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A Dietary Supplement Jinghuosu Ameliorates Reproductive Damage Induced by Tripterygium Glycosides

Chinese Journal of Integrative Medicine 2024年第4期30卷 330-338页

作者： MA Jing SUN Bo TE Li-ger huang xin ZUO xin HAN Xiao-ke WANG Shu-song Hebei Key Laboratory of Reproductive Medicine Hebei Institute of Reproductive HealthHebei Reproductive Health HospitalShijiazhuang(050071)China Graduate School of Hebei Medical University Shijiazhuang(050017)China School of Chemistry and Materials Science Hebei Normal UniversityShijiazhuang(050024)China xingtai Infertility Specialist Hospital XingtaiHebei Province(054000)China

Objective To determine the possible protective effects of Jinghuosu,a dietary supplement(DS),on tripterygium glycosides(TG)-induced reproductive system injury in rats and its underlying mechanisms.Methods A reproductive damage model was established in rats by feeding of TGs.Twenty-eight male Sprague Dawley rats were randomly divided into 4 groups using a random number table(n=7 in each):control(C)group,model(M)group,DS group and L-carnitine(LC)group.Rats in M,DS and LC groups received 40 mg/kg TGs orally.Starting from the 5th week,after administration of TGs for 4 h every day,rats in DS and LC groups were administered with 2.7 g/kg DS and 0.21 g/kg LC,respectively,for protective treatment over the next 4 weeks.Rats in Group C continued to receive the control treatment.Hematoxylin-eosin staining was used for histopathological analysis of rat testicular tissues.Enzyme-linked immunosorbent assay was performed to measure alkaline phosphatase(ALP),lactate dehydrogenase,alcohol dehydrogenase,total antioxidant capacity(T-AOC),superoxide dismutase,glutathione peroxidase(GSH-Px),and malondialdehyde(MDA)concentrations.Chemiluminescence assay was used to determine the serum testosterone content.Quantitative real-time PCR and Western blotting were conducted to analyze the expression of genes and proteins related to the testosterone synthesis pathway and the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 antioxidant pathway.Results Oral administration of TGs induced significant increases in the testicular levels of zinc transporter 1 and MDA(P<0.05).On the other hand,sperm concentration,sperm motility,and serum testosterone,serum zinc,testicular zinc,Zrt-,Irt-like protein 1,ALP,luteinizing hormone(LH)receptor,steroidogenic acute regulatory protein,Cytochrome P450 family 11 subfamily A member 1,3β-hydroxysteroid dehydrogenase 1 T-AOC,GSH-Px,nuclear factor erythroid 2-related factor 2,heme oxygenase-1 and NAD(P)H:quinone oxidoreductase 1 levels decreased following TGs exposure(P<0.05).All of these phenotypes were

关键词： dietary supplement Jinghuosu tripterygium glycosides reproductive damage infertility

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Multiple Nanoparticles Coupling Strategy for Enhancing Optical Filter Performance of Spectral Splitter Used in Photovoltaic/Thermal System

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Journal of Thermal Science 2024年第1期33卷 368-382页

作者： LIANG Huaxu huang xin WANG Fuqiang CHENG Ziming DONG Yan School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China School of New Energy Harbin Institute of Technology at WeihaiWeihai 264209China School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore

Selective absorptive nanofluid can pre-absorb certain sunlight wavelength that cannot be used by PV and transmits remaining sunlight to the surface of PV,which can decouple PV from the thermal receiver spatially.In order to improve the harvesting of electricity and high-temperature thermal nanofluid,it is important to design an optimal optical filter window(transmit sunlight with wavelengths of 732-1067 nm to the surface of the photovoltaic cell and absorb the remaining sunlight).However,designing optimal optical filter is facing following challenges:(1) inherently narrow selective absorptivity property of single nanoparticle;(2) simplified numerical calculation method calculating transmittance;(3) ignoring the shape of the nanoparticle.In this study,the idea of using multiple nanoparticles coupling effect to design an optical filter is proposed,which can superimpose the narrow absorption bandwidth of different nanoparticles to obtain a wide absorption bandwidth of the whole system.In addition,an improved transmission method considering light-matter interaction at air/vessel and liquid/vessel interfaces is adopted to compute the transmittance.The results calculated by improved transmission method are more accurate than widely used traditional Lambert-Beer law,which is verified by experimental test.Furthermore,the effect of nanoparticle shape on spectral transmittance is also investigated,which shows that spiny Ag can approximately extend absorbance from 400 nm to 600 nm compared to nanosphere silver.Finally,the results show that optical filter efficiency of nanofluids with multiple nanoparticles coupling(Ag,spiny Ag,ZnO,ITO) can reached up to 35%.

关键词： solar energy PV/T nanofluid optimal optical filter radiative transfer spectral splitting

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From“Car Priority”to“People Priority”: Exploring New Ideas for Refined Road Space Design

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Journal of Landscape Research 2024年第2期16卷 25-29页

作者： huang xin Guangzhou Urban Planning and Design Company Limited GuangzhouGuangdong 510000China

Roads are crucial public spaces in cities and serve as a window to showcase the city’s characteristics.They serve not only as a means of urban transportation but also as a crucial spatial carrier for urban communication activities and a significant location for meeting the increasing demands of people for a better quality of life.The current road infrastructure prioritizes the right of way for cars,neglecting the design of sidewalks and green belts within the road’s boundaries,and extension spaces between buildings and boundary lines of roads.There is a pressing need to improve street space in response to the demand for development transformation and the creation of a warmer city.This paper summarizes common problems in current road spaces,draws on the experience of excellent urban road spaces in foreign countries,discusses new ideas for the refined design of road spaces based on the transformation of road planning concepts,and suggests a reference standard for guiding detailed design.Simultaneously,the review of road construction will incorporate the detailed design of road space to enhance the role of planning in guiding and controlling the construction of road works.

关键词： Road space Refined design Communication space City perception

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Facile synthesis of high-brightness green-emitting carbon dots with narrow bandwidth towards backlight display

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Chinese Chemical Letters 2024年第5期35卷 277-282页

作者： Rui Cheng Tingting Zhang xin huang Jian Yu State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 210009China

High-performance carbon dots(CDs)allowing the application in high-end display devices are highly desirable and usually limited by the absence of simple and easy synthesis methods.In this work,we exploited an easy-to-implement strategy for the one-step synthesis of green-emitting CDs(G-CDs)with superb optical properties.The G-CDs were synthesized using m-phenylenediamine(m-PD)as a single precursor,and the reaction reacted at 180℃for 12 h The resultant G-CDs exhibit high-purity and excitationindependent green fluorescence with the photoluminescence(PL)peak located at 516 nm,full width at half maximum(FWHM)of 46 nm,and PL quantum yield(QY)of∼80%under the 470nm excitation light.The G-CDs and corresponding composite film prepared with polyvinyl butyral(G-CDs@PVB)exhibit good PL stability after undergoing long-time storage for one year and 360 h exposure under 460nm blue light.The G-CDs@PVB film was used as color-conversion materials in green-emitting light-emitting diode(LED)application,exhibiting a Commission internationale de l’Eclairage(CIE)chromaticity coordinate of(0.21,0.44).The film was also used in CD-based liquid crystal display(CD-LCD)application,achieving a color gamut value of 85%.This work will offer a working basis for the synthesis of high-performance CDs as well as their application in displays.

关键词： Carbon dots One-step synthesis Narrow bandwidth High quantum yield Display

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Long-term exposure to aryl hydrocarbon receptor agonist neburon induces reproductive toxicity in male zebrafish(Danio rerio)

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Journal of Environmental Sciences 2024年第8期142卷 193-203页

作者： Fucong Zhang Chen Tang Yue Zhu Qian Wang xin huang Chunyan Yang Chengyong He Zhenghong Zuo Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems School of Life SciencesXiamen UniversityXiamen 361102China

Neburon is a phenylurea herbicide that is widely used worldwide,but its toxicity is poorly studied.In our previous study,we found that neburon has strong aryl hydrocarbon receptor(AhR)agonist activity,but whether it causes reproductive toxicity is not clear.In the present study,zebrafish were conducted as a model organism to evaluate whether environmental concentrations of neburon(0.1,1 and 10μg/L)induce reproductive disorder in males.After exposure to neburon for 150 days from embryo to adult,that the average spawning egg number in high concentration group was 106.40,which was significantly lower than 193.00in control group.This result was mainly due to the abnormal male reproductive behavior caused by abnormal transcription of genes associated with reproductive behavior in the brain,such as secretogranin-2a.The proportions of spermatozoa in the medium and high concentration groups were 82.40%and 83.84%,respectively,which were significantly lower than 89.45%in control group.This result was mainly caused by hormonal disturbances and an increased proportion of apoptotic cells.The hormonal disruption was due to the significant changes in the transcription levels of key genes in the hypothalamus-pituitary-gonadal axis following neburon treatment.Neburon treatment also significantly activated the AhR signaling pathway,causing oxidative stress damage and eventually leading to a significant increase in apoptosis in the exposed group.Together,these data filled the currently more vacant profile of neburon toxicity and might provide information to assess the ecotoxicity of neburon on male reproduction at environmentally relevant concentrations.

关键词： Zebrafish Neburon Male reproductive toxicity HPG axis AhR agonist

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Effect of proppant sizes and injection modes on proppant transportation and distribution in the tortuous fracture model

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Particuology 2024年第1期84卷 261-280页

作者： Jun Li Xu Han Siyuan He Mingyi Wu xin huang Nianyin Li State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500China Chongqing Industry Polytechnic College Chongqing401120China Sichuan Particles Energy and Technology Co. LtdChengdu611630China Engineering Technology Research Institute of PetroChina Southwest Oil and Gas Field Company Chengdu610017China

Particle-fluid transport and placement mechanism in tortuous fracture played a crucial role in uncon-ventional reservoirs.Currently,most studies focused on mono-size proppant with fluid transport pro-cesses in tortuous fractures.However,the mixture-size proppant with fluid movement mechanism in tortuous fracture was still uncommon.Therefore,this study designed and applied a series of experiments with a physical analog model of a tortuous fracture with 120°and 90°-angled bends and combined high-speed camera-based equipment.This experimental system was used to track different-mixture-sized proppant particle motion trajectories for a series of proppant injection schemes;The following conclu-sions were drawn from this study:1.The pile-up processes mechanism in all investigated schemes were similar and could be reduced to four main stages.2.The packing structure at both sides of the fracture wall had different variation rates,which were controlled by the mix ratio(change from 1∶1-1∶5)of proppant size.3.Some new packing patterns,such as Zebra Stripe,had occurred,controlled by the different proppant injection sequences.4.Small-sized mono-proppant(30/50 mesh)had the highest transport efficiency in the tortuous fracture,followed by the mixed-sized multi-proppant(10/20 mesh:30/50 mesh),large-sized proppant(10/20 mesh)was the worst.5.An optimized alternating in-jection mode was recommended as injecting small-sized proppant first(30/50 mesh)and followed by mixed-sized multi-proppant(10/20 mesh:30/50 mesh),which could contribute to obtaining the optimal both proppant packing height and travel distance in tortuous fracture.6.Two correlations were devel-oped for predicting the proppant packing height and transportation distance.

关键词： Tortuous fracture model Mixed-sized proppant Multi-sized proppant injection mode Proppant motion and distribution Packing mechanism

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A performance-based hybrid deep learning model for predicting TBM advance rate using Attention-ResNet-LSTM

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 65-80页

作者： Sihao Yu Zixin Zhang Shuaifeng Wang xin huang Qinghua Lei Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghaiChina Key Laboratory of Geotechnical and Underground Engineering Ministry of EducationTongji UniversityShanghaiChina Department of Earth Sciences ETH ZürichZürichSwitzerland Department of Earth Sciences Uppsala UniversityUppsalaSweden

The technology of tunnel boring machine(TBM)has been widely applied for underground construction worldwide;however,how to ensure the TBM tunneling process safe and efficient remains a major concern.Advance rate is a key parameter of TBM operation and reflects the TBM-ground interaction,for which a reliable prediction helps optimize the TBM performance.Here,we develop a hybrid neural network model,called Attention-ResNet-LSTM,for accurate prediction of the TBM advance rate.A database including geological properties and TBM operational parameters from the Yangtze River Natural Gas Pipeline Project is used to train and test this deep learning model.The evolutionary polynomial regression method is adopted to aid the selection of input parameters.The results of numerical exper-iments show that our Attention-ResNet-LSTM model outperforms other commonly-used intelligent models with a lower root mean square error and a lower mean absolute percentage error.Further,parametric analyses are conducted to explore the effects of the sequence length of historical data and the model architecture on the prediction accuracy.A correlation analysis between the input and output parameters is also implemented to provide guidance for adjusting relevant TBM operational parameters.The performance of our hybrid intelligent model is demonstrated in a case study of TBM tunneling through a complex ground with variable strata.Finally,data collected from the Baimang River Tunnel Project in Shenzhen of China are used to further test the generalization of our model.The results indicate that,compared to the conventional ResNet-LSTM model,our model has a better predictive capability for scenarios with unknown datasets due to its self-adaptive characteristic.

关键词： Tunnel boring machine(TBM) Advance rate Deep learning Attention-ResNet-LSTM Evolutionary polynomial regression

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Employee Stock Ownership Plans and Stock-price Informativeness

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China & World Economy 2024年第3期32卷 162-190页

作者： Yuehua Zuo xin huang Xiaojun Liu Yunhao Dai School of Economics Huazhong University of Science and TechnologyChina School of Economics and Modern Economics Research Center Huazhong University of Science and TechnologyChina

This study examines the impact of employee stock ownership plans(ESOPs)on stock-price informativeness in Chinese stock markets.Its findings indicate that firms implementing ESOPs experienced an average 11.89 percent increase in stock-price informativeness.The plans improved stock-price informativeness through increased external attention and supervision.An event study shows that ESOPs gave rise to an announcement effect,driven by anticipated performance improvements and the novelty associated with ESOPs.A mechanism analysis demonstrates that the implementation of ESOPs attracted market attention,and the increased market supervision resulting from this mitigated the moral hazards of management associated with ESOPs.Plans with more positive signals exerted a greater influence.Notably,ESOPs that prioritized management incentives gained more recognition in the market.As the incentive effects of ESOPs were weaker than those of equity incentive plans and the ESOPs lost novelty over time,the annual announcement effect diminished gradually.These findings underscore the necessity of strengthening ESOP incentives for continued optimization of priceefficiency.

关键词： announcement effect corporate governance employee stock ownership plan stock-price informativeness

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Clinical Manifestations and Surgical Outcomes of Primary Rhegmatogenous Retinal Detachment in Patients < 30 Years of Age with High Myopia

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Biomedical and Environmental Sciences 2023年第7期36卷 644-648页

作者： WANG xin ZHANG Ting TANG Wen Yi huang xin Eye Institute and Department of Ophthalmology Eye&ENT HospitalFudan UniversityShanghai 200031China NHC Key Laboratory of Myopia(Fudan University Key Laboratory of Myopia)Chinese Academy of Medical SciencesShanghai 200031China Shanghai Key Laboratory of Visual Impairment and Restoration Shanghai 200031China

Primary rhegmatogenous retinal detachment(RRD)is a major cause of visual impairment.Extensive studies have shown that high myopia is a significant risk factor for RRD[1].A bimodal age distribution of RRD has been reported in Chinese populations,with a major peak in the group of 60–69 years old and a smaller peak in the group of 20–29 years old[2].A study in China has revealed a similar distribution and further indicated that the proportion and number of patients with RRD and high myopia peaked at the age range of 20–29 years[3].Correspondingly,a high prevalence of myopia has been reported in Asians aged 20–29 years[4].Thus,patients<30 years with RRD and high myopia require special attention.However,limited studies have been conducted on RRD in young individuals with high myopia.Therefore,this study aimed to describe the clinical characteristics and surgical outcomes of patients<30 years with RRD and high myopia.Furthermore,we focused on various factors that may correlate with surgical outcomes.

关键词： Primary patients Surgical

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The generation and use of animal models of osteosarcoma in cancer research

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Genes & Diseases 2024年第2期11卷 664-674页

作者： Feifei Pu Haoyu Guo Deyao Shi Fengxia Chen Yizhong Peng xin huang Jianxiang Liu Zhicai Zhang Zengwu Shao Department of Orthopedics Wuhan Hospital of Traditional Chinese and Western Medicine (Wuhan No.1 Hospital)Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Radiation and Medical Oncology Zhongnan HospitalWuhan UniversityWuhanHubei 430071China Hubei Cancer Clinical Study Center Zhongnan HospitalWuhan UniversityWuhanHubei 430071China

Osteosarcoma is the most common malignant bone tumor affecting children and adolescents.Currently,the most common treatment is surgery combined with neoadjuvant chemotherapy.Although the survival rate of patients with osteosarcoma has improved in recent years,it remains poor when the tumor(s)progress and distant metastases develop.Therefore,better animal models that more accurately replicate the natural progression of the disease are needed to develop improved prognostic and diagnostic markers,as well as targeted therapies for both primary and metastatic osteosarcoma.The present review described animal models currently being used in research investigating osteosarcoma,and their characteristics,advantages,and disadvantages.These models may help elucidate the pathogenic mechanism(s)of osteosarcoma and provide evidence to support and develop clinical treatment strategies.

关键词： Animal model Cancer Osteosarcoma Pathogenic mechanism Translational research

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