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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-Wen Alvin huang john Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

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英语自学 2008年第3期 34-38页

作者：秀实 Harry j.huang 罗平

临床诊疗路径在致病动物模型外科手术教学中的应用初探

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中国医学教育技术 2018年第4期32卷 448-450,464页

作者：黄晶甘肃医学院外科教研室甘肃平凉744000

为了提高手术学教学效果,培养学生生命伦理学意识,该文以急性阑尾炎动物模型为载体,通过"临床手术患者诊疗模拟体验",开展贯穿术前准备、术中操作、术后观察及处理的实验教学活动,提高学生在学习中的参与感和解决问题能力,以增强其职业... 详细信息

为了提高手术学教学效果,培养学生生命伦理学意识,该文以急性阑尾炎动物模型为载体,通过"临床手术患者诊疗模拟体验",开展贯穿术前准备、术中操作、术后观察及处理的实验教学活动,提高学生在学习中的参与感和解决问题能力,以增强其职业认同感,激发学习兴趣。这种教学方法以训练临床操作基本功与加强临床综合能力培养相结合,既可提高手术学教学效果,又能使学生尽早适应临床工作。

关键词：外科手术教学临床诊疗路径动物模型改进措施

High-temperature-tolerant flexible supercapacitors: Gel polymer electrolytes and electrode materials

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journal of Energy Chemistry 2025年第1期100卷 426-457页

作者： Chong Peng Xinyi huang Mingwei Zhao Shuling Liao Quanhong Yang Nianjun Yang Siyu Yu School of Chemistry & Chemical Engineering Southwest University Nanoyang Group Tianjin Key Laboratory of Advanced Carbon and Electrochemical Energy Storage School of Chemical Engineering and Technology and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin University Department of Chemistry & IMO-IMOMEC Hasselt University

The development of flexible supercapacitors(FSCs) capable of operating at high temperatures is crucial for expanding the application areas and operating conditions of supercapacitors. Gel polymer electrolytes and electrode materials stand as two key components that significantly impact the efficacy of hightemperature-tolerant FSCs(HT-FSCs). They should not only exhibit high electrochemical performance and excellent flexibility, but also withstand intense thermal stress. Considerable efforts have been devoted to enhancing their thermal stability while maintaining high electrochemical and mechanical performance. In this review, the fundamentals of HT-FSCs are outlined. A comprehensive overview of state-of-the-art progress and achievements in HT-FSCs, with a focus on thermally stable gel polymer electrolytes and electrode materials is provided. Finally, challenges and future perspectives regarding HT-FSCs are discussed, alongside strategies for elevating operational temperatures and *** review offers both theoretical foundations and practical guidelines for designing and manufacturing HT-FSCs, further promoting their widespread adoption across diverse fields.

关键词： Flexible supercapacitors High-temperature tolerance Gel polymer electrolytes Electrode materials

Ru doping triggering reconstruction of cobalt phosphide for coupling glycerol electrooxidation with seawater electrolysis

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journal of Energy Chemistry 2025年第1期100卷 317-326页

作者： Binglu Deng jie Shen jinxing Lu Chuqiang huang Zhuoyuan Chen Feng Peng Yunpeng Liu School of Materials Science and Hydrogen Energy Foshan University School of Chemistry and Chemical Engineering Guangzhou University Guangdong Key Laboratory for Hydrogen Energy Technologies

Seawater electrolysis is a promising approach for sustainable energy without relying on precious ***,the large-scale seawater electrolysis is hindered by low catalytic efficiency and severe anode corrosion caused by the harmful *** contrast to the oxygen evolution reaction （OER）and chlorin ion oxidation reaction （ClOR）,glycerol oxidation reaction （GOR） is more thermodynamically and kinetically favorable ***,a Ru doping cobalt phosphide （Ru-CoP2） is proposed as a robust bifunctional electrocatalyst for seawater electrolysis and GOR,for the concurrent productions of hydrogen and value-added *** in situ and ex situ characterization analyses demonstrated that Ru doping featured in the dynamic reconstruction process from Ru-CoP2to Ru-CoOOH,accounting for the superior GOR *** coupling GOR with hydrogen evolution was realized by employing Ru-CoP2as both anode and cathode,requiring only a low voltage of 1.43 V at 100 mA cm-2,which was 250 m V lower than that in alkaline *** work guides the design of bifunctional electrocatalysts for energy-efficient seawater electrolysis coupled with biomass resource upcycling.

关键词： Glycerol electrooxidation Hydrogen evolution Ru doping Cobalt phosphide Bifunctional electrocatalysts

Dynamic fracture of carbon nanotube-epoxy composites under high strain-rate loading

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Dynamic fracture of carbon nanotube-epoxy composites under h...

Depolarization of intense laser beams by dynamic plasma density gratings

第十三届全国物理力学学术会议

作者： B.X.Bie j.H.Han L.Lu X.M.Zhou H.j.huang Z.Zhang S.N.Luo School of Science Wuhan University of Technology The Peac Institute of Multiscale Sciences National Center for Nanoscience and Technology CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern MechanicsUniversity of Science and Technology of China

We investigate dynamic fracture of three types of multiwalled carbon nanotube(CNT)-epoxy composites and neat epoxy under high strain-rate loading(105-106 s-1).The composites include randomly dispersed,1 wt\%,functionalized and pristine CNT-epoxy composites,as well as laminated,0 wt\%CNT-epoxy *** pristine and functionalized CNT composites demonstrate spall strength and fracture

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High Power Laser Science and Engineering 2023年第3期11卷 48-56页

作者： Y.X.Wang S.M.Weng P.Li Z.C.Shen X.Y.jiang j.huang X.L.Zhu H.H.Ma X.B.Zhang X.F.Li Z.M.Sheng j.Zhang Key Laboratory for Laser Plasmas(MoE) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghaiChina Research Center of Laser Fusion of China Academy of Engineering Physics MianyangChina College of Physics and Electronics Engineering Northwest Normal UniversityLanzhouChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina

As a typical plasma-based optical element that can sustain ultra-high light intensity,plasma density gratings driven by intense laser pulses have been extensively studied for wide ***,we show that the plasma density grating driven by two intersecting driver laser pulses is not only nonuniform in space but also varies over ***,the probe laser pulse that passes through such a dynamic plasma density grating will be depolarized,that is,its polarization becomes spatially and temporally *** importantly,the laser depolarization may spontaneously take place for crossed laser beams if their polarization angles are arranged *** laser depolarization by a dynamic plasma density grating may find application in mitigating parametric instabilities in laser-driven inertial confinement fusion.

关键词： depolarization high-power laser plasma density grating

内分泌因子、生长因子、细胞因子与卵巢卵泡的发育

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中国组织工程研究与临床康复 2007年第19期11卷 3821-3828页

作者：罗丽莉黄菊傅玉才汕头大学医学院第一附属医院妇产科广东省汕头市515041 汕头大学医学院细胞衰老实验室广东省汕头市515041

目的:探讨内分泌因子、生长因子、细胞因子等因素对卵巢卵泡发育以及凋亡调控机制的研究进展。资料来源:应用计算机检索PubMed数据库1995-01/2006-09关于卵巢卵泡发育和卵泡凋亡研究的文章,检索词“follicular development,follicular a... 详细信息

目的:探讨内分泌因子、生长因子、细胞因子等因素对卵巢卵泡发育以及凋亡调控机制的研究进展。资料来源:应用计算机检索PubMed数据库1995-01/2006-09关于卵巢卵泡发育和卵泡凋亡研究的文章,检索词“follicular development,follicular atresia,oocyte,apoptosis”,限定文章的语言种类为English。资料选择:对资料进行初筛,选取近年发表的关于卵巢卵泡发育和卵泡凋亡的文献,纳入标准:①具有原创性,论点论据可靠的试验文章。②观点明确,分析全面的文章。③文献主体内容与此课题联系紧密的文章。排除标准:实验设计不合理的文章及观点模糊的综述。资料提炼:共检索到225篇关于卵巢卵泡发育和卵泡凋亡研究的文献,最终纳入56篇符合标准的文献。资料综合:哺乳动物卵巢卵泡发育和凋亡过程包括卵母细胞凋亡、原始卵泡形成、原始卵泡发育启动、卵泡发育成熟和卵泡闭锁等阶段。在卵泡腔形成前,卵泡的存亡不依赖于促性腺激素,主要是受各种生长因子和细胞因子的调节;卵泡腔形成后,促性腺激素是卵泡的主要存活因子,它主导卵泡的命运。本文拟对内分泌因子、生长因子、细胞因子等因素对卵巢内生殖细胞和卵泡的存活以及凋亡调控的机制进行综述。结论:在哺乳动物卵巢中,雌性生殖细胞的发育和凋亡是一个复杂的多因素调控过程,除遗传因素外,内分泌因子、生长因子、细胞因子等也起关键性作用。

关键词：卵母细胞,卵泡,凋亡,闭锁综述文献