样性决定类胡萝卜素单体的数量和含量,影响辣椒果实呈现的颜色。基于目前研究进展,该文对未来辣椒类胡萝卜素代谢研究进行了展望,以期为今后培育富含类胡萝卜素的生物强化型辣椒新品种提供新思路。

关键词：辣椒类胡萝卜素生物合成分子遗传学辣椒果实颜色

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Highly efficient perovskite solar cells by building 2D/3D perovskite heterojuction in situ for interfacial passivation and energy level adjustment

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Science China Chemistry 2023年第2期66卷 449-458页

作者： yaoyao huang Zhangyu Yuan Jia Yang Shungao Yin Aihui Liang Gang Xie Chuizheng Feng Zhisheng Zhou Qifan Xue Yang Pan Fei huang Yiwang Chen National Engineering Research Center for Carbohydrate Synthesis/Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education Jiangxi Normal UniversityNanchang330022China College of Chemistry and Chemical Engineering/Institute of Polymers and Energy Chemistry(IPEC) Nanchang UniversityNanchang330031China State Key Laboratory of Luminescent Materials and Devices Institute of Polymer Optoelectronic Materials and DevicesSchool of Materials Science and EngineeringSouth China University of TechnologyGuangzhou510640China

Passivating the interfacial defects and reducing the interfacial non-radiative recombination losses are the keys to improving the photovoltaic performance of three-dimensional(3D)perovskite solar cells(PVSCs).Stacking two dimensional(2D)perovskites on 3D perovskite is a promising method for interfacial treatment that improves the stability and efficiency of ***,we developed conjugated fluorinated benzimidazolium cation(FBIm+)which can be inserted between 3D perovskite and holetransporting layer(HTL)to form 2D perovskite in *** 2D single crystal structures of(FBIm)_(2)Pb I4and(FBIm)_(2)Pb Br_(4)were achieved and confirmed by single-crystal X-ray diffraction(XRD),while few single crystals of 2D perovskite based on imidazolium or benzimidazolium anchors have been *** 2D perovskite can passivate the interfacial defects,induce better crystallinity and orientation,conduct lower trap density and extend carrier ***,the energy level arrangement can be regulated by changing the counterion from iodide to bromide,which can efficiently improve the hole extraction and device *** a consequence,the best efficiency of 23.00%for FBIm Br-incorporated devices was achieved,while only 20.72%for the control ***,the PVSCs modified by FBIm Br displayed excellent environmental stability due to the constructed hydrophobic 2D perovskite layer which can effectively block moisture *** work develops a new path to design novel conjugated organic passivants to form 2D/3D perovskite structures.

关键词： organic-inorganic halide perovskites solar cells passivation engineering 2D/3D perovskites

Effect of non-uniform swelling on coal multiphysics during gas injection: The triangle approach

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1362-1372页

作者： Yifan huang Jishan Liu yaoyao Zhao Derek Elsworth Yee-Kwong Leong Department of Chemical Engineering School of EngineeringThe University of Western Australia35 Stirling HighwayWA 6009Australia State Key Laboratory of Coal Resources & Safe Mining China University of Mining& TechnologyBeijing100803China Department of Energy and Mineral Engineering G3 Centre and Energy InstituteThe Pennsylvania State UniversityUniversity ParkPA16802USA

In current dual porosity/permeability models,there exists a fundamental assumption that the adsorption-induced swelling is distributed uniformly within the representative elementary volume (REV),irrespective of its internal structures and transient ***,both internal structures and transient processes can lead to the non-uniform *** this study,we hypothesize that the non-uniform swelling is responsible for why coal permeability in experimental measurements is not only controlled by the effective stress but also is affected by the adsorption-induced *** propose a concept of the swelling triangle composed of swelling paths to characterize the evolution of the non-uniform swelling and serve as a core link in coupled multiphysics.A swelling path is determined by a dimensionless volumetric ratio and a dimensionless swelling *** swelling paths have the same start and end point,and each swelling path represents a unique swelling *** swelling path as the diagonal of the triangle represents the case of the uniform swelling while that as the two perpendicular boundaries represents the case of the localized *** paths of all intermediate cases populate inside the *** corresponding relations between the swelling path and the response of coal multiphysics are established by a non-uniform swelling *** define this method as the triangle approach and corresponding models as swelling path-based *** proposed concept and models are verified against a long-term experimental measurement of permeability and strains under constant effective *** results demonstrate that during gas injection,coal multiphysics responses have a close dependence on the swelling path,and that in both future experiments and field predictions,this dependence must be considered.

关键词： Transient process Heterogeneity Swelling triangle Swelling path Non-uniform swelling coefficient

Recent Progresses on Dopant-Free Organic Hole Transport Materials toward Efficient and Stable Perovskite Solar Cells

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Chinese Journal of Chemistry 2023年第22期41卷 3133-3166页

作者： Gang Xie Jintao Chen Huiyu Li Jianxin Yu Haoran Yin Zhiping Wang yaoyao huang Chuizheng Feng Yang Pan Aihui Liang Yiwang Chen National Engineering Research Center for Carbohydrate Synthesis/Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education Jiangxi Normal University99Ziyang AvenueNanchangJiangxi330022China College of Chemistry and Chemical Engineering/Institute of Polymers and Energy Chemistry(IPEC) Nanchang University99 Xuefu AvenueNanchangJiangxi330031China

As the third generation new battery,the power conversion efficiency(PCE)of metal halide perovskite solar cells(PsCs)has increased from 3.8%in 2009 to 25.8%currently certified,which fully shows that they have great research value and development *** one of the main components of high-efficiency PSCs,hole transport materials(HTMs)play an important role in extracting and transporting holes and inhibiting charge ***,commonly used HTMs require doping,and the hygroscopicity and corrosiveness of the dopants will destroy the stability of PsCs and hinder their ***,it is of great significance to develop dopant-free HTMs.

关键词： Organic hole transport materials Dopant-free Perovskite solar cells Efficient Stable

Usefulness of myocardial performance index for assessing right ventricular function after percutaneous closure of atrial septal defect

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Journal of Geriatric Cardiology 2007年第4期4卷 220-224页

作者： Jingdong Ding Genshan Ma yaoyao huang Xiaoli Zhang Jian Zhu Rong Yang Fengxiang Lu Department of Cardiology Zhongda Hospital&School of Clinical MedicineSoutheast UniversityNanjing 210009China Department of Cardiology the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210009China

Objective Assessment of right ventricular function in patients with atrial septal defect(ASD)is *** Doppler myocardial performance index(MPI)may provide a method of assessing function in these *** purposes of this study were to evaluate the right ventricular function and its changes in patients with ASD after transcatheter closure of *** MPI,defined as the sum of isovolumic relaxation time and isovolumic contraction time derived by ejection time,was measured from tricuspid inflow and right ventricular outflow;Doppler velocity profiles recorded during routine *** nine patients(13 men,16 women;mean age 25.28±12.69,range 6 to 57 years)were diagnosed to secundum ASD[the stretched diameters of ASD were from 9 To 36(24.91±7.98)mm],and had a successfully placed Amplatzer septal occluder(ASO)(the sizes of ASO were from 11 to 40 mm);there were 81 sex-matched,age-matched healthy people(control group 41men,40 women;mean age 29.02±14.22,range 4 to 45 years).MPI was measured again on 3 days and 1 month after closure of *** in the study group was assessed and compared to the control subjects with structurally normal hearts.A complete 2-dimensional and Doppler echocardiographic examination was performed in all study *** 1)The isovolumic relaxation and isovolumic contraction times[respectively(77.59±14.39)ms vs(60.93±12.94)ms,P<0.0001;(28.28±10.88)ms vs(23.64±9.01)ms,P=0.027]were prolonged,and ejection time[(260.65±21.86)ms vs(271.85±21.92)ms,P=0.033]was shortened in patients with ASD compared with that in control subjects,resulting in a marked increase in the MPI(0.40±0.07 vs 0.31±0.05,P<0.0001)from normal values;2)by Pearson's correlations,the MPI had no correlation with heart rate and blood pressure in control subjects and patients with ASD,but it correlated positively with age in patients with ASD;3)by Pearson's correlations,the MPI correlated positively with the diameter of ASD and pulmonary artery pressure;4)aft

关键词： heart atrial septal defect right ventricular function myocardial performance index

Electronic interaction between single Pt atom and vacancies on boron nitride nanosheets and its influence on the catalytic performance in the direct dehydrogenation of propane

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Chinese Journal of Catalysis 2019年第6期40卷 819-825页

作者： Xiaoying Sun Meijun Liu yaoyao huang Bo Li Zhen Zhao Institute of Catalysis for Energy and Environment College of Chemistry and Chemical EngineeringShenyang Normal UniversityShenyang 110034LiaoningChina State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249China Institute of Metal Research Chinese Academy of SciencesShenyang 110016LiaoningChina

The electronic metal-support interaction(EMSI)is one of most intriguing phenomena in heterogeneous *** this work,this subtle effect is clearly demonstrated by density functional theory(DFT)calculations of single Pt atom supported on vacancies in a boron nitride ***,the relation between the EMSI and the performance of Pt in propane direct dehydrogenation(PDH)is investigated in *** charge state and partial density of states of single Pt atom show distinct features at different anchoring positions,such as boron and nitrogen vacancies(Bvac and Nvac,respectively).Single Pt atom become positively and negatively charged on Bvac and Nvac,***,the electronic structure of Pt can be adjusted by rational deposition on the ***,Pt atoms in different charge states have been shown to have different catalytic abilities in *** DFT calculations reveal that Pt atoms on Bvac(Pt-Bvac)have much higher reactivity towards reactant/product adsorption and C–H bond activation than Pt supported on Nvac(Pt-Nvac),with larger adsorption energy and lower barrier along the reaction ***,the high reactivity of Pt-Bvac also hinders propene desorption,which could lead to unwanted deep ***,the results obtained herein suggest that a balanced reactivity for C–H activation in propane and propene desorption is required to achieve optimum *** on this descriptor,a single Pt atom on a nitrogen vacancy is considered an effective catalyst for ***,the deep dehydrogenation of the formed propene is significantly suppressed,owing to the large barrier on *** current work demonstrates that the catalytic properties of supported single Pt atoms can be tuned by rationally depositing them on a boron nitride nanosheet and highlights the great potential of single-atom catalysis in the PDH reaction.

关键词： Propane Direct dehydrogenation Platinum Boron nitride Single atom catalysis Density functional theory Electronic metel-support interaction