检索结果-南通市图书馆

Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu Wei huang Jiayi Wen xin Xiong Ting Xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li Weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

在线全文

学校读者我要写书评

暂无评论

PET成像及其在中国发展的建议

中国医疗器械信息 2003年第5期9卷 17-20页

作者：包尚联黄新瑞邹润磊北京大学物理学院重离子研究所

在分析PET成像的优势和弱点的基础上,提出国内发展PET技术、开辟应用渠道的建议。文章指出:基因序列公布之后,研究体内生物分子和DNA、RNA的关系成为生命科学中最重要的研究方向之一,PET是其中最重要的研究工具,今后20年会有巨大的发展;... 详细信息

在分析PET成像的优势和弱点的基础上,提出国内发展PET技术、开辟应用渠道的建议。文章指出:基因序列公布之后,研究体内生物分子和DNA、RNA的关系成为生命科学中最重要的研究方向之一,PET是其中最重要的研究工具,今后20年会有巨大的发展;PET作为目前国民发病和死亡率最高的肿瘤和心脑血管疾病早期诊断的有效工具,在临床上的应用还需要扩大;而PET的最大优势实际上是在药物开发领域,我国在这方面的工作还没有开展。无论是基础研究、医学临床还是药物开发,国内阻碍PET发展的主要原因是没有一支理工医结合的强有力的研发队伍;PET应用方面的最大问题是没有专门分析和计算物理师。

关键词： PET成像中国发展药物开发数据处理

Circulation in the South China Sea is in a state of forced oscillation:Results from a simple reduced gravity model with a closed boundary

在线全文

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2022年第7期41卷 1-12页

作者： rui xin huang Hui Zhou Woods Hole Oceanographic Institution Woods HoleFalmouthMassachusetts02543USA Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao266071China Laboratory for Ocean Dynamics and Climate Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao266237China University of Chinese Academy of Sciences Beijing100049China

The South China Sea(SCS)is a narrow semi-enclosed basin,ranging from 4°–6°N to 21°–22°N *** is forced by a strong annual cycle of monsoon-related wind *** Coriolis parameter f increases at least three times from the southern basin to the northern *** a result,the basin-cross time for the first baroclinic Rossby wave in the southern part of the basin is about 10-times faster than that in the northern part,which plays the most vitally important role in setting the *** the northernmost edge of SCS,the first baroclinic Rossby wave takes slightly less than 1 year to move across the basin,however,it takes only 1–2 months in the southernmost ***,circulation properties for a station in the model ocean are not solely determined by the forcing at that time instance only;instead,they depend on the information over the past *** combination of a strong annual cycle of wind forcing and large difference of basin-cross time for the first baroclinic Rossby wave leads to a strong seasonal cycle of the circulation in the SCS,hence,the circulation is dominated by the forced oscillations,rather than the quasi-steady state discussed in many *** circulation in the SCS is explored in detail by using a simple reduced gravity model forced by seasonally varying zonal wind *** particular,for a given time snap the western boundary current in the SCS cannot play the role of balancing mass transport across each latitude nor balancing mechanical energy and vorticity in the whole *** a departure from the steady wind-driven circulation discussed in many existing textbooks,the circulation in the SCS is characterized by the imbalance of mechanical energy and vorticity for the whole basin at any part of the seasonal *** particular,the western boundary current in the SCS cannot balance the mass,mechanical energy,and vorticity in the seasonal cycle of the ***,the circulation near the western boundary cannot be i

关键词： South China Sea ocean circulation annual cycle first baroclinic Rossby wave propagation western boundary current forced ossilation

安徽铜陵典型矿区周边土壤重金属污染评价及来源解析

在线全文

学校读者我要写书评

暂无评论

环境科学 2024年第9期45卷 5494-5505页

作者：林曼利胡振琪彭位华叶文玲张春雷黄欣瑞陈松桂和荣中国矿业大学环境与测绘学院徐州221116 宿州学院资源与土木工程学院宿州234000 安徽农业大学资源与环境学院合肥230036 安徽省地质实验研究所合肥230001

为探究铜陵典型矿区周边土壤重金属污染水平、生态风险及污染来源,共采集研究区150个土壤样品,分析了As、Cd、Cr、Cu、Hg、Mn、Ni、Pb、Fe和Zn等10种元素含量特征;运用富集因子法、地累积指数法、单因子污染指数法、内梅罗综合污染指数... 详细信息

为探究铜陵典型矿区周边土壤重金属污染水平、生态风险及污染来源,共采集研究区150个土壤样品,分析了As、Cd、Cr、Cu、Hg、Mn、Ni、Pb、Fe和Zn等10种元素含量特征;运用富集因子法、地累积指数法、单因子污染指数法、内梅罗综合污染指数法和潜在生态风险指数法对研究区土壤重金属污染状况进行评价;利用相关性分析、聚类分析和主成分分析探究土壤重金属来源.结果表明,除Cr和Fe外,其余8种重金属含量平均值均高于研究区土壤背景值,其中Pb、Zn、As、Cu和Cd变异程度大,受外界干扰显著;空间分布表明,Cr和Ni均呈由边缘向中心区域递减趋势,而其余8种重金属均呈由中心区域向四周递减趋势;研究区土壤中Cd和Cu的污染程度较为严重;生态风险整体处于中低生态风险水平,且Cd和Hg是主要贡献因子;As、Cd、Cu、Fe、Mn、Pb和Zn主要来自农业、工业和交通综合源,而Cr和Ni主要为自然源,Hg的来源相对较复杂.研究结果可为金属矿区土壤重金属污染防治和治理修复提供科学依据.

关键词：土壤重金属污染评价源解析铜陵矿区

水膜厚度对掺滑石粉自密实混凝土流动性能的影响研究

在线全文

学校读者我要写书评

暂无评论

五邑大学学报（自然科学版） 2020年第4期34卷 70-75页

作者：黄锐新陈嘉健刘炽豪佛山科学技术学院土木工程系广东佛山528000

自密实混凝土高效的自流平能力被广泛应用于各个行业及结构,但对其流动性能的影响机理及规律尚未能定量化,亟待找出一种合适的解释方法.水膜厚度被认为是影响砂浆及水泥浆流动性能的关键影响因素之一,但在混凝土中的研究还比较缺乏,本... 详细信息

自密实混凝土高效的自流平能力被广泛应用于各个行业及结构,但对其流动性能的影响机理及规律尚未能定量化,亟待找出一种合适的解释方法.水膜厚度被认为是影响砂浆及水泥浆流动性能的关键影响因素之一,但在混凝土中的研究还比较缺乏,本文基于水膜厚度理论创新开展相关试验研究.为进一步改善自密实混凝土的流动性能,按照一定梯度单掺滑石粉,通过24个新拌自密实混凝土流动性能试验及填充密度测量试验,观察水膜厚度与混凝土流动性能之间的关系.结果表明,混凝土的流动性能与水膜厚度存在较强的相关性,二者呈正相关;加入滑石粉可以提高自密实混凝土的流动性能,在掺入5%的滑石粉置换水泥时流动性能达到最优.

关键词：自密实混凝土流动性能滑石粉水膜厚度填充密度

Role of nutrition in diabetes mellitus and infections

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第3期13卷 1-8页

作者： Xue-Lu Yu Li-Yun Zhou Xiao huang xin-Yue Li Ming-Ke Wang Ji-Shun Yang Naval Medical Center of PLA Naval Medical UniversityShanghai 200052China

In this editorial,we have commented on the article that has been published in the recent issue of World Journal of Clinical *** authors have described a case of unilateral thyroid cyst and have opined that the acute onset of infection may be linked to diabetes mellitus(DM).We have focused on the role of nutrition in the association between DM and *** with DM are at a high risk of infection,which could also be attributed to nutrition-related *** interventions for patients with diabetes are mainly based on a low-calorie diet,which can be achieved by adhering to a low-carbohydrate ***,dietary fiber supplementation is recommended to maintain the diversity of the gut ***,high-quality protein can prevent the increased risk of infection due to *** of vitamins C,vitamins A,vitamins D,and folic acid improves blood sugar control and facilitates immune *** deficiencies augment the risk of infection,but the relationship with diabetes is mostly U-shaped and a good intake should be maintained.

关键词： Diabetes mellitus Infection Macronutrients Vitamins Minerals

聚乙烯醇辅助治疗中央型肺癌的疗效和安全性评估

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

新医学 2018年第8期49卷 575-578页

作者：梁卫明梁克谢锐黄昕陈建业广东医科大学附属医院介入病区湛江524000

目的研究聚乙烯醇辅助治疗中央型肺癌的疗效和安全性。方法纳入70例中央型肺癌患者作为研究对象,分为观察组和对照组,每组各35例。观察组行经微导管灌注化学治疗再进行聚乙烯醇栓塞治疗,对照组行常规支气管动脉内灌注化学治疗。比较2组... 详细信息

目的研究聚乙烯醇辅助治疗中央型肺癌的疗效和安全性。方法纳入70例中央型肺癌患者作为研究对象,分为观察组和对照组,每组各35例。观察组行经微导管灌注化学治疗再进行聚乙烯醇栓塞治疗,对照组行常规支气管动脉内灌注化学治疗。比较2组近期疗效和安全性,随访记录2组患者远期预后。结果 2组患者介入治疗均获得成功,观察组治疗后近期总体疗效优于对照组(P0.05)。治疗结束后5年,观察组的生存率为23%(8/35),生存时间(22.8±7.7)月,无进展生存率11%(4/35),无进展生存时间(18.3±5.7)月;对照组的生存率为17%(6/35),生存时间(19.0±8.1)月,无进展生存率9%(3/35),无进展生存时间(15.3±6.2)月。2组总生存率和无进展生存率比较差异均无统计学意义(P均>0.05)。结论聚乙烯醇经微导管栓塞治疗中央型肺癌近期疗效好,安全性高,但其对改善患者远期生存率的效果有限。

关键词：聚乙烯醇微导管栓塞中央型肺癌

Facile synthesis of high-brightness green-emitting carbon dots with narrow bandwidth towards backlight display

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第5期35卷 277-282页

作者： rui Cheng Tingting Zhang xin huang Jian Yu State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 210009China

High-performance carbon dots(CDs)allowing the application in high-end display devices are highly desirable and usually limited by the absence of simple and easy synthesis *** this work,we exploited an easy-to-implement strategy for the one-step synthesis of green-emitting CDs(G-CDs)with superb optical *** G-CDs were synthesized using m-phenylenediamine(m-PD)as a single precursor,and the reaction reacted at 180℃for 12 h The resultant G-CDs exhibit high-purity and excitationindependent green fluorescence with the photoluminescence(PL)peak located at 516 nm,full width at half maximum(FWHM)of 46 nm,and PL quantum yield(QY)of∼80%under the 470nm excitation *** G-CDs and corresponding composite film prepared with polyvinyl butyral(G-CDs@PVB)exhibit good PL stability after undergoing long-time storage for one year and 360 h exposure under 460nm blue *** G-CDs@PVB film was used as color-conversion materials in green-emitting light-emitting diode(LED)application,exhibiting a Commission internationale de l’Eclairage(CIE)chromaticity coordinate of(0.21,0.44).The film was also used in CD-based liquid crystal display(CD-LCD)application,achieving a color gamut value of 85%.This work will offer a working basis for the synthesis of high-performance CDs as well as their application in displays.

关键词： Carbon dots One-step synthesis Narrow bandwidth High quantum yield Display

Urban expansion patterns of 291 Chinese cities, 1990–2015

在线全文

学校读者我要写书评

暂无评论

International Journal of Digital Earth 2019年第1期12卷 62-77页

作者： xin huang Jiahao Xia rui Xiao Tao He School of Remote Sensing and Information Engineering Wuhan UniversityWuhanPeople’s Republic of China State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhanPeople’s Republic of China

China has experienced rapid and massive urban expansion in recent *** address the opportunities and challenges posed by urbanization,it is important to investigate this *** many studies have characterized China’s urbanization,mainly based on individual cities or urban agglomerations,few studies have compared the urban expansion patterns among cities of different regions and sizes at a national ***,the source of the newly developed urban land has largely been ignored in previous *** fill these gaps,we provide a comprehensive view of the growth patterns of 291 Chinese cities during 1990–2015,quantifying the rates,spatial forms,and corresponding landscape characteristics of the urban *** importantly,we further investigate what their new urban land is converted *** findings include:(1)the annual expansion(AE)and annual growth rate(AGR)of all 291 cities were 1869.81 km2 and 4.81%during 1990–2015;(2)cropland and rural settlements were the predominant source,accounting for 65.22%and 17.49%of the new urban land during 1990–2015;(3)edge-expansion was the dominant growth form for most cities,followed by infilling and leapfrogging growth;and(4)the landscape characteristics of the occupied cropland differed across various cities.

关键词： Urban expansion spatiotemporal pattern China land use/cover dataset(CLUD) economicgeographical zoning