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The role of axon guidance molecules in the pathogenesis of epilepsy

Neural Regeneration Research 2025年第5期20卷 1244-1257页

作者： Zheng Liu Chunhua Pan Hao huang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms and mechanisms of action. Increasing evidence suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules is associated with epilepsy susceptibility. In this review, we discuss the essential role of axon guidance molecules in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plasticity and brain tissue remodeling. Furthermore, we examine the relationship between axon guidance molecules and neuroinflammation, as well as the structural changes in specific brain regions that contribute to the development of epilepsy. Ample evidence indicates that axon guidance molecules, including semaphorins and ephrins, play a fundamental role in guiding axon growth and the establishment of synaptic connections. Deviations in their expression or function can disrupt neuronal connections, ultimately leading to epileptic seizures. The remodeling of neural networks is a significant characteristic of epilepsy, with axon guidance molecules playing a role in the dynamic reorganization of neural circuits. This, in turn, affects synapse formation and elimination. Dysregulation of these molecules can upset the delicate balance between excitation and inhibition within a neural network, thereby increasing the risk of overexcitation and the development of epilepsy. Inflammatory signals can regulate the expression and function of axon guidance molecules, thus influencing axonal growth, axon orientation, and synaptic plasticity. The dysregulation of neuroinflammation can intensify neuronal dysfunction and contribute to the occurrence of epilepsy. This review delves into the mechanisms associated with

关键词： axon guidance drug-resistant epilepsy epilepsy nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity neurons synaptic remodeling

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Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi huang Meiyu Zhang Yanyu Zhang Yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

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人胚胎干细胞和诱导性多功能干细胞饲养层细胞的制备方法

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国际口腔医学杂志 2014年第3期41卷 268-271页

作者：谭小兵 George T-j huang 云南省第一人民医院口腔内科昆明650032 美国波士顿大学牙学院牙体牙髓病学系波士顿ma02118

目的建立一种能维持人胚胎干细胞（ESC）和诱导性多功能干细胞（iPSC）生长的饲养层细胞的标准制备方法。方法选取受孕12．5-14．5d的CF-1雌鼠，原代培养的鼠胚胎成纤维细胞（MEF）经丝裂霉素C处理后作为饲养层细胞，观察其维持人ESC和i... 详细信息

目的建立一种能维持人胚胎干细胞（ESC）和诱导性多功能干细胞（iPSC）生长的饲养层细胞的标准制备方法。方法选取受孕12．5-14．5d的CF-1雌鼠，原代培养的鼠胚胎成纤维细胞（MEF）经丝裂霉素C处理后作为饲养层细胞，观察其维持人ESC和iPSC的生长情况；同时研究不同培养器具所需细胞数量，制备高质量饲养层细胞。结果经丝裂霉素C处理后，MEF可很好维持人ESC和iPSC的生长，使其保持自我更新能力和未分化状态；控制铺板的细胞密度，可得到高质量饲养层细胞。结论本实验得到的饲养层细胞能很好支持人ESC和iPSC生长，可作为饲养层细胞制备的标准方法使用。

关键词：人胚胎干细胞人诱导性多功能干细胞饲养层细胞鼠胚胎成纤维细胞

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肥厚型心肌病MRI T1 mapping：对无延迟钆剂增强及血流动力学障碍病人的评价（DOI:10.19300/j.2020.r0203）

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国际医学放射学杂志 2020年第2期 237-238页

作者： j.Xu B.Zhuang A.Sirajuddin S.Li j.huang G.Yin 李璐 Department of Magnetic Resonance Imaging Fuwai Hospital State Key Laboratory of Cardiovascular Disease Chinese Academy of Medical Sciences and Peking Union Medical College

无延迟钆剂增强(LGE)和血流动力学障碍的肥厚型心肌病(HCM)病人,其固有心肌T1mapping和细胞外容积(ECV)分数值目前尚不清楚。目的用固有心肌T1mapping

关键词： MRI T1 mapping 肥厚型心肌病 DOI.19300/j.2020.r0203 流动力学

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人类排放情景的设计与全球变暖预估

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气候变化研究进展 2024年第2期20卷 261-264页

作者：赵宗慈罗勇黄建斌清华大学地球系统科学系北京100084 中国气象局国家气候中心北京100081 中国科学院大学资源环境学院北京100049

1气候变化的原因全球气候变化除地球系统内部变率外,自然强迫和人为强迫是重要的外部驱动力。其中自然强迫包括太阳活动和火山活动。人为强迫即人类活动,包括大量化石燃料燃烧排放温室气体、土地利用,以及气溶胶与污染排放等,其强度取... 详细信息

1气候变化的原因全球气候变化除地球系统内部变率外,自然强迫和人为强迫是重要的外部驱动力。其中自然强迫包括太阳活动和火山活动。人为强迫即人类活动,包括大量化石燃料燃烧排放温室气体、土地利用,以及气溶胶与污染排放等,其强度取决于人口发展与变化、社会经济发展、技术变化及其内部的协调性等。本文重点给出人类强迫的影响。IPCC第六次评估报告明确表明,近百年特别是近几十年来观测到的全球变暖归因为人类活动的影响。

关键词：太阳活动火山活动排放情景全球变暖社会经济发展全球气候变化人类强迫变率

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全球变暖与沙尘暴

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气候变化研究进展 2023年第5期19卷 667-671页

作者：赵宗慈罗勇黄建斌清华大学地球系统科学系北京100084 中国气象局国家气候中心北京100081 中国科学院大学资源环境学院北京100049

沙尘暴是一种灾害性天气现象,全球每年大约有20亿t的沙尘排放到大气中,包括自然和人为因素造成。世界气象组织(WMO)从2017年开始每年发布《大气浮尘公报》,介绍自2016年以来每年全球沙尘变化[1-2]。全球变暖对沙尘暴的发生和变化有什么... 详细信息

沙尘暴是一种灾害性天气现象,全球每年大约有20亿t的沙尘排放到大气中,包括自然和人为因素造成。世界气象组织(WMO)从2017年开始每年发布《大气浮尘公报》,介绍自2016年以来每年全球沙尘变化[1-2]。全球变暖对沙尘暴的发生和变化有什么影响,是公众关心的问题,本文综述观测到的沙尘暴的变化特征和未来在全球变暖的背景下对沙尘暴变化的预估与展望。

关键词：世界气象组织灾害性天气沙尘暴全球变暖浮尘 WMO 人为因素沙尘排放

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A QFD-ENABLED DESIGN FOR MANUFACTURING APPROACH VIA DESIGN KNOWLEDGE HIERARCHY AND RCE NETWORK

A QFD-ENABLED DESIGN FOR MANUFACTURING APPROACH VIA DESIGN K...

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2006年中国机械工程学会年会暨中国工程院机械与运载工程学部首届年会

作者： CHANG D. F., YAN W., huang Y. F., MI W. j., huang S. j. Logistics Engineering School, Shanghai Maritime University, 1550 Pu Dong Da Dao, Shanghai 200135, China

In recent years, owing to the rapid changing customer needs and short product life cycle than ever before, employing more effective and flexible approaches for new product development (NPD), product c

关键词： Design for manufacturing quality function deployment laddering technique design knowledge hierarchy restricted coulomb energy neural network.

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Effects of hydrogen plasma etching treatment on the structural and optical properties of nano-crystalline diamond films

Effects of hydrogen plasma etching treatment on the structur...

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第18届国际真空大会

作者： L.j. Wang * j. huang R. Xu K. Tang j.j. Zhang Y. B. Xia School of Materials Science & Engineering Shanghai University Shanghai 200072 China

X-ray lithography （XRL） is one of the next generation lithography （NGL） which is the lithography technology slated to replace photolithography beyond the 32 nm node. One of the key factors in X-ray lithography using synchrotron radiation is the manufacture of reliable masks on suitable substrate materials. Diamond has potential as an X-ray mask carrier due to its unique characteristics. However, the surfaces roughness is the greatest obstacle of traditional diamond film for the applications in optical use. Thus, efficient approaches have to be exploited to grow transparent diamond film through reducing micrometer scale diamond grains down to the nanometer scale. In this thesis, nano-crystalline diamond （NCD） films are investigated for X-ray mask to obtain sufficient optical transmittance and surface roughness.

关键词： Nano-crystalline diamond film optical properties chemical vapor deposition

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Influence of the diamond grain size on the electrical properties of nano-crystalline diamond film detectors

Influence of the diamond grain size on the electrical proper...

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第18届国际真空大会

作者： L.j. Wang * j. huang R. Xu K. Tang j.j. Zhang Y. B. Xia School of Materials Science & Engineering Shanghai University Shanghai 200072 China

Recently, there has been increasing scientific interest in the synthesis and characterization of nanocrystalline diamond （NCD） films since these films possess smoother surfaces and lower friction coefficients than microcrystalline diamond （MCD） films. This makes them a better coating material for mechanical applications without tedious, time-consuming, and costly postpolishing. Furthermore, the smoother surfaces and wide band gap make NCD films candidates for advanced optical or electronic components. Especially, diamond film radiation hardness and chemical resistance strongly motivate its use for fabricating detectors operating in hostile environments such as those encountered in the nuclear industry and high energy physics. However, a high surface roughness, up to several hundred nanometers or several microns, makes polycrystalline MCD films unfit for conventional process technique of microelectronics.

关键词： Nano-crystalline diamond film radiation detector chemical vapor deposition

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Local-contrastive-learning machine with both generalization and adversarial robustness: A statistical physics analysis

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 109-123页

作者： Mingshan Xie Yuchen Wang Haiping huang PMI Lab School of Physics Sun Yat-sen University Guangdong Provincial Key Laboratory of Magnetoelectric Physics and Devices Sun Yat-sen University

Distinct from human cognitive processing, deep neural networks trained by backpropagation can be easily fooled by adversarial examples. To design a semantically meaningful representation learning, we discard backpropagation, and instead, propose a local contrastive learning, where the representations for the inputs bearing the same label shrink(akin to boson) in hidden layers,while those of different labels repel(akin to fermion). This layer-wise learning is local in nature, being biologically plausible.A statistical mechanics analysis shows that the target fermion-pair-distance is a key parameter. Moreover, the application of this local contrastive learning to MNIST benchmark dataset demonstrates that the adversarial vulnerability of standard perceptron can be greatly mitigated by tuning the target distance, i.e., controlling the geometric separation of prototype manifolds.

关键词： machine learning statistical mechanics adversarial robustness neural networks

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