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A dynamic model of calcium signaling in mast cells and LTC_4 release induced by mechanical stimuli

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Chinese Science Bulletin 2014年第10期59卷 956-963页

作者： Wei Yao Huaxiong huang Guanghong Ding Department of Mechanics and Engineering Science Fudan University Department of Mathematics and Statistics York University

Mast cells(MCs) play an important role in the immune system. It is known that mechanical stimuli can induce intracellular Ca2+signal and release a variety of mediators, including leukotriene C4(LTC4), leading to other cellular and physiological changes. In this paper, we present a mathematical model to explore signalling pathways in MCs, by including cellular mechanisms for intracellular Ca2t increase and LTC4release in response to mechanical stimuli, thapsigargin(TG, SERCA pump inhibitor), and LTC4 stimuli. We show that(i) mechanical stimuli activate mechano-sensitive ion channels and induce inward ion fluxes and Ca2?entry which increases intracellular Ca2+concentration and releases LTC4;(ii) TG inhibits SERCA pumps, empties the internal Ca2+ stores,which activates Ca2+release-activated Ca2+channels and results in sustained intracellular Ca2+increase; and(iii)LTC4activates receptors on MCs surface and increases intracellular Ca2+concentration. Our results are consistent with experimental observations, and furthermore, they also reveal that mechanical stimuli can increase intracellular Ca2+even when LTC4release is blocked, which suggests a feed forward loop involved in LTC4production. This study may facilitate our understanding of the mechanotransduction process in MCs and provide a useful modeling tool for quantitatively analyzing immune mechanisms involving MCs.

关键词： cells Calcium signaling LTC4 release Dynamics Mechanical stimuli

Complementary Sliding Mode Speed Control with Saturation Function Boundary Layer Optimization

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Journal of Harbin Institute of Technology(New Series) 2019年第5期26卷 67-71页

作者： Yanwei huang Yuqing Xie Wenchao huang College of Electrical Engineering and Automation Fuzhou University

A simple method is proposed to optimize the thickness parameter of the boundary layer of the saturation function in the Complementary Sliding Mode Control (CSMC). A pair of complementary sliding surfaces are constructed. And the Taylor series is used to estimate the steady state error of CSMC system to optimize the parameter value for the boundary layer of the saturation function without artificial settings. This proposed CSMC strategy is applied to the speed regulation in permanent magnet synchronous motor with lump uncertainties. The experimental results show that the proposed CSMC strategy can obtain an optimal value for the boundary layer parameter effectively suppressing the chattering and keep an excellent system performance.

关键词： CSMC saturation function boundary layer parameter Taylor series speed regulation

Managing Discretionary Services: A Review and Research Opportunities

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Journal of Systems Science and Systems Engineering 2021年第1期30卷 1-16页

作者： Xiaofang Wang Rongyi huang Junguang Gao Laurens G.Debo School of Business Renmin University of ChinaBeijing100872China Business School Beijing Technology and Business UniversityBeijing100038China Tuck School of Business Dartmouth CollegeHanoverNH03755USA

Discretionary services typically refer to professional work and complex service work by physicians,software developers,web designers,lawyers,or financial analysts,where there are no standard working processes and customer perceived quality of service increases with the time spent on ***,research on these services,especially the corresponding speed-quality tradeoff problem,has gained more and more *** paper reviews both the analytical models and the empirical studies in this area,highlighting their contributions and pointing out potential directions for future research.

关键词： Discretionary service speed-quality tradeoff queueing

Allowance Extraction Considering of Inner and Outer Contour and Experimental Research on Belt Grinding of Hollow Blade

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Chinese Journal of Mechanical Engineering 2023年第3期36卷 230-240页

作者： Yun huang Ming Wei Guijian Xiao Shuai Liu Yuan Wu College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing 400044China

Aero-engine fan blades of ten use a cavity structure to improve the thrust-to-weight ratio of the ***,the use of the cavity structure brings a series of difficulties to the manufacturing and processing of the *** to the limitation of blade manufacturing technology,it is difficult for the internal cavity structure to achieve the designed contour shape,so the blade has uneven wall thickness and poor consistency,which affects the fatigue performance and airflow dynamic performance of the *** order to reduce the influence of uneven wall thickness,this paper proposes a grinding allowance extraction method considering the double dimension constraints(DDC)of the inner and outer contours of the hollow *** the two dimensions of the inner and outer contours of the hollow *** the premise of satisfying the outer contour constraints,the machining model of the blade is modified according to the distribution of the inwall contour to obtain a more reasonable distribution of the grinding *** the premise of satisfying the contour constraints,according to the distribution of the inwall contour,the machining model of the blade is modified to obtain a more reasonable distribution of the grinding *** the grinding experiment of the hollow blade,the surface roughness is below Ra0.4μm,and the contour accuracy is between-0.05~0.14 mm,which meets the processing *** with the allowance extraction method that only considers the contour,the problem of poor wall thickness consistency can be effectively *** can be used to extract the allowance of aero-engine blades with hollow features,which lays a foundation for the study of hollow blade grinding methods with high service performance.

关键词： Double dimension constraints Allowance extraction Abrasive belt grinding

Energy-efficient joint UAV secure communication and 3D trajectory optimization assisted by reconfigurable intelligent surfaces in the presence of eavesdroppers

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Defence Technology（防务技术） 2024年第1期31卷 537-543页

作者： huang Hailong Mohsen Eskandari Andrey V.Savkin Wei Ni The Department of Aeronautical and Aviation Engineering The Hong Kong Polytechnic UniversityHong KongChina School of Electrical Engineering and Telecommunications University of New South WalesSydney2052Australia Data61 CSIROAustralia

We consider a scenario where an unmanned aerial vehicle(UAV),a typical unmanned aerial system(UAS),transmits confidential data to a moving ground target in the presence of multiple *** friendly reconfigurable intelligent surfaces(RISs) help to secure the UAV-target communication and improve the energy efficiency of the *** formulate an optimization problem to minimize the energy consumption of the UAV,subject to the mobility constraint of the UAV and that the achievable secrecy rate at the target is over a given *** present an online planning method following the framework of model predictive control(MPC) to jointly optimize the motion of the UAV and the configurations of the *** effectiveness of the proposed method is validated via computer simulations.

关键词： Unmanned aerial systems(UASs) Unmanned aerial vehicle(UAV) Communication security Eaves-dropping Reconfigurable intelligent surfaces(RIS) Autonomous navigation and placement Path planning Model predictive control

The transcriptome analysis of cleft lip/palate-related PTCH1 variants in GMSM-K cells show carcinogenic potential

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BIOCELL 2023年第1期47卷 205-214页

作者： MINGZHAO LI QIAN ZHANG WENBIN huang SHIYING ZHANG NAN JIANG XIAOSHUAI huang FENG CHEN Department of Orthodontics Peking University School and Hospital of StomatologyBeijingChina Central Laboratory Peking University School and Hospital of StomatologyBeijingChina Biomedical Engineering Department Peking UniversityBeijingChina

Cancer progression involves the sonic hedgehog(SHH)pathway,in which the receptor PTCH1 actives the downstream *** of PTCH1 can lead to nevoid basal cell carcinoma Syndrome(NBCCs)including neoplastic disease and congenital *** evaluate the relationship between PTCH1 and cancer,we applied the CRISPR/Cas9 system to knock out PTCH1 in oral nontumorous epithelial cells(GMSM-K).Then we screened six PTCH1 variants associated with cleft lip/palate(CL/P),one of the congenital disorders in NBCCs,and generated PTCH1 variant and wild-type recombinant PTCH1^(−/−)GMSM-K cell *** sequencing was conducted in these cell *** results revealed that differentially expressed genes(DEGs)in PTCH1^(−/−)GMSM-K were enriched in extracellular compartments,contributing epithelial diseases by pathway enrichment ***-PCR confirmed that KRT34,KRT81,KRT86,PDGFB,and WNT10B genes,associated with extracellular compartments were highly expressed in PTCH1^(−/−).The Kyoto Encyclopedia of Genes and Genomes analysis also suggested that DEGs are closely related to focal adhesion,transcriptional misregulation,and proteoglycans in breast and gastric *** analysis of samples revealed that the CL/P-associated PTCH1 variants A443G and V908G are potentially *** findings provide new insights into the carcinogenic potential of PTCH1 dysfunction.

关键词： CRISPR/Cas9 PTCH1 variant Carcinogenic potential Transcriptome sequencing

Inhibitory effects of patchouli alcohol on stress-induced diarrhea-predominant irritable bowel syndrome

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World Journal of Gastroenterology 2018年第6期24卷 693-705页

作者： Tian-Ran Zhou Jing-Jing huang Zi-Tong huang Hong-Ying Cao Bo Tan The Research Center for Integrative Medicine School of Basic Medical Sciences Guangzhou University of Chinese Medicine School of Chinese Materia Medica Guangzhou University of Chinese Medicine

AIM To elucidate the mechanism of patchouli alcohol(PA) in treatment of rat models of diarrhea-predominant irritable bowel syndrome(IBS-D).METHODS We studied the effects of PA on colonic spontaneous motility using its cumulative log concentration(3 × 10^(-7) mol/L to 1 × 10^(-4)mol/L). We then determined the responses of the proximal and distal colon segments of rats to the folowing stimuli:(1) carbachol(1 × 10^(-9) mol/L to 1 × 10^(-5) mol/L);(2) neurotransmitter antagonists including N~ω-nitro-l-arginine methyl ester hydrochloride(10μmol/L) and(1 R~*, 2 S~*)-4-[2-Iodo-6-(methylamino)-9 Hpurin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hexane-1-methanol dihydrogen phosphate ester tetraammonium salt(1 μmol/L);(3) agonist α,β-methyleneadenosine 5′-triphosphate trisodium salt(100 μmol/L); and(4) single KCl doses(120 mmol/L). The effects of blockers against antagonist responses were also assessed by pretreatment with PA(100 μmol/L) for 1 min. Electrical-field stimulation(40 V, 2-30 Hz, 0.5 ms pulse duration, and 10 s) was performed to observe nonadrenergic, noncholinergic neurotransmitter release in IBS-D rat colon. The ATP level of Kreb's solution was also *** PA exerted a concentration-dependent inhibitory effect on the spontaneous contraction of the colonic longitudinal smooth muscle, and the half maximal effective concentration(EC_(50)) was 41.9 μmol/L. In comparison with the KCl-treated IBS-D group, the contractile response(mg contractions) in the PA + KCl-treated IBS-D group(11.87 ± 3.34) was significantly decreased in the peak tension(P < 0.01). Compared with CCh-treated IBS-D rat colon, the cholinergic contractile response of IBS-D rat colonic smooth muscle(EC_(50) = 0.94 μmol/L) was significantly decreased by PA(EC_(50) = 37.43 μmol/L)(P < 0.05). Lack of nitrergic neurotransmitter release in stress-induced IBS-D rats showed contraction effects on colonic smooth muscle. Pretreatment with PA resulted in inhibitory effect on l-NAME-induced(10 μmol/L) con

关键词： Patchouli alcohol Colonic longitudinal smooth muscles Diarrhea-predominant irritable bowel syndrome Enteric nervous system Cholinergic nerves Non-adrenergic non-cholinergic Potassium channel

A 400MHz Single-Chip CMOS Transceiver for Long Range High Definition Video Transmission in UAV Application

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Chinese Journal of Electronics 2020年第3期29卷 554-562页

作者： huang Shuigen LIN Min WANG Ruoyu CHEN Zhuojun DONG Yemin Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai University

A fully-integrated 400MHz transceiver for high definition video transmission in Unmanned aerial vehicle（UAV） is presented. The transceiver integrates a Receiver（RX）, a Transmitter（TX）, a tunable multi-mode complex filter, two sigma-delta fractional-N PLL frequency synthesizers and some baseband calibration circuits, which is applicable for both Time division duplex（TDD） and Frequency division duplex（FDD） systems. In order to meet different data rate and sensitivity requirements for control signal and video signal transmission, the transceiver supports BPSK/QPSK/QAM *** receiver sensitivity is –75dBm and the transmitter provides emission power up to 12dBm. Besides, the Error vector magnitude（EVM） of –35dB is measured under 64QAM modulation with 54Mbps data *** in a standard 130nm CMOS process and operated at 1.2V supply for most circuits excluding PA,3.3V supply for PA, the receiver and the transmitter consume 68.2mW and 164.3mW, including the frequency synthesizer, respectively. The total chip area with pads is 6.25 mm;.

关键词： CMOS Transceiver Unmanned aerial vehicle(UAV) Wireless video transmission

Gradient-based method for the identification of multi-nodes in sugarcane

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Information Processing in Agriculture 2020年第4期7卷 491-499页

作者： Rui Yang Jie Li Qi Liu Wenshan huang Kai Yin Xi Qiao Yiqi huang College of Mechanical Engineering GuangXi UniversityNanNingChina Guangdong Laboratory of Lingnan Modern Agriculture ShenzhenGenome Analysis Laboratory of the Ministry of Agriculture and Rural AreaAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China

In view of the obvious changes in color between the upper and lower leaf scar in sugarcane nodes,a method of simultaneous multi-nodes identification on a single sugarcane stem was proposed based on the analysis of gradient characteristics of sugarcane *** combination with image processing and machine vision recognition technology,two cameras were used to acquire different parts of sugarcane images,and the two images were integrated into a complete image of sugarcane by image *** Sobel operator is used to calculate the gradient of the sugarcane image in a horizontal direction,and the gradient image is *** sugarcane gradient image was scanned by a rectangular template with a width of 14 pixels and a step length of 12 *** features of average gradient and variance gradient were used to identify sugarcane nodes for the first *** experimental results showed that the recognition accuracy was 96.8952%,and there were fewer false detected sugarcane *** detection efficiency could be improved by detecting multi-nodes on a single sugarcane stem at the same time.

关键词： Multi-nodes identification Sugarcane image mosaicking Gradient mean Gradient variance