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Absorbable 3D-printed pancreaticojejunostomy device with a dual-layer drug coating for the prevention of postoperative local recurrence of pancreatic cancer

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Journal of Materials Science & Technology 2023年第23期154卷 178-188页

作者： Maoen Pan Tingting huang Zeya Xu Wei Luo Yuanyuan Yang Tianhong Teng heguang huang Department of General Surgery Fujian Medical University Union Hospital Fuzhou China Key Laboratory of Optoelectronic Materials Chemical and Physics Chinese Academy of Sciences Fujian Institute of Research on the Structure of Matter Fuzhou China

The high local recurrence rate of pancreatic cancer after surgery is one of the important risk factors affecting patient *** traditionally used silicone tube stent is not only complicated to operate but also lacks antitumor *** purpose of this study was to develop a dual-layer drug-coated pancreaticojejunostomy *** coating consisted of two layers,an outer basic fibroblast growth factor(bFGF)coating layer and an inner nanoparticle albumin-bound paclitaxel(nab-PTX)coating layer with chitosan as the drug-carrying *** to the diffusion barrier from the outer coating,the release of nab-PTX from the inner layer was delayed and slowed *** studied the degradation rates,mechanical properties,surface morphologies,drug release kinetics,promoting the growth of fibroblasts and antitumor properties of the coated *** was found that 100 ng of bFGF and 50µg of nab-PTX were suitable drug concentrations that can effectively promote the growth of fibroblasts and inhibit pancreatic cancer *** results also confirmed that the dual-layer drug-coated pancreaticojejunostomy device showed good antitumor activity both in vitro and in vivo without obvious systemic *** addition,the device has a suitable degradation *** conclusion,this biodegradable dual-layer drug-coated pancreaticojejunostomy device can potentially inhibit the local recurrence of pancreatic cancer after surgery and promote the healing of pancreaticointestinal *** device has great potential to treat pancreatic cancer in the future.

关键词： Pancreaticojejunostomy device 3D printing Drug coating Anti-tumor effect Pancreatic cancer

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Advances in hydrogel materials applied to pancreatic-related diseases

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Journal of Pancreatology 2024年第3期7卷 222-232页

作者： Yuan Zhou Maoen Pan Ronggui Lin heguang huang Department of General Surgery Fujian Medical University Union HospitalFuzhouFujianPeople’s Republic of China

The pancreas is a glandular organ that maintains internal homeostasis through its endocrine and exocrine *** functions are vital for overall ***,environmental and lifestyle changes have led to an increasing incidence of pancreatic diseases,including pancreatic cancer,pancreatitis,and pancreatic neuroendocrine *** conditions profoundly impact the health and quality of life of affected *** existing diagnostic and treatment approaches for pancreatic diseases exhibit limitations and shortcomings,necessitating exploring novel *** recent years,advancements in medicine and bioengineering have fostered multidisciplinary and interdisciplinary innovations,introducing fresh avenues for diagnosing and treating pancreatic ***,emerging as a biomaterial,represent highly hydrated cross-linked hydrophilic polymer *** exceptional biodegradability and biocompatibility have rendered them instrumental in various medical ***,with their macromolecular porous structures,are efficient carriers for drug delivery and controlled *** materials have garnered substantial attention for their unique properties and diverse applications in the context of pancreatic *** article aims to provide an overview of the current limitations in diagnosing and treating pancreatic diseases while highlighting the latest trends and advancements in developing hydrogel carrier materials tailored for these conditions,primarily focusing on strategies for pancreatitis,pancreatic cancer,and pancreatic neuroendocrine *** article endeavors to give researchers and clinicians a comprehensive grasp of this field,offering valuable insights into prospective research directions and emerging trends.

关键词： Biomaterials Hydrogel materials Pancreatic disease Therapeutic strategies

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Synergistic inhibition of pancreatic cancer with anti-PD-L1 and c-Myc inhibitor JQ1

Synergistic inhibition of pancreatic cancer with anti-PD-L1 ...

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2019年中国肿瘤标志物学术大会暨第十三届肿瘤标志物青年科学家论坛

作者： PAN,YU Lu,Fengchun Fei,Qinglin Pan,Minggui huang,heguang Fujian Medical university Union Hospital Department of Oncology and Hematology and Division of Research Kaiser Permanente

Human pancreatic ductal adenocarcinoma(PDAC) exhibits marginal responses to anti-PD-1/PD-L1 immunotherapy and its mechanism remains poorly *** have investigated the effect of anti-PD-L1 and c-Myc inhibition in *** 87 patients with PDAC from our hospital database we found significant correlation between the expression of PD-L1 and ***,expression of both PD-L1 and c-Myc was associated with poor overall *** addition we confirmed this finding with the PDAC patients in the TCGA *** several PDAC cell lines we demonstrated significant correlation between the expression of PD-L1 and *** also found that expression of PD-L1 correlated with high-grade ***1,an inhibitor of c-Myc inhibited PD-L1 expression and tumor *** xenograft models,we demonstrated that combination of JQ1 and anti-PD-L1 antibody exerted synergistic inhibition of PDAC *** data demonstrated that expression of PD-L1 and c-Myc may be helpful prognostic biomarkers and their inhibition may potentially serve as an effective treatment for PDAC.

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Clinical application of 3D reconstruction in pancreatic surgery:a narrative review

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Journal of Pancreatology 2022年第1期5卷 153-176页

作者： Yiming Zhang Yuanyuan Yang Shu Chen Jianbing Ji Huiting Ge heguang huang Department of General Surgery Fujian Medical University Union HospitalFuzhou 350001P.R.China Faculty of Innovation and Design City University of MacaoMacao 999078P.R.China College of Physics and Information Engineering Fuzhou UniversityFuzhou 350012P.R.China College of Information Engineering Fujian Business UniversityFuzhou 350012P.R.China Department of Image Fujian Medical University Union HospitalFuzhou 350001P.R.China

Progress in medicine requires not only innovation and development in the medical field but also the integration of the technology of other fields into the medical *** an important technological advancement,three-dimensional(3D)reconstruction transforms traditional two-dimensional images into 3D images that are more consistent with the physiological habits of human *** has been applied to the bones,heart,liver,and maxillofacial area,promoting the progress of medical technology and *** paper introduces the progress of 3D reconstruction technology in the clinical application of pancreatic surgery,from the preoperative,intraoperative,and postoperative perspectives,as well as the education of young *** also puts forward new ideas for the further development of pancreatic surgery.

关键词： Three-dimensionalreconstruction Vascular reconstruction Peripancreatic blood vessels Pancreatic surgery Clinical application

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Serum biomarker CD163 predicts overall survival in patients with pancreatic ductal adenocarcinoma

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Journal of Pancreatology 2020年第3期3卷 147-153页

作者： Qinglin Fei Yu Pan Xingxing Yu Ronggui Lin Xianchao Lin heguang huang Department of General Surgery Fujian Medical University Union HospitalFuzhouChina

The serum soluble CD163(sCD163)is elevated in patients with inflammatory disease and several types of ***,the prognostic value of serum sCD163 in pancreatic ductal adenocarcinoma(PDAC)has not yet been *** this study,serum level of sCD163 was measured by using the peripheral blood of 54 patients with PDAC,20 patients with benign tumor of pancreas,and 30 healthy volunteers(healthy controls).The association between serum sCD163 level and overall survival was *** operating characteristic(ROC)curves were generated,and areas under the curve(AUC)were compared to evaluate the diagnostic accuracy,including CA 19-9,CEA,CA 125,CA 153,and serum sCD163 *** sCD163 level of patients with PDAC was significantly higher than patients with benign tumor(P=.002)and health controls(P<.001).Using ROC curves,we found that the AUC values of serum sCD163 were higher than those of CA 125 and CA 153,but lower than those of CA 19-9 and *** sCD163 was negatively correlated with lymphocyte to monocyte ratio(LMR;r=0.428,P=.001).In addition,the prognosis of PDAC patients with sCD163median was worse than sCD163

关键词： Pancreatic ductal adenocarcinoma Prognosis Serum soluble CD163 Tumor-associated macrophages

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Mesenchymal stem cells decrease blood-brain barrier permeability in rats with severe acute pancreatitis

Mesenchymal stem cells decrease blood-brain barrier permeabi...

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中国解剖学会2021年年会

作者： Lin Ronggui Li Ming Luo Meiqin Teng Tianhong Pan Yu huang heguang Department of General surgery Fujian Medical University Union Hospital Department of Histology and Embryology Hunan University of Medicine Department of Orthopedics Fujian Medical University Union Hospital

Impairment of the blood-brain barrier (BBB) could result in secondary cerebral edema and lifethreatening pancreatic encephalopathy in patients with severe acute pancreatitis (SAP).Mesenchymal stem cells(MSCs) have been widely adopted in clinical research because of their pleiotropic *** aim of this study was to investigate the impact of MSCs on BBB permeability in SAP and the potential mechanisms driving these effects.

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sublay技术在腹外疝修补术中的应用

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中华消化外科杂志 2020年第7期19卷 733-737页

作者：黄鹤光林荣贵福建医科大学附属协和医院基本外科福州350001

腹外疝主要包括腹股沟疝、腹壁疝等,无张力修补术是成人腹外疝的主要治疗手术方式。sublay技术是腹外疝修补的理想技术,其将补片置于肌后、腹膜前间隙,修补可靠,疝复发率低,术后并发症少;补片不与腹腔脏器接触,可避免术后腹腔粘连等补... 详细信息

腹外疝主要包括腹股沟疝、腹壁疝等,无张力修补术是成人腹外疝的主要治疗手术方式。sublay技术是腹外疝修补的理想技术,其将补片置于肌后、腹膜前间隙,修补可靠,疝复发率低,术后并发症少;补片不与腹腔脏器接触,可避免术后腹腔粘连等补片相关并发症发生。近年来,随着腹外疝修补理念的不断更新,疝与腹壁外科专家更倾向将腹壁问题留在腹壁层次解决。因此,sublay技术备受疝外科医师重视。基于sublay技术的各种新技术、新手术方式层出不穷,越来越广泛地应用于开放、腹腔镜或达芬奇机器人手术系统腹外疝修补术中。笔者总结sublay技术在腹股沟疝和腹壁疝修补术中的应用,介绍应用sublay技术治疗腹股沟疝和腹壁疝的经典手术和新手术,旨在推进腹外疝的规范治疗。

关键词：疝腹股沟疝腹壁疝 sublay技术手术修补

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以主胰管处理为导向对若干胰腺术式的探讨

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中华外科杂志 2022年第7期60卷 651-654页

作者：黄鹤光潘茂恩福建医科大学附属协和医院基本外科福州350001

随着腹腔镜和机器人技术的逐渐普及,胰腺手术正朝着减少并发症、保留更多胰腺功能的方向发展。主胰管是胰腺外分泌液的重要流出通道,精准处理主胰管可有效降低胰腺术后并发症的发生率。本文围绕胰肠吻合、胰腺远端切除、胰腺假性囊肿与... 详细信息

随着腹腔镜和机器人技术的逐渐普及,胰腺手术正朝着减少并发症、保留更多胰腺功能的方向发展。主胰管是胰腺外分泌液的重要流出通道,精准处理主胰管可有效降低胰腺术后并发症的发生率。本文围绕胰肠吻合、胰腺远端切除、胰腺假性囊肿与主胰管的关系及胰腺部分切除术等难点,重点介绍腹腔镜和机器人技术下常见胰腺术式中主胰管的处理方法。同时,提出"胰管黏膜对黏膜六针法"进行胰腺中段切除、端端吻合的手术方式,利用微创技术达到最佳手术效果,让更多患者获益。

关键词：胰腺切除术腹腔镜机器人手术胰管空肠吻合术主胰管

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重症急性胰腺炎并发肝功能不全的特点和治疗

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中国实用外科杂志 2006年第5期26卷 334-336页

作者：黄鹤光陈燕昌福建医科大学附属协和医院普外科福建福州350001

重症急性胰腺炎(SAP)并发肝功能不全,在很大程度上影响病人病情转归,给SAP其他并发症的处理带来很大困难。选择性手术的病人,术前检查尚可对肝脏储备功能,肝功代偿能力状况较充分了船,但急性胰腺炎因起病急,发病时肝功能储备和代偿能力... 详细信息

重症急性胰腺炎(SAP)并发肝功能不全,在很大程度上影响病人病情转归,给SAP其他并发症的处理带来很大困难。选择性手术的病人,术前检查尚可对肝脏储备功能,肝功代偿能力状况较充分了船,但急性胰腺炎因起病急,发病时肝功能储备和代偿能力一时难以估计。另外,SAP并发肝功能不全个体差异很大,多与原有肝脏疾病,肝功能储备,病因及病情程度有关,临床应做综合分析。[第一段]

关键词：重症急性胰腺炎肝功能不全并发症肝功能储备治疗肝脏储备功能代偿能力选择性手术病情转归术前检查

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三维打印技术在胰腺外科领域的发展现状

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中华外科杂志 2017年第10期55卷 795-797页

作者：杨媛媛黄鹤光福建医科大学附属协和医院基本外科福州350001

三维打印技术最早兴起于20世纪70年代末,作为全球第三次工业革命的代表性技术之一,三维打印技术在机械制造、工业设计、建筑构型、生物医学等领域都有着飞速发展.本文仅就三维打印技术在胰腺外科领域的研究及应用现状做一整理,旨在明确... 详细信息

三维打印技术最早兴起于20世纪70年代末,作为全球第三次工业革命的代表性技术之一,三维打印技术在机械制造、工业设计、建筑构型、生物医学等领域都有着飞速发展.本文仅就三维打印技术在胰腺外科领域的研究及应用现状做一整理,旨在明确现阶段三维打印技术在胰腺外科领域的发展水平和研究进展,并对其在胰腺外科领域的研究前景及发展方向提出意见.

关键词：胰腺外科三维打印研究进展

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