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The clinical features and potential mechanisms of cognitive disorders in peripheral autoimmune and inflammatory diseases

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Fundamental Research 2024年第2期4卷 226-236页

作者： Ke-qi Fan Tao huang Jian-shuai Yu Yi-yuan Li jin jin MOE Laboratory of Biosystem Homeostasis and Protection and Life Sciences InstituteZhejiang UniversityHangzhou 310058China Department of Gastroenterology Sir Run Shaw HospitalCollege of Medicine Zhejiang UniversityHangzhou 310016China Key Laboratory for Developmental Genes and Human Disease Ministry of EducationInstitute of Life SciencesJiangsu Province High-Tech Key Laboratory for Bio-Medical ResearchSoutheast UniversityNanjing 210096China

According to a study from World Health Organization’s Global Burden of Disease,mental and neurological disorders have accounted for 13%of global diseases in recent years and are on the *** conditions or neuroinflammatory disorders are linked by the presence of an exaggerated immune response both peripherally and in the central nervous system(CNS).Cognitive dysfunction(CD)encompasses a complex group of diseases and has frequently been described in the field of autoimmune diseases,especially in multiple non-CNS-related autoimmune *** studies have provided various hypotheses regarding the occurrence of cognitive impairment in autoimmune diseases,including that abnormally activated immune cells can disrupt the integrity of the blood-brain barrier(BBB)to trigger a central neuroinflammatory *** the BBB is intact,autoantibodies and pro-inflammatory molecules in peripheral circulation can enter the brain to activate microglia,inducing CNS inflammation and ***,the mechanisms explaining the association between the immune system and neural function and their contribution to diseases are *** this review,we used clinical statistics to illustrate the correlation between CD and autoimmune diseases that do not directly affect the CNS,summarized the clinical features and mechanisms by which autoimmune diseases trigger cognitive impairment,and explored existing knowledge regarding the link between CD and autoimmune diseases from the perspective of the field of neuroimmunology.

关键词： Autoimmune diseases Neuroinflammation Central nervous system dysfunction Autoantibodies Inflammatory cytokines

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东西部地区之间公益林生态补偿负担与分摊

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生态经济 2007年第3期23卷 53-55页

作者：王翊黄金玲广东商学院广州510320 广州大学广州510006

由于东部和西部地区之间自然和社会经济条件的差别,在公益林生态补偿问题上将会存在严重的地区之间生态建设责任与利益不平衡,因此需要建立地区之间的财政支付方式来平衡这种不公平状况,以利于公益林生态补偿制度的建立和完善。

关键词：公益林生态补偿转移支付财政支付方式

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Scalable graphene foam with ultrahigh conductivity for stabilizing Pt towards efficient hydrogen evolution

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Nano Research 2024年第8期17卷 6968-6976页

作者： Ming Zhao Meng huang Huihui jin Dayin He Wei Qian Zixin Zhang Daping He State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Hubei Engineering Research Center of RF-Microwave Technology and Application Wuhan University of TechnologyWuhan 430070China School of Information Engineering Wuhan University of TechnologyWuhan 430070China School of Chemistry and Materials Science University of Science and Technology of ChinaHefei 230026China Sanya Science and Education Innovation Park of Wuhan University of Technology Sanya 572000China

For the carbon-based catalyst to be active and stable,especially in harsh electrochemical environments,the key is to decrease the concentration of defects and raise the degree of graphitization of the carbon ***,we develop a highly graphitized graphene foam with multiplicated structure to fabricate self-supporting Pt-based catalysts for efficient and stable hydrogen evolution reaction(HER)*** foam(GO-2850)is obtained through an ultra-high temperature treatment at 2850℃,with perfect graphene structure and extremely low defect,ensuring high electrical conductivity and corrosion ***,its multiplicated structure provides an inherently favorable environment for the dispersion of Pt nanoparticles(Pt NPs)and offers abundant channels for electrolyte infiltration during the catalytic *** a result,the as-prepared Pt/GO-2850 is far active and stable than the Pt NPs supported on commercial carbon paper(Pt/CP)counterpart toward catalyzing HER,exhibiting an outstanding activity and long-term durability(300 h@10 mA·cm^(−2))in acidic/alkaline/seawater *** can be attributed to the stronger interaction between the lower-defect GO-2850 substrate and Pt,as evidenced by characterization and theoretical *** work extends further insight into the design self-supporting catalysts of high activity and stability with promising prominent application toward green energy devices.

关键词： graphene foam high graphitization Pt nanoparticles hydrogen evolution reaction long-term stability

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Renewable conversion of coal gangue to 13-X molecular sieve for Cd^(2+)-containing wastewater adsorption performance

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Rare Metals 2024年第2期43卷 702-710页

作者： Le Kang Si-Fan Liu Da-Wei Yi Kai Wang Hui-ling Du Hao-Qi huang Peng Chen College of Materials Science and Engineering Xi’an University of Science and TechnologyXi’an710054China School of Electrical Engineering Weihai Innovation Research InstituteQingdao UniversityQingdao266000China School of Metallurgy Northeastern UniversityShenyang110819China School of Materials and Chemical Engineering Tongren UniversityTongren554300China

Using coal gangue(CG)as raw material,a new type of all solid-waste-based 13-X molecular sieve material was controllably prepared by alkali fusion-hydrothermal *** synthetic molecular sieve was used as a solid adsorbent to treat Cd^(2+)-containing wastewater,and its adsorption behavior on Cd^(2+)in aqueous solution was studied and *** microstructure and morphology of the molecular sieve were investigated by X-ray diffraction(XRD),field emission scanning electron microscopy(FESEM)and specific surface area *** results show that the synthesized 13-X molecular sieve has higher Brunauer–Emmett–Teller(BET)specific surface area with higher crystallinity and higher adsorption capacity for the heavy metal Cd^(2+).The adsorption process of Cd^(2+)by molecular sieve conforms to the Langmuir isotherm adsorption equation and Lagergren pseudo-second-order rate *** with thermodynamic calculation,it can be concluded that the adsorption process is physically monolayer,spontaneous and *** this study,a low-cost and naturally available synthesis method of 13-X molecular sieve is *** with its adsorption mechanism for Cd^(2+),it provides a feasible and general method for removing heavy metal ions from coal gangue and also provides a new way for the utilization of coal gangue with high added value.

关键词： Coal gangue Hydrothermal synthesis 13-X molecular sieve Adsorption Wastewater containing Cd^(2+)

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磷酸酯酶D在肿瘤发生发展中的作用研究进展

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中国药理学与毒理学杂志 2023年第4期37卷 289-294页

作者：洪星辉黄金玲安徽中医药大学中西医结合学院安徽合肥230038

磷酸酯酶D(PLD)作为一种调控机体磷脂代谢的水解酶,其水解产物磷脂酸和二酰基甘油均为细胞内重要的第二信使,参与多种细胞生理功能。PLD在胃癌、结直肠癌、食管癌、肺癌、甲状腺癌和乳腺癌等多种恶性肿瘤中均高表达,通过肿瘤相关信号通... 详细信息

磷酸酯酶D(PLD)作为一种调控机体磷脂代谢的水解酶,其水解产物磷脂酸和二酰基甘油均为细胞内重要的第二信使,参与多种细胞生理功能。PLD在胃癌、结直肠癌、食管癌、肺癌、甲状腺癌和乳腺癌等多种恶性肿瘤中均高表达,通过肿瘤相关信号通路促进细胞癌变和增殖、促进肿瘤细胞浸润和迁移、加速上皮间充质转化和微血管生成及增强免疫逃逸等进程,而靶向诱导PLD蛋白功能缺失可逆转上述进程。PLD在肿瘤发生发展中的作用机制以及PLD抑制剂的研究目前已成为国内外的研究热点。本文从原位肿瘤发生发展、肿瘤侵袭过程、血管生成和肿瘤细胞微环境等方面综述PLD对肿瘤进展的作用,为靶向PLD治疗肿瘤提供临床依据。

关键词：磷酸酯酶D 肿瘤增殖侵袭转移信号通路

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The optimal atropine concentration for myopia control in Chinese children: a systematic review and network Metaanalysis

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1128-1137页

作者： Xiao-Yan Wang Hong-Wei Deng Jian Yang Xue-Mei Zhu Feng-ling Xiang jing Tu Ming-Xue huang Yun Wang jin-Hua Gan Wei-Hua Yang School of Nursing Southwest Medical UniversityLuzhou 646600Sichuan ProvinceChina Shenzhen Eye Institute Shenzhen Eye HospitalJinan UniversityShenzhen 518040Guangdong ProvinceChina Luzhou Traditional Chinese Medicine Hospital Luzhou 646000Sichuan ProvinceChina The Affiliated Hospital of Southwest Medical University Luzhou 646099Sichuan ProvinceChina

AIM:To figure out whether various atropine dosages may slow the progression of myopia in Chinese kids and teenagers and to determine the optimal atropine concentration for effectively slowing the progression of ***:A systematic search was conducted across the Cochrane Library,PubMed,Web of Science,EMBASE,CNKI,CBM,VIP,and Wanfang database,encompassing literature on slowing progression of myopia with varying atropine concentrations from database inception to January 17,*** extraction and quality assessment were performed,and a network Meta-analysis was executed using Stata version 14.0 *** were visually represented through ***:Fourteen papers comprising 2475 cases were included;five different concentrations of atropine solution were *** network Meta-analysis,along with the surface under the cumulative ranking curve(SUCRA),showed that 1%atropine(100%)>0.05%atropine(74.9%)>0.025%atropine(51.6%)>0.02%atropine(47.9%)>0.01%atropine(25.6%)>control in refraction change and 1%atropine(98.7%)>0.05%atropine(70.4%)>0.02%atropine(61.4%)>0.025%atropine(42%)>0.01%atropine(27.4%)>control in axial length(AL)***:In Chinese children and teenagers,the five various concentrations of atropine can reduce the progression of *** the network Meta-analysis showed that 1%atropine is the best one for controlling refraction and AL change,there is a high incidence of adverse effects with the use of 1%***,we suggest that 0.05%atropine is optimal for Chinese children to slow myopia progression.

关键词： atropine China children and adolescents myopia network Meta-analysis

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Cell Wall Fixation,Translocation,and Vacuolar Detoxification of Cadmium Contribute to Differential Grain Cadmium Accumulation in Two Rice Cultivars

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Rice science 2024年第3期31卷 241-244,I0008-I0010页

作者： ZHU Xiaofang ZHAO ling huang jing HE Jiatong SONG Jiayin TENG Ying SHEN Renfang State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of ScienceNanjing 210008China State Key Laboratory of Subtropical Silviculture Zhejiang A&F UniversityHangzhou 311300China

Cadmium(Cd)toxicity in rice is a major concern for human health and the environment,as it can accumulate in rice grains when grown in Cd-contaminated *** mitigate the risk of Cd toxicity,it is crucial to cultivate rice varieties with low grain Cd *** the summers of 2021 and 2022,we conducted Cd analysis on two rice cultivars,Tianyouhuazhan(TYHZ)and Xiushui 14,grown in fields with varying Cd pollution *** cultivars were also subjected to hydroponic treatment with or without 1μmol/L Cd for 7 d to assess Cd accumulation,nitric oxide(NO)production。

关键词： cultivar soils pollution

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Effect of cardiac rehabilitation care after coronary intervention on cardiac function recovery and negative mood in patients with myocardial infarction

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World Journal of Clinical Cases 2024年第1期12卷 59-67页

作者： Ming Yang Yuan-Tao huang Xi-Wen Hu Chun-ling Wu Division of Cardiovascular First Ward Departments of Internal MedicineLiyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430077Hubei ProvinceChina Division of Cardiovascular First Ward Departments of Internal MedicineJianli People's HospitalJianli 433300Hubei ProvinceChina Department of Integrated Traditional Chinese and Western Medicine People's Hospital of Dongxihu DistrictWuhan 430040Hubei ProvinceChina

BACKGROUND Cardiovascular disease,particularly myocardial infarction(MI)profound impact on patients'quality of life and places a substantial burden on the healthcare and economy *** in medical technology have led to the emer-gence of coronary intervention as an essential method for treating *** To assess the effects of cardiac rehabilitation care on cardiac function recovery and negative emotions in MI after coronary *** This study included a total of 180 patients with MI during the period from June 2022 to July *** patients were divided into two groups:An observation group,which receiving cardiac rehabilitation care;a control group,which re-ceiving conventional *** comparing multiple observation indicators such as cardiac function indicators,blood pressure,exercise tolerance,occurrence of adverse cardiac events,and negative emotion scores between the two groups of *** the data were analyzed and compared between two *** There were 44 males and 46 females in the observation group with an average age of 36.26±9.88 yr;there were 43 males and 47 females in the control group,with an average age of 40.87±10.5 *** receiving the appropriate postoperative nursing measures,the results of the observation group showed significant improvement in several indicators compared with the control *** of cardiac function,such as left ventricular end-diastolic internal diameter and left ventricular ejection fraction were significantly better in the observation group than in the control group(P<0.05).Exercise endurance assessment showed that the 6-minute walking test distance was significantly increased in the patients of the observation group(P<0.01).In addition,the incidence of adverse cardiac events was significantly lower in the observation group,and negative mood scores were significantly reduced(P<0.05).CONCLUSION Cardiac rehabilitation care after coronary intervention has a significant positive

关键词： Myocardial infarction Coronary artery intervention Cardiac rehabilitation Cardiac function recovery Negative emotions

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Unlocking the secrets of TGR5: a new dawn in treating diabetic cardiomyopathy

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Biophysics Reports 2024年第4期10卷 254-256页

作者： jin Li He huang Institute of Metabolism and Integrative Biology State Key Laboratory of Genetic Engineering School of Life Sciences and Zhongshan Hospital Fudan University

Diabetic cardiomyopathy, marked by dysregulation of lipid metabolism leading to cardiac remodeling and dysfunction, highlights the critical need for balancing fatty acid transport(Karwi et al. 2022; van de Weijer et al. 2011). CD36 stands as the predominant fatty acid transporter within cardiomyocytes, and its function is intricately tied to its expression and localization(Glatz and Luiken 2018; Shu et al. 2022). Despite recent progress in elucidating the mechanisms behind CD36's hyperactivity, strategies to manage its localization are still emerging.

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Boosting solar hydrogen production via electrostatic interaction mediated ***-TiO_(2−x)biohybrid system

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Nano Research 2024年第6期17卷 5390-5398页

作者： Xingxing Lv Weicheng huang Ya Gao Rui Chen Xiaowei Chen Danqing Liu ling Weng Liangcan He Shaoqin Liu School of Material Science and Chemical Engineering Harbin University of Science and TechnologyHarbin 150040China School of Medicine and Health and Key Laboratory of Micro-systems and Micro-structures Manufacturing of Ministry of EducationHarbin Institute of TechnologyHarbin 150001China Department of Physics School of ScienceJimei UniversityXiamen 361021China Zhengzhou Research Institute Harbin Institute of TechnologyZhengzhou 450046China

Hydrogen is garnering growing attention as a green energy source with zero carbon ***,most hydrogen production technologies still rely on the consumption of fossil fuels and are therefore *** has driven the search for more environmentally friendly methods of hydrogen *** this work,we present an innovative approach to enhance hydrogen generation via electrostatic interaction in the Escherichia coli and defective titanium dioxide(TiO_(2−x))*** method involves narrowing the forbidden bandwidth of TiO2 while introducing defect bands into its conduction band to facilitate visible light absorption and efficient charge *** biohybrid system,consisting of *** and TiO_(2−x),demonstrates a remarkable capability to produce 1.25 mmol of hydrogen within a 3-h timeframe under visible light *** accomplishment signifies a 3.31-fold rise in hydrogen production in comparison to ***,signifying a substantial enhancement in hydrogen production ***,we delve into the alterations in biological metabolites associated with hydrogen production and the changes in electron transfer in different biohybrid *** provides valuable insights into the understanding of the intrinsic mechanisms that drive the *** work introduces a novel and promising avenue for achieving this exciting goal.

关键词： Escherichia coli TiO_(2−x)nanoparticles biohybrid system hydrogen production

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