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Higher palaeoelevation in the Baoshan Basin:Implications for landscape evolution at the southeastern margin of the Tibetan Plateau

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Journal of Palaeogeography 2024年第3期13卷 563-580页

作者： Yong-Jiang huang Hao-Ran Zong Shi-Tao Zhang Arata Momohara jin-jin Hu Lin-Bo Jia Yun-Heng Ji Zhe-Kun Zhou Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201Yunnan ProvinceChina College of Forestry Shandong Agricultural UniversityTai'an 271018Shandong ProvinceChina Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunming 650093Yunnan ProvinceChina Graduate School of Horticulture Chiba UniversityChiba 271-8510Japan Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303Yunnan ProvinceChina

Surface uplift at the southeastern margin of the Tibetan Plateau has been widely studied,but more palaeoaltimetry data are required to better understand the elevation history of this geologically complex *** this study,fossil leaves of Abies(Pinaceae),a cool-temperate element,recovered from the latest Miocene-Pliocene Yangyi Formation of the southern Baoshan Basin,were used as a proxy to estimate the local *** on the regional modern altitude range(2100-4280 m)of the genus as well as regional temperature discrepancy(1.5℃)between the past and present,the palaeoelevation of the study area was calculated to be>2360 m above sea level as compared to 1670 m at *** result suggests that the southern Baoshan Basin experienced pronounced uplift prior to the time of fossil deposition,probably as a result of crustal shortening and thickening of the northern Baoshan Terrane during the *** infer that surface growth in areas south of the Dali Basin may have been greater than previously interpreted,and that a widespread plateau or plateau patches higher than 2000 m probably extended southwards into at least the Baoshan Basin by the latest *** also infer that the elevation of the southern Baoshan Basin has decreased by at least 690 m since then,in contrast to most other scenarios in which the elevation of the southeastern margin of the Tibetan Plateau has increased or remained close to modern levels since the late *** major cause of the inferred altitude decline is likely tectonic *** a transtensional graben basin,the Baoshan Basin has experienced pull-apart and base-fall movement since the late Miocene,which would reduce the altitude of its southern part located on the hanging *** erosion associated with the increased summer rainfall might also have played a role especially in reducing the local relief,although its contribution can be *** study provides one of the few palaeoelevation

关键词： Abies Lapse rate Palaeoaltimetry Surface uplift Tectonic movement Tibetan plateau

Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3467-3482页

作者： Zhan-Li Chen Chen Xie Wei Zeng Rui-Qi huang jin-E Yang jin-Yu Liu Ya-jing Chen Shi-Mei Zhuang MOE Key Laboratory of Gene Function and Regulation Guangdong Province Key Laboratory of Pharmaceutical Functional GenesSchool of Life SciencesState Key Laboratory of Oncology in Southern ChinaSun Yat-sen UniversityGuangzhouPR China Key Laboratory of Liver Disease of Guangdong Province The Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630PR China

Mitotic catastrophe(MC),which occurs under dysregulated mitosis,represents a fascinating tactic to specifically eradicate tumor *** pyroptosis can be a death form of MC remains ***-mediated protein degradation is crucial for ***(BTZ),which inhibits the 20S catalytic particle of proteasome,is approved to treat multiple myeloma and mantle cell lymphoma,but not solid tumors due to primary *** date,whether and how proteasome inhibitor affected the fates of cells in M-phase remains ***,we show that BTZ treatment,or silencing of PSMC5,a subunit of 19S regulatory particle of proteasome,causes G2-and M-phase arrest,multi-polar spindle formation,and consequent caspase-3/GSDME-mediated pyroptosis in M-phase(designated as mitotic pyroptosis).Further investigations reveal that inhibitor of WEE1/PKMYT1(PD0166285),but not inhibitor of ATR,CHK1 or CHK2,abrogates the BTZ-induced G2-phase arrest,thus exacerbates the BTZ-induced mitotic arrest and *** BTZ and PD0166285 treatment(named BP-Combo)selectively kills various types of solid tumor cells,and significantly lessens the IC50 of both BTZ and PD0166285 compared to BTZ or PD0166285 *** using various mouse models show that BP-Combo has much stronger inhibition on tumor growth and metastasis than BTZ or PD0166285 monotreatment,and no obvious toxicity is observed in BP-Combo-treated *** findings disclose the effect of proteasome inhibitors in inducing pyroptosis in M-phase,characterize pyroptosis as a new death form of mitotic catastrophe,and identify dual inhibition of proteasome and WEE family kinases as a promising anti-cancer strategy to selectively kill solid tumor cells.

关键词： proteasome inhibiting catastrophe

Non-invasive Healthcare Analytical Platform Based on Organic Electrochemical Transistors

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Chemical Research in Chinese Universities 2024年第5期40卷 824-848页

作者： HU Xingyu MAO Ning YAN Xinwen huang ling LIU Xu YANG Huige SUN Qingqing LIU Xuying JIA Hanyu School of Materials&Engineering Zhengzhou UniversityZhengzhou450001P.R.China Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education&Hubei Key Laboratory of Catalysis and Materials Science Hubei R&D Center of Hyperbranched Polymers Synthesis and ApplicationsSouth-Central University for NationalitiesWuhan430074P.R.China Science&Technology Innovation Center for Advanced Materials of Intelligent Equipment Longmen LaboratoryLuoyang471000P.R.China

Non-invasive bioelectronics,especially organic electrochemical transistors(OECTs),have drawn extensive attentions of academical and medical communities by virtue of their efficient bio-electronic interfacing,water-involved ionic transport,excellent ionic-electronic coupling,ultralow power consumption,wide detectable range,and outstanding detection *** structure diversity,low-temperature solution processability,facile bio/chemical functionalization,and excellent biocompatibility of organic mixed ionic-electronic conductors(OMIECs)render OECTs particularly suitable for non-invasive or minimally invasive healthcare analytical ***,we comprehensively review recent advances of the non-invasive analytical healthcare applications based on OECTs,especially on the detection of biomarkers or metabolites in the excretory biofluids,as well as the recording of electrophysiological signals.A brief introduction of OECT and its comparison with other organic thin-film transistors upon device configuration and working mechanism are firstly ***-of-the-art non-invasive OECT-based biosensors are summarized on their detection of ionic and molecular biomarkers,following with circuit design strategies of OECTs for real-time and in-situ electrophysiological recording from skin *** conclusion,remaining barriers and future challenges of non-invasive OECT-based bioelectronics towards lower detection limit,more accurate quantitative relationship between analyte concentrations and measured parameters,more intimate device-tissue interface,and long-term operation stability are deeply analyzed with a critical outlook.

关键词： Organic electrochemical transistor Non-invasive Bioelectronics Ion-selective Electrophysiological monitoring

Nano-frictional mechano-reinforcing porous nanowires scaffolds

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Friction 2024年第5期12卷 968-980页

作者： Licheng HUA Conghu HU jingkang ZHANG jin LI Chenjie GU Bin huang Guangyong LI Jianke DU Wanlin GUO Smart Materials and Advanced Structures Laboratory School of Mechanical Engineering&MechanicsNingbo UniversityNingbo315211China Key Laboratory for Intelligent Nano Materials and Devices of Ministry of Education Nanjing University of Aeronautics and AstronauticsNanjing210016China Key Laboratory of Impact and Safety Engineering Ministry of EducationSchool of mechanical Engineering and MechanicsNingbo UniversityNingbo315211China Department of Microelectronics and Engineering Ningbo UniversityNingbo315211China

Artificial biomaterials with dynamic mechano-responsive behaviors similar to those of biological tissues have been drawing great *** this study,we report a TiO_(2)-based nanowire(TiO_(2)NWs)scaffolds,which exhibit dynamic mechano-responsive behaviors varying with the number and amplitude of nano-deformation *** is found that the elastic and adhesive forces in the TiO_(2)NWs scaffolds can increase significantly after multiple cycles of *** nanofriction experiments show the triboelectric effect of increasing elastic and adhesive forces during the nano-deformation cycles of TiO_(2)NWs *** properties allow the TiO_(2)NW scaffolds to be designed and applied as intelligent artificial biomaterials to simulate biological tissues in the future.

关键词： TiO_(2)NWs scaffolds nano-deformation mechano-reinforcing triboelectric effect intelligent artificial biomaterials

Predict the evolution of mechanical property of Al-Li alloys in a marine environment

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Defence Technology（防务技术） 2024年第1期31卷 557-566页

作者： Wei Li Lin Xiang Guang Wu Hongli Si jinyan Chen Yiming jin Yan Su Jianquan Tao Chunyang huang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100036China Chongqing Innovation Center Beijing Institute of TechnologyChongqing400044China First Research Institute of the Ministry of Public Security for PR China Beijing100036China Southwest Technology and Engineering Research Institute Chongqing400039China

The ocean is one of the essential fields of national defense in the future,and more and more attention is paid to the lightweight research of Marine equipment and *** study it is to develop a Machine learning(ML)-based prediction method to study the evolution of the mechanical properties of Al-Li alloys in the marine *** obtained the mechanical properties of Al-Li alloy samples under uniaxial tensile deformation at different exposure times through Marine exposure *** obtained the strain evolution by digital image correlation(DIC).The strain field images are voxelized using 2D-Convolutional Neural Networks(CNN)autoencoders as input data for Long Short-Term Memory(LSTM)neural ***,the output data of LSTM neural networks combined with corrosion features were input into the Back Propagation(BP)neural network to predict the mechanical properties of Al-Li *** main conclusions are as follows:*** variation law of mechanical properties of2297-T8 in the Marine atmosphere is *** the increase in outdoor exposure test time,the tensile elastic model of 2297-T8 changes slowly,within 10%,and the tensile yield stress changes significantly,with a maximum attenuation of 23.6%.*** prediction model can predict the strain evolution and mechanical response simultaneously with an error of less than 5%.*** study shows that a CNN/LSTM system based on machine learning can be built to capture the corrosion characteristics of Marine exposure *** results show that the relationship between corrosion characteristics and mechanical response can be predicted without considering the microstructure evolution of metal materials.

关键词： Marine environment Al-Li alloy Machine learning Corrosion

Frequency-tunable single-photon router based on a microresonator containing a driven three-level emitter

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Chinese Physics B 2024年第6期33卷 377-381页

作者：黄劲松胡菁兰李艳玲徐中辉 School of Information Engineering Jiangxi University of Science and TechnologyGanzhou 341000China Faculty of Science Jiangxi University of Science and TechnologyGanzhou 341000China

We propose a frequency-tunable router of single photons with high routing efficiency, which is constructed by two waveguides mediately linked by a single-mode whispering gallery resonator with a driven three-level emitter. Quantum routing probability in the output port is obtained via the real-space Hamiltonian. By adjusting the resonator–emitter coupling and the drive, the desired continuous central frequencies for the resonance peaks of routing photons can be manipulated nearly linearly, with the assistance of Rabi splitting effect and optical Stark shift. The proposed routing system may provide potential applications in designing other frequency-modulation quantum optical devices, such as multiplexers,filters, and so on.

关键词： quantum routing scattering theory optical waveguide microresonator

Flexible and multifunctional triboelectric nanogenerator based on liquid metal/polyvinyl alcohol hydrogel for energy harvesting and self-powered wearable human-machine interaction

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Rare Metals 2024年第3期43卷 1186-1196页

作者： Hou-Wang Zhou Cong Zhao Ze-Yu Zhao Jun-Chen Jiang Hui-Le jin Shun Wang Shuang Pan Min-Yi Xu Yi-huang Chen Hai-Ming jin Department of Orthopaedics The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou325027China College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou325035China Dalian Key Laboratory of Marine Micro/Nano Energy and Self-Powered Systems Marine Engineering CollegeDalian Maritime UniversityDalian116026China

Hydrogel-based triboelectric nanoge nerator(TENG)has a promising applied prospect in wearable electronic ***,its low performance,poor stability,insufficient recyclability and inferior self-healing seriously hinder its ***,we report a robust route to a liquid metal(LM)/polyvinyl alcohol(PVA)hydrogel-based TENG(LP-TENG).Owing to the intrinsically liquid feature of conductive LM within the flexible PVA hydrogel,the as-prepared LP-TENG exhibited comprehensiye advantages of adaptability,biocompatibility,outstanding electrical performance,superior stability,recyclability and diverse applications,which were unattainable by traditional ***,the LP-TENG delivered appealing open circuit voltage of 250 V,short circuit current of 4μA and transferred charge of 120 nC with high stability,outperforming most advanced TENG *** LP-TENG was successfully employed for versatile applications with multifunctionality,including human motion detection,handwriting recognition,energy collection,message transmission and human-machine *** work presents significant prospects for crafting advanced materials and devices in the fields of wearable electronics,flexible skin and smart robots.

关键词： Liquid metal Hydrogel Wearable TENG Multifunctionality Human-machine interaction

Hexafluoropropylene oxide trimer acid,a perfluorooctanoic acid alternative,induces cardiovascular toxicity in zebrafish embryos

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Journal of Environmental Sciences 2024年第5期139卷 460-472页

作者： Sujie Sun Li Zhang Xue Li Lu Zang ling huang Junquan Zeng Zigang Cao Xinjun Liao Zilin Zhong Huiqiang Lu Jianjun Chen Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases Jiangxi Key Laboratory of Developmental Biology of OrgansCenter for Clinical Research Center of the Affiliated Hospital of Jinggangshan UniversityJi’an 343009China Translational Research Institute of Brain and Brain-like Intelligence Shanghai Key Laboratory of Anesthesiology and Brain Functional ModulationDepartment of PediatricsShanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants School of Environmental Sciences and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Interventional and Vascular Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343009China Department of Internal Medicine and Hematology Affiliated Hospital of Jinggangshan UniversityJi’an 343009China

As an increasingly used alternative to perfluorooctanoic acid(PFOA),hexafluoropropylene oxide trimer acid(HFPO-TA)has been widely detected in global water ***,little is known regarding its toxic effects on cardiovascular ***,zebrafish embryos were treated with egg water containing 0,60,120,or 240 mg/L *** showed that HFPO-TA treatment led to a significant reduction in both larval survival percentage and heart ***,HFPO-TA exposure caused severe pericardial edema and elongation of the sinus venous to bulbus arteriosus distance(SV-BA)in Tg(myl7:GFP)transgenic larvae,disrupting the expression of genes involved in heart development and thus causing abnormal heart *** sprouting angiogenesis was observed in the 120 and 240 mg/L exposed Tg(fli:GFP)transgenic ***-TA treatment also impacted the mRNA levels of genes involved in the vascular endothelial growth factor(VEGF)pathway and embryonic vascular ***-TA exposure significantly decreased erythrocyte number in Tg(gata1:DsRed)transgenic embryos and influenced gene expression associated with the heme metabolism ***-TA also induced oxidative stress and altered the transcriptional levels of genes related to cell cycle and apoptosis,inhibiting cell proliferation while promoting ***,HFPO-TA exposure may induce abnormal development of the cardiovascular and hematopoietic systems in zebrafish embryos,suggesting it may not be a suitable or safe alternative for PFOA.

关键词： Hexafluoropropylene oxide trimer acid Heart development Vascular development Hemopoiesis Zebrafish embryos

Biomechanical analysis of an absorbable material for treating fractures of the inferior orbital wall

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1331-1336页

作者： jin-Hai Yu Ze-Xi Sang huang Zhang Qi-Hua Xu Qin huang Hong-Fei Liao Yao-Hua Wang School of Optometry Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Jiangxi Research Institute of Ophthalmology and Visual Science Nanchang 330006Jiangxi ProvinceChina Jiangxi Provincial Key Laboratory for Ophthalmology Nanchang 330006Jiangxi ProvinceChina National Clinical Research Center for Ocular Diseases Jiangxi Province Division Nanchang 330006Jiangxi ProvinceChina The Affiliated Eye Hospital Jiangxi Medical CollegeNanchang 330006Jiangxi ProvinceChina Jiangxi Clinical Research Center for Ophthalmic Disease Nanchang 330006Jiangxi ProvinceChina

AIM:To investigate the biomechanical properties and practical application of absorbable materials in orbital fracture ***:The three-dimensional(3D)model of orbital blowout fractures was reconstructed using Mimics21.0 *** repair guide plate model for inferior orbital wall fracture was designed using 3-matic13.0 and Geomagic wrap 21.0 *** finite element model of orbital blowout fracture and absorbable repair plate was established using 3-matic13.0 and ANSYS Workbench 21.0 *** mechanical response of absorbable plates,with thicknesses of 0.6 and 1.2 mm,was modeled after their placement in the *** patients with inferior orbital wall fractures volunteered to receive single-layer and double-layer absorbable plates combined with 3D printing technology to facilitate surgical treatment of orbital wall ***:The finite element models of orbital blowout fracture and absorbable plate were successfully *** element analysis(FEA)showed that when the Young’s modulus of the absorbable plate decreases to 3.15 MPa,the repair material with a thickness of 0.6 mm was influenced by the gravitational forces of the orbital contents,resulting in a maximum total deformation of approximately 3.3 ***,when the absorbable plate was 1.2 mm thick,the overall maximum total deformation was around 0.4 *** half-year follow-up results of the clinical cases confirmed that the absorbable plate with a thickness of 1.2 mm had smaller maximum total deformation and better clinical ***:The biomechanical analysis observations in this study are largely consistent with the clinical *** use of double-layer absorbable plates in conjunction with 3D printing technology is recommended to support surgical treatment of infraorbital wall blowout fractures.

关键词： orbital blowout fracture absorbable material finite element analysis 3D printing technology