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Effect of Tiantai No.1 (天泰1号) on β-Amyloid-induced Neurotoxicity and NF-κ B and cAMP Responsive Element-binding Protein

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Chinese journal of Integrative Medicine 2008年第4期14卷 286-292页

作者：吴正治 Andrew C.j.huang jean de Vellis 李映红 Shenzhen Institute of Integrated Traditional and Western Medicine Department of Medicine Division of EndocrinologyLarry Hillblom Islet Research CenterDavid Geffen School of MedicineUCLALos AngelesCalifornia 90095-7073U.S.A Department of Neurobiology Mental Retardation Research CenterNeuropsychiatric Institute David Geffen School of Medicine at UCLALos AngelesCalifornia 90024-1759U.S.A.

Objective： To investigate the effect and molecular mechanism of Tiantai No.1 （天泰1号）, a compound Chinese herbal preparation, for the prevention and reduction of neurotoxicity induced by betaamyloid peptides （Abeta） in vitro and its effects on nuclear factor-κB （NF-κB） and cAMP responsive element-binding protein （CREB） pathways using the gene transfection technique. Methods： B104 neuronal cells were used to examine the effects of Tiantai No.1 on lowering the neurotoxicity induced by Abeta. The cells were pre-treated with Tiantai No.1 at doses of 50, 100,150, or 200μg/mL respectively for 3 days and co-treated with Tiantai No.1 and beta-amyloid peptidel-40 （Aβ 1-40, 10 μmol/L） for 48 h or post-treated with Tiantai No.1 for 48 h after the cells were exposed to beta-amyloid peptides25-35 （Aβ 25-35） for 8 h. In gene transfection assays, cells were treated with Tiantai No.1 at 50 μg/mL and 150μg/mL for 5 days or co-treated with Tiantai No.1 and A 13 1-40 （5 μmo/L） for 3 days after electroporation for the evaluation of NF- κB and CREB expression. Results： Pre-treating and co-treating B104 neuronal cells with Tiantai No.1 lowered the neurotoxicity induced by Abeta, and post-treating with Tiantai No.1 reduced or blocked B104 neuronal apoptotic death induced by Abeta （P〈0.05, P〈0.01）. With a dose-dependent relationship, the same treatments increased the expression of NF-κB or CREB in B104 neuronal cells （P〈0.05, P〈0.01）. Meanwhile, Tiantai No.1 reduced Aβ-40 induced inhibition on NF-κB expression （P〈0.01）. Conclusions： Tiantai No.1 can protect neurons against the neurotoxicity induced by Abeta. The neuroprotective mechanisms may be associated with the activation of NF-κB and cAMP cellular signal pathways.

关键词： Alzheimer's disease beta-amyloid peptide apoptosis nuclear factor-κB cAMP responsive element-binding protein Tiantai No. 1

Numerical Simulation of Mechanical Properties of Nano Particle Modified Polyamide 6 via RVE Modeling

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journal of Materials Science and Chemical Engineering 2015年第1期3卷 95-102页

作者： j. huang M. Uhrig U. Weber S. Schmauder Institute for Materials Testing Materials Science and Strength of Materials University of Stuttgart Stuttgart Germany

In this paper the physical influences on the mechanical behavior of a Polyamide 6 (PA 6)/Mont- morillonit (MMT)-nanocomposite are examined by a selected structure modification in a numerical parameter study. Experimental data of tensile tests of three different volume fractions at ambient temperature are used as reference. These were compared to homogenized stress-strain curves calculated with 3D representative volume elements (RVE) under periodic boundary conditions, in which the curve areas are considered until the tensile yield strength is reached. Besides the influence of filler orientation, exfoliation and its volume fraction, both adhesive interface behavior between the filler and matrix, and local partially crystalline interphases around the MMT-plates were also taken into account. A good approximation of the numerical representation of the experimental curves was achieved only after the introduction of the 30 - 40 nm thick partially crystalline interphases with higher stiffness and strength around the MMT-plates. The use of an exclusively isotropic matrix led to an underestimation of the mechanical values. The local modifications of the morphology were assumed to be transversely isotropic both in the elastic and in the plastic region. The transverse plane is defined by the lateral particle surface. Compared with the experimentally determined values of the corresponding Young’s Modulus, an excellent correlation was achieved. The yield strength for the largest volume fraction shows the best agreement with experimental values.

关键词： PA 6 Nanocomposite RVE Modeling Mechanical Properties

ECONOMIC ANALYSIS OF SOLAR-POWERED LED ROADWAY LIGHTING

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ECONOMIC ANALYSIS OF SOLAR-POWERED LED ROADWAY LIGHTING

Research and Application of Safety Information and Control System of Nuclear Power Station

2007世界太阳能大会：太阳能与人类居住

作者： B.j.huang Min-Sheng Wu H.H.huang j.W.Chen New Energy Center Department of Mechanical Engineering Taiwan University Taipei Taiwan China

＜正＞The optical efficacy of light emitting diode （LED） has exceeded 72 lm/W in *** implies that energy can be saved about 75%,as compared to mercury lamps used in roadway *** some remote areas where the grid power cannot reach,solar-powered lighting using high-power LED provides a promising ***, the cost of solar photovoltaic device may cause the application of solar-powered LED roadway lighting to be not economically feasible. The present study investigates the design of the solar-powered LED roadway lighting using high-power LED luminaire （100W） and estimate the installation cost for I0 km highway with 2 *** luminaries are installed on both sides of the road with staggered *** pole distance is *** cost comparison of LED lighting using grid and solar power with the conventional mercury lamps was carried *** shows that the installation cost is 22.48 million USD for LED lighting powered by grid power and 30.91 million USD for *** total installation cost of conventional mercury lighting is 18.82 million *** excess cost of LED mainly comes from the cost of LED lamp and solar ***,the cost of power generation and electrical transmission line can be greatly reduced since about 75% energy was saved for *** permits the use of smaller copper wire and shorter line length for solar-powered system which in turns saves installation cost. The payback period for the excess investment of LED is 1.2 years for LED using grid power and 3.3 years for LED using solar power.

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journal of Energy and Power Engineering 2011年第12期5卷 1159-1162页

作者： L.M. Zhang W.j. huang Y.B. Sun G.j. jiang China Nuclear Power Design Co. LTD. Shenzhen 518045 China

The thesis researches the safety infonnation and control system （SICS） design principle and introduces engineering application in CPR1000 nuclear power station in China. The SICS provides sufficient control and monitoring means to bring and maintain the plant in a safe state as a backup of main computerized control mean （MCM）, in any plant conditions that are probable during a planed or unplanned unavailability of the MCM. The successful engineering applications of SICS in different digital I＆C system platform are introduced in the paper. The thesis gives the research conclusion for new general SICS of digital I＆C system.

关键词： Safety information and control system back-up panel emergency control panel.

Estimation of Spring Wheat Water Use Efficiency by Remote Sensing in the Yingke Oasis of Heihe Drainage Area

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Estimation of Spring Wheat Water Use Efficiency by Remote Se...

Fruits and vegetables and risk of stroke

作者： G.j.Yang Z.R.Xing Y.G.Feng W.j.huang China National Engineering Research Center for Information Technology in Agriculture Shandong University of Science and Technology Department of Photogrammetry and Remote Sensing

It has played an important role in precision agriculture for referring to water management,which was accomplished by quantitative remote sensing technology to estimate crop water use ***,it can be useful to improve the benefit of agricultural water *** this study,the selected data were acquired in the growth season of spring *** june,2008,the field measurement was carried out with synchronization of satellite,airborne passing *** production of spring wheat and the water use under the water balance condition as variables,water use efficiency was *** results showed that using remote sensing technology to achieve evaluation of water use efficiency was able to meet the need of agriculture production,and also be worth of application and popularization.

关键词： Quantitative Remote Sensing Heihe Drainage Spring Wheat Water Use Efficiency

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中华物理医学与康复杂志 2014年第8期36卷 613-613页

作者： Hu D huang j Wang Y

BACKGROUND AND OBjECTIVE Improved diet and lifestyle are critical features in cardiovascular disease risk *** cohort studies concerning the effects of fruit and vegetable consumption on the risk of stroke have produced both positive and negative *** meta-analysis was designed to better understand this *** Relevant studies were identified by searching PubMed and EMBASE,including those which measured fruit and vegetable

关键词：蔬菜水果风险中风心血管疾病生活方式队列研究饮食

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郴州市国内旅游客源市场结构研究

消费经济 2006年第2期22卷 59-61,66页

作者：黄静波湘南学院社科系

本文以旅游客源市场结构的有关理论为基础,采用问卷调查法,对郴州市旅游客源市场的空间结构、时间结构、旅游类型结构进行了分析,并就如何开拓郴州市国内旅游客源市场进行了探索。

关键词：客源市场市场结构郴州市旅游市场空间结构时间结构旅游类型结构

Aberrant DKK3 Expression in the Oral Leukoplakia and Oral Submucous Fibrosis: A Comparative Immunohistochemical Study

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Aberrant DKK3 Expression in the Oral Leukoplakia and Oral Su...

PERSPECTIVES IN MECHANICS OF HETEROGENEOUS SOLIDS

2018口腔病理年会暨第十二次全国口腔病理学术会议

作者： T.Al-dhohrah M.Mashrah Z.Yao j.huang Department of Oral Pathology Xiangya Stomatology Hospital Central South University Clinical fellow Department of Oral and Maxillofacial Surgery Xiangya Hospital College of Stomatology Central South University

【Objective】: We aimed to assess and compare the expression of Dickkopf homolog 3(DKK3), a possible tumor suppressor gene(TSG), in oral leukoplakia(OLK) and oral submucous fibrosis(OSF) using immunohistochemistry. 【Methods】: Seventy-five cases of normal oral mucosa(NOM), OLK, OSF, and squamous cell carcinoma(OSCC) were studied. 【Results】: DKK3 was expressed in all cases of NOM, OLK and OSCC. There was steady increases in the percentage of the positive cells progressing toward OSCC. The expression was localized in the cytoplasm and cell membrane of cell affected by OLK with mild dysplasia and OLK with severe dysplasia. No significant association was observed between DKK3 expression and dysplastic status of OLK. Loss of DKK3 expression was observed in 15 of 30 cases in the OSF group, which was significantly associated with histological grade of OSF(P<0.0001). The percentage of positive cells gradually declined with the increasing severity of epithelial atrophy. A significant difference(P<0.01) was observed when comparing DKK3 expression among different groups of OLK and OSF cases. 【Conclusion】: DKK3 may have diverse expressions in oral premalignant lesions. Loss of DKK3 expression in dysplastic/advanced stage of OSF may imply a high risk of progression to oral cancer.

关键词： Oral leukoplakia oral submucous fibrosis DKK3 immunohistochemistry

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Acta Mechanica Solida Sinica 2011年第1期24卷 1-26页

作者： C.Q. Chen j.Z. Cui H.L. Duan X.Q. Feng L.H. He G.K. Hu M.j. huang Y.Z. Huo B.H. ji B. Liu X.H. Peng H.j. Shi Q.P. Sun j.X. Wang Y.S. Wang H.P. Zhao Y.P. Zhao Q.S. Zheng W.N. Zou Department of Engineering Mechanics AML Tsinghua University Beijing 100084 China Academy of Mathematics and Systems Sciences Chinese Academy of Sciences Beijing 100190 China State Key Laboratory for Turbulence and Complex System and Department of Mechanics and Aerospace Engineering College of Engineering Peking University Beijing 100871 China CAS Key Laboratory of Mechanical Behavior and Design of Materials University of Science and Technology of China Hefei Anhui 230026 China School of Aerospace Engineering Beijing Institute of Technology Beijing 100081 China Institute for Advanced Study Nanchang University Nanchang 330031 China Depariment of Mechanics and Engineering Sciences Fudan University 220 Handa Road Shanghai 200433 China Department of Mechanical Engineering Hong Kong University of Science and Technology Hong KongChina Department of Mechanical Engineering Hong Kong University of Science and Technology Hong Kong China Institute of Engineering Mechanics Beijing Jiaotong University Beijing 100044 China State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China

The Micro- and Nano-mechanics Working Group of the Chinese Society of Theoretical and Applied Mechanics organized a forum to discuss the perspectives, trends, and directions in mechanics of heterogeneous materials in january 2010. The international journal, Acta Mechanica Solida Sinica, is de- voted to all fields of solid mechanics and relevant disciplines in science, technology, and engineering, with a balanced coverage on analytical, experimental, numerical and applied investigations. On the occasion of the 30TM anniversary of Acta Mechanica Solida Sinica, its editor-in-chief, Professor Q.S. Zheng invited some of the forum participants to review the state-of-the-art of mechanics of heterogeneous solids, with a particular emphasis on the recent research development results of Chinese scientists. Their reviews are organized into five research areas as reported in different sections of this paper. ~I firstly brings in fo- cus on micro- and nano-mechanics, with regards to several selective topics, including multiscale coupled models and computational methods, nanocrystal superlattices, surface effects, micromechanical damage mechanics, and microstructural evolution of metals and shape memory alloys. ~II shows discussions on multifield coupled mechanical phenomena, e.g., multi-fields actuations of liquid crystal polymer networks, mechanical behavior of materials under radiations, and micromechanics of heterogeneous materials. In ~III, we mainly address the multiscale mechanics of biological nanocomposites, biological adhesive surface mechanics, wetting and dewetting phenomena on microstructured solid surfaces. The phononic crystals and manipulation of elastic waves were elaborated in ~IV. Finally, we conclude with a series of perspectives on solid mechanics. This review will set a primary goal of future science research and engineering application on solid mechanics with the effort of social and economic development.

关键词： heterogeneous materials smart materials biological materials multiscale mechanics micro- and nano-mechanics damage and fracture constitutive relation elastic wave surface effects